Downloads

ClinVar provides files for download in several formats and with different degrees of coverage.

XML files

• FTP directory for XML files
• XML files represent the complete public data set, including all variants in ClinVar and all data types for each variant
• XML is available aggregated by variant (VCV files) or aggregated by variant-condition pairs (RCV files)
• Updated weekly; only the release on the first Thursday of the month is archived
• More information is available in the README for ClinVar's XML files

VCF

• FTP directory for VCF files based on GRCh37
• FTP directory for VCF files based on GRCh38
• Limited to variants with a precise location
  • variants with imprecise start and stop, such as exon deletions and CNVs detected by microarray, are not available in VCF files
• Limited to summary-level data for each variant
• Updated weekly; only the release on the first Thursday of the month is archived
• More information is available in the README for ClinVar's VCF files

ClinVar TSV files

• FTP directory for TSV files
• TSV files provide several slices of summary-level data for variants, genes, and submitting organizations
• Files are comprehensive for all variants in ClinVar
• Updated weekly; see the README file for which TSV files are archived monthly

Other TSV files

• disease names lists the preferred names and database identifiers used in GTR and ClinVar for diseases
• gene_condition_source_id lists gene-disease relationships used in ClinVar, Gene, GTR and MedGen
• Files are comprehensive for all diseases in ClinVar
• Updated daily

More information is available about ClinVar's release cycle and about ClinVar's FTP files.