MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems ranging from cell culture to mice.

The color palette viridis is replacing rainbow color schemes in scientific figures, for good reason.

This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.

The method to reprogram fully differentiated cells using transcription factors retools cells — and has retooled many a scientist’s trajectory. Here, researchers comment on this ‘remodeling’ and the future they foresee.

NicheTrans is a multimodal framework that enables translation of spatial data across modalities.

This Registered Report presents the results of a study to evaluate the performance of sequence-based protein localization predictors on a curated test dataset of 3,814 human proteins.

EviAnn surpasses existing genome annotation methods by leveraging gene expression and protein sequence homology evidence to achieve higher accuracy and efficiency.

ClairS accurately detects somatic small variants using long-read sequencing data from tumor–normal pair samples.

RNAbpFlow generates all-atom RNA conformational ensembles for single-chain RNA monomers without the explicit or implicit use of evolutionary information or homologous structural templates.

Spatio-DARLIN combines the DARLIN mouse model with sequencing-based spatial transcriptomics to enable high-resolution spatial lineage tracing in mice.

We share some recent staff updates at Nature Methods.