Highs are predicted to reach the mid-90s before a storm system is expected to hit the region, plummeting temperatures more than 20 degrees in some areas.
Wildfires caused evacuations in California, 7 million people in the Midwest face flood watches and 32 million in the Northeast were under heat advisories.
The community of Martinez Lake in Arizona hit a jaw-dropping 110 degrees Fahrenheit on Thursday — the highest March temperature in U.S. recorded history.
Arizona and Nevada are likely to see temperatures in the triple digits, while cities such as San Francisco, L.A. and Denver could experience record highs.