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I have configured a new SQL Server 2017.XXX instance in my Windows 10. Then, created a new database called CUSTOMER_DEVICES. I tried to connect to database using pyodbc. I could not and got below error:

Error - pyodbc.OperationalError: ('08001', u'[08001] [Microsoft][ODBC SQL Server Driver]

When I use the same code in existing production server it works. Code below 

import pyodbc
conn = pyodbc.connect(r'Driver={SQL Server};Server=localhost;Database=CUSTOMER_DEVICES;Trusted_Connection=yes;')
cursor = conn.cursor()
print(cursor)
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1 Answer 1

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Check if SQL server Configuration Management is configured. Enable TCP, IP. Check below link Check here

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