The radiation sensitivity index (RSI) is a gene-expression–based model developed to estimate the intrinsic radiosensitivity of tumor cells. RSI was created by correlating cancer cell line survival after ionizing radiation with baseline gene-expression patterns, identifying a set of genes predictive of cellular response to radiation.[1]
RSI has been evaluated across multiple cancer types and clinical cohorts, and serves as the genomic basis of the genomic adjusted radiation dose (GARD), a framework integrating radiosensitivity with the linear–quadratic model to estimate the biological effect of a given radiation dose.[2]
See also
editReferences
edit- ^ Eschrich SA, Pramana J, Zhang H, et al. (2009). "A gene expression model of intrinsic tumor radiosensitivity: prediction of response and survival after radiotherapy". International Journal of Radiation Oncology, Biology, Physics. 75 (2): 489–496. doi:10.1016/j.ijrobp.2009.06.014. PMC 3548658. PMID 19616795.
- ^ Scott JG, Berglund A, Schell MJ, et al. (2017). "A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study". The Lancet. Oncology. 18 (2): 202–211. doi:10.1016/S1470-2045(16)30648-9. PMC 7771305. PMID 27993569.