Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This article explores the phenomenon of object performance in the US and France in the late 1970s and early 1980s, variously described as tabletop spectacles, ready-made puppetry, and théâtre d’objets. It focuses on the late-1970s work of three artists: Stuart Sherman, Paul Zaloom, and Christian Carrignon (of Théâtre de Cuisine), whose work in this “minor genre” has been widely influential. Examining the shared and diverging formal aspects of their object work, this article argues that their performances are marked (...) by an implied or explicit ecological consciousness and a connection to childhood and play. Situating the emergence of tabletop object performance within the end of the postwar economic boom, the article claims that these artists working in affluent economies invented a playful and incisive response to the growing crisis of the accumulation of waste. Drawing on Michael Marder’s Dump Philosophy, the essay argues that these object performances intervene in the epistemological and material dump of postwar consumer capitalism, offering playful strategies of navigating a world of refuse. The article suggests that these performances continue to resonate in the present day, with object play remaining a viable mode of grappling with the material and psychological overwhelm of our current ecological crises. (shrink)

This book is the first to offer a detailed analysis of Aristotelian and Kantian ethics together, in a way that remains faithful to the texts and responsive to debates in contemporary ethics. Recent moral philosophy has seen a revival of interest in the concept of virtue, and with it a reassessment of the role of virtue in the work of Aristotle and Kant. This book brings that re-assessment to a new level of sophistication. Nancy Sherman argues that Kant preserves (...) a notion of virtue in his moral theory that bears recognisable traces of the Aristotelian and Stoic traditions, and that his complex anthropology of morals brings him into surprising alliance with Aristotle. She develops her argument through close readings of major texts by both Aristotle and Kant, illustrating points of congruence and contrast. (shrink)

Jonathan Lear in Radical Hope tackles the idea of cultural devastation, in the specific case of the Crow Indians. What do we mean by “annihilation” of a culture? The moral point of view that he imagines as he reconstructs the eve and aftermath of this annihilation is not second personal, of obligation, but first personal, in the collective and singular, as told by the Crows, with Lear as “analyst.” Radical Hope is a study of representative character of a people—of virtue, (...) courage, resilience, and hope in the face of cultural collapse. The leading questions are shaped by ancient Greek ethics, but with a twist: On the brink of cultural death , what counts for us as good living and what is the nature of the virtues or excellences that constitute it? How might a leader, a phronimos , exemplify it? This puts it too narrowly. The questions, also, are Wittgensteinian: How does a nation go on, when the concepts and way of life it has lived by for centuries are no more? What does it mean to go on? What does it mean to stop when the marks of going on are no longer? (shrink)

Highlighting the contemporary resurgence of interest in Aristotle's ethical theory, this text contributes to the debate by asserting that, in Aristotle's view, excellence of character is constituted both by the sentiments and by practical reason.

The papers collected in this book share a common motivation: All respond to certain kinds of injustice that unfairly and unreasonably prevent the insights and intellectual abilities of vulnerable and stigmatized groups from being given their due recognition. Most people are opposed to injustice in principle, and do not want to have mistaken views about others. But research in the social sciences reveals a disturbing truth: Even people who intend to be fair-minded and unprejudiced are influenced by unconscious biases and (...) stereotypes, as well as social structures and institutions that lead to unjust judgments. We may sincerely want to be epistemically just, but we frequently fail, and simply thinking harder about it will not fix the problem. -/- This volume collects 17 new essays that draw from cutting-edge social science research, to suggest how we can better manage our own unjust reactions, as well as resist patterns of epistemic injustice that we may face. The volume concludes with an afterward by Miranda Fricker, reflecting on these new lines of research and potential future directions to explore. (shrink)

A deeply informed exploration of what Stoic ideas have to offer us today Stoicism is the ideal philosophy of life for those seeking calm in times of stress and uncertainty. For many, it has become the new Zen, with meditation techniques that help us face whatever life throws our way. Indeed, the Stoics address a key question of our time: how can we be masters of our fate when the outside world threatens to unmoor our well-being? In Stoic Wisdom, Georgetown (...) philosophy professor Nancy Sherman, an expert in ancient and modern ethics, shows what a practical modern Stoicism really looks like. Drawing on the wisdom of Stoic thinkers Epictetus, Marcus Aurelius, Seneca and others, Sherman paints a portrait that uncovers the true subtlety and power of Stoic ideas. That portrait reveals a truth often ignored: that the Stoics never thought self-sufficiency was only about rugged self-reliance and mental discipline. We are at home in the world, they taught, when we are connected to each other in cooperative efforts. While mastery of one's self is essential, we also must draw on our deepest relationships for true strength and resilience. Bringing these ancient ideas to bear on 21st century environments-from Silicon Valley to first responders in a pandemic, to soldiers on the battlefield-Sherman shows how Stoicism can both prepare us for an uncertain future and help us cope with traumatic events. Stoic Wisdom will appeal to anyone feeling helpless or looking for deeper, meaningful strength and goodness in addressing life's biggest and smallest challenges. (shrink)

Drawing on in-depth interviews with service women and men, Nancy Sherman weaves narrative with a philosophical and psychological analysis of the moral and emotional attitudes at the heart of the afterwars. Afterwar offers no easy answers for reintegration. It insists that we widen the scope of veteran outreach to engaged, one-on-one relationships with veterans.

How do attempts to foresee the future actually change it? For thousands of years, humans have called upon foresight to shape their own actions in order to adapt and survive; as Charles Darwin revealed in his theory of natural selection, the capacity to do just that is key to the origin of species. The uses of foresight, however, can also be applied to help us further our understanding across a variety of realms in everything from warfare, journalism and music, to (...) ancient civilizations, space weather and science. In a thought-provoking new addition to the Darwin College Lecture Series, eight distinguished authors each present an essay from their area of expertise devoted to the theme of 'foresight'. This provocative read reveals foresight as a process that can be identified across all areas of human endeavour, an art which can not only predict the future, but make it anything but inevitable. (shrink)

Jeremy Sherman distills Terrence Deacon's breakthrough natural science hypothesis for the emergence of agents and agency, selves and aims in an otherwise aimless universe. The theory cuts a new path through the dualistic spirit vs. mechanism debate, unifying the hard and soft sciences and suggesting new solutions to philosophical mysteries.

IN THIS PAPER I CONSIDER THE VALUE OF FRIENDSHIP FROM AN ARISTOTELIAN POINT OF VIEW. THE ISSUE IS OF CURRENT INTEREST GIVEN RECENT CHALLENGES TO IMPARTIALIST ETHICS TO TAKE MORE SERIOUSLY THE COMMITMENTS AND ATTACHMENTS OF A PERSON. HOWEVER, I ENTER THAT DEBATE IN ONLY A RESTRICTED WAY BY STRENGTHENING THE CHALLENGE ARTICULATED IN ARISTOTLE'S SYSTEMATIC DEFENSE OF FRIENDSHIP AND THE SHARED LIFE. AFTER SOME INTRODUCTORY REMARKS, I BEGIN BY CONSIDERING ARISTOTLE'S NOTION THAT GOOD LIVING OR HAPPINESS ("EUDAIMONIA") FOR AN (...) INDIVIDUAL NECESSARILY INCLUDES THE HAPPINESS OF OTHERS. SHARED HAPPINESS ENTAILS THE RATIONAL CAPACITY FOR JOINTLY PROMOTING COMMON ENDS AS WELL AS THE CAPACITY TO IDENTIFY WITH AND COORDINATE SEPARATE ENDS. THIS EXTENDED NOTION OF HAPPINESS PRESUPPOSES THE EXTENSION OF SELF THROUGH ATTACHMENTS, AND I NEXT CONSIDER CERTAIN MINIMAL CONDITIONS NECESSARY FOR ATTACHMENT. FINALLY, I DISCUSS HOW ARISTOTLE'S NOTION OF A FRIEND AS "ANOTHER SELF" IS COMPATIBLE BOTH WITH A CONCEPTION OF THE SEPARATENESS OF THE INDIVIDUALS AND OF THE DISTINCTIVE WAYS IN WHICH EACH INDIVIDUAL REALIZES VIRTUE WITHIN A SHARED LIFE. (shrink)

While few soldiers may have read the works of Epictetus or Marcus Aurelius, it is undoubtedly true that the ancient philosophy known as Stoicism guides the actions of many in the military. Soldiers and seamen learn early in their training “to suck it up,” to endure, to put aside their feelings and to get on with the mission. This book explores what the Stoic philosophy actually is, the role it plays in the character of the military (both ancient and modern), (...) and its powerful value as a philosophy of life. Marshalling anecdotes from military history—ranging from ancient Greek wars to World War II, Vietnam, and Iraq—the book illuminates the military mind and uses it as a window on the virtues of the Stoic philosophy, which are far richer and more interesting than our popularized notions. The book explores the deep, lasting value that Stoicism can yield, in issues of military leadership and character; in the Stoic conception of anger and its control (does a warrior need anger to go to battle?); and in Stoic thinking about fear and resilience, grief and mourning, and the value of camaraderie and brotherhood. The book concludes by recommending a moderate Stoicism, where the task for the individual, both civilian and military, youth and adult, is to temper control with forgiveness, and warrior drive and achievement with humility and humor. (shrink)

Miranda Fricker’s book Epistemic Injustice calls attention to an important sort of moral and intellectual wrongdoing, that of failing to give others their intellectual due. When we fail to recognize others’ knowledge, or undervalue their beliefs and judgments, we fail in two important respects. First, we miss out on the opportunity to improve and refine our own sets of beliefs and judgments. Second—and more relevant to the term “injustice”—we can deny people the intellectual respect they deserve. Along with describing the (...) wrong of epistemic injustice, Fricker proposes that epistemic justice is a virtue we “can, and should, aim for in practice”. But I argue that there are two major problems. First, it is not clear that it is reasonable to imagine there is any such stable disposition—that is, any such virtue—as the sort of justice she imagines. Second, even if there could be such a virtue, her theory of epistemic justice does not provide good guidance for avoiding epistemic injustice. While it could.. (shrink)

In this paper I explore the Stoic view on attachment to external goods, or what the Stoics call “indifferents.” Attachment is problematic, on the Stoic view, because it exposes us to loss and exacerbates the fragility that comes with needing others and things. The Stoics argue that we can build resilience through a robust reeducation of ordinary emotions and routine practice in psychological risk management techniques. Through a focus on selected writings of Seneca as well as Cicero’s Tusculan Disputations and (...) Marcus Aurelius’s Meditations, I nonetheless ask whether Stoicism leaves any room for grief and distress. I argue that it does, and that consolation comes not from a retreat to some inner citadel, but from the support and sustenance of social connections. (shrink)

Moral emotions are evolved mechanisms that function in part to optimize social relationships. We discuss two moral emotions— disgust and the “cuteness response”—which modulate social-engagement motives in opposite directions, changing the degree to which the eliciting entity is imbued with mental states (i.e., mentalized). Disgust-inducing entities are hypo-mentalized (i.e., dehumanized); cute entities are hyper-mentalized (i.e., “humanized”). This view of cuteness—which challenges the prevailing view that cuteness is a releaser of parental instincts (Lorenz, 1950/1971)—explains (a) the broad range of affiliative behaviors (...) elicited by cuteness, (b) the marketing of cuteness to children (by toy makers and animators) to elicit play, and (c) the apparent ease and frequency with which cute things are anthropomorphized. (shrink)

It is commonly held that the context with respect to which an indexical is interpreted is determined independently of the interpretation of the indexical. This view, which I call Context Realism, has explanatory significance: it is because the context is what it is that an indexical refers to what it does. In this paper, I provide an argument against Context Realism. I then develop an alternative that I call Context Constructivism, according to which indexicals are defined not in terms of (...) features of utterance situations, but rather in terms of roles that objects could play. (shrink)

Sherman presents a slightly revised definition of empathy, in which empathy is the cognitive ability to place oneself in the world of another, imagining all of the realities, feelings, and circumstances of that person in the context of their world.

We often hold people morally responsible for their emotions. We praise individuals for their compassion, think less of them for their ingratitude or hatred, reproach self-righteousness and unjust anger. In the cases I have in mind, the ascriptions of responsibility are not simply for offensive behaviors or actions which may accompany the emotions, but for the emotions themselves as motives or states of mind. We praise and blame people for what they feel and not just for how they act. In (...) cases where people may subtly mask their hatred or ingratitude through more kindly actions, we still may find fault with the attitude we see leaking through the disguise. (shrink)

When epistemologists talk about knowledge, the discussions traditionally include only a small class of other epistemic notions: belief, justification, probability, truth. In this paper, we propose that epistemologists should include an additional epistemic notion into the mix, namely the notion of assuming or taking for granted.

Algorithms are powerful because we invest in them the power to do things. With such promise, they can transform the ordinary, say snapshots along a robotic vacuum cleaner’s route, into something much more, such as a clean home. Echoing David Graeber’s revision of fetishism, we argue that this easy slip from technical capabilities to broader claims betrays not the “magic” of algorithms but rather the dynamics of their exchange. Fetishes are not indicators of false thinking, but social contracts in material (...) form. They mediate emerging distributions of power often too nascent, too slippery or too disconcerting to directly acknowledge. Drawing primarily on 2016 ethnographic research with computer vision professionals, we show how faith in what algorithms can do shapes the social encounters and exchanges of their production. By analyzing algorithms through the lens of fetishism, we can see the social and economic investment in some people’s labor over others. We also see everyday opportunities for social creativity and change. We conclude that what is problematic about algorithms is not their fetishization but instead their stabilization into full-fledged gods and demons – the more deserving objects of critique. (shrink)

Smart city discourses often invoke the Panopticon, a disciplinary architecture designed by Jeremy Bentham and popularly theorized by Michel Foucault, as a model for understanding the social impact of AI technologies. This framing focuses attention almost exclusively on the negative ramifications of Urban AI, correlating ubiquitous surveillance, centralization, and data consolidation with AI development, and positioning technologies themselves as the driving factor shaping privacy, sociality, equity, access, and autonomy in the city. This paper describes an alternative diagram for Urban AI—the (...) Polyopticon: a distributed, polyvalent, multi-modal network of synthetic intelligences. It posits that fourth industrial revolution technologies change the political, social, and psychodynamic relationships of sentience and witness in the city, shifting the effects of watching and watched beyond the exclusive domain of top-down surveillance and discipline. The Polyopticon poses a more expansive and ambivalent spectrum of possibilities for Urban AI scenarios, one that undermines the totalizing, singular, and cerebral notion of intelligence that so often characterizes Urban AI and smart city critiques. (shrink)

This essay explores a set of attitudes and capacities that I describe as eudaimonist virtues of argumentation. These include an ability to enter into alternative viewpoints, a genuine desire to persuade rather than merely to seem clever, an understanding of human nature and motives, and a recognition that much of what matters most is hard to define and impossible to measure. What makes these attitudes and capacities eudaimonist virtues rather than merely epistemic virtues is that they make possible a way (...) of arguing which is conducive not just to knowledge and truth but to also thriving more broadly. This way of arguing, rooted in empathetic engagement, is conducive to thriving because it calls upon and thus helps nurture forms of insight that can help us live rich and full lives both as individuals and in community. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

Why can I not appropriately utter ‘It must be raining’ while standing outside in the rain, even though every world consistent with my knowledge is one in which it is raining? The common response to this problem is to hold that epistemic must, in addition to quantifying over epistemic possibilities, carries some additional evidential information concerning the source of one'S evidence. I argue that this is a mistake: epistemic modals are mere quantifiers over epistemic possibilities. My central claim is that (...) the seeming anomaly of the data above arises from a mistaken conception of what a possibility is. Instead of conceiving of possibilities as possible worlds, I argue that we should conceive of possibilities as answers to open questions. (shrink)

When we think about Kantian virtue, what often comes to mind is the notion of respect. Respect is due to all persons merely in virtue of their status as rational agents. Indeed, on the Kantian view, specific virtues, such as duties of beneficence, gratitude, or self-perfection, are so many ways of respecting persons as free rational agents. To preserve and promote rational agency, to protect individuals from threats against rational agency, i.e., to respect persons, is at the core of virtue. (...) No doubt, part of the appeal of the Kantian notion of respect is that it offers an intuitive way of talking about the wrongness of manipulation and coercion, and in general, the wrongness of unfairly taking advantage of another. For to respect persons is to take seriously their status as persons, and to forswear, at some level, actions and attitudes that would compromise their dignity. Talking about respect has become shorthand for signaling deontological concerns. More formally, within recent Kantian exegesis, respect is viewed as yielding a more accessible and less contrived account of the Categorical Imperative than the more traditional criterion of universalizability and the contradictions tests applied to it. Within the Kantianinspired political theory of John Rawls, respect is also a core notion, representing a pervasive good, the bases of which, just states have an obligation to distribute to their members. Yet, for all its appeal, respect is an odd feature of Kantian ethics. For it is an emotion in a theory that prides itself in grounding morality in principles of reason alone. In this essay, I draw attention to the importance of respect in Kant's account in order to show just how he makes room for the emotions. Indeed, I shall argue that on Kant's account of full moral agency, we are emotional as well as rational creatures. Although Kant often portrays respect as an abstract emotional attitude mysteriously connected to our rationality, I argue that on a suitable revision, respect can be transformed into a more concrete attitude, cultivated and expressed alongside other emotions requisite for full virtue. (shrink)

In the current race to develop general-purpose artificial intelligence (AI), there is a growing trend to overlook safety and ethical considerations. As general-purpose AI evolves, especially if it advances into a new species, will it compete with and eventually replace humans? This article argues that AI is merely a small technical domain within the broader human automation technology system and therefore cannot replace humans. However, due to its inherent limitation of possessing instrumental rationality but lacking value rationality, AI may be (...) misused in ways that could destroy humanity. The article concludes by pointing out that technical research and application, including AI, if overly focused on instrumental rationality while neglecting value rationality, will ultimately serve as fuel for yet another human disaster. (shrink)

In this article, we describe four theoretical and methodological problems that have impeded implicit attitude research and the popular understanding of its findings. The problems all revolve around assumptions made about the relationships among measures, constructs, cognitive processes, and features of processing. These assumptions have confused our understandings of exactly what we are measuring, the processes that produce implicit evaluations, the meaning of differences in implicit evaluations across people and contexts, the meaning of changes in implicit evaluations in response to (...) intervention, and how implicit evaluations predict behavior. We describe formal modeling as one means to address these problems, and provide illustrative examples. Clarifying these issues has important implications for our understanding of who has particular implicit evaluations and why, when those evaluations are likely to be particularly problematic, how we might best try to change them, and what interventions are best suited to minimize the effects of implicit evaluations on behavior. (shrink)

In this paper I explore the role of manners and morals. In particular, what is the connection between emotional demeanor and the inner stuff of virtue? Does the fact that we can pose faces and hide our inner sentiments, i.e., 'fake it,' detract from or add to our capacity for virtue? I argue, following a line from the Stoics, that it can add to our virtue and that, as a result, moral education needs to take seriously both a commitment to (...) good character and a commitment to the 'aesthetic' of character. (shrink)

The Equal Weight View holds that, when we discover we disagree with an epistemic peer, we should give our peer’s judgment as much weight as our own. But how should we respond when we cannot tell whether those who disagree with us are our epistemic peers? I argue for a position I will call the Earn-a-Spine View. According to this view, parties to a disagreement can remain confdent, at least in some situations, by fnding justifable reasons to think their opponents (...) are less credible than themselves, even if those reasons are justifable only because they lack information about their opponents. (shrink)

According to Thomas Kelly, traditional skeptical arguments can be conceived in terms of bias. The main aim of this paper is not to challenge Kelly’s conclusions, but rather to draw some interesting consequences from them. Specifically, in addition to cases of biased judgments, which draw the ire of the skeptic, there are also cases of biased suspension of judgment. By examining cases of racially biased suspension of judgment and comparing them to cases of skepticism, I argue that we can help (...) to uncover the mechanism that underlies the skeptic’s accusation of bias. In particular, I aim to show that it is the conclusiveness of one’s evidence, rather than the likelihood of the possibility at issue, that matters to the skeptic. (shrink)

Focusing on the notion of the subject in Sartre's and Adorno's philosophies, David Sherman argues that they offer complementary accounts of the subject that ...

The Equal Weight View holds that, when we discover we disagree with an epistemic peer, we should give our peer’s judgment as much weight as our own. But how should we respond when we cannot tell whether those who disagree with us are our epistemic peers? I argue for a position I will call the Earn-a-Spine View. According to this view, parties to a disagreement can remain confident, at least in some situations, by finding justifiable reasons to think their opponents (...) are less credible than themselves, even if those reasons are justifiable only because they lack information about their opponents. (shrink)