This study assessed self-reported health-related quality of life and psychological adjustment in 43 adolescents and young adults with congenital melanocytic nevi and examined associations with sociodemographic variables, characteristics of the CMN, perceived social reactions, and cognitive emotion regulation strategies. Outcome measures included the Pediatric Quality of Life Inventory™ 4.0 and the Strengths and Difficulties Questionnaire. Findings suggest impaired psychosocial health and psychological adjustment in youth with CMN compared to community norms. Impairments were associated with higher age of participants, lower socioeconomic (...) status, visibility of the skin lesion, perceived stigmatization, poorer perceived social support, and maladaptive cognitive emotion regulation strategies, but not with sex of participants, extent of the skin lesion, and surgical removal of the nevus. Implications for clinical practice and future research are discussed. (shrink)

Normativism in the theory of meaning and content is the view that linguistic meaning and/or intentional content are essentially normative. As both normativity and its essentiality to meaning/content can be interpreted in a number of different ways, there is now a whole family of views laying claim to the slogan “meaning/content is normative”. In this essay, we discuss a number of central normativist theses, and we begin by identifying different versions of meaning normativism, presenting the arguments that have been put (...) forth for and against them. (shrink)

As meaning's claim to normativity has grown increasingly suspect the normativity thesis has shifted to mental content. In this paper, we distinguish two versions of content normativism: 'CE normativism', according to which it is essential to content that certain 'oughts' can be derived from it, and 'CD normativism', according to which content is determined by norms in the first place. We argue that neither type of normativism withstands scrutiny. CE normativism appeals to the fact that there is an essential connection (...) between content and correctness conditions. But, we argue, this fact is by itself normatively innocent, and attempts to add a normative dimension via the normativity of belief ultimately fail. CD normativism, in turn, falls prey to the 'dilemma of regress and idleness': the appeal to rules either leads to some form of regress of rules, or the notion of rule-following is reduced to an idle label. We conclude by suggesting that our arguments do not support naturalism: it is a mistake to assume that normativism and naturalism are our only options. (shrink)

Today, many philosophers think that perceptual experiences are conscious mental states with representational content and phenomenal character. Subscribers to this view often go on to construe experience more precisely as a propositional attitude sui generis ascribing sensible properties to ordinary material objects. I argue that experience is better construed as a kind of belief ascribing 'phenomenal' properties to such objects. A belief theory of this kind deals as well with the traditional arguments against doxastic accounts as the sui generis view. (...) Moreover, in contrast to sui generis views, it can quite easily account for the rational or reason providing role of experience. (shrink)

We have argued against the thesis that content is essentially normative (Glüer & Wikforss 2009). In the course of doing so, we also presented some considerations against the thesis that belief is essentially normative. In this paper we clarify and develop these considerations, thereby paving the road for a fully non-normative account of the nature of belief.

We explore the possibility of characterizing belief wholly in terms of its first-order functional role, its input (evidence) and output (further beliefs and actions), by addressing some common challenges to the view. One challenge concerns the fact that not all belief is evidence-sensitive. In response to this, normativists and teleo-functionalists have concluded that something over and above functional role is needed, a norm or a telos. We argue that both allow for implausibly much divergence between belief and evidence. Others have (...) suggested that belief should be saved as the evidence-sensitive attitude, by making it share its motivational role with an unrecognized state: alief. We argue that the appeal to alief faces a dilemma: Either explanation of intentional action by means of alief is a species of intentional explanation, in which case it becomes hard to distinguish alief from (irrational) belief, or alief is sufficiently different from belief, but then neither the explanation nor the explanandum (action) are recognizably intentional any longer. We conclude that the most promising way forward is an account of belief that makes use of the full functional role of belief, including its role in theoretical reasoning. (shrink)

Natural kind terms have exercised philosophical fancy ever since Kripke, in Naming and Necessity, claimed them to be rigid designators. He there drew attention to the peculiar, name-like behavior of a family of prima facie loosely related general terms of ordinary English: terms such as ‘water’, ‘tiger’, ‘heat’, and ‘red’. Just as for ordinary proper names, Kripke argued that such terms cannot be synonymous with any of the definite descriptions ordinary speakers associate with them. Rather, the name-like behavior of these (...) so-called natural kind terms is to be explained, just as in in the case of proper names, by the doctrine of rigid designation. And as a consequence of thus extending the notion of rigid designation to general terms, he famously endorsed the claim that so-called ‘theoretical identifications’, i.e. statements like (1) Water is H2O, are necessary, if true. (shrink)

According to the received view the later Wittgenstein subscribed to the thesis that speaking a language requires being guided by rules (thesis RG). In this paper we question the received view. On its most intuitive reading, we argue, (RG) is very much at odds with central tenets of the later Wittgenstein. Giving up on this reading, however, threatens to deprive the notion of rule-following of any real substance. Consequently, the rule-following considerations cannot charitably be read as a deep and subtle (...) defense of (RG) against the threat of paradox, as proponents of the received view are wont to do. Instead, we argue, the rule-following considerations provide Wittgenstein's deep and subtle reasons for rejecting the very idea that speaking a language involves rule-guidance. Although Wittgenstein subscribed to (RG) during his middle period writings, his later remarks on rules, far from being a clarification and elaboration of his earlier views, are directed against the claim of the middle period that speaking a language is an essentially rule-guided activity. (shrink)

Donald Davidson famously held that only beliefs provide reasons for belief. Perceptual experiences, he held, are not even propositional attitudes, and thus doubly disqualified from being reason providers. John McDowell and others have tried to restore the intuitive reason-providing role of experience by suggesting that experiences do have contents. However, on McDowell’s account, experiences provide ‘reasons’ in a sense very different from the Davidsonian. In this paper, I argue that there is a better way of rescuing the reason-providing role of (...) experience: Construed as a (special) kind of belief, experience provides reasons for belief in precisely the Davidsonian sense. Moreover, the doxastic account of experience I suggest integrates naturally both with the Davidsonian picture of content determination and, consequently, with Davidsonian anti-skepticism. (shrink)

In previous work, I have defended a non-standard version of intentionalism about perceptual experience. According to the doxastic account, visual experience is a peculiar kind of belief: belief with “phenomenal” or looks-content. In this paper, I investigate what happens if this account of experience is combined with another idea I find very plausible: That the colors are to be understood in terms of color experience. I argue that the resulting phenomenal account of color experience captures everything essential to what has (...) been called the “natural concept of color”. And I show that circularity worries are not aggravated by adopting this account instead of more standard forms of intentionalism—rather, they can be dispelled along the same lines. (shrink)

A natural way of understanding (non-epistemic) looks talk in natural language is phenomenalist: to ascribe looks to objects is to say something about the way they strike us when we look at them. This explains why the truth values of looks-sentences intuitively vary with the circumstances with respect to which they are evaluated. But Mike Martin (2010) argues that there is no semantic reason to prefer a phenomenalist understanding of looks to “Parsimony”, the position according to which looks are basic (...) visible properties. He suggests a semantics for looks-sentences that explains their intuitive truth values and is compatible with Parsimony. I argue that there is semantic reason to prefer a phenomenalist understanding of looks to a parsimonious one since there is a simpler semantics compatible with a phenomenalist understanding of looks, but not with Parsimony. This semantics provides a better explanation of the relevant truth value distribution. (shrink)

Or, in Donald Davidson’s much quoted words: “What is it for words to mean what they do?” (Davidson 1984, xiii). Davidson himself suggested approaching this matter by asking two different questions: What form should a formal semantics take? And: What is it that makes a semantic theory correct for a particular language, i.e. what determines meaning? The second question concerns the place of semantic facts in a wider metaphysical space: How do these facts relate to non-semantic facts? Can they be (...) reduced to non-semantic facts, do they merely supervene on non-semantic facts, or are they something like metaphysical primitives? In the second half of the Twentieth Century, philosophers of language have been especially interested in the relation between semantic facts and facts that can be described in naturalistic terms, and different versions of reductive and non-reductive naturalism have been discussed. Another, though related, debate concerns the question whether the facts determining meaning (and thought content) are facts in some sense internal, or external, to the subject saying or thinking something. (shrink)

Eukaryotic DNA replication initiates at multiple origins. In early fly and frog embryos, chromosomal replication is very rapid and initiates without sequence specificity. Despite this apparent randomness, the spacing of these numerous initiation sites must be sufficiently regular for the genome to be completely replicated on time. Studies in various eukaryotes have revealed that there is a strict temporal separation of origin “licensing” prior to S phase and origin activation during S phase. This may suggest that replicon size must be (...) already established at the licensing stage. However, recent experiments suggest that a large excess of potential origins are assembled along chromatin during licensing. Thus, a regular replicon size may result from the selection of origins during S phase. We review single molecule analyses of origin activation and other experiments addressing this issue and their general significance for eukaryotic DNA replication. BioEssays 25:116–125, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In the haptic domain, a double dissociation can be proposed on the basis of neurological deficits between tactile information for action, represented by tactile apraxia, and tactile information for perception, represented by tactile agnosia. We suggest that this dissociation comes from different networks, both involving the anterior intraparietal area of the posterior parietal cortex.

In dieser Arbeit werden die Verhandlungen in der UNO uber eine internationale Regelung des Humanklonens analysiert: vom Beginn der Verhandlungen, uber die jahrelangen Debatten, bis zum Abbruch der Bemuhungen, werden die Ereignisse zunachst chronologisch aufgearbeitet und erlautert. Dem folgt eine genaue Darstellung der verschiedenen Positionen in der UNO. Anschliessend werden die Hintergrunde der Verhandlungen naher beleuchtet und die Ursachen fur deren Scheitern erforscht. Dazu wird zum einen auf die ethische und rechtliche Bewertung des Humanklonens und den Einfluss der Religionen eingegangen. (...) Zum anderen werden nationale Regelungen ausgewahlter Lander dargestellt und andere politische Einflusse betrachtet. Die Arbeit endet mit der Suche nach alternativen Losungsmoglichkeiten.". (shrink)

In _Form, Matter, Substance_, Kathrin Koslicki defends a hylomorphic analysis of concrete particular objects (e.g., living organisms). The Aristotelian doctrine of hylomorphism holds that those entities that fall under it are compounds of matter (hulē) and form (morphē or eidos). Koslicki argues that a hylomorphic analysis of concrete particular objects is well-equipped to compete with alternative approaches when measured against a wide range of criteria of success. A successful application of the doctrine of hylomorphism to the special case of (...) concrete particular objects, however, hinges on how hylomorphists conceive of the matter composing a concrete particular object, its form, and the hylomorphic relations which hold between a matter-form compound, its matter and its form. Through the detailed answers to these questions Koslicki develops in this book, matter-form compounds, despite their metaphysical complexity, emerge as occupying the privileged ontological status traditionally associated with substances, due in particular to their high degree of unity. (shrink)

The potential of large language models (LLM) has captured the imagination of the public and researchers alike. In contrast to previous generations of machine learning models, LLMs are general-purpose tools, which can communicate with humans. In particular, they are able to define terms and answer factual questions based on some internally represented knowledge. Thus, LLMs support functionalities that are closely related to ontologies. In this perspective article, I will discuss the consequences of the advent of LLMs for the field of (...) applied ontology. (shrink)

New techniques for the genetic modification of organisms are creating new strategies for addressing persistent public health challenges. For example, the company Oxitec has conducted field trials internationally—and has attempted to conduct field trials in the United States—of a genetically modified mosquito that can be used to control dengue, Zika, and some other mosquito-borne diseases. In 2016, a report commissioned by the National Academies of Sciences, Engineering, and Medicine discussed the potential benefits and risks of another strategy, using gene drives. (...) Driving a desired genotype through a population of wild animals or insects could lead to irreversible genetic modification of an entire species. The NASEM report recommends community, stakeholder, and public engagement about potential uses of the technology, and it argues that the engagement should occur as research advances, well before gene drives are deployed. Yet what “engagement” means in practice is unclear. This article seeks clarity on this problem by offering a justification for community engagement and drawing out implications of this argument for the implementation and desired outcomes of community engagement. Community engagement is essential when it comes to research that would release genetically modified insects or animals into the environment. By contrast, obtaining informed consent from people who live near such a proposed field trial is neither necessary nor sufficient. Drawing on the epistemic and moral arguments for deliberative democracy, I propose two discrete mechanisms of community engagement: community advisory boards and deliberative forums, neither of which has been systematically incorporated into research governance. The proposed mechanisms would engender respect for persons who live near field trials, even when the results of deliberation override some individuals’ preferences. Community engagement foregrounds the community in our thinking about humans’ relationship to nature, and it implies that deciding to release genetically modified insects or animals into the wild ought to be a collective decision, not one made by product developers, policy-makers, private companies, research funders, or scientists alone. (shrink)

Ontology development methodologies emphasise knowledge gathering from domain experts and documentary resources, and knowledge representation using an ontology language such as OWL or FOL. However, working ontologists are often surprised by how challenging and slow it can be to develop ontologies. Here, with a particular emphasis on the sorts of ontologies that are content-heavy and intended to be shared across a community of users (reference ontologies), we propose that a significant and heretofore under-emphasised contributor of challenges during ontology development is (...) the need to create, or bring about, consensus in the face of disagreement. For this reason reference ontology development cannot be automated, at least within the limitations of existing AI approaches. Further, for the same reason ontologists are required to have specific social-negotiating skills which are currently lacking in most technical curricula. (shrink)

The objects we encounter in ordinary life and scientific practice - cars, trees, people, houses, molecules, galaxies, and the like - have long been a fruitful source of perplexity for metaphysicians. The Structure of Objects gives an original analysis of those material objects to which we take ourselves to be committed in our ordinary, scientifically informed discourse. Koslicki focuses on material objects in particular, or, as metaphysicians like to call them "concrete particulars", i.e., objects which occupy a single region of (...) space-time at each time at which they exist and which have a certain range of properties that go along with space-occupancy, such as weight, shape, color, texture, and temperature. The Structure of Objects focuses in particular on the question of how the parts of such objects, assuming that they have parts, are related to the wholes which they compose. (shrink)

In this paper, I interrogate an ethical obligation to participate in genomics research on the basis of solidarity. I explore two different ways in which solidarity is used to motivate participation in genomics research: as an appeal to participate in genomic research because it cultivates solidarity and as an appeal to participate in genomic research because it expresses solidarity. I critique those appeals and draw lessons from them for how we ought to understand solidarity. The working definition of solidarity that (...) I defend is that solidarity involves recognizing another creature, person, or persons as, like ourselves, vulnerable to injustice and entails acting in ways that contribute to creating, reforming, and participating in institutions that are aimed at enhancing their flourishing. I argue that participating in genomics research is not an expression of solidarity. Participation in research may be praiseworthy, a “good thing to do,” but actually cultivating and expressing solidarity requires much more of us. (shrink)

One of the tasks of ontology in information science is to support the classification of entities according to their kinds and qualities. We hold that to realize this task as far as entities such as material objects are concerned we need to distinguish four kinds of entities: substance particulars, quality particulars, substance universals, and quality universals. These form, so to speak, an ontological square. We present a formal theory of classification based on this idea, including both a semantics for the (...) theory and a provably sound axiomatization. (shrink)

The goal of the 2010 Ontology Summit was to address the current shortage of persons with ontology expertise by developing a strategy for the education of ontologists. To achieve this goal we studied how ontologists are currently trained, the requirements identified by organizations that hire ontologists, and developments that might impact the training of ontologists in the future. We developed recommendations for the body of knowledge that should be taught and the skills that should be developed by future ontologists; these (...) recommendations are intended as guidelines for institutions and organizations that may consider establishing a program for training ontologists. Further, we recommend a number of specific actions for the community to pursue. (shrink)

Vielen Menschen ist die Bekämpfung des Klimawandels wichtig. Studien zeigen, dass die Mehrheit der Deutschen den Klimawandel als Bedrohung wahrnimmt und neben großen Unternehmen und politischen Akteuren auch jedem Einzelnen eine Verantwortung dafür zuschreibt. Trotz der verbreiteten Ansicht, dass ein nachhaltiger Lebensstil etwas bewirken kann, handeln sehr viele Menschen häufig nicht dementsprechend. Dieses Phänomen, welches die Diskrepanz zwischen der Einstellung und dem Verhalten einer Person beschreibt, nennt man Attitude-Behavior-Gap. In diesem Beitrag wird ein Brettspiel vorgestellt, das bereits mit Schülerinnen und (...) Schülern der Sekundarstufe I gespielt werden kann und drei Ziele verfolgt. Zunächst soll die individuelle Lücke zwischen Einstellung und Verhalten ermittelt und veranschaulicht werden. Danach werden die vielfältigen Gründe für den Attitude-Behavior-Gap offengelegt und schließlich Möglichkeiten für die Verkleinerung der individuellen Einstellungs-Verhaltens-Lücke erkundet. (shrink)

It is now increasingly accepted that many existing biological and medical ontologies can be improved by adopting tools and methods that bring a greater degree of logical and ontological rigor. In this chapter we will focus on the merits of a logically sound approach to ontologies from a methodological point of view. As we shall see, one crucial feature of a logically sound approach is that we have clear and functional definitions of the relational expressions such as ‘is a’ and (...) ‘part of ’. (shrink)

The question “What is it to be an artifact?” must be distinguished from the question “What is it to be an artifact of kind K?”. Failure to distinguish between these two questions leads to an exaggeration of the role of intentions in the philosophy of artifacts. We accept that intentions are necessary to define the category of artifacts, but we reject the view that intentions are constitutive of what makes something a specific kind of artifact. In the first part of (...) this paper, we discuss a series of cases involving what we call “faith-based artifacts” which often exhibit a social dimension. These cases, we argue, constitute counterexamples to the thesis that something is an artifact of a specific kind if it was produced with the intention that it be an object of that kind. In the second part of the paper, we explain how a capacity-based approach to artifacts, by contrast, can accommodate faith-based artifacts. In the last section, we address an objection to the capacity-based approach. (shrink)

Der Klimawandel ist eine der größten - wenn nicht sogar die größte - Herausforderung unserer Zeit. Bereits heute sind deutliche Auswirkungen auf Ökosysteme, Wirtschaft und soziokulturelle Strukturen spürbar, und es ist zu erwarten, dass diese in Zukunft weiter zunehmen werden. Dass wir Menschen maßgeblich zu diesem Problem beigetragen haben, ist inzwischen überwiegender Konsens. Auch sind sich die meisten Menschen darüber bewusst, dass Maßnahmen ergriffen werden müssen, um dem fortschreitenden Klimawandel entgegenzuwirken. Doch welche konkreten Schritte sind erforderlich? Und wer trägt dafür (...) die Verantwortung? Diesen und anderen Fragen widmen sich die interdisziplinären Beiträge in diesem Buch. Die Diskussion wird ergänzt durch praxisnahe Unterrichtsbeispiele sowie Vorschläge für die Implementierung einer Bildung für nachhaltige Entwicklung (BNE) in der Lehrkräfteausbildung. Die HerausgeberinMeike Neuhaus ist Philosophin und lehrt Philosophiedidaktik und Angewandte Ethik an der Technischen Universität Dortmund. (shrink)

Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human suffering due to autism spectrum disorders, depression, and schizophrenia. These calls, however, typically do not acknowledge, much less address, criticisms of model creation and validation, or concerns about scientific conduct more generally. The ethical justification for the use of nonhuman animals in research depends on the production of benefits to humans based on such research. But the assessment and production of (...) benefits are highly uncertain and rife with both practical and conceptual challenges. This essay provides a general framework for classifying the benefits of biomedical research and then focuses on two factors that directly impact—and threaten—the production of knowledge in research that models neuropsychiatric disorders. (shrink)

This inaugural lecture, delivered on 17 November 2021 at the University of Neuchâtel, addresses the question: Are material objects analyzable into more basic constituents and, if so, what are they? It might appear that this question is more appropriately settled by empirical means as utilized in the natural sciences. For example, we learn from physics and chemistry that water is composed of H2O-molecules and that hydrogen and oxygen atoms themselves are composed of smaller parts, such as protons, which are in (...) turn composed of yet smaller parts, such as quarks, and so on. While the question at the center of this lecture might thus appear to fall more appropriately into the empirical domain of natural science, I argue that metaphysics in fact has an important role to play in determining how best to answer the question before us. More concretely, I propose that the Aristotelian doctrine of hylomorphism, when appropriately interpreted, provides the best metaphysical answer to the question of whether and how material objects are analyzable into more basic constituents. Hylomorphism holds that those entities to which this doctrine applies are, in some sense, compounds of matter (“hylē”) and form (“morphē” or “eidos”). Thus, the title of this lecture, “Form, Matter, Substance”, refers to the claim that lies at the center of the doctrine of hylomorphism, as applied to the domain of material objects, namely that sensible substances are the result of combining matter and form in the right sort of way; or, for short, “form + matter = substance”. I begin in Section II by providing some historical background which brings out Aristotle’s motivations for proposing the doctrine of hylomorphism in the context of his analysis of change. Section III turns to some of the main features of the contemporary hylomorphic theory I have defended especially in Koslicki (2008) and Koslicki (2018). Section IV discusses some challenging questions concerning artifacts which arise for both hylomorphic and other approaches to the metaphysics of concrete particular objects. Section V concludes by summarizing why, as contemporary metaphysicians, we should prefer a hylomorphic theory over its competitors as an analysis of concrete particular objects that is compatible with our current scientific understanding of the world. (shrink)

The aim of this paper is to clarify the distinctive and the shared features of the three phenomena: irony, understatement, and litotes. These rhetorical figures have been defined as synonymous, distinct or overlapping in various accounts. This indicates an interrelation but also a need for clearer definitions. Here, each of these rhetorical figures is defined via two jointly necessary conditions. This approach sharpens the categories, enables clear-cut distinctions and helps to explain cases of overlap. German corpus data and examples from (...) the literature as a basis, allow differentiating between cases of understatement as a means of irony, and cases of litotes as a means of understatement. Beyond that, litotes and understatement allow for non-ironic uses. Interestingly, litotic irony is built on litotic understatement. This is due to the overt contrast necessary for both understatement and irony. (shrink)

A significant reorientation is currently under way in analytic metaphysics, away from an almost exclusive focus on questions of existence and towards a greater concentration on questions concerning the dependence of one type of phenomenon on another. Surprisingly, despite the central role dependence has played in philosophy since its inception, interest in a systematic study of this concept has only recently surged among contemporary metaphysicians. In this paper, I focus on a promising account of ontological dependence in terms of a (...) non-modal and sufficiently constrained conception of essence developed by Kit Fine. I argue that even this essentialist account is, as it stands, not fine-grained enough to recognize different varieties of dependence which ought to be distinguished even within the realm of ontology. In some cases, an entity may be ontologically dependent on its essential constituents out of which it is constructed; but in other cases, an entity may be ontologically dependent on another for a different reason. A framework which glosses over these differences does not offer a proper diagnosis of why one entity ontologically depends on another. (shrink)

Anthropogenic climate change poses a significant threat to the environment and society, requiring comprehensive Education for Sustainable Development (ESD) to promote sustainable thinking and action. Philosophy education faces the challenge of balancing value-based teaching with fostering critical thinking skills. Additionally, educators must address issues such as climate-change-helplessness and the attitude-behavior-gap. This paper explores how philosophy education can support a reflective and action-oriented approach to climate change and evaluates the Future-Workshop-method through an empirical pilot study conducted at two schools in North (...) Rhine-Westphalia. (shrink)

The following paper discusses Schiller’s interpretation of the German concept of Bildung. Bildung appears to be a central term in Germany’s culture, especially (but not limited to) the educational realm. As Bildung underwent massive transformations and has been re-interpreted multiple times throughout German history, this paper will start with a definitory exercise trying to organize the dynamics surrounding the term. Secondly, a two-fold historical context – firstly regarding the wider political and social dynamics of the time and secondly, a more (...) biographical approach focusing on Schiller – will be provided. These contextualizing efforts will be succeeded by elaborations on Schiller’s concept of Herzensbildung. The paper closes with a summary of key insights and further potential endeavors. (shrink)

Non-human animal models of human diseases advance our knowledge of the genetic underpinnings of disease and lead to the development of novel therapies for humans. While mice are the most common model organisms, their usefulness is limited. Larger animals may provide more accurate and valuable disease models, but it has, until recently, been challenging to create large animal disease models. Genome editors, such as Clustered Randomised Interspersed Palindromic Repeat, meet some of these challenges and bring routine genome engineering of larger (...) animals and non-human primates well within reach. There is growing interest in creating NHP models of brain disorders such as autism, depression and Alzheimer’s, which are very difficult to model or study in other organisms, including humans. New treatments are desperately needed for this set of disorders. This paper is novel in asking: Insofar as NHPs are being considered for use as model organisms for brain disorders, can this be done ethically? The paper concludes that it cannot. Notwithstanding ongoing debate about NHPs’ moral status, animal welfare concerns, the availability of alternative methods of studying brain disorders and unmet expectations of benefit justify a stop on the creation of NHP model organisms to study brain disorders. The lure of using new genetic technologies combined with the promise of novel therapeutics presents a formidable challenge to those who call for slow, careful, and only necessary research involving NHPs. But researchers should not create macaques with social deficits or capuchin monkeys with memory deficits just because they can. (shrink)

This essay provides an opinionated survey of some recent developments in the literature on ontological dependence. Some of the most popular definitions of ontological dependence are formulated in modal terms; others in non-modal terms (e.g., in terms of the explanatory connective, ‘because’, or in terms of a non-modal conception of essence); some (viz., the existential construals of ontological dependence) emphasise requirements that must be met in order for an entity to exist; others (viz., the essentialist construals) focus on conditions that (...) must be satisfied in order for an entity to be the very entity it is at each time at which it exists; some are rigid, in the sense that they concern a relation between particular entities; others are generic, in the sense that they involve only a relation between an entity and some entities or other, which bear certain characteristics. I identify three potential measures of success with respect to which these different definitions of ontological dependence can be evaluated and consider the question of how well they in fact meet these desiderata. I end by noting that certain challenges face even the most promising essentialist construals of ontological dependence. (shrink)

Essences have been assigned important but controversial explanatory roles in philosophical, scientific, and social theorizing. Is it possible for the same organism to be first a caterpillar and then a butterfly? Is it impossible for a human being to transform into an insect like Gregor Samsa does in Franz Kafka’s The Metamorphosis? Is it impossible for Lot’s wife to survive being turned into a pillar of salt? Traditionally, essences (or natures) have been thought to help answer such central questions about (...) existence, identity, persistence, and modality. These questions are not only of great philosophical interest, they also are of great interest to society at large. This Handbook surveys the state of the art on essence. Core issues about essence are discussed in 33 chapters, all of them written exclusively for this volume by leading experts. (shrink)