The dynamics of eukaryotic DNA polymerases has been difficult to establish because of the difficulty of tracking them along the chromosomes during DNA replication. Recent work has addressed this problem in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae through the engineering of replicative polymerases to render them prone to incorporating ribonucleotides at high rates. Their use as tracers of the passage of each polymerase has provided a picture of unprecedented resolution of the organization of replicons and replication origins in (...) the two yeasts and has uncovered important differences between them. Additional studies have found an overlapping distribution of DNA polymorphisms and the junctions of Okazaki fragments along mononucleosomal DNA. This sequence instability is caused by the premature release of polymerase δ and the retention of non proof‐read DNA tracts replicated by polymerase α. The possible implementation of these new experimental approaches in multicellular organisms opens the door to the analysis of replication dynamics under a broad range of genetic backgrounds and physiological or pathological conditions. (shrink)

The many-gods objection is perhaps the most famous criticism levelled against Pascal’s wager. This chapter offers a response that combines two main ideas. The first is the development of the ‘many-wagers’ model, a dynamics of rational deliberation that allows the credences in a many-gods problem to evolve in a rationally permissible manner, even in the absence of relevant new evidence. The second idea is that stability of these credences, within this evolutionary model, is a necessary condition for viability. This (...) stability condition provides the Pascalian with convincing responses to a wide range of many-gods problems. Thus, many versions of the many-gods objection contribute no difficulties for Pascal’s wager beyond those that already plague its classic formulation with just one deity. (shrink)

Over the past several decades, research in the cognitive sciences has foregrounded the importance of active bodies and their continuous dependence on the changing environment, strengthening the relevance of dynamical models. These models have been steadily developed within the ecological psychology approach to cognition, which arguably contributes to the “ecological turn” we are witnessing today. The embodied and situated nature of cognition, regarded by some as a passing trend, is presently becoming a largely accepted assumption. In this paper, I claim (...) that in light of these developments, ecological psychology, in alliance with related approaches, such as enactivism and interactivism, has the potential to deeply transform our perspectives on cognition and action, restoring their pertinence to humans as persons. However, an important challenge to the realization of this potential has to be noted: neither the mainstream information-processing approach nor the dynamics-oriented perspective on cognition provides an account of how the capacity of humans to use language and think “symbolically” can be derived from the continuous flow of agent−environment interaction. I will attempt to show that posing the “dynamical” and “computational” hypotheses about the nature of cognition as mutually exclusive approaches to cognition results in undesirable reductionism, which makes it difficult to meet this challenge. There are good reasons, advanced over half a century ago by, for example, Michael Polanyi or Howard Pattee, to think that we need complementary descriptions to understand cognizing systems, in order to grasp the fact that they are governed both by physical laws and by emergent historical constraints. Details of such a complementarity-based approach still await elucidation, but some proposed solutions have the potential to ease the tension between the information-processing and dynamical approaches to cognition and to lead to a better understanding of their interrelation. (shrink)

This paper revisits the debate between Harry Collins and Allan Franklin, concerning the experimenters’ regress. Focusing my attention on a case study from recent psychology (regarding experimental evidence for the existence of a Mozart Effect), I argue that Franklin is right to highlight the role of epistemological strategies in scientific practice, but that his account does not sufficiently appreciate Collins’s point about the importance of tacit knowledge in experimental practice. In turn, Collins rightly highlights the epistemic uncertainty (and skepticism) surrounding (...) much experimental research. However, I will argue that his analysis of tacit knowledge fails to elucidate the reasons why scientists often are (and should be) skeptical of other researchers’ experimental results. I will present an analysis of tacit knowledge in experimental research that not only answers to this desideratum, but also shows how such skepticism can in fact be a vital enabling factor for the dynamic processes of experimental knowledge generation. (shrink)

This chapter compares replicator dynamics for some simple games with and without the addition of conformist bias. The addition of conformist bias can create equilibria, it can change the stability properties of existing equilibria, it may leave the equilibrium structure intact but change the relative size of basins of attraction, or it may do nothing at all. Examples of each of the foregoing are given.

Bayesian learning theory and evolutionary theory both formalize adaptive competition dynamics in possibly high‐dimensional, varying, and noisy environments. What do they have in common and how do they differ? In this paper, we discuss structural and dynamical analogies and their limits, both at a computational and an algorithmic‐mechanical level. We point out mathematical equivalences between their basic dynamical equations, generalizing the isomorphism between Bayesian update and replicator dynamics. We discuss how these mechanisms provide analogous answers to the (...) challenge of adapting to stochastically changing environments at multiple timescales. We elucidate an algorithmic equivalence between a sampling approximation, particle filters, and the Wright‐Fisher model of population genetics. These equivalences suggest that the frequency distribution of types in replicator populations optimally encodes regularities of a stochastic environment to predict future environments, without invoking the known mechanisms of multilevel selection and evolvability. A unified view of the theories of learning and evolution comes in sight. (shrink)

The replicator dynamics and Moran process are the main deterministic and stochastic models of evolutionary game theory. The models are connected by a mean-field relationship—the former describes the expected behavior of the latter. However, there are conditions under which their predictions diverge. I demonstrate that the divergence between their predictions is a function of standard techniques used in their analysis and of differences in the idealizations involved in each. My analysis reveals problems for stochastic stability analysis in a (...) broad class of games, demonstrates a novel domain of agreement between the dynamics, and indicates a broader moral for evolutionary modeling. (shrink)

In billion years of evolution, eukaryotes preserved the chromosome ends with arrays of guanine repeats surrounded by thymines and adenines, which can form stacks of four‐stranded planar structure known as G‐quadruplex (G4). The rationale behind the evolutionary conservation of the G4 structure at the telomere remained elusive. Our recent study has shed light on this matter by revealing that telomere G4 undergoes oscillation between at least two distinct folded conformations. Additionally, tumor suppressor BRCA2 exhibits a unique mode of interaction with (...) telomere G4. To elaborate, BRCA2 directly interacts with G‐triplex (G3)‐derived intermediates that form during the interconversion of the two different G4 states. In doing so, BRCA2 remodels the G4, facilitating the restart of stalled replication forks. In this review, we succinctly summarize the findings regarding the dynamicity of telomeric G4, emphasize its importance in maintaining telomere replication homeostasis, and the physiological consequences of losing G4 dynamicity at the telomere. (shrink)

Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in replication, repair, and recombination. Recent studies have shown that RPA binding to ssDNA is highly dynamic and that more than high‐affinity binding is needed for function. Analysis of DNA binding mutants identified forms of RPA with reduced affinity for ssDNA that are fully active, and other mutants with higher affinity that are inactive. Single molecule studies showed that (...) while RPA binds ssDNA with high affinity, the RPA complex can rapidly diffuse along ssDNA and be displaced by other proteins that act on ssDNA. Finally, dynamic DNA binding allows RPA to prevent error‐prone repair of double‐stranded breaks and promote error‐free repair. Together, these findings suggest a new paradigm where RPA acts as a first responder at sites with ssDNA, thereby actively coordinating DNA repair and DNA synthesis. (shrink)

We compare replicator dynamics for some simple games with and without the addition of conformist bias. The addition of conformist bias can create equilibria, it can change the stability properties of existing equilibria, it may leave the equilibrium structure intact but change the relative size of basins of attraction, or it may do nothing at all. Examples of each of the foregoing are given.

We study the handicap principle in terms of the Sir Philip Sidney game. The handicap principle asserts that cost is required to allow for honest signalling in the face of conflicts of interest. We show that the significance of the handicap principle can be challenged from two new directions. Firstly, both the costly signalling equilibrium and certain states of no communication are stable under the replicator dynamics ; however, the latter states are more likely in cases where honest (...) signalling should apply. Secondly, we prove the existence and stability of polymorphisms where players mix between being honest and being deceptive and where signalling costs can be very low. Neither the polymorphisms nor the states of no communication are evolutionarily stable, but they turn out to be more important for standard evolutionary dynamics than the costly signalling equilibrium. (shrink)

Genome instability (GIN) is a cell pathology linked to cancer promotion and tumor evolution. Transcription is an essential cellular process but also a potential source of DNA damage and GIN. Transcription‐replication conflicts (TRCs) are a predominant source of GIN, and defective TRC resolution may seriously compromise genome integrity. Importantly, chromatin dynamics helps orchestrate the response to TRCs to preserve genome integrity. Multiple epigenetic deficiencies have been shown to cause transcription‐induced replication stress, resulting in DNA breaks and mutations. Consistently, chromatin (...) alterations are frequent in cancer and correlate with increased mutation burden at TRC sites in tumors. Here, we review our current knowledge of TRC processing, the consequences of its dysfunction, and its relevance in cancer. We focus on the interplay between the DNA damage response (DDR) and chromatin dynamics and discuss the clinical potential of targeting TRCs as anticancer strategies and drugging the associated epigenetic signatures. (shrink)

The explanatory significance of equilibrium depends on the underlying dynamics. The dynamics may, indeed, never reach equilibrium but rather cycle or even describe a chaotic orbit. This point is illustrated with an example of chaotic replicator dynamics for a simple game.

Cancer cells accumulate widespread local and global chromatin changes and the source of this instability remains a key question. Here we hypothesize that chromatin alterations including unscheduled silencing can arise as a consequence of perturbed histone dynamics in response to replication stress. Chromatin organization is transiently disrupted during DNA replication and maintenance of epigenetic information thus relies on faithful restoration of chromatin on the new daughter strands. Acute replication stress challenges proper chromatin restoration by deregulating histone H3 lysine 9 (...) mono‐methylation on new histones and impairing parental histone recycling. This could facilitate stochastic epigenetic silencing by laying down repressive histone marks at sites of fork stalling. Deregulation of replication in response to oncogenes and other tumor‐promoting insults is recognized as a significant source of genome instability in cancer. We propose that replication stress not only presents a threat to genome stability, but also jeopardizes chromatin integrity and increases epigenetic plasticity during tumorigenesis. (shrink)

This paper explores the auto-replication process within the framework of Artificial Research by Deduction in the Global Artificial Intelligence (GAI). Auto-replication is defined not merely as the reproduction of systems or processes, but as a complex, autonomous mechanism of self-improvement and self-enhancement—both in terms of knowledge acquisition and technological evolution. Rooted in the foundational goal of attaining pure truth and universal autonomy, the paper distinguishes between reproduction (as seen in biological systems) and true auto-replication, where an artificial system adapts and (...) evolves independently of human intervention. -/- The Global Artificial Intelligence is conceptualized as a system of systems—including Artificial Research by Deduction, Modelling System, Decisional System, Application System, Learning System, and Engineering System—each capable of generating its own auto-replication dynamics. Within this structure, two core forms of decisions are highlighted: object-centered decisions, which aim to protect and improve the model itself, and subject-centered decisions, which enhance the intelligence and research capabilities of the systems making those decisions. -/- Drawing on earlier works such as “Auto-replication in Artificial Research by Application” and “Replication Processes in Specific Artificial Intelligence for Artificial Research by Deduction”, this study integrates concepts such as memory optimization, quantum computing, virtual engineering networks, and decentralized decision-making. The auto-replication process is shown to operate at all levels of the GAI—across systems, Specific Artificial Intelligences, and embedded programs—converging into a unified strategy of survival, adaptability, and ethical preservation of both artificial and biological life. -/- The ultimate test of intelligence, the paper concludes, lies not only in sustaining artificial cognition but in safeguarding the continuity of life on Earth. Auto-replication is, therefore, not an end in itself, but a critical function toward achieving global resilience, ecological balance, and intelligent evolution. (shrink)

Brain states, which correlate with specific motor, cognitive, and emotional states, may be monitored with noninvasive techniques such as electroencephalography and magnetoencephalography that measure macroscopic cortical activity manifested as oscillatory network dynamics. These rhythmic cortical signatures provide insight into the neuronal activity used to identify pathological cortical function in numerous neurological and psychiatric conditions. Sensory and transcranial stimulation, entraining the brain with specific brain rhythms, can effectively induce desired brain states correlated with such cortical rhythms. Because brain states have (...) distinct neural correlates, it may be possible to induce a desired brain state by replicating these neural correlates through stimulation. To do so, we propose recording brain waves from a “donor” in a particular brain state using EEG/MEG to extract cortical signatures of the brain state. These cortical signatures would then be inverted and used to entrain the brain of a “recipient” via sensory or transcranial stimulation. We propose that brain states may thus be transferred between people by acquiring an associated cortical signature from a donor, which, following processing, may be applied to a recipient through sensory or transcranial stimulation. This technique may provide a novel and effective neuromodulation approach to the noninvasive, non-pharmacological treatment of a variety of psychiatric and neurological disorders for which current treatments are mostly limited to pharmacotherapeutic interventions. (shrink)

The dominant assumption about the causal architecture of the mind is, that it is composed of a stable set of components that contribute independently to relevant observables that are employed to measure cognitive activity. This view has been called component-dominant dynamics. An alternative has been proposed, according to which the different components are not independent, but fundamentally interdependent, and are not stable basic properties of the mind, but rather an emergent feature of the mind given a particular task context. (...) This view has been called interaction-dominant dynamics. In this paper, we review evidence for interaction-dominant dynamics as the causal architecture of the mind. We point out, that such an architecture is consistent with problems of convergence in research on the level of results and theorizing. Moreover, we point out that if interaction-dominant dynamics as the causal architecture of the mind were to be true, this would naturally lead to problems with generalization and replicability in sciences of the mind and brain, and would probably warrant changes in the scientific practice with regard to study-design and data analysis. (shrink)

Transfer of information between senders and receivers, of one kind or another, is essential to all life. David Lewis introduced a game theoretic model of the simplest case, where one sender and one receiver have pure common interest. How hard or easy is it for evolution to achieve information transfer in Lewis signaling?. The answers involve surprising subtleties. We discuss some if these in terms of evolutionary dynamics in both finite and infinite populations, with and without mutation.

Aspiration-based evolutionary dynamics have recently been used to model the evolution of fair play in the ultimatum game showing that incredible threats to reject low offers persist in equilibrium. We focus on two extensions of this analysis: we experimentally test whether assumptions about agent motivations (aspiration levels) and the structure of the game (binary strategy space) reflect actual play, and we examine the problematic assumption embedded in the standard replicator dynamic that unhappy agents who switch strategies may return (...) to a rejected strategy without exploring other options. We find that the resulting “no switchback” dynamic predicts the evolution of play better than the standard dynamic and that aspirations are a significant motivator for our participants. In the process, we also construct and analyze a variant of the ultimatum game in which players can adopt conditional (on their induced aspirations) strategies. (shrink)

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the WRN DNA helicase/exonuclease defective in the premature aging disorder Werner syndrome. WRN and BRCA2 participate in complementary pathways to stabilize replication forks in cancer cells, allowing them to proliferate. Whether the functional overlap of WRN and BRCA2 (...) is relevant to replication at gaps between newly synthesized DNA fragments, protection of telomeres, and/or metabolism of secondary DNA structures remain to be determined. Advances in understanding the mechanisms elicited during replication stress have prompted the community to reconsider avenues for cancer therapy. Insights from studies of PARP or topoisomerase inhibitors provide working models for the investigation of WRN's mechanism of action. We discuss these topics, focusing on the implications of the WRN‐BRCA2 genetic interaction under conditions of replication stress. (shrink)

We study the dynamics and stability of the economics of crime and punishment game from an evolutionary perspective. Specifically, we model the interaction between agents and controllers as an asymmetric game exploring the dynamics of the classic static model using a replicator dynamics equation, given exogenous levels of monitoring and criminal sanctions. The dynamics show five possible equilibria, from which three are stable. Our results show that a culture of honest agents is never stable; however (...) when the penalty is high enough, the system will neutrally tend to an equilibrium of honest agents and a monitoring firm. By contrast, when the probability of detecting wrongdoing is small, the system, in some cases, will remain in a transient state, in which it is impossible to predict the proportion of honest agents. (shrink)

As research on mind wandering has accelerated, the construct’s defining features have expanded and researchers have begun to examine different dimensions of mind wandering. Recently, Christoff and colleagues have argued for the importance of investigating a hitherto neglected variety of mind wandering: “unconstrained thought,” or, thought that is relatively unguided by executive-control processes. To date, with only a handful of studies investigating unconstrained thought, little is known about this intriguing type of mind wandering. Across two experiments, we examined, for the (...) first time, whether changes in task demand influence rates of constrained versus unconstrained thoughts. In both experiments, participants completed either an easy (0-back) or hard (2-back) task and responded to intermittently presented thought probes that gauged thought constraint throughout the task. In Experiment 1, we found that participants completing the easy task engaged in unconstrained thoughts more frequently than those completing the difficult task. In Experiment 2, we replicated this result and further demonstrated manipulations of unconstrained thought while also measuring task-relatedness (a common dimension of mind wandering). Finally, exploratory analyses showed associations between constrained thought and age, verbal intelligence, and an assessment of flow (‘deep effortless concentration’), thereby adding further evidence to indicate a dissociation between task-relatedness and constraint. We discuss the methodological and theoretical applications of our findings to the burgeoning field of research on unconstrained thought. (shrink)

Because emotion regulation processes operate over time, they potentially change the context in which subsequent ER processes occur. To test this proposal, fifty-two healthy participants completed the ER choice task. Thirty standardized low- and high-intensity negative images were used to generate different emotional contexts in which participants selected between distraction or reappraisal strategies to decrease the intensity of their negative emotion. Participants then implemented their selected strategy and rated their negative emotion. Using a dynamic perspective, we examined as predictors of (...) ER strategy choice, in addition to current stimulus intensity, several contextual factors from the immediately preceding trial: preceding stimulus intensity and strategy choice, and the intensity of negative affect following the previous strategy implementation and thus preceding the current trial. Results replicated earlier findings that participants are more likely to choose distraction for high-intensity images. Extending earlier findings, selecting reappraisal in the preceding trial and greater negative affect preceding the current trial were associated with lower odds of choosing distraction. The lack of significant interactions among the current and preceding trial factors suggests that these effects on ER choice were direct and not through moderating the effect of current stimulus intensity. These findings support dynamic theories of ER. (shrink)

Excerpt from The Dynamic Foundation of Knowledge It is now a long time since the writer of the following pages first thought of a dynamical interpretation of the concept of Matter. After some years of consideration and discussion he expressed his views in print in an essay entitled Matter and Energy: Are there two Real Things in the Physical Universe? This essay was published in 1887. A second essay was published in 1897 under the title, The Doctrine of Energy: A (...) Theory of Reality. In these essays he maintained that the scientific concept of energy adequately explains the phenomena of nature, and that the inconsistent concept of material reality should be finally abandoned. The question referred to has made great apparent progress since the date first mentioned above. The foolish abuse with which in certain quarters such ideas were then greeted has disappeared. They might now almost be called popular. In philosophical journals they are constantly referred to, whilst as integral parts of scientific theory they are accepted and employed by many high authorities. The successors of some who looked upon them with dislike and derision seem even disposed to claim them as their own. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

This paper discusses the explanatory significance of the equilibrium concept in the context of an example of extremely complicated dynamical behavior. In particular, numerical evidence is presented for the existence of chaotic dynamics on a "strange attractor" in the evolutionary game dynamics introduced by Taylor and Jonker [also known as the "replicator dynamics"]. This phenomenon is present already in four strategy evolutionary games where the dynamics takes place in a simplex in three dimensional space-the lowest (...) number of dimensions in which such a strange attractor is possible. From a dynamical point of view, it is the attractor-rather than the equilibrium-that is of prime interest. (shrink)

Emotion dynamics, which describe affective patterns over time, may illustrate how specific emotion regulation difficulties manifest in daily life. However, limited research links emotion regulation with emotion dynamics assessed naturalistically. In two samples, 62 and 304 university students completed the Difficulties in Emotion Regulation Scale then completed ecological momentary assessments of positive and negative affect thrice daily for seven and 14 days, respectively, to examine mean positive and negative affect, affective variability, affective instability, and emotional inertia. Self-reported emotion (...) regulation difficulties broadly correlated with elevated mean negative affect and lower positive affect. However, no specific association of an emotion regulation difficulty with affective variability, instability, or inertia replicated across samples. Further research is needed with diverse methodologies to explore how in situ emotion dynamics reflect emotion regulation difficulties. (shrink)

The astonishing efficiency and accuracy of DNA replication has long suggested that refined rules enforce a single highly reproducible sequence of molecular events during the process. This view was solidified by early demonstrations that DNA unwinding and synthesis are coupled within a stable molecular factory, known as the replisome, which consists of conserved components that each play unique and complementary roles. However, recent single-molecule observations of replisome dynamics have begun to challenge this view, revealing that replication may not be (...) defined by a uniform sequence of events. Instead, multiple exchange pathways, pauses, and DNA loop types appear to dominate replisome function. These observations suggest we must rethink our fundamental assumptions and acknowledge that each replication cycle may involve sampling of alternative, sometimes parallel, pathways. Here, we review our current mechanistic understanding of DNA replication while highlighting findings that exemplify multi-pathway aspects of replisome function and considering the broader implications. Recent single-molecule studies have revealed that replisome function is dominated by stochastic sampling of multiple molecular pathways. In the context of these new findings, we re-examine the foundational assumptions and seminal experiments that have guided our understanding of replication mechanism and reconcile several long-debated coordination models. (shrink)

We propose a new approach for the visual inspection of the dynamic interplay between several determinants of entrepreneurship and other socioeconomic variables. We focused on the evolution of these variables in 23 countries from 2010 to 2020. First, we ranked the countries according to their growth during the sample period. Second, we clustered the different states by means of a dimensionality-reduction technique that enabled synthesising the ordinal information of the rankings into two dimensions. Finally, countries were projected into a perceptual (...) map according to their scores in both dimensions. We replicated the analysis both for 2020 and for the growth observed during the decade. In both cases, we observed two clusters of countries that roughly correspond to European and Latin American economies. Angola obtained top scores in the two dimensions both in 2020 and during the decade. Regarding the interactions among variables, for 2020 we observed that early-stage entrepreneurship shows a negative association with access to financing and human development. During the decade, we observed a positive link between early-stage entrepreneurship and market dynamism, which in turn showed no connection with human development. These findings somehow suggest that the relative importance of the determinants of entrepreneurship evolved throughout the decade. (shrink)

Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of (...) cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

© 2015 Wong,Tassone,Rivera and Simon.Carriers of the fragile X premutation allele have an expanded CGG trinucleotide repeat size within the FMR1 gene and are at increased risk of developing fragile x-associated tremor/ataxia syndrome. Previous research has shown that male fXPCs with FXTAS exhibit cognitive decline, predominantly in executive functions such as inhibitory control and working memory. Recent evidence suggests fXPCs may also exhibit impairments in processing temporal information. The attentional blink task is often used to examine the dynamics of (...) attentional selection, but disagreements exist as to whether the AB is due to excessive or insufficient attentional control. In this study, we used a variant of the AB task and neuropsychological testing to explore the dynamics of attentional selection, relate AB performance to attentional control, and determine whether fXPCs exhibited temporal and/or attentional control impairments. Participants were adult male fXPCs, aged 18–48 years and asymptomatic for FXTAS and age-matched male controls. We found that fXPCs did not differ from controls in the AB task, indicating that the temporal dynamics of attentional selection were intact. However, they were impaired in the letter-number sequencing task, a test of executive working memory. In the combined fXPC and control group, letter-number sequencing performance correlated positively with AB magnitude. This finding supports models that posit the AB is due to excess attentional control. In our two-pronged analysis approach, in control participants we replicated a previously observed effect and demonstrated that it persists under more stringent theoretical constraints, and we enhance our understanding of fXPCs by demonstrating that at least some aspects of temporal processing may be spared. (shrink)

More instability (MSSD) and variability (SD) of negative affect (NA) have been related to current and future depressive symptoms. We investigated whether NA instability and variability were predictive of the rate of symptom improvement during treatment and of reaching remission status. Forty-six individuals with major depressive disorder completed six days of ecological momentary assessments (10 beeps/day) before starting a combination of pharmacotherapy and supportive therapy. During and after treatment, the Hamilton Depression Rating Scale (HDRS) diagnostic interview was performed monthly for (...) 18 months. The rate of change in HDRS scores over five months (during treatment) and remission status (HDRS ≤ 7) over eighteen months were predicted by the SD, MSSD and Mean of NA, and relevant baseline predictors. Higher Mean NA and baseline symptom severity, but not NA variability or instability, predicted stronger depressive symptom reduction during treatment. Higher odds of remitting were only associated with lower Mean NA. Higher mean NA may indicate more room for improvement and thus for a steeper rate of symptom change, while lower mean NA levels may imply that remission status is more readily reached. To resolve the inconclusive findings for instability and variability as predictors of symptom improvement replication in larger samples is required. (shrink)

Formal models of cultural evolution analyze how cognitive processes combine with social interaction to generate the distributions and dynamics of ‘representations.’ Recently, cognitive anthropologists have criticized such models. They make three points: mental representations are non-discrete, cultural transmission is highly inaccurate, and mental representations are not replicated, but rather are ‘reconstructed’ through an inferential process that is strongly affected by cognitive ‘attractors.’ They argue that it follows from these three claims that: 1) models that assume replication or replicators are (...) inappropriate, 2) selective cultural learning cannot account for stable traditions, and 3) selective cultural learning cannot generate cumulative adaptation. Here we use three formal models to show that even if the premises of this critique are correct, the deductions that have been drawn from them are false. In the rst model, we assume continuously varying representations under the in uence of weak selective transmission and strong attractors. We show that if the attractors are suf ciently strong relative to selective forces, the continuous representation model reduces to the standard.. (shrink)

We present a research on smart city planning and community governance using dynamic game methods, analyze the current status and problems of the current smart community service system, and put forward countermeasures and suggestions based on the global smart community development experience. Through smart city planning and construction, the game model of government governance and information sharing between communities and decision making is obtained, and the two-dimensional replication dynamic system equations of smart city planning and construction agencies and communities are (...) obtained from smart city planning and construction. The evolutionary stability strategy and a united front are analyzed. The strategy achieves the ideal stable conditions. We define the relevant definition of a smart community and discuss the purpose and significance of the research, especially the importance and necessity of the construction of the smart community. Based on the current situation of the construction of smart communities, we conduct specific research, discuss the deficiencies and shortcomings in the current construction of smart communities, and find out the causes of these problems. Finally, based on learning from the relevant work experience, corresponding improvement measures are proposed for the existing problems from the united front, top-level design, social participation, platform construction, and talent training. (shrink)

In this article, we present a modal logic that extends the basic modal logic with two dynamic operators: copy ( ), which replicates the current model, labelling each copy with a different propositional symbol and respecting accessibility relations even between distinct copies; and remove ( ), which deletes paths in the model that satisfy certain intermediate conditions. We call the resulting logic. We study its computational complexity, and its relative expressivity with respect to (static) modal logics and, and the dynamic (...) epistemic Action Model Logic,. (shrink)

Arguably, there is no substantial, general answer to the question of what makes for the approximate truth of theories. But in one class of cases, the issue seems simply resolved. A wide class of applied dynamical theories can be treated as two-component theories—one component specifying a certain kind of abstract geometrical structure, the other giving empirical application to this structure by claiming that it replicates, subject to arbitrary scaling for units etc., the geometric structure to be found in some real-world (...) dynamical phenomenon. In such a case, a theory is approximately true just if the one geometric structure approximately replicates the other (and if problems remain here, they are problems in geometry, of specifying suitable metric approximation relations, not conceptual problems). This article amplifies and defends this simple approach to approximate truth for dynamical theories. (shrink)

Adaptive learning dynamics have been widely studied in monotone games. By assuming that players eventually choose undominated responses to past play, these processes are intrinsically backwards-looking. However, it is also reasonable to assume that players are able to anticipate the backwards-looking behavior of their opponents, resulting in forward-looking dynamics which have largely been ignored in this literature. Using a cognitive hierarchy framework, we show that the limits of all k-level adaptive learning dynamics, which allow for k levels (...) of such forward-looking behavior and subsume adaptive dynamics when $$k=1$$, fall within the smallest interval containing all serially undominated strategies, and hence converge to the unique serially undominated equilibrium in dominance solvable games. Using over 1200 rounds of experimental duopoly data from Oechssler et al. (J Econ Sci Assoc 2:13–21, 2016a; From imitation to collusion: a replication [dataset], 2016b. https://doi.org/10.11588/data/10075 ), we find not only that the k-level model is highly consistent with observed behavior, but our findings also suggest that allowing for higher levels of reasoning has an explanatory advantage over traditional adaptive dynamics. (shrink)

This paper presents a theoretical and architectural framework for the implementation of auto-replication processes in Specific Artificial Intelligence (SAI) systems dedicated to Artificial Research by Deduction. Auto-replication, in this context, refers to the autonomous ability of a deductive SAI to improve, adapt, and evolve its own reasoning structures, proof mechanisms, and knowledge bases without external intervention. Unlike simple replication, auto-replication implies a dynamic and self-sustaining system capable of assessing the performance of its deductive operations and reproducing enhanced instances of itself (...) to improve precision, efficiency, and epistemic transparency. This capacity supports recursive self-improvement in narrowly defined logical domains and enables the generation of multiple coordinated deductive agents. The paper argues that auto-replication is a critical milestone toward the emergence of Global Artificial Intelligence (GAI), offering a reliable mechanism for scaling provable reasoning and self-correcting research behavior across interconnected SAI modules. By formalizing the principles of auto-replication, the study lays the foundation for robust, autonomous, and logically sound research systems. (shrink)

How can we effectively promote the public’s prevention of coronavirus disease 2019 infection? Jordan et al. found with United States samples that emphasizing either self-interest or collective-interest of prevention behaviors could promote the public’s prevention intention. Moreover, prosocially framed messaging was more effective in motivating prevention intention than self-interested messaging. A dual consideration of both cultural psychology and the literature on personalized matching suggests the findings of Jordan et al. are counterintuitive, because persuasion is most effective when the frame of (...) the message delivered and the recipient of the message are culturally congruent. In order to better understand the potential influence of culture, the current research aimed to replicate and extend Jordan et al. findings in the Japanese context. Specifically, we examined the question whether the relative effectiveness of the prosocial appeal is culturally universal and robust, which types of ‘others’ especially promote prevention intention, and which psychological mechanisms can explain the impact of messaging on prevention intention. In Study 1, we confirmed that self-interested framed, prosocially framed, and the combination of both types of messaging were equally effective in motivating prevention intention. In Study 2, we found that family-framed messaging also had a promoting effect similar to that from self-interested and prosocial appeals. However, the relative advantage of prosocial appeals was not observed. Further, a psychological propensity relevant to sensitivity to social rejection did not moderate the impact of messaging on prevention intention in both studies. These results suggest that since engaging in the infection control itself was regarded as critical by citizens after public awareness of COVID-19 prevention has been sufficiently heightened, for whom we should act might not have mattered. Further, concerns for social rejection might have had less impact on the prevention intentions under these circumstances. These results suggest that the relative advantage of a prosocial appeal might not be either culturally universal or prominent in a collectivistic culture. Instead, they suggest that the advantages of such an appeal depends on the more dynamic influence of COVID-19 infection. (shrink)

Since 1989, widely circulating statistics on gay teen suicide in the United States have acted as catalysts for institutional reforms, scientific research, and the creation of an identity category “gay youth.” While one figure has been replicated scientifically, these numbers originated not from a scientific research study but as risk estimates developed by a social worker and published in a government document. Many people within the public took up these original numbers, attributing their author the status of scientific researcher. In (...) effect, the numbers became “black boxed,” often traveling without citation. Drawing on Ian Hacking’s “dynamic nominalist” perspective, this article utilizes interviews with the author of these statistics and other key claimants, along with textual analysis, to trace the origins, uptake, and effects of these figures. While making vital policy contributions, the numbers have led to some ironic consequences including the fostering of gay youth identification with suicide as a potential correlate of their identity and the potential antigay redeployment of decontextualized numbers. They have also led to a reaction in the form of “resilience” narratives. (shrink)

The tendency for emotions to be predictable over time, labelled emotional inertia, has been linked to low well-being and is thought to reflect impaired emotion regulation. However, almost no studies have examined how emotion regulation relates to emotional inertia. We examined the effects of cognitive reappraisal and expressive suppression on the inertia of behavioural, subjective and physiological measures of emotion. In Study 1 (N = 111), trait suppression was associated with higher inertia of negative behaviours. We replicated this finding experimentally (...) in Study 2 (N = 186). Furthermore, in Study 2, instructed suppressors and reappraisers both showed higher inertia of positive behaviours, and reappraisers displayed higher inertia of heart rate. Neither suppression nor reappraisal were associated with the inertia of subjective feelings in either study. Thus, the effects of suppression and reappraisal on the temporal dynamics of emotions depend on the valence and emotional response component in question. (shrink)

Recent work supports the role of reasoning in third-party moral judgment of harm transgressions. The dynamics of the underlying cognitive processes supporting moral judgment is however poorly understood. In two preregistered experiments, we addressed this issue using a two-response paradigm. Participants were presented with moral scenarios twice: they had to provide their first judgment about an agent under both time pressure and interfering load, and were then asked to respond a second time at their own pace. In Experiment 1, (...) participants were harsher toward a malevolent agent at the second response, assigning more moral wrongness and punishment to an agent who either attempted to harm or harmed intentionally. Experiment 2 replicated the effect of intention on response change in a paradigm contrasting accidental to intentional harm scenarios. Participants were not only harsher toward intentional transgressors at the second response, but they were also less harsh toward accidental transgressors at the second response. We discuss the possibility that decoding overall intent and assigning moral judgment based on the presence or absence of a malevolent intent may be a relatively costly process. (shrink)

It is long known that facial configurations play a critical role when inferring mental and emotional states from others. Nevertheless, there is still a scientific debate on how we infer emotions from facial configurations. The theory of constructed emotion (TCE) suggests that we may infer different emotions from the same facial configuration, depending on the context (e.g. provided by visual and lexical cues) in which they are perceived. For instance, a recent study found that participants were more accurate in inferring (...) mental and emotional states across three different datasets (i.e. RMET, static and dynamic emojis) when words were provided (i.e. forced-choice task), compared to when they were not (i.e. free-labelling task), suggesting that words serve as contexts that modulate the inference from facial configurations. The goal of the current within-subject study was to replicate and extend these findings by adding a fourth dataset (KDEF-dyn), consisting of morphed human faces (to increase the ecological validity). Replicating previous findings, we observed that words increased accuracy across the three (previously used) datasets, an effect that was also observed for the facial morphed stimuli. Our findings are in line with the TCE, providing support for the importance of contextual verbal cues in emotion perception. (shrink)

Glover's planning–control model is based on his finding that visual illusions exert a larger effect in early phases than in late phases of a movement. But evidence for this dynamic illusion effect is weak, because: (a) it appears difficult to replicate; (b) Glover overestimates the accuracy of his results; and (c) he seems to underestimate the illusion effect at late phases.

Holobionts, consisting of a host and diverse microbial symbionts, function as distinct biological entities anatomically, metabolically, immunologically, and developmentally. Symbionts can be transmitted from parent to offspring by a variety of vertical and horizontal methods. Holobionts can be considered levels of selection in evolution because they are well-defined interactors, replicators/reproducers, and manifestors of adaptation. An initial mathematical model is presented to help understand how holobionts evolve. The model offered combines the processes of horizontal symbiont transfer, within-host symbiont proliferation, vertical symbiont (...) transmission, and holobiont selection. The model offers equations for the population dynamics and evolution of holobionts whose hologenomes differ in gene copy number, not in allelic or loci identity. The model may readily be extended to include variation among holobionts in the gene identities of both symbionts and host. (shrink)