DO: 4428; MONDO: 0010348;
Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38) : X:143,000,001-148,000,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| Xq27.3 | {Dyslexia, susceptibility to, 9} | 300509 | 2 |
For a phenotypic description and a discussion of genetic heterogeneity of susceptibility loci for dyslexia, see DYX1 (127700).
Using genomewide parametric linkage analysis in a large Dutch family recruited for a linkage study of dyslexia through an advertisement campaign in newspapers and magazines, de Kovel et al. (2004) found evidence for a dyslexia susceptibility locus on Xq27.3 (multipoint lod score = 3.68 at theta = 0 for marker DXS8043), close to a locus described by Fisher et al. (2002).
de Kovel, C. G. F., Hol, F. A., Heister, J. G. A. M., Willemen, J. J. H. T., Sandkuijl, L. A., Franke, B., Padberg, G. W. Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family. J. Med. Genet. 41: 652-657, 2004. [PubMed: 15342694] [Full Text: https://doi.org/10.1136/jmg.2003.012294]
Fisher, S. E., Francks, C., Marlow, A. J., MacPhie, I. L., Newbury, D. F., Cardon, L. R., Ishikawa-Brush, Y., Richardson, A. J., Talcott, J. B., Gayan, J., Olson, R. K., Pennington, B. F., Smith, S. D., DeFries, J. C., Stein, J. F., Monaco, A. P. Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Nature Genet. 30: 86-91, 2002. [PubMed: 11743577] [Full Text: https://doi.org/10.1038/ng792]