DO: 4428; MONDO: 0012168;
Cytogenetic location: 1p36-p34 Genomic coordinates (GRCh38) : 1:1-46,300,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 1p36-p34 | {Dyslexia, susceptibility to, 8} | 608995 | Autosomal dominant; Multifactorial | 2 |
For a phenotypic description and a discussion of genetic heterogeneity of susceptibility loci for dyslexia, see DYX1 (127700).
Rabin et al. (1993) reported linkage to RH (111700) on chromosome 1p36-p34 in several families with dyslexia.
Grigorenko et al. (2001) performed linkage analysis of 8 families with dyslexia. Multipoint analysis suggested linkage to chromosome 1p.
Using a qualitative definition of dyslexia in 100 affected Canadian families, Tzenova et al. (2004) identified a dyslexia susceptibility locus, termed DYX8, on chromosome 1p36-p34 (maximum lod score of 3.65 at marker D1S507, distal to D1S199). Quantitative trait locus (QTL) linkage analysis for phonologic awareness, phonologic coding, spelling, and rapid automatized naming speed yielded multipoint lod scores proximal to D1S199 (between D1S552 and D1S1622), with peaks of 4.01 for spelling and 1.65 for phonologic coding.
Among 108 Dutch nuclear families, de Kovel et al. (2008) found linkage for the categorical trait of dyslexia to chromosome 1p36 (nonparametric lod score of 2.1 at D1S199). Scores for the quantitative traits of word reading, nonword reading, and rapid naming peaked near the same location as the categorical trait. Nonword repetition showed little phenotypic correlation with dyslexia or with the other quantitative traits.
de Kovel, C. G. F., Franke, B., Hol, F. A., Lebrec, J. J. P., Maassen, B., Brunner, H., Padberg, G. W., Platko, J., Pauls, D. Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a Dutch sib-pair collection. Am. J. Med. Genet. 147B: 294-300, 2008. [PubMed: 17886254] [Full Text: https://doi.org/10.1002/ajmg.b.30598]
Grigorenko, E. L., Wood, F. B., Meyer, M. S., Pauls, J. E. D., Hart, L. A., Pauls, D. L. Linkage studies suggest a possible locus for developmental dyslexia on chromosome 1p. Am. J. Med. Genet. 105: 120-129, 2001. [PubMed: 11424982] [Full Text: https://doi.org/10.1002/1096-8628(20010108)105:1<120::AID-AJMG1075>3.0.CO;2-T]
Rabin, M., Wen, X. L., Hepburn, M., Lubs, H. A. Suggestive linkage of developmental dyslexia to chromosome 1p34-p36. (Letter) Lancet 342: 178 only, 1993. [PubMed: 8101276] [Full Text: https://doi.org/10.1016/0140-6736(93)91384-x]
Tzenova, J., Kaplan, B. J., Petryshen, T. L., Field, L. L. Confirmation of a dyslexia susceptibility locus on chromosome 1p34-p36 in a set of 100 Canadian families. Am. J. Med. Genet. 127B: 117-124, 2004. [PubMed: 15108193] [Full Text: https://doi.org/10.1002/ajmg.b.20139]