Floating in deep space with the city's protective shield failing, the team must do all they can to keep Atlantis alive. Meanwhile, a radical injury threatens Dr. Weir's life.
Colonel Sheppard and his team embark on a risky mission to steal a Z.P.M. power module from the Replicators – but must rely on a compromised Dr. Weir to succeed.
When a group of Ronon's people enlist the team's help in raiding a Wraith weapons facility, Ronon reconsiders whether his future lies in Atlantis or with his friends.
During an off-world mission Colonel Sheppard unknowingly becomes host to an alien entity, which infects others in Atlantis and afflicts them with terrifying nightmares.
Colonel Sheppard is captured by the inhabitants of a generational ship and their beautiful leader, who wish to use his ability to use Ancient technology for their own ends.
When a virus causes amnesia in everyone except Teyla and Ronon, the Atlantis team must work together to find a cure before their memories fade entirely.
The team meets a man with extraordinary prophetic abilities, who gives them a dark prediction about Atlantis's future. Meanwhile, the Wraith seek a new alliance with Atlantis in their war with the Replicators.
A mysterious drone crashes into Atlantis, indicating that the Replicators may have found the city. But when Elizabeth Weir appears, the team realizes that the probe is just a part of a bigger mystery.
Colonel Sheppard and Dr. McKay must protect a child princess on a pilgrimage before she can become queen, and learn that she has dangerous enemies threatening her life.
Teal'c visits Atlantis to counsel a headstrong Ronon, who is up for review by the I.O.A. But the two must work together when the Wraith invade the Midway space station in order to reach Earth.
As a mysterious new illness sweeps through the Pegasus Galaxy, Teyla is convinced by a vision that the father of her child is trying to communicate with her.
Sheppard returns to Atlantis after a mission and finds the city abandoned, all systems dead – and instead of ocean, sand dunes as far as the eye can see.