📢 Just published! Introducing Isopeptor: a computational tool for detecting intramolecular isopeptide bonds in protein structures with high precision and recall.
Francesco Costa
@atsoCF
PhD student at Alex Bateman's group, EBI
Joined October 2021
- Check out this article about my research at @emblebi where I focus on protein modelling and on the study of fibrillar adhesins. Recently, we developed a method to detect isopeptide bonds, a key stabilizing feature in bacterial proteins. Big thanks to @oanastroe123!!👇Meet Francesco Costa @atsoCF 🇮🇹 – a PhD student at EMBL-EBI, focusing on protein science. Francesco is fascinated by protein design, and his recent work helped ‘rescue’ low-confidence #AlphaFold protein structure predictions. embl.org/news/people-pe… #PhD
- Excited to announce our latest publication: “Keeping it in the family: Using protein family templates to rescue low confidence AlphaFold2 models” where we explore plDDT variability in #AF2 models of @PfamDB domains. doi.org/10.1093/bioadv… 1/7
- Feature 932 appears to associate with Asn involved in isopeptide bonds. Very cool work! (PDB IDs: 4OFQ, 2OKM, 1AMX)Replying to @liambai21Nonetheless, we’re excited to have deciphered (to some extent) the missing cysteine feature. But we have so many questions… If you’re interested in playing around with our SAE features, they’re all available at interprot.com.
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