- Billing Displacement: While Penélope Cruz had second billing and was featured prominently on the cover art along with Johnny Depp, she doesn't show up in the film until over an hour in and was on-screen for a total of less than 20 minutes.
- Blooper: The desert scene where they are driving the RV, look closely at the front windshield to see the camera crew.
- Dyeing for Your Art: The already slender Penélope Cruz lost six pounds to play the part, and looks skeletal. Johnny Depp also dyed his hair blonde and later red.
- Fake Nationality: Cliff Curtis, a Polynesian Maori from New Zealand, plays Columbian Pablo Escobar.
- Queer Character, Queer Actor: Camp Gay Derek Foreal is played by Closet Gay actor Paul Reubens.
- Throw It In: A lot of Johnny Depp's dialogue was improvised, including the scene where they are trying to find a place to put all their money from selling coke and his line "We're gonna need a bigger boat".
- What Could Have Been:
- John Leguizamo was offered a role in this film, but turned it down because he was already working on Moulin Rouge.
- Denis Leary was originally cast as Derek Foreal.
- James Gandolfini was considered for Fred Jung.
http://tvtropes.org/pmwiki/pmwiki.php/Trivia/Blow
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