Current Issue Highlights

Latest Articles

  • Image

    Antibiotic-Loaded Ceramic Bone Grafts Exhibit Burst, Not Sustained, Gentamicin Release

    JBJS. August 17, 2026

    Background:

    Antibiotic-loaded ceramic bone grafts (ACBGs) are widely assumed to provide extended local antimicrobial protection, maintaining concentrations above the minimum inhibitory concentration (MIC) for 28 to 42 days. However, this time frame is mainly based on in vitro elution assays with simplified washout models, and its relevance to in vivo performance is uncertain. This study compared the in vivo and in vitro release and behavior of gentamicin from 2 commercial ACBGs.

    Methods:

    Gentamicin-loaded hydroxyapatite/calcium sulfate (HA-CS) and calcium sulfate (CS) composites were investigated using a murine implantation model and in vitro elution assays. Gentamicin content in recovered depot material and elution media was quantified by liquid chromatography with tandem mass spectrometry. Model calculations evaluated how the assay design affects the estimated time above the MIC.

    Results:

    Both ACBGs released >98% of gentamicin within 6 hours and >99% within 24 hours in vivo. In vitro assays likewise indicated early depot depletion, with concentration-time profiles beyond 48 hours driven by serial dilution rather than release. Model calculations suggested that the apparent prolonged antibiotic activity in previous in vitro assays was largely due to the assay design, not to sustained release, implying that freely administered antibiotics could produce similar profiles.

    Conclusions:

    Neither ACBG demonstrated measurable sustained release beyond an initial 24-hour burst phase. This may have important clinical implications, as expectations of prolonged local antimicrobial protection are not supported by the cumulative-release data showing rapid antibiotic depot depletion.

  • Image

    The Surgeon-Jurist: Reclaiming Judgment in an Era of Defensive Medicine

    JBJS. August 17, 2026

    Orthopaedic practice is increasingly shaped by evidence-based guidelines, quality metrics, documentation requirements, insurer authorization pathways, and medicolegal scrutiny. These developments have improved care in important ways, but they may also narrow the space for individualized clinical reasoning when protocols are applied too rigidly. This Viewpoint argues that orthopaedic judgment should be understood not as a license to depart casually from evidence-based care, nor as a defense of paternalism, but as the professional capacity to integrate evidence, clinical context, and patient preferences through shared decision-making. I suggest that the standard of care is best conceptualized as transparent, well-documented, context-sensitive reasoning. When several reasonable options exist, the task of the surgeon is to help patients navigate uncertainty, tradeoffs, and real-world constraints rather than to simply default to the most defensible-looking protocol. Examples from osteoarthritis, distal radial fracture care, and complex trauma illustrate how judgment remains necessary even in an era of guidelines and metrics. The surgeon-jurist, as a conceptual figure, reminds us that responsible care depends not only on evidence and accountability but also on deliberation, communication, and discretion.

Most Popular Articles

Featured Jobs