Vitamin D and COVID‐19: How much more evidence do we need?
et al., Nutrition in Clinical Practice, doi:10.1002/ncp.11349, Jul 2025
Vitamin D for COVID-19
8th treatment shown to reduce risk in
October 2020, now with p < 0.00000000001 from 138 studies, recognized in 18 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,600+ studies for
220+ treatments. c19early.org
|
Discussion of clinical evidence supporting vitamin D treatment for COVID-19. Authors highlight Vasconcelos et al. showing reduced all-cause mortality, and cite their own systematic review and meta-analysis of 19 RCTs that found a significant mortality reduction2. They argue that RCT findings, along with vitamin D’s immunomodulatory and anti-inflammatory actions, render further confirmatory trials unnecessary and expose an ethical inconsistency in delaying adoption when costlier, risk-laden COVID-19 therapies entered practice on slimmer evidence. Emphasising vitamin D’s safety, affordability, and the high prevalence of deficiency, authors call on clinicians and policymakers to integrate treatment as a standard adjunctive therapy while future work fine-tunes dosing and administration.
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Kow et al., 6 Jul 2025, peer-reviewed, 3 authors.
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