That there is a heritable or familial component of susceptibility to chronic non‐communicable diseases such as type 2 diabetes, obesity and cardiovascular disease is well established, but there is increasing evidence that some elements of such heritability are transmitted non‐genomically and that the processes whereby environmental influences act during early development to shape disease risk in later life can have effects beyond a single generation. Such heritability may operate through epigenetic mechanisms involving regulation of either imprinted or non‐imprinted genes but (...) also through broader mechanisms related to parental physiology or behaviour. We review evidence and potential mechanisms for non‐genomic transgenerational inheritance of ‘lifestyle’ disease and propose that the ‘developmental origins of disease’ phenomenon is a maladaptive consequence of an ancestral mechanism of developmental plasticity that may have had adaptive value in the evolution of generalist species such as Homo sapiens. BioEssays 29: 145–154, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

While heredity is predominantly controlled by what deoxyribonucleic acid (DNA) sequences are passed from parents to their offspring, a small but growing number of traits have been shown to be regulated in part by the non‐genetic inheritance of information. Transgenerational epigenetic inheritance is defined as heritable information passed from parents to their offspring without changing the DNA sequence. Work of the past seven decades has transitioned what was previously viewed as rare phenomenology, into well‐established paradigms by which (...) numerous traits can be modulated. For the most part, studies in model organisms have correlated transgenerational epigenetic inheritance phenotypes with changes in epigenetic modifications. The next steps for this field will entail transitioning from correlative studies to causal ones. Here, we delineate the major molecules that have been implicated in transgenerational epigenetic inheritance in both mammalian and non‐mammalian models, speculate on additional molecules that could be involved, and highlight some of the tools which might help transition this field from correlation to causation. (shrink)

Sperm, eggs and embryos are made up of more than genes, and there are indications that changes to non‐genetic structures in these elements of the germline can also be inherited. It is, therefore, a mistake to treat phrases like ‘germline inheritance’ and ‘genetic inheritance’ as simple synonyms, and bioethical discussion should expand its focus beyond alterations to the genome when considering the ethics of germline modification. Moreover, additional research on non‐genetic inheritance draws attention to a variety of (...) means whereby differences can be inherited in offspring generations that do not rely on differences in germline structures. Research on these diverse forms of inheritance challenges the notion that there is some special form of ethical concern that falls on germline interventions in general, and on interventions to the nuclear genome within the germline in particular. (shrink)

It is becoming increasingly clear that most, if not all, animals and plants are associated with a diverse array of resident gut microbiota. This symbiosis is regulated by host-microbiome interactions which influence the development, homeostasis, adaptation and evolution of the host. Recent evidence indicated that these interactions can also affect the host germline and have a potential of supporting transgenerational effects, including inheritance of acquired characteristics. Taken together, the influence of gut bacteria on the host soma and germline (...) could potentially give rise to emergent phenotypes, which may be partially inherited by three distinguishable modes of transgenerational influence of gut bacteria: 1) “soma-to-soma” 2) “soma-to-germline” and 3) “soma-germline-soma”. Here, we discuss these possibilities in light of evidence supporting bacterial-mediated modes of transgenerational inheritance. All animals are consortiums of hosts and microbiota. Their interactions influence many aspects of the adaptation and evolution of the Holobiont. The host germline can also be affected which can give rise to new modes of transgenerational influence of gut bacteria: 1) “soma-to-soma” 2) “soma-to-germline,” and 3) “soma-germline-soma.”. (shrink)

Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated that epigenetic information is also inherited through DNA methylation, histone modifications, and small RNAs. Several examples of transgenerational epigenetic inheritance of traits have been documented in plants and animals. These include even the inheritance of traits acquired through the soma during the life of an organism, implicating the transfer of epigenetic information via the germline to the next generation. Small RNAs appear to play a (...) significant role in carrying epigenetic information across generations. This review focuses on how epigenetic information in the form of small RNAs is transmitted from the germline to the embryos through the gametes. We also consider how inherited epigenetic information is maintained across generations in a small RNA‐dependent and independent manner. Finally, we discuss how epigenetic traits acquired from the soma can be inherited through small RNAs. (shrink)

Throughout evolution, there has been interaction and exchange between RNA pools in the environment, and DNA and RNA pools of eukaryotic organisms. Metagenomic and metatranscriptomic sequencing of invertebrate hosts and their microbiota has revealed a rich evolutionary history of RNA virus shuttling between species. Horizontal transfer adapted the RNA pool for successful future interactions which lead to zoonotic transmission and detrimental RNA viral pandemics like SARS‐CoV2. In eukaryotes, noncoding RNA (ncRNA) is an established mechanism derived from prokaryotes to defend against (...) viral attack through innate immunity and regulation of host‐derived mRNA. Transgenerational inheritance of ncRNA is evidence for feedforward adaptive immunity and epigenetically encoded environmental change across generations, which may explain the ‘‘missing heritability’’ of common disease. Causal graph theory and the Price Equation can model epigenetic inheritance involving dynamic internal and external RNA pools. Experimental designs should include metatranscriptomic analyses to understand how ncRNA responds to rapidly changing environmental conditions, within and between organisms, and across generations. (shrink)

Abstract: Inheritance theory is broadening by emphasizing two kinds of diversity, both justified by recent empirical advances: the material substrates of inheritance beyond genes, and the directions of inheritance relationships beyond vertical, parent-to-offspring transmission. There are different inheritance materials—genetic, epigenetic, parental, cultural—and inheritance directions—vertical, oblique, horizontal. This shift is accompanied by theoretical reconceptualizations associated with developmental and organismal views of inheritance, which understand inheritance as the transgenerational reconstruction of traits that explain trait (...) persistence across a lineage. Within this framework, this article draws attention to inverted inheritance: inheritance relationships that run from a younger generation to an older one. Although this idea may initially seem at odds with how inheritance is generally understood and studied, this article argues that inverted inheritance is compatible with—and indeed illuminated by—the current expansion of inheritance theory. While it highlights relationships that invite empirical investigation, it also sheds light on our conceptualization of what inheritance is. (shrink)

Mature spermatozoa are permeable to foreign DNA and RNA molecules. Here I propose a model, whereby extrachromosomal genetic information, mostly encoded in the form of RNA in somatic cells, can cross the Weismann barrier and reach epididymal spermatozoa. LINE‐1 retrotransposon‐derived reverse transcriptase (RT) can play key roles in the process by expanding the RNA‐encoded information. Retrotransposon‐encoded RT is stored in mature gametes, is highly expressed in early embryos and undifferentiated cells, and becomes downregulated in differentiated cells. In turn, RT plays (...) a role in developmental control, as its inhibition arrests developmental progression of early embryos with globally altered transcriptomic profiles. Thus, sperm cells act as recipients, and transgenerational vectors of somatically derived genetic information which they pass to the next generation with the potential to modify the fate of the developing embryos. (shrink)

In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive immune systems. One question that has not been addressed yet is the transgenerational aspect of the CRISPR-Cas9-based response. If immunity is acquired and inherited, how to distinguish evolutionary from immunological adaptation? To shed (...) light on this issue and obtain conceptual clarity, I will investigate the inheritance of small RNA responses to pathogens in the nematode C. elegans as a further potential instantiation of a transgenerational adaptive immune system. I will explore how to make sense of systems that lie at the crossroads between genetic, immunological, and evolutionary spheres and explore the consequences of a transgenerational perspective on immune systems for immunology and its philosophy. (shrink)

Today, there is a growing interest in the ethics of the human and social sciences, and in the discussions surrounding these topics, notions such as responsibility toward the past are often invoked. But those engaged in these discussions seldom acknowledge that there are at least two distinct logics of responsibility underlying many debates. These logics permeate a Western scholarly tradition but are seldom explicitly discussed. The two logics follow the Latin and Hebrew concepts of responsibility: spondeo and acharayut. The purpose (...) of this article is to make an ethical argument: to explain, based on the work of Emmanuel Levinas and others, what kind of ethical-existential logic of responsibility acharayut is and how it differs from and challenges other concepts of responsibility in moral philosophy and the human sciences. I am especially concerned with what this logic implies with regard to reading and writing about the past. Responsibility is not necessarily congruent with performing a scientific (historical) task or defending the (political, juridical) interests of a group of people. Instead, a “guiltless responsibility” to people of other generations points to something that I refer to as a transgenerational responsibility. I contrast this transgenerational responsibility to inherited guilt and related ideas of generational interconnectedness, which follow the logic of spondeo. Inherited guilt suggests that a responsible relation the past is to either identify with or blame a group of people in the past. Contrary to inherited guilt, a commitment to acharayut means constantly probing one’s responsibility to people of the past (for their posterity) and people of the future (as their predecessors) precisely because people of the present are not people of the past or people of the future. (shrink)

This article examines how people of color can biologically inherit the deleterious effects of white racism. Drawing primarily on the field of epigenetics, I demonstrate how transgenerational racial disparities are in fact racist disparities that can be manifest physiologically, helping constitute the chemicals, hormones, cells, and fibers of the human body. Epigenetics can be used to demonstrate how white racism can have durable effects on the biological constitution of human beings that are not limited to the specific person who (...) is the target of white racism, but instead extend to that person's offspring. In this way, the field of epigenetics can help philosophers and others understand the transgenerational biological impact of social forces such as white racism. It reveals that the damage done by white racism is more extensive than critical philosophers of race might have realized, and also that interventions against white racism must address not just the economic, geographical, social, and psychological, but also the biological aspects of human existence. In particular, the article examines racist disparities in preterm birth rates and argues that the scope and significance of prenatal care for African American women must be expanded intergenerationally and include wide-scale forms of racial justice. (shrink)

The article proposes to further develop the ideas of the Extended Evolutionary Synthesis by including into evolutionary research an analysis of phenomena that occur above the organismal level. We demonstrate that the current Extended Synthesis is focused more on individual traits (genetically or non-genetically inherited) and less on community system traits (synergetic/organizational traits) that characterize transgenerational biological, ecological, social, and cultural systems. In this regard, we will consider various communities that are made up of interacting populations, and for which (...) the individual members can belong to the same or to different species. Examples of communities include biofilms, ant colonies, symbiotic associations resulting in holobiont formation, and human societies. The proposed model of evolution at the level of communities revises classic theorizing on the major transitions in evolution by analyzing the interplay between community/social traits and individual traits, and how this brings forth ideas of top-down regulations of bottom-up evolutionary processes (collaboration of downward and upward causation). The work demonstrates that such interplay also includes reticulate interactions and reticulate causation. In this regard, we exemplify how community systems provide various non-genetic ‘scaffoldings’, ‘constraints’, and ‘affordances’ for individual and sociocultural evolutionary development. Such research complements prevailing models that focus on the vertical transmission of heritable information, from parent to offspring, with research that instead focusses on horizontal, oblique and even reverse information transmission, going from offspring to parent. We call this reversed information transfer the ‘offspring effect’ to contrast it from the ‘parental effect’. We argue that the proposed approach to inheritance is effective for modelling cumulative and distributed developmental process and for explaining the biological origins and evolution of language. (shrink)

Since the 1990s, the terms “Lamarckism” and “Lamarckian” have seen a significant resurgence in biological publications. The discovery of new molecular mechanisms have been interpreted as evidence supporting the reality and efficiency of the inheritance of acquired characters, and thus the revival of Lamarckism. The present paper aims at giving a critical evaluation of such interpretations. I argue that two types of arguments allow to draw a clear distinction between the genuine Lamarckian concept of inheritance of acquired characters (...) and transgenerational epigenetic inheritance. The first concerns the explanandum of the processes under consideration: molecular mechanisms of transgenerational epigenetic inheritance are understood as evolved products of natural selection. This means that the kind of inheritance of acquired characters they might be responsible for is an obligatory emergent feature of evolution, whereas traditional Lamarckisms conceived the inheritance of acquired characters as a property inherent in living matter itself. The second argument concerns the explanans of the inheritance of acquired characters: in light of current knowledge, epigenetic mechanisms are not able to drive adaptive evolution by themselves. Emergent Lamarckian phenomena would be possible if and only if individual epigenetic variation allowed the inheritance of acquired characters to be a factor of unlimited change. This implies specific requirements for epigenetic variation, which I explicitly define and expand upon. I then show that given current knowledge, these requirements are not empirically grounded. (shrink)

What kind mechanisms one deems central for the evolutionary process deeply influences one's understanding of the nature of organisms, including cognition. Reversely, adopting a certain approach to the nature of life and cognition and the relationship between them or between the organism and its environment should affect one's view of evolutionary theory. This paper explores this reciprocal relationship in more detail. In particular it argues that the view of living and cognitive systems, especially humans, as deeply integrated beings embedded in (...) and transformed by their genetic, epigenetic, behavioral, ecological, socio-cultural and cognitive-symbolic legacies calls for an extended evolutionary synthesis that goes beyond either a theory of genes juxtaposed against a theory of cultural evolution and or even more sophisticated theories of gene-culture coevolution and niche construction. Environments, particularly in the form of developmental environments, do not just select for variation, they also create new variation by influencing development through the reliable transmission of non-genetic but heritable information. This paper stresses particularly views of embodied, embedded, enacted and extended cognition, and their relationship to those aspects of extended inheritance that lie between genetic and cultural inheritance, the still gray area of epigenetic and behavioral inheritance systems that play a role in parental effect. These are the processes that can be regarded as transgenerational developmental plasticity and that I think can most fruitfully contribute to, and be investigated by, developmental psychology. (shrink)

The article examines biological, evolutionary and biosemiotic precursors of distributed, supraindividual, and ‘transitive’ memory. Genetic and epigenetic inheritance, the origin of instincts, and the nature of immunity are conceptualised as specific (rudimentary) forms of memory with similar features to neurologically based individual and social memory. Some researchers _hypothesise_ that instincts, as a kind of ‘unconscious memory’, may originate through learning and epigenetic inheritance. The article provides examples of specific instincts (e.g., honeybee dance language or the seasonal migration of (...) butterflies) whose acquisition requires social learning, transgenerational and ‘shared’ memory (genetic or epigenetic) and distributed actions. The research integrates theories of ecological inheritance and ecosemiotics with concepts of distributed, semiotically scaffolded and directed evolution. It posits that ‘soft inheritance’ (epigenetic, behavioural, cultural, symbolic) and the sign systems connected with it allows organisms to sidestep the slowly changing genetic constraints of ‘hard inheritance’, thereby providing a foundation for cumulative, distributed, and extended social development. Both ‘hard’ and ‘soft’ inheritance systems are re-examined in the article as memory systems with supraindividual, ‘transitive’ and wave-like characteristics. Additionally, the study addresses methodological and theoretical debates concerning the nature of memory: whether it is a structure or process, storage or action, code or semiosis. As a resolution to memory’s antinomies, the article proposes principles of complementarity and nonlocality, borrowed from physics. (shrink)

Our view of heredity can potentially be distorted by the ease of introducing heritable changes in the replicating gene sequences but not in the cycling assembly of regulators around gene sequences. Here, key experiments that have informed the understanding of heredity are reinterpreted to highlight this distortion and the possible variety of heritable changes are considered. Unlike heritable genetic changes, which are always associated with mutations in gene sequence, heritable epigenetic changes can be associated with physical or chemical changes in (...) molecules or only changes in the system. The transmission of cycling stores along the continuous lineage of cells that connects successive generations creates waves of activity and localization of the molecules that together form the cell code for development in each generation. As a result, heritable epigenetic changes can include any that can alter a wave such as changes in form, midline, frequency, amplitude, or phase. Testing this integrated view of all heritable information will require the concerted application of multiple experimental approaches across generations. (shrink)

Recent investigations with non‐model species and whole‐genome approaches have challenged several paradigms in animal epigenetics. They revealed that epigenetic variation in populations is not the mere consequence of genetic variation, but is a semi‐independent or independent source of phenotypic variation, depending on mode of reproduction. DNA methylation is not positively correlated with genome size and phylogenetic position as earlier believed, but has evolved differently between and within higher taxa. Epigenetic marks are usually not completely erased in the zygote and germ (...) cells as generalized from mouse, but often persist and can be transgenerationally inherited, making them evolutionarily relevant. Gene body methylation and promoter methylation are similar in vertebrates and invertebrates with well methylated genomes but transposon silencing through methylation is variable. The new data also suggest that animals use epigenetic mechanisms to cope with rapid environmental changes and to adapt to new environments. The main benefiters are asexual populations, invaders, sessile taxa and long‐lived species. (shrink)

In this essay, Emerson Bodde argues that class ought to be viewed as a “real social identity” in the sense developed by Linda Alcoff to describe race and gender as bodily, hermeneutic, and historically shaped social categories. Taking inspiration especially from Alcoff's arguments concerning gender, Bodde argues class is just as “real” and “embodied” while rejecting Alcoff's own anti-realist evaluation of class. In the same way that the differential relationship to sexual reproduction anchors the social category of gender as an (...) underdetermining element for a social identity, work and its effect upon the embodied subject does the same for class. The anthropological necessity of work, the wracking of the body by work, and the determinate autonomy one exercises in “dealing with” exhaustion—these all situate work as a subjectivity-forming phenomenon that forms differential groupings. The argument is further defended by linking this account with Shannon Sullivan's argument that epigenetic inheritance serves as a key element of the transgenerational dimensions of anti-black racism and racial injustice. Bodde concludes by suggesting that a fully sufficient elaboration of social class as a real social identity must be supplemented by an account of society and the reproduction of such identities over time. (shrink)

Members of a political society typically regard themselves as participating in intergenerational relationships of obligation and entitlement. They value the inheritance they received from past generations, regard themselves as indebted to their forebears, and accept an obligation to pass on their heritage to their descendants. Liberalism, with its emphasis, on rights, contracts, and welfare of existing people, does not provide an adequate basis for intergenerational obligations. Communitarianism, by stressing communal values of the embedded self, is in a better position (...) to explain why obligations in respect to the past as well as the future should play a central role in conceptions of justice. This chapter critically examines communitarian approaches to intergenerational obligations, and argues for an account of the self in which lifetime-transcending interests play an important role. It presents a theory of intergenerational obligations which makes use of communitarian insights but is also compatible with basic assumptions of liberalism. (shrink)

Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle‐related conditions suggest a paternal influence on the offspring's future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic (...) components. In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health‐related effects in future generations. (shrink)

Parents influence the development of their offspring in many ways beyond the transmission of DNA. This includes transfer of epigenetic states, nutrients, antibodies and hormones, and behavioural interactions after birth. While the evolutionary consequences of such nongenetic inheritance are increasingly well understood, less is known about how inheritance mechanisms evolve. Here, we present a simple but versatile model to explore the adaptive evolution of non-genetic inheritance. Our model is based on a switch mechanism that produces alternative phenotypes (...) in response to different inputs, including genes and non-genetic factors transmitted from parents and the environment experienced during development. This framework shows how genetic and non-genetic inheritance mechanisms and environmental conditions can act as cues by carrying correlational information about future selective conditions. Differential use of these cues is manifested as different degrees of genetic, parental or environmental morph determination. We use this framework to evaluate the conditions favouring non-genetic inheritance, as opposed to genetic determination of phenotype or within-generation plasticity, by applying it to two putative examples of adaptive non-genetic inheritance: maternal effects on seed germination in plants and transgenerational phase shift in desert locusts. Our simulation models show how the adaptive value of non-genetic inheritance depends on its mechanism, the pace of environmental change, and life history characteristics. (shrink)

Model organisms have long occupied a central place in the life sciences, driving major discoveries and stabilizing knowledge about biological mechanisms conserved across taxa. However, their dominance has often eclipsed experimental model organisms—specimens chosen for their capacity to illuminate local hypotheses, usually associated with organism-specific features. This paper advances a twofold argument. First, I contend that overreliance on model organisms constrains the generation of novel hypotheses and narrows the conceptual landscape of biological inquiry. Using epigenetic inheritance as a case (...) study, I show how this focus has systematically marginalized forms of inheritance that depart from conventional assumptions (i.e., germline/material overlap and transgenerational stability). Here, I concentrate on external intergenerational epigenetic inheritance. Second, I argue that merely vindicating the use of experimental model organisms is insufficient without examining the philosophical assumptions that structure their epistemic function. Specifically, I demonstrate that the representationalist conception—models as surrogates for target systems—permeates the conceptualization of experimental model organisms through the idea of representational function, thereby reinforcing framed trajectory-dependent inquiry. This representationalist conceptualization undermines the capacity of experimental model organisms to support framing exploratory inquiry oriented to test conceptually disruptive ideas, such as external intergenerational epigenetic inheritance. To overcome this limitation, I develop a Pragmatist–Artifactualist framework that reconceptualizes the epistemic role of experimental model organisms and restores their potential to expand the boundaries of biological understanding. (shrink)

The contribution of inherited non‐genetic factors to complex diseases is of great current interest. The ways in which mothers and fathers can affect their offspring's health clearly differ as a result of the intimate interactions between mother and offspring during pre‐ and postnatal life. There is, however, potential for some overlap in mechanisms, particularly epigenetic mechanisms. A small number of epidemiological studies and animal models have investigated the non‐genetic contribution of the parents to offspring health. Discovering new mechanisms of disease (...) inheritance is technically difficult, especially in genetically, socially and environmentally heterogeneous human populations. Therefore, rigorous experimental design, appropriate sample numbers and the use of high‐throughput technologies are necessary to provide convincing evidence. Based on recent examples from the literature, here we propose several ways to improve human studies that aim to identify the underlying mechanisms of transgenerational inheritance of metabolic disease. (shrink)

There is increasing evidence for epigenetically mediated transgenerational inheritance across taxa. However, the evolutionary implications of such alternative mechanisms of inheritance remain unclear. Herein, we show that epigenetic mechanisms can serve two fundamentally different functions in transgenerational inheritance: (i) selection-based effects, which carry adaptive information in virtue of selection over many generations of reliable transmission; and (ii) detection-based effects, which are a transgenerational form of adaptive phenotypic plasticity. The two functions interact differently with a (...) third form of epigenetic information transmission, namely information about cell state transmitted for somatic cell heredity in multicellular organisms. Selection-based epigenetic information is more likely to conflict with somatic cell inheritance than is detection-based epigenetic information. Consequently, the evolutionary implications of epigenetic mechanisms are different for unicellular and multicellular organisms, which underscores the conceptual and empirical importance of distinguishing between these two different forms of transgenerational epigenetic effect. (shrink)

Life is perpetuated through a single-cell bottleneck between generations in many organisms. Here, I highlight that this cell holds information in two distinct stores: in the linear DNA sequence that is replicated during cell divisions, and in the three-dimensional arrangement of molecules that can change during development but is recreated at the start of each generation. These two interdependent stores of information – one replicating with each cell division and the other cycling with a period of one generation – coevolve (...) while perpetuating an organism. Unlike the genome sequence, the arrangement of molecules, including DNA, RNAs, proteins, sugars, lipids, etc., is not well understood. Because this arrangement and the genome sequence are transmitted together from one generation to the next, analysis of both is necessary to understand evolution and origins of inherited diseases. Recent developments suggest that tools are in place to examine how all the information to build an organism is encoded within a single cell, and how this cell code is reproduced in every generation. Life relies on the information for making organisms that is encoded in single cells and transmitted between generations. These cell codes include interdependent stores of information that replicate and that cycle. Understanding evolution and the origins of inherited diseases requires analysis of cell codes. (shrink)

Thomas Kuhn described the progress of science as comprising occasional paradigm shifts separated by interludes of ‘normal science’. The paradigm that has held sway since the inception of molecular biology is that genes (mainly) encode proteins. In parallel, theoreticians posited that mutation is random, inferred that most of the genome in complex organisms is non‐functional, and asserted that somatic information is not communicated to the germline. However, many anomalies appeared, particularly in plants and animals: the strange genetic phenomena of paramutation (...) and transvection; introns; repetitive sequences; a complex epigenome; lack of scaling of (protein‐coding) genes and increase in ‘noncoding’ sequences with developmental complexity; genetic loci termed ‘enhancers’ that control spatiotemporal gene expression patterns during development; and a plethora of ‘intergenic’, overlapping, antisense and intronic transcripts. These observations suggest that the original conception of genetic information was deficient and that most genes in complex organisms specify regulatory RNAs, some of which convey intergenerational information. Also see the video abstract here: https://youtu.be/qxeGwahBANw. (shrink)

How can constituent power be simultaneously constrained by law and genuinely democratic? This question has haunted constitutional theory since Sieyès distinguished constituent from constituted power. This article argues that political liberalism’s attempts to resolve this paradox generate two structural aporias. First, anti-foundationalist approaches to constituent power inevitably produce an invisible foundation: normative standards like “the most reasonable” operate as quasi-transcendental constraints even while disclaiming metaphysical commitments. Second, locating sovereignty in a transgenerational people creates an absent sovereign: ultimate democratic authority (...) resides in an entity accessible only through juridical interpretation, never directly present to living citizens. Through critical engagement with Alessandro Ferrara’s Sovereignty across Generations (2023) and recent scholarship on intergenerational constitutionalism, I demonstrate that these aporias are not contingent flaws in particular theories but constitutive features of political liberalism’s broader project. Drawing on Lefort’s concept of democracy’s “empty place of power” and Arendt’s notion of natality, I argue that constitutional democracy depends on sustaining permanent tensions between popular sovereignty and normative constraint, between democratic self-governance and inherited commitments. Political liberalism’s future lies in embracing rather than eliminating its internal contradictions, accepting that sovereignty must remain contested if freedom is to endure without metaphysical foundations. (shrink)

Considering the recent epigenetic studies on the transgenerational transmission of trauma, this article aims to 1) explore its ethical implications for the concept and nature of moral damage, and 2) offer normative suggestions on collective responsibilities both synchronic and diachronic. To do so, I first address recent epigenetic studies’ showing the crystallization of emotional information through generations, and second, defend that a unified approach to the concept of ghost damage may be useful to categorize this phenomenon, facilitate future research (...) on this type of moral damage, and recognize its importance in the identification of hermeneutical injustice. Finally, I suggest that granting a right to transgenerational information may help avoid the perpetuation of inherited damage that jeopardize mental and physical health in the offspring. (shrink)

This chapter examines non-genetic, psychophysiological inheritance across generational lines in the context of white domination. Focusing on the effects of racism in black bodies, this chapter draws on the field of epigenetics to show how people of color can biologically inherit the deleterious effects of racism. Examining disparities in preterm birth rates between African American and white women, Chapter 3 details how transgenerational racial health disparities are in fact racist health disparities that can be manifest physiologically, helping constitute (...) the chemicals, hormones, cells, and fibers of the human body. Epigenetics helps demonstrate how racism can have durable effects on the biological constitution of human beings that are not limited to the specific person who is the target of racism, but instead extend to that person’s children and grandchildren. In this way, the field of epigenetics can help philosophers and others understand the transgenerational biological impact of social forces such as racism. (shrink)

The dichotomy between Nature and Nurture, which has been dismantled within the framework of development, remains embodied in the notions of plasticity and evolvability. We argue that plasticity and evolvability, like development and heredity, are neither dichotomous nor distinct: the very same mechanisms may be involved in both, and the research perspective chosen depends to a large extent on the type of problem being explored and the kinds of questions being asked. Epigenetic inheritance leads to transgenerationally extended plasticity, and (...) developmentally-induced heritable epigenetic variations provide additional foci for selection that can lead to evolutionary change. Moreover, hereditary innovations may result from developmentally induced large-scale genomic repatterning events, which are akin to Goldschmidtian “systemic mutations”. The epigenetic mechanisms involved in repatterning can be activated by both environmental and genomic stress, and lead to phylogenetic as well as ontogenetic changes. Hence, the effects and the mechanisms of plasticity directly contribute to evolvability. (shrink)

In this paper it is analyzed from the informational perspective the relation between mind and body, an ancient philosophic issue defined as a problem, which still did not receive up to date an adequate solution. By introducing/using the concept of information, it is shown that this concept includes two facets, one of them referring to the common communications and another one referring to a hidden/structuring matter-related information, effectively acting in the human body and in the living systems, which determines the (...) dynamic inter-change of information between specific structures of the organism by electric/electronic/chemical agents and genetic/epigenetic processes. It is shown that the maintenance of body, permanently and obligatory depending on the external matter (foods, air, water) resources, needed to provide both the structuring/restructuring basic material and energy, determines the necessary existence of an info-managing system, administrating the internal mechano-chemical/physical processes. As a natural consequence, such a system should organize and assure own survival by an effective informational operability to detect the external food resources, to select the appropriate interest information and to decide as a function of circumstances. One important component in such an informational system is memory, allowing to dispose of the reference informational data for analysis/comparison and the selection between good and bad binary possible decisions. The memory receives and stores therefore signals from external reality and from the body itself, referring to the emotional reaction, digestion status, creation, and inherited predilections, within specific info-neural communication circuits between the brain and body execution/sensitive organs, the human body appearing as an integrated info-matter self-managed dynamic system. The specific body components memorize information with different degrees of info-integration: short/long-term integration, emotive/action reaction, info-abilities, culminating with the integration in the chromosomal structures by epigenetic processes. The new acquired information is transgenerationally transmissible, and is manifested as new traits, showing the adaptation capability of the human and close relation between mind and body. Analyzing the results of such a mind-body informational model in comparison with the earlier assumed/proposed/asserted archaic, Greek and Occidental philosophies, which represent only partial aspects of this relation, it is shown that this informational model, elaborated in terms of information on the basis of scientific reasons and arguments, constitutes a general, realist, and coherent model of the mind-body relation, able to integrate and/or explain most of the others. (shrink)

Over 30 million people worldwide have taken a commercial at-home DNA test, because they were interested in their genetic ancestry, disease predisposition or inherited traits. Yet, these consumer DNA data are also increasingly used for a very different purpose: to identify suspects in criminal investigations. By matching a suspect’s DNA with DNA from a suspect’s distant relatives who have taken a commercial at-home DNA test, law enforcement can zero in on a perpetrator. Such forensic use of consumer DNA data has (...) been performed in over 200 criminal investigations. However, this practice of so-called investigative genetic genealogy raises ethical concerns. In this paper, we aim to broaden the bioethical analysis on IGG by showing the limitations of an individual-based model. We discuss two concerns central in the debate: privacy and informed consent. However, we argue that IGG raises pressing ethical concerns that extend beyond these individual-focused issues. The very nature of the genetic information entails that relatives may also be affected by the individual customer’s choices. In this respect, we explore to what extent the ethical approach in the biomedical genetic context on consent and consequences for relatives can be helpful for the debate on IGG. We argue that an individual-based model has significant limitations in an IGG context. The ethical debate is further complicated by the international, transgenerational and commercial nature of IGG. We conclude that IGG should not only be approached as an individual but also—and perhaps primarily—as a collective issue. There are no data in this work. (shrink)

Engaging with current protests for climate justice on university campuses, this paper discusses how matters of concern are shared in the university and how cohabitation on campus itself becomes a public matter. Multiple ecological and political crises shed light on the interdependence between the public and the communal dimension of university. Drawing on Jan Masschelein and Maarten Simons, the paper outlines the importance of shared attention to form a public university, which, however, raises questions concerning the relation between speaking subject (...) and listening public in times of problematic social cohesion. It then turns to Jürgen Habermas’ theoretical figures of the public to discuss the projective as well as resistant moments of publicness as significant features of communalization in the university. Regarding its transgenerational presuppositions and withdrawals, cohabitation in a university’s public can be considered as a matter of ecological and cultural inheritance. (shrink)

Much of modern technology critique inherits Heidegger’s ontico-ontological distinction. In this paper, following Stiegler’s linking of the ontic to the transgenerational, I argue that Heidegger leaves the materiality of technics as a potential site for difference in the wake. Put differently, Heidegger “declines the gift of the ontic,” instead constructing an order of an imagined Graeco-German inheritance—a culturally and linguistically specific “saving-power” against the ills of modern technology. Through Derrida’s inheritance of Heidegger’s work—marked by a different language (...) and positionality—I reconsider ontico-ontological difference as an opening to a co-constitutive productivity of world and thing, where the passing on of mnemonic inheritance features multiplicities of languages and cultural techniques that preempt Heidegger’s “Graeco-German monolingualism.” This calls for a central positioning of the politics of memory and inheritance within modern technology critique, thereby attending both to the material realities as well as the cultural differences of technics. (shrink)

At the heart of this article is the question: what might it mean for us to become literate in our mothers’ melancholia? Drawing on the ambivalence of two domestic scenes—its melancholia, its unbearability, its haptic residue—this article accesses a brown feminine and feminist lieux de memoir (place of memory). I argue that for brown immigrant daughters, feminism is inherited, not as rebukes, admonitions, endorsements, condemnations, but by entering the scene of violence, laterally, repetitively, reiteratively, vertiginously. In so doing, what we (...) inherit might be understood as a poetics—a sensuous thought form, an undergirding system of citation, seeming arbitrariness and repetition (litany if you will), a haptic sensation of bearing the unbearable, of feeling the wretchedness, the torment, and the ethics that characterise our transgenerational diasporic inheritance. (shrink)

What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can (...) this be translated to humans? To date, literature on fathers is scarce. Human studies do not always incorporate appropriate tools to evaluate paternal influences or epigenetic effects. In reviewing the literature, I stress the need to explore and recognize paternal contributions to offspring's health within the Developmental Origins of Health and Disease hypothesis, and coin this new concept the Paternal Origins of Health and Disease paradigm. A better understanding of preconceptional origins of disease through the totality of paternal exposures, or the paternal exposome, will provide evidence-based public health recommendations for future fathers. A father's hereditary contribution exceeds that of his DNA sequence. The environment can regulate systems such as the sperm epigenome, which is inheritable as well and may steer the genome and health status of his offspring. We here suggest a new concept, the Paternal Origins of Health and Disease, as part of the DOHaD theory. (shrink)

This study examines representations of transgenerational trauma and healing strategies in Chika Unigwe’s The Middle Daughter. The analysis of the novel pays critical attention to the intergenerational transmission of trauma within the mother–middle daughter relationship. Drawing on the tenets of Trauma Theory, the study reveals how silence, emotional repression, and culturally shaped parenting practices contribute to the psychological distress of the protagonist, Nani. Through a close investigation of characterization and events in the narrative, the paper shows how the often-overlooked (...) role of the middle daughter affects emotional visibility and self-perception within the family, yielding to traumatic flashbacks. The analysis further demonstrates that unresolved maternal trauma and cultural expectations influence Nani’s romantic and non-romantic relationships, shaping her vulnerability and internalized guilt. Finally, the study discusses Nani’s path to healing, through narration, maternal agency, and personal autonomy, arguing that recovery begins with reclaiming one’s story and voice. By closely reading the novel alongside the postulations of trauma scholars such as Judith Herman, Cathy Caruth, Marianne Hirsch, C. N. Van der Merwe, and Pumla Gobodo-Madikizela, the research contributes to trauma studies in African literature by highlighting the psychological cost of inherited silence and the therapeutic import of emotional truth-telling. (shrink)

Transformations of Lamarckism is an edited volume arising from a workshop to commemorate the bicentenary of the publication of Philosophie Zoologique. The contributed chapters discuss the history of Lamarckism, present new developments in biology that could be considered to vindicate Lamarck, and argue for a revision, if not a revolution, in evolutionary theory. My review argues that twentieth and twenty-first century conceptions of Lamarckism can be considered a reaction to August Weismann’s uncompromising rejection of the inheritance of acquired characters (...) in the late nineteenth century. Weismann rejected the inheritance of acquired characters both as a proximate mechanism of heredity and as an ultimate cause of adaptation. I argue that Weismann’s proximate claim is still valid for the kind of mechanism that he had in mind but that the inheritance of acquired characters has come to refer to many different processes, some of which undoubtedly do occur. However, processes of physiological adaptation and adaptive plasticity, even if transgenerational, do not challenge Weismann’s claim about the ultimate causes of adaptation because these processes can be understood as evolving by natural selection. Finally, I discuss some of the emotional and aesthetic reasons why many find Lamarckism an attractive alternative to hard-core neo-Darwinism. (shrink)

The possible evolutionary significance of epigenetic memory and codes is a key problem for extended evolutionary synthesis and biosemiotics. In this paper, some less known original works are reviewed which highlight theoretical parallels between current evolutionary epigenetics, on the one hand, and its predecessors in the eco-physiology of higher nervous activity, on the other. Recently, these areas have begun to converge, with first evidence now indicating the possibility of transgenerational epigenetic inheritance of conditional associations in the mammalian nervous (...) system, and related findings in other taxa. This can serve as an interesting example of evolutionary code-making, where the molecular mechanisms underlying arbitrary associations between stimuli involve lasting changes in gene expression that may be transmitted epigenetically across generations, and which in some cases could be further assimilated into the genome over subsequent evolution. Although preliminary, such epigenetic scenarios would also offer an interesting, if so far overlooked parallel to earlier research carried out by one of I.P. Pavlov’s leading students, acad. P.K. Anokhin, and his colleagues, but also by eminent eco-physiologists of the time, several of whom offered arguments for the possibility of unconditional reflexes representing evolutionarily later, specialized, and reduced forms of associative reflexes, from which they may be derived. Although discarded under the growing dominance of modern synthesis, these early epigenetic investigations may deserve renewed attention in the modern context, and if further confirmed, could open essentially new perspectives on the morphofunctional evolution of the nervous system. (shrink)

During mammalian development, maintenance of cell fate through mitotic divisions require faithful replication not only of the DNA but also of a particular epigenetic state. Germline cells have the capacity of erasing this epigenetic memory at crucial times during development, thereby resetting their epigenome. Certain marks, however, appear to escape this reprogramming, which allows their transmission to the offspring and potentially guarantees transgenerational epigenetic inheritance. Here we discuss the molecular requirements for faithful transmission of epigenetic information and our (...) current knowledge about the transmission of epigenetic information through generations. (shrink)

The environment can have a long‐lasting influence on an individual's physiology and behavior. While some environmental conditions can be beneficial and result in adaptive responses, others can lead to pathological behaviors. Many studies have demonstrated that changes induced by the environment are expressed not only by the individuals directly exposed, but also by the offspring sometimes across multiple generations. Epigenetic alterations have been proposed as underlying mechanisms for such transmissible effects. Here, we review the most relevant literature on these changes (...) and the developmental stages they affect the most. We discuss current evidence for transgenerational effects of prenatal and postnatal factors on bodily functions and behavioral responses, and the potential epigenetic mechanisms involved. We also discuss the need for a careful evaluation of the evolutionary importance with respect to health and disease, and possible directions for future research in the field. (shrink)

Stress is one of the most powerful experiences to influence health and disease. Through epigenetic mechanisms, stress may generate a footprint that propagates to subsequent generations. Programming by prenatal stress or adverse experience in parents, grandparents, or earlier generations may thus be a critical determinant of lifetime health trajectories. Changes in regulation of microRNAs (miRNAs) by stress may enhance the vulnerability to certain pathogenic factors. This review explores the hypothesis that miRNAs represent stress‐responsive elements in epigenetic regulation that are potentially (...) heritable. Recent findings suggest that miRNAs are key players linking adverse early environments or ancestral stress with disease risk, thus they represent useful predictive disease biomarkers. Since miRNA signatures of disease are potentially heritable, big data management platforms will be vital to harness multi‐generational information and capture succinct yet potent biomarkers capable of directing preventative treatments. This feature would offer a unique window of opportunity to advance personalized medicine. (shrink)

Trauma and traumatization have arguably always been part of the human experience yet have in the last few decades come to occupy a prominent place in various popular and academic contexts. This chapter offers an interdisciplinary and comparative investigation of trauma and traumatization in different historical contexts. More specifically, my aim is to discuss whether the rich bodies of research in trauma and traumatization in Holocaust survivors and their descendants yield relevant insights for post-slavery contexts. It has been shown that (...) children of Holocaust survivors suffer from stress and other symptoms related to their parents’ traumatization which influence the interactions with their environments. Such results made me wonder whether the traumatic impact of chattel slavery—which has been abolished some 160 years ago—might have a similar impact, yet now across several generations. Issues of the transmission and current persistence of trauma are inherently linked to questions of social justice, recognition and reparations. This chapter is meant, however, as an exploration of interdisciplinary connections that should be studied in concert to account for the traumatic impact of historical and present day experiences. It starts by discussing the concepts of trauma and post-traumatic stress disorder. Continuing by exploring the phenomenon of the inter- and transgenerational transmission of trauma, it relies in part on the important body of research conducted on families of Holocaust survivors. I then turn to the much less researched ‘post-traumatic slave syndrome’ (DeGruy) and discuss two factors that might contribute to the transgenerational transmission of trauma in the families of former enslaved: epigenetics and the continuation of traumatization even after the abolition of slavery as articulated in Historical Trauma theory. Drawing upon these insights, I conclude that it is plausible that a continuing transgenerational transmission of trauma might occur in some families of slavery survivors, the knowledge of which might help to break the chains of such traumatization across generations. (shrink)

On the “Isolation Account” of belief’s ethical significance, our beliefs can be noninstrumentally ethically significant independently of their epistemic status and in isolation from other attitudes or actions. However, critics object that fundamental ethical significance should instead be located in nondoxastic attitudes in belief’s vicinity. This article develops an alternative view—the “Constitutive Inheritance Account”—on which our beliefs can inherit ethical significance from the more fundamental ethical significance of the attitudes they partly or fully constitute. The Constitutive Inheritance Account (...) incorporates the objection’s insight while accommodating the intuitions motivating the Isolation Account and better explaining belief’s noninstrumental ethical significance. (shrink)

There is broad egalitarian agreement that inheritance results in distributive injustice and indirectly delegitimises the political process; we should abolish it. But until we do this, and put in place public safety nets, parents do no wrong in insuring their children against destitution. Both procreative liability and parental love generate duties that justify some bequests, limited in size and form. In the aggregate, however, the bequests are likely to be substantial, impeding egalitarian reforms. The stringency and demandingness of procreative (...) and parental duties provide (would-be) parents with special and powerful reason to support justice and, in particular, public safety nets. (shrink)

The notion of transgenerational community is usually based on two diachronic interactions. The first interaction consists of present generations taking up the legacy (not only economic, but also institutional, artistic, cultural, and so forth) of past generations and giving it continuity, exercising a form of active agency. The second interaction occurs when present generations pass on their legacy to future generations. This is supposed to expand the boundaries of the community in a transgenerational sense (both backward- and forward-looking). (...) In this article we argue that the transgenerational community can be grounded on a different ontological insight: future generations play the role of fictional actors for present generations, i.e., present generations entertain a present-time interaction with future generations, insofar as future generations are functional for the realization of transgenerational actions. This lays the foundations for more solid community-based bonds of intergenerational justice. (shrink)

According to the received view of evolution, only genes are inherited. From this view it follows that only genetically-caused phenotypic variation is selectable and, thereby, that all selection is at bottom genetic selection. This paper argues that the received view is wrong. In many species, there are intergenerationally-stable phenotypic differences due to environmental differences. Natural selection can act on these nongenetically-caused phenotypic differences in the same way it acts on genetically-caused phenotypic differences. Some selection is at bottom nongenetic selection. The (...) argument against the received view involves a reformulation of the concepts of inheritance and heritability. Inherited factors are all those developmental factors responsible for parent–offspring similarity; some inherited factors are genetic and some are not. Heritable variation is intergenerationally-stable phenotypic variation; some such variation is genetically-caused and some is not. The received view and its critics The possibility of nongenetic selection (the lucky butterfly) The reality of nongenetic selection 3.1 Imprinting mechanisms 3.2 Other learning mechanisms 3.3 Other nongenetic mechanisms Genetic and nongenetic inheritance mechanisms Genetic and nongenetic inherited factors Genetic and nongenetic heritability Conclusions + Current address: Dr Matteo Mameli, Research Fellow, King's College, Cambridge, CB2 1ST, United Kingdom, matteo.mameli{at}kings.cam.ac.uk' + u + '@' + d + ''//-->. (shrink)