TICAM2

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene. Historically, it was often called TRIF-related adaptor molecule (TRAM).

TICAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M1W
Identifiers
Aliases	TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2, TIR domain containing adaptor molecule 2
External IDs	OMIM: 608321; MGI: 3040056; HomoloGene: 11014; GeneCards: TICAM2; OMA:TICAM2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q22.3 Start 115,578,496 bp End 115,602,479 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 C Start 46,690,358 bp End 46,707,600 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle granulocyte Achilles tendon endometrium Descending thoracic aorta right adrenal cortex stromal cell of endometrium spleen lymph node Top expressed in ureter granulocyte epiblast embryo morula tail of embryo bone marrow spleen thymus zygote More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity protein binding Cellular component cytoplasm endosome late endosome Golgi apparatus early endosome membrane membrane late endosome membrane plasma membrane early endosome endoplasmic reticulum endosome membrane secretory granule membrane Biological process toll-like receptor 4 signaling pathway negative regulation of chemokine (C-C motif) ligand 5 production immune system process TRAM-dependent toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling inflammatory response cellular response to lipopolysaccharide I-kappaB kinase/NF-kappaB signaling negative regulation of toll-like receptor 4 signaling pathway MyD88-independent toll-like receptor signaling pathway signal transduction necroptosis apoptotic signaling pathway negative regulation of MyD88-independent toll-like receptor signaling pathway innate immune response neutrophil degranulation positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of interleukin-18-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353376 225471 Ensembl ENSG00000243414 ENSMUSG00000056130 UniProt Q86XR7 Q8BJQ4 RefSeq (mRNA) NM_021649 NM_173394 RefSeq (protein) NP_067681 NP_001157940 NP_001157941 NP_775570 Location (UCSC) Chr 5: 115.58 – 115.6 Mb Chr 18: 46.69 – 46.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

TICAM2 is a Toll/interleukin-1 receptor domain-containing adaptor protein involved in Toll receptor signaling.

Further reading

• Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
• Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. Bibcode:2006PNAS..103.6299R. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
• Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004. S2CID 13016860.
• Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
• Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

External links

• Overview of all the structural information available in the PDB for UniProt: Q86XR7 (TIR domain-containing adapter molecule 2) at the PDBe-KB.