UCSF648

UCSF648
Identifiers
	IUPAC name N-[(5-chloroquinolin-8-yl)methyl]-3-ethylsulfonylpropan-1-amine;
CAS Number	2637090-56-1;
PubChem CID	154864756;
ChemSpider	115008020;
ChEMBL	ChEMBL5079940;
Chemical and physical data
Formula	C15H19ClN2O2S
Molar mass	326.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCS(=O)(=O)CCCNCC1=C2C(=C(C=C1)Cl)C=CC=N2;
	InChI InChI=1S/C15H19ClN2O2S/c1-2-21(19,20)10-4-8-17-11-12-6-7-14(16)13-5-3-9-18-15(12)13/h3,5-7,9,17H,2,4,8,10-11H2,1H3; Key:GNNSPXBPLMMQSR-UHFFFAOYSA-N;

UCSF648 is an experimental drug which acts as a selective partial agonist for the 5-HT_5A serotonin receptor. Very few selective ligands are available for this receptor, and UCSF648 is expected to be useful in researching its structure and function.^[1]

References

^ Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, et al. (March 2022). "Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor". Journal of Medicinal Chemistry. 65 (5): 4201–4217. doi:10.1021/acs.jmedchem.1c02031. PMC 9116900. PMID 35195401.

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[pmid35195401-1] Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, et al. (March 2022). "Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor". Journal of Medicinal Chemistry. 65 (5): 4201–4217. doi:10.1021/acs.jmedchem.1c02031. PMC 9116900. PMID 35195401.

[1]

Identifiers

IUPAC name N-[(5-chloroquinolin-8-yl)methyl]-3-ethylsulfonylpropan-1-amine
CAS Number	2637090-56-1
PubChem CID	154864756
ChemSpider	115008020
ChEMBL	ChEMBL5079940
Chemical and physical data
Formula	C₁₅H₁₉ClN₂O₂S
Molar mass	326.84 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCS(=O)(=O)CCCNCC1=C2C(=C(C=C1)Cl)C=CC=N2
InChI InChI=1S/C15H19ClN2O2S/c1-2-21(19,20)10-4-8-17-11-12-6-7-14(16)13-5-3-9-18-15(12)13/h3,5-7,9,17H,2,4,8,10-11H2,1H3 Key:GNNSPXBPLMMQSR-UHFFFAOYSA-N