There is much evidence, both in humans and rodents, that while navigating males tend to use geometric information whereas females rely more on landmarks. The present work attempts to alter the geometry bias in female rats. In Experiment 1 three groups of female rats were trained in a triangular-shaped pool to find a hidden platform, whose location was defined in terms of two sources of information, a landmark outside the pool and a particular corner of the pool. On a (...) subsequent test trial with the triangular pool and no landmark, females with prior experience with two other pool shapes–with a kite-shaped pool and with a rectangular-shaped pool, were significantly more accurate than control rats without such prior experience. Rats with a short previous experience–with the rectangular-shaped pool only did not differ from Group NPE. These results suggest that the previous experience with different shaped-pools could counteract the geometry bias in female rats. Then, Experiment 2A directly compared the performance of LPE males and females of Experiment 1, although conducting several test trials. The differences between males and females disappeared in the three tests. Moreover, in a final test trial both males and females could identify the correct corner in an incomplete pool by its local, instead of global, properties. Finally, Experiment 2B compared the performance of NPE rats, males and females, of Experiment 1. On the test trial with the triangular pool and no landmark, males were significantly more accurate than females. The results are explained in the framework of selective attention. (shrink)

Although VL30 retrotransposable elements have been associated with certain cancers for nearly twenty years, because of their expression in rodent malignancies and recombination into murine sarcoma viruses, their causative role, if any, in cancer has been uncertain and enigmatic. Recent findings suggest loss of normal transcriptional control of specific VL30 element expression may make a critical contribution to tumor progression at a step associated with malignant conversion, by bringing into play a cellular program normally involved in wound healing. This program, (...) the fibroblast anoxic response system, includes an adaptation to glycolytic metabolism, secretion of metalloproteinases, and activation of an endonuclease. While appropriate for facilitating debris removal during wound healing, loss of control of this program in a cell which has already progressed to the benign neoplastic state has the potential to simultaneously produce the invasiveness and genomic instability charateristic of malignancy. Examination of tumors and tumor derived cell lines has confirmed that key aspects of this system are in fact activated in cancer. (shrink)

An unprecedented level of confidence has recently crystallized around a new hypothesis of how living placental mammals share a pattern of common descent. The major groups are afrotheres (e.g., aardvarks, elephants), xenarthrans (e.g., anteaters, sloths), laurasiatheres (e.g., horses, shrews), and euarchontoglires (e.g., humans, rodents). Compared with previous hypotheses this tree is remarkably stable; however, some uncertainty persists about the location of the placental root, and (for example) the position of bats within laurasiatheres, of sea cows and aardvarks within afrotheres, (...) and of dermopterans within euarchontoglires. A variety of names for sub‐clades within the new placental mammal tree have been proposed, not all of which follow conventions regarding priority and stability. More importantly, the new phylogenetic framework enables the formulation of new hypotheses and testing thereof, for example regarding the possible developmental dichotomy that seems to distinguish members of the newly identified southern and northern radiations of living placental mammals. (shrink)

The idea that the thalamo-cortical system is the crucial constituent of the neurobiological mechanisms of consciousness has a long history. For the last few decades, however, consciousness research has to a large extent overlooked the interplay between the cortex and thalamus. Here we revive an integrated view of the neurobiology of consciousness by presenting and discussing several recent major findings about the role of the thalamocortical interactions in consciousness. Based on these findings we propose a specific cellular mechanism how thalamic (...) nuclei modulate the integration of different processing streams within single cortical pyramidal neurons. This theory is inspired by recent work done in rodents, but it integrates decades of work conducted on various species. We illustrate how this new view readily explains various properties and experimental phenomena associated with conscious experience. We discuss the implications of this idea and some of the experiments that need to be done in order to test it. Our view bridges two long-standing perspectives on the neural mechanisms of consciousness and proposes that cortical and thalamo-cortical processing interact at the level of single pyramidal cells. (shrink)

an inquiry into recent animal experimentation at Sick Kids Hospital, including detailed accounts of pain research and fear conditioning on neonatal rodents, induced lung trauma on piglets, and the infection of impregnated mice with malaria. appended with three 2018 Press Releases that provoked Sick Kids to contact Toronto police and ban me from their premises and from contacting their researchers.

The current model of adult neurogenesis in mammals suggests that adult‐born neurons are generated by stem cells that undergo long‐term self‐renewal, and that a lifetime supply of stem cells resides in the brain. In contrast, it has recently been demonstrated that adult‐born neurons in crayfish are generated by precursors originating in the immune system. This is particularly interesting because studies done many years ago suggest that a similar mechanism might exist in rodents and humans, with bone marrow providing stem (...) cells that can generate neurons. However, the relevance of these findings for natural mechanisms underlying adult neurogenesis in mammals is not clear, because of uncertainties at many levels. We argue here that the recent findings in crayfish send a strong signal to re‐examine existing data from rodents and humans, and to design new experiments that will directly test the contributions of the immune system to adult neurogenesis in mammals. (shrink)

The management of the sanitary status of laboratory animals is essential both from an animal welfare and a scientific standpoint. Poor sanitary status may have clinical impact and lead to invalid and/or irreproducible scientific results. Most of the laboratory animals are bred for research under strict hygienic procedures in order to exclude microorganisms that can impact their health and the outcome of experimental procedures. In these circumstances, the microbiological component of the animal models is defined by an exclusion list, i.e. (...) the animals are free of certain microorganisms. In certain fields of research, the microbiota carried by the animals (microorganisms present in the animal, at interfaces with the environment, i.e. skin, mouth, nose, respiratory tract, genital tract, digestive tract) needs to be defined, and therefore gnotobiotic animals need to be used. Indeed, the phenotype of an animal depends on both its genotype and the envirotype, and like the genome, the microbiota can be manipulated to investigate its impact on the biology of the host.In this chapter, we will answer to practical questions to understand the procedures to put in place when building a standard biosecurity program, and the specific ones that need to be implemented to produce germ-free and gnotobiotic animals.We will focus mainly on laboratory rodents, but the main principles may apply to other species used in research. (shrink)

This paper explores the many meanings attached to the designation,"the rodent in the laboratory". Generations of selective breeding have created these rodents. They now differ markedly from their wild progenitors, nonhuman animals associated with carrying all kinds of diseases.Through selective breeding, they have moved from the rats of the sewers to become standardized laboratory tools and saviors of humans in the fight against disease. This paper sketches two intertwined strands of metaphors associated with laboratory rodents.The first focuses on (...) the idea of medical/scientific progress; in this context, the paper looks at laboratory rodents often depicted as epitomizing medical triumph or serving as helpers or saviors. The second strand concerns the ambiguous status of the laboratory rodent who is both an animal and not an animal.The paper argues that, partly because of these ambiguous and multiple meanings, the rodent in the laboratory is doubly "othered"—first in the way that animals so often are made other to ourselves and then other in the relationship of the animal in the laboratory to other animals. (shrink)

In contrast to the views put forth by Stein & Glasier, we support the use of inbred strains of rodents in studies of the immunobiology of neural transplants. Inbred strains demonstrate homology of the major histocompatibility complex (MHC). Virtually all experimental work in transplantation immunology is performed using inbred strains, yet very few published studies of immune rejection in intracerebral grafts have used inbred animals.

This chapter proposes that a remaining frontier of morality research is to understand how and why humans perform moral and immoral actions, particularly those related to unjustified violence. It is argued that the best way to do this would be to incorporate neuroscience research using rodent models of negative intersubjectivity into empirical investigations of morality. The relationship between negative intersubjectivity and moral action is reviewed, and rodent models of negative intersubjectivity are evaluated. The chapter concludes by discussing how these rodent (...) models can be used and expanded to develop treatments for clinically violent behavior, as well as to deepen our understanding of other types of morally relevant action. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.2 (2001) 197-214 [Access article in PDF] The Origin of Stories:Horton Hears a Who Brian Boyd Works of art die without attention, and we should expect that any critical theory that cannot explain why we attend to art ought itself to be moribund. Yet the currently dominant approach to criticism, which I will dub Cultural Critique, 1 explains art in terms of the limited and suspect (...) perspectives of the culture (society, group, era) that produced it, or as the site of contestation or locus of imbrication of the ideological discourses of its time. Why anyone would want to attend to art, defined thus, becomes a mystery, unless audiences always do indeed crave ideological nourishment or indigestion. Surely we can do better.I would like to offer the outline of an alternative: an evolutionary explanation first for art, then for narrative, then for fiction. Then, since ontogeny recapitulates phylogeny, or at least sometimes helps us retrieve it, and since we have no printouts of Pleistocene potboilers, I will color in the outline by way of Dr. Seuss's children's classic, Horton Hears a Who, contrasting a sample evolutionary analysis of a single work of fiction with the kind of response typical of Cultural Critique.In art we do or make things simply in order to engage our attention, for the sake of attention, and we are not the only species to do so. Intelligence began to evolve because the world is full of potential information that can suggest advantageous courses of behavior. Curiosity evolved on top of intelligence--especially in the species that Konrad Lorenz liked to call "specialists in non-specialization," such as rats among rodents, corvids among songbirds, and humans among primates 2 --because it extends the range of information creatures can attend to and act on. As a result rats can prefer cognitive stimulation to food and sex. 3 As the most intelligent and versatile of species, we humans particularly like directing our attention to what repays our curiosity. [End Page 197]And like other particularly intelligent species, we like to do things that provide cognitive stimulation, whether they have any immediate survival value or not. Corvids (together with psittacines, the most intelligent of birds) enjoy a kind of aerial acrobatics that Lorenz unashamedly labels art. 4 Dolphins in a Hawaiian marine park have developed, without any human prompting, what has been called "air art," a kind of rhythmic gymnastics in which they deploy air bubbles from their blowholes like gymnasts' ribbons or hoops, or, to stress the affinity to art, a kind of aquatic analogue of light sculpture. 5 Chimpanzees appear to engage both in solitary imaginative play, like Kakama with the stick he famously and repeatedly handled as if it were a toy baby, 6 and in group activity, like rhythmic dances, 7 for the sheer pleasure they produce. In art as in so much else we had thought uniquely human, like tool-using or tool-making, like counting or culture, we are finding there are precursors elsewhere in nature. 8Because we are such a highly social species, we crave the attention of others. Human infants are distressed at adults who do not respond to them; 9 infants and children across cultures punish others by withdrawing attention. 10 At any age we like to command attention in ways we choose, for the ability to compete successfully for attention is closely correlated with status, 11 which raises rates of survival and reproduction. 12 And we can recognize something artistic in such forms of competitive animal attention-getting as the dances of lekking birds, the songs of songbirds or whales, or the extravagant architecture of bowerbirds. Not only do we like to command attention, we also enjoy simply sharing it with others, because this cements our place in a social group whose support we need. 13 Again, there are precursors in other species: the elaborate song of duetting songbirds, 14 or the communal dances of chimpanzees.Curiosity directed at what we can do that gives us cognitive pleasure, whether by engaging our own attention or... (shrink)

The view that female mammals are more docile appears to arise in part from imposing human values on animal studies. Many reports of sexual dimorphism in physical aggression favouring the male in laboratory rodents appear to select circumstances where that expectation is supported. Other situations that favour the expression of conflict in females have been (until recently) relatively little studied. Although female rodents generally do not show the “ritualised” forms of conflict that characterise male sexual competition, they can (...) use notably damaging strategies (especially if they are of short duration). Such considerations might weigh in the selection of strategies by our own species. (shrink)

Technological advancement has an ambivalent character concerning the impact on biodiversity. It accounts for major detrimental environmental impacts and aggravates threads to biodiversity. On the other hand, from an application perspective of environmental science, there are technical advancements, which increase the potential of analysis, detection and monitoring of environmental changes and open a wider spectrum of sustainable use strategies.The concept of biodiversity emerged in the last two decades as a political issue to protect the structural and functional basis of earthbound (...) life. In this respect, it represents a great challenge for science, in particular for ecology, which is the scientific discipline mainly involved in contributing to understand biodiversity issues.In this paper, we state a strong necessity for ecologists to work in close connection with other disciplines and within their own discipline across the different organisation levels. Each level has some specific properties to which ecological terminology has been adapted, and joint views are necessary to understand complex networks. In this context, ecological theory provides the background to analyse biological complexity and the relationship of structure and dynamics on different integration levels and provides the interface to mediate social and political issues.Important features of new technologies for advances in ecological theory refer to an increase in information processing capacities, more efficient automatic data acquisition and device operation, and an increase in resolution.One crucial consideration we analyse is the trend that a quantitative development in one particular discipline may open a new potential for qualitative advancement in other disciplines when the quantitative advancement is applied in a new disciplinary context.We illustrate these qualitative developments that are based on technological advancements and which helped to advance ecological theory qualitatively with two examples: The underlying mechanisms causing regularly oscillating rodent populations are subject to a decade long discussion in ecology. Using the possibilities of modern information processing, it is possible to represent the discussed hypotheses in an integrative object oriented model and analyse how the underlying causal net works. The second example originates from biosafety research dealing with the environmental impact of genetically modified organisms. The project GenEERA develops a complex up-scaling procedure from below field-level information to the landscape scale in order to investigate spread and persistence of GM oil seed rape under different scenarios. The approach gives an example, how ecological modelling can be used to combine different information levels to derive conclusions on a higher spatial scale.In an overall conclusion we relate the described approaches to a wider system analytical context in which we interpret theory developments and biodiversity issues with a system theoretical description of growth processes. We obtain the view that in self-organising systems there is a tendency for autonomous development which tends to be dominating far away from capacity limitations. However, while approaching capacity limitations, a tendency towards closer coupling of internal and external cause-effect networks emerges. We also find that the relation of biodiversity, ecosystem services, and social dynamics can be interpreted in this framework. In this context, the demand for closer interdisciplinary cooperation to solve existing problems appears as an indication of emerging capacity limitations both, in the theoretical as well as in the physical domain. (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1, which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization of (...) SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

The presence of general intelligence poses a major evolutionary puzzle, which has led to increased interest in its presence in nonhuman animals. The aim of this review is to critically evaluate this question and to explore the implications for current theories about the evolution of cognition. We first review domain-general and domain-specific accounts of human cognition in order to situate attempts to identify general intelligence in nonhuman animals. Recent studies are consistent with the presence of general intelligence in mammals ( (...) class='Hi'>rodents and primates). However, the interpretation of a psychometricgfactor as general intelligence needs to be validated, in particular in primates, and we propose a range of such tests. We then evaluate the implications of general intelligence in nonhuman animals for current theories about its evolution and find support for the cultural intelligence approach, which stresses the critical importance of social inputs during the ontogenetic construction of survival-relevant skills. The presence of general intelligence in nonhumans implies that modular abilities can arise in two ways, primarily through automatic development with fixed content and secondarily through learning and automatization with more variable content. The currently best-supported model, for humans and nonhuman vertebrates alike, thus construes the mind as a mix of skills based on primary and secondary modules. The relative importance of these two components is expected to vary widely among species, and we formulate tests to quantify their strength. (shrink)

Assessments of animal experience and consciousness are embedded in all issues of animal welfare policy, and the field of animal welfare science has been developed to make these evaluations. In light of modern studies of the social construction of scientific knowledge, it is surprising how little attention has been paid to date on how crucial evaluations about animals are made. In this paper, I begin to fill that gap by presenting a historical case study of the attempt to define the (...) pain and distress of one common practice in animal research-the use of the tabletop guillotine to decapitate laboratory rodents. I describe the negotiations involved in reaching consensus on the meaning of the available data and caution animal care and use committees that they should always work with the realization that our scientific knowledge of what animals experience is partial and provisional knowledge at best. (shrink)

This alliteratively titled assemblage is both attractive and absorbing. Far from the ossified remains one might dread from old texts, dry excavations, or sterile laboratories, the conference proceedings bring to light a variety of fresh data and new perspectives. We learn about such poorly understood but everyday life events as the extraction of marrow, bones as the chew-toys of dogs and rodents, not to mention the virtually ubiquitous presence of shells and little bits of fish. No one studyi...

Adult neurogenesis is an exciting and rapidly advancing field of research. It addresses basic biological questions, such as the how and why of de novo neuronal production during adulthood, as well as medically relevant issues, including the potential link between adult neural stem cells and psychiatric disorders, or how stem cell manipulation might be used as a strategy for neuronal replacement. Current research mainly focuses on rodents, but we review here recent examination of non‐mammalian vertebrates, which demonstrates that bona (...) fide adult neural stem cells exist in these species. Importantly, especially in teleost fish, these cells can be abundant and located in various brain areas. Hence, non‐mammalian vertebrate species provide invaluable comparative material for extracting core mechanisms of adult neural stem cell maintenance and fate. BioEssays 29:745–757, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

We have demonstrated, using the Cantor dust method, that the statistical distribution of appearance and disappearance of rodents species (Arvicolid rodent radiation in Europe) follows power laws strengthening the evidence for a fractal structure set. Self-similar laws have been used as model for the description of a huge number of biological systems. With Nottale we have shown that log-periodic behaviors of acceleration or deceleration can be applied to branching macroevolution, to the time sequences of major evolutionary leaps (global life (...) tree, sauropod and theropod dinosaurs postural structures, North American fossil equids, rodents, primates and echinoderms clades and human ontogeny). The Scale-Relativity Theory has others biological applications from linear with fractal behavior to non-linear and from classical mechanics to quantum mechanics. (shrink)

Background and Objective: Pulsed dye laser treatment of cutaneous vascular lesions is associated with variable and unpredictable efficacy. Thus, alternative treatment modalities are needed. Previous in vitro and in vivo studies have demonstrated enhanced selective vascular destruction with benzoporphyrin derivative monoacid ring A photodynamic therapy followed immediately by PDL irradiation. Here, we evaluate PDT alone, PDL alone, and PDT+PDL protocols using an optimized in vivo rodent dorsal window chamber model. Study Design/Materials and Methods: A dorsal window chamber was surgically installed (...) on male Golden Syrian hamsters. BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions included: Control ; Control ; PDT alone ; PDL alone at 7 J/cm 2 ; and PDT +PDL. Laser speckle imaging was used to monitor blood flow dynamics before, immediately after, and 1, 3, and 5 days post-intervention. Results: Perfusion reduction on day 1 post-intervention was achieved with PDT>50 J/cm2, PDL alone, and PDT+PDL. However, by day 5 post-intervention, recovery of flow was observed with PDT alone at 50 J/cm2 and PDL alone. PDT +PDL resulted in the greatest prolonged reduction in vascular perfusion. Conclusions: Our in vivo data suggest that the PDT+PDL therapeutic protocol can result in enhanced and persistent vascular shutdown compared to PDT or PDL alone. The PDT+PDL approach has potential for considerable superficial vascular destruction and should be considered as a treatment modality for cutaneous vascular lesions. Monitoring of blood flow changes for as long as possible is crucial for accurate assessment of light-based vascular interventions. © 2008 Wiley-Liss, Inc. (shrink)

Unlike nearly all science books which tell of successful ventures and satisfactory conclusions, this book reveals the harsher but more common side of scientific research. Written by one of this century's most distinguished small mammal ecologists, it is both a personal history of and an apology for a life in science spent working on problems for which no final dramatic closure was reached. Included along the way are important anecdotes and history about Charles Elton and his pioneering work at the (...) Bureau of Animal Population at Oxford University, from which much of modern population has grown, and insights on the philosophy and practice of science. This eye-opening account of a scientific career should be read by everyone in life sciences or the history and philosophy of science. (shrink)

Provision of environmental enrichment has become a basic consideration for the animals used in research. Societal concerns, ethical aspects, legal requirement, and quality of research have made animal housing conditions evolve significantly in recent years. Barren cages have been replaced by a variable spectrum of enriched environments. This poses several challenges for both animal care staff and researchers, and therefore, for institutions. In this chapter, responses to some practical questions on provision of environmental enrichment to several of the most commonly (...) used species (rodents, rabbits, dogs, pigs, and macaques) are offered. The general concepts in the rodent section are applicable to all species. (shrink)

Cet article essaie de distinguer trois strates au sein de ce qu’il est convenu d’appeler « humanités numériques » ( hum num ) ou « humanités digitales ». Les hum num 1.0 font le travail concret de numérisation, balisage, reformatage, design d’interfaces en reprenant le plus souvent des corpus déjà identifiés et circonscrits. Les hum num 2.0 tirent de ce travail de numérisation l’opportunité de constituer de nouveaux corpus et d’expérimenter de nouvelles procédures et de nouvelles formes de collaboration, qui (...) débordent et érodent les frontières entre les disciplines, comme entre l’université et ses dehors. Les hum num 3.0 essaient de comprendre comment les pratiques et savoirs constitués depuis des siècles autour des humanités peuvent nous aider à comprendre et à nous repérer dans les façons dont le numérique informe de plus en plus profondément nos modes de subjectivation. (shrink)

I argue that a critical feature of language that distinguishes it from animal communication isdisplacement,the means to communicate about the non-present. This implies a capacity for mental travels in time and space, which is the ability to call to mind past episodes, imagine future ones or purely fictitious ones, and locate them in different places. While mental travel in time, in particular, is often considered to be unique to humans, behavioral and neurophysiological evidence suggests that it is evident in some (...) form, at least, in nonhuman animals, including rodents, and may go far back in the evolution of animals that move. The linguistic capacity to share experiences that transcend space and time evolved much more recently, accelerating during the Pleistocene with increasing demands for effective cooperation and long-distance planning. The expansion of mental time travel probably co-evolved with the development of language itself, because the sharing of memories, plans, and stories vastly added to our own individual experiences. From this perspective, the critical period of the Road Map runs from the emergence of the genusHomoaround 2 million years ago to the present. (shrink)

Partner preferences are expressed by many social species, including humans. They are commonly observed as selective contacts with an individual, more time spent together, and directed courtship behavior that leads to selective copulation. This review discusses the effect of conditioning on the development of heterosexual and homosexual partner preferences in rodents. Learned preferences may develop when a conditioned stimulus (CS) is associated in contingency with an unconditioned stimulus (UCS) that functions as a reinforcer. Consequently, an individual may display preference (...) for a partner that bears a CS. Some UCS may be more or less reinforcing, depending on when they are experienced, and may be different for males and females. For example, it could be that, only during periods of early development, that stimuli associated with nurture and juvenile play become conditioned. In adulthood, other stimuli such as sexual reward, cohabitation, mild stress, or even pharmacological manipulations may function as reinforcers to condition partner preferences. Evolutionary biologists and psychologists must take into consideration the idea that an individual’s experience with reward (i.e. sexual and pharmacological) can override presumably ‘innate’ mate choices (e.g. assortativeness and orientation) or mate strategies (e.g. monogamy or polygamy) by means of Pavlovian and operant contingencies. In fact, it is likely as innate to learn about the environment in ways that maximize reward and minimize aversive outcomes, making so-called ‘proximate’ causes (e.g. pleasure) ultimately more powerful predictors of social behavior and choice than so-called ‘ultimate’ causes (e.g. genetic or reproductive fitness). Keywords: pavlovian; operant; learning; sex; copulation (Published: 15 March 2012) Citation: Socioaffective Neuroscience & Psychology 2012, 2 : 17340 - DOI: 10.3402/snp.v2i0.17340. (shrink)

The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of (...) the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18 The amygdala plays a central role in regulating many aspects of behavior in rodents and humans, from pain responding to social interaction and psychiatric function. Accumulating evidence suggests microbiota-to-amygdala communication along the gut-brain axis is a key modulator of these amygdala-dependent behaviors, with critical implications for health and disease. (shrink)

The claim of consistent hemispheric specialisations across classes of chordates is undermined by the absence of population-based directional asymmetry of paw/hand use in rodents and primates. No homologue of the cerebral torque from right frontal to left occipital has been established in a nonhuman species. The null hypothesis that the torque is the sapiens-specific neural basis of language has not been disproved.

Nell restricts cruelty to hominids, although good evidence suggests that secondary aggression in rodents and particularly primates may be considered cruel. A considerable literature shows that glucocorticoid secretion stimulated by stress facilitates learning, memory, arousal, and aggressive behavior. Either secondary aggression (to a conspecific) or increased affiliative behavior reduces stressor-induced activity, suggesting the reward system can be satisfied by other behaviors than cruelty.

The creation of chimeras by introducing human stem cells into nonhu- man animals has provoked intense concerns. Addressing objections that appeal to human dignity, I focus in this essay on stem cell research intended to generate human neurons in Great Apes and rodents. After considering samples of dignity- based objections from the literature, I examine the underlying assumption that nonhuman animals have lower moral status than personsFwith particular attention to what it means to speak of higher and lower moral (...) statusFbefore evaluating the chimera research in question. I argue that (1) such experiments involving Great Apes should be prohibited out of respect for the research subjects and (2) such experiments involving rodents may or may not be permissible, depending on how we answer unresolved questions regarding rodents’ moral status. In the end, concerns about human dignity prove insignificant. (shrink)

It may be possible, one day, to use gene therapy to treat diseases whose genetic defects have been discerned. Because many genes responsible for inherited eye disorders within the retina have been identified, diseases of the eye are prime candidates for this form of therapy. The eye also has the advantage of being highly accessible with altered immunological properties, important considerations for easy delivery of virus and avoidance of systemic immune responses. Currently, adenovirus, adeno‐associated virus and lentivirus have been used (...) to successfully transfer genetic material to retinal pigment epithelium and photoreceptor cells. By harnessing therapeutic genes to these viruses, researchers have been able to demonstrate rescue in rodent models of retinitis pigmentosa, providing evidence that this form of therapy can be effective in delaying photoreceptor cell death. Future challenges include confirming therapeutic effects in animal models with eyes more anatomically similar to those of humans and demonstrating long‐term rescue with minimal toxicity. BioEssays 23:662–668, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Multivariate pattern analysis can reveal new information from neuroimaging data to illuminate human cognition and its disturbances. Here, we develop a methodological approach, based on multivariate statistical/machine learning and time series analysis, to discern cognitive processing stages from functional magnetic resonance imaging (fMRI) blood oxygenation level dependent (BOLD) time series. We apply this method to data recorded from a group of healthy adults whilst performing a virtual reality version of the delayed win-shift radial arm maze (RAM) task. This task has (...) been frequently used to study working memory and decision making in rodents. Using linear classifiers and multivariate test statistics in conjunction with time series bootstraps, we show that different cognitive stages of the task, as defined by the experimenter, namely, the encoding/retrieval, choice, reward and delay stages, can be statistically discriminated from the BOLD time series in brain areas relevant for decision making and working memory. Discrimination of these task stages was significantly reduced during poor behavioral performance in dorsolateral prefrontal cortex (DLPFC), but not in the primary visual cortex (V1). Experimenter-defined dissection of time series into class labels based on task structure was confirmed by an unsupervised, bottom-up approach based on Hidden Markov Models. Furthermore, we show that different groupings of recorded time points into cognitive event classes can be used to test hypotheses about the specific cognitive role of a given brain region during task execution. We found that whilst the DLPFC strongly differentiated between task stages associated with different memory loads, but not between different visual-spatial aspects, the reverse was true for V1. Our methodology illustrates how different aspects of cognitive information processing during one and the same task can be separated and attributed to specific brain regions based on information contained in multivariate patterns of voxel activity. (shrink)

A review of research with chicks, songbirds, rodents, and nonhuman primates indicates that the brain is lateralized for a number of behavioral functions. These findings can be understood in terms of three hypothetical brain processes derived from a brain model based on general systems theory: hemispheric activation, interhemispheric inhibition, and interhemispheric coupling.Left-hemisphere activation occurs in songbirds and nonhuman primates in response to salient auditory or visual input, or when a communicative output is required. The right hemisphere is activated in (...) rats when spatial performance is required, and in chicks when they are placed in an emotion-provoking situation. In rats and chicks interhemispheric activation and inhibition occur when there is an affective component in the environment (novelty, aversive conditioning) or when an emotional response is emitted (copulation, attack, killing). An interhemispheric coupling (correlation) found in rats and rabbits implies that the hemispheres are two major components in a control system with a negative feedback loop. Early-experience variables in rats can induce laterality in a symmetric brain or facilitate its development in an already biased brain.It is predicted that functional lateralization, when present, will be similar across species: the left hemisphere will tend to be involved in communicative functions while the right hemisphere will respond to spatial and affective information; both hemispheres will often interact via activation-inhibition mechanisms when affective or emotional processes are involved. Homologous brain areas and their connecting callosal fibers must be intact at birth and must remain intact throughout development for lateralization to reach its maximum level. Injury to any portion of this unit will result in hemispheric redundancy rather than specialization. One major function of early experience is to provide stimulation during development, which acts to enhance the growth and development of the corpus callosum, thereby giving rise to a more specialized brain. (shrink)

In Kafka’s literary world, several animals emerge; they belong to an odd and enigmatic fauna, on the edge between violence and artistry but also between stillness and music; according to the writer, scripture represents both the fault and the punishment waiting for the solitary artist. Animals, especially depicted as hordes of small mice or other rodents, also hint to the heterogeneous structure of the Self, who doesn’t manage to keep under control all the divisions in his ambiguous dentity. Through (...) opposition between the point of view of the subject, who considers his own isolation as indispensable to carry on writing, and the multitude of escaping small animals, Kafka also expresses and experiences his own impossibility of “description” (Beschreibung). In the meantime, Kafka’s animals embody the creatural and unconscious sources of imagination the writer draws from that constantly escape his own control and willingness, pushing forwards into an unknown and inhospitable region, towards the wasteland, the eternal winter that can be identified with scripture. In writing, a deep metamorphosis of the Self takes place. Kafka shares this belief with one of the writers he most admired and considered his master, Gustave Flaubert, who firmly thought that, while writing, one loses his previous identity, becoming someone else, even assuming the appearence of the “otherness”. We can state that Kafka’s imagery of animals takes to the extreme the paradox and ambiguity the idea of writing relies on, also reproducing, especially, in his hybrid creatures, the feeling of uncertainty and lack of safety of the assimilated Jewish artist. (shrink)

We compiled published values of mammalian maximum oxygen consumption during exercise and supplemented these data with new measurements of V O2,max for the largest rodent, 20 species of smaller-bodied rodents, two species of weasels and one small marsupial. Many of the new data were obtained with running-wheel respirometers instead of the treadmill systems used in most previous measurements of mammalian V O2,max. We used both conventional and phylogenetically informed allometric regression models to analyze V O2,max of 77 species' in (...) relation to body size, phylogeny, diet and measurement method. Both body mass and allometrically mass-corrected V O2,max showed highly significant phylogenetic signals. The Akaike information criterion corrected for sample size was used to compare 27 candidate models predicting V O2,max. In addition to mass, the two best-fitting models included dummy variables coding for three species previously shown to have high V O2,max, and incorporated a transformation of the phylogenetic branch lengths under an OrnsteinUhlenbeck model of residual variation. We found no statistical difference between wheel-and treadmill-elicited values, and diet had no predictive ability for V O2,max. Averaged across all models, the allometric scaling exponent was 0.839, with 95% confidence limits of 0.795 and 0.883, which does not provide support for a scaling exponent of 0.67, 0.75 or unity. © 2013. Published by The Company of Biologists Ltd. (shrink)

Researchers working on rodent in maze studies claim that organisms use distal (far) and proximal (near) visual cues differently. I characterize the dominant working definitions researchers use for distal and proximal cues, where distal cues sit beyond an experimental apparatus (like a maze) and proximal cues sit within. Then, I present a problem: the relevant experimental apparatuses are confined to labs and cannot be used to study real-life navigation behaviors like long-distance migration. It follows that the working definitions do not (...) identify difference makers beyond those settings and do not allow for claims about distal and proximal cues to play explanatory or predictive roles for real-life navigation. Despite this, I argue that researchers should continue to treat these as working definitions for concepts that work more generally in natural environments. This calls for some conceptual engineering however, since the more generally useful concepts of “proximal” and “distal” are not well-defined. To remedy this, I present more general, ecologically valid definitions in terms of neural information about visual cues. (shrink)

Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor. Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1, and the beta amyloid precursor cleaving (...) enzyme. In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

Cet article traite d’une question rarement abordée et pourtant cruciale dans le monde académique: l’hégémonie épistémique de la langue anglaise et ses effets néfastes sur les personnes chercheuses non anglophones. En nous appuyant sur des écrits existants, des notions théoriques de nature éthique et nos savoirs expérientiels, nous mettons en lumière certaines des injustices épistémiques et linguistiques au cœur de la recherche. Cette domination linguistique sape la crédibilité de certaines personnes chercheuses, perpétue l’exclusion et a un impact sur la production (...) de connaissances. Nous réalisons des exercices de pensée à partir d’expériences vécues pour illustrer comment cette hégémonie linguistique pénalise les personnes qui sont contraintes d’écrire, de présenter et de publier dans une langue autre que leur langue maternelle. Ces pratiques accentuent les sentiments de honte, érodent la confiance en soi et restreignent l’accès aux financements, aux distinctions et aux lieux de publication réputés. Nous utilisons le coin model de Nixon pour souligner comment des privilèges non mérités sont conférés aux personnes chercheuses anglophones, alors que les personnes chercheuses non anglophones sont confrontées à plusieurs barrières invisibles. Bien que l’anglais puisse servir de médium unificateur en science, son hégémonie réduit la diversité des perspectives, pourtant nécessaires pour faire face aux crises mondiales urgentes. Les injustices linguistiques et épistémiques nuisent non seulement à la carrière des personnes chercheuses non anglophones, mais aussi à l’effort scientifique collectif, en excluant des corpus de connaissances publiées ou partagées dans d’autres langues que l’anglais. Suivant Amano et ses collègues, nous plaidons en faveur d’une diffusion multilingue, d’un engagement conscient à l’égard des écrits non anglophones et d’une reconnaissance des contributions des personnes chercheuses non anglophones. Il importe d’établir un dialogue plus ouvert en faveur de la diversité linguistique en recherche. (shrink)

There are two main approaches within classical cognitive science to explaining how humans can entertain mental states that integrate contents across domains. The language-based framework states that this ability arises from higher cognitive domain-specific systems that combine their outputs through the language faculty, whereas the language-independent framework holds that it comes from non-language-involving connections between such systems. This article turns on its head the most influential empirical argument for the language-based framework, an argument that originates from research on spatial reorientation. (...) I make the case that neuroscientific findings about spatial reorientation in rodents and humans bolster the language-independent framework instead. (shrink)

Thomas Kuhn's account of the development of science famously divides the history of a scientific community into revolutionary and normal periods. During normal periods, a scientific community has a paradigm. A paradigm can be understood in at least two senses: (i) a set of assumptions made by all community members, typically highly general; or (ii) an example of problem-solving accepted by all community members as ideal and looked to as a guide for future problem-solving. Now during the normal period, novel (...) data of relevance for the scientific community, given its official object of research, is largely ignored. Scientists concentrate on a few problems, a few puzzles, trying to solve them, and ignore data which pose other puzzles. But there is a build up of puzzling data and the community eventually loses shared confidence in the paradigm. Then a revolutionary period is initiated, during which there is a search for a new paradigm. The establishment of a new paradigm marks the end of this period and the beginning of a new period of normal science. Kuhn seems to assume that the level of "novelty-suppression" in one period of normal science and another is the same. A doubt occurred to me about this assumption, but I was led to it by reflecting on a discipline outside the disciplines that Kuhn focuses on, the natural sciences. (The doubt seems quite important to me; please cite if you substantiate it one day!) The discipline is philosophy. Imagine a community of philosophers whose paradigm is a kind of conceptual analysis: the defining of concepts. Community members accept that definition should not go on forever and so that there must be some undefined concepts (atomic concepts). For example, one defines the concept of a bachelor using the concepts of being unmarried and of being a human male, then one defines these concepts, and so on; at some point there must be some undefined concepts, to avoid circularity. The aim is to produce analyses of concepts which define a given concept purely in terms of atomic concepts. What community members accept about definition can be called a paradigm, in sense (i). Now given their aim and the size of the community, it is rational to mainly attempt definitions where the aim of producing a totally atomic analysis is within closer reach. (This will, I assume, often involve focusing on concepts for which an analysis can borrow from clarificatory work by others.) Otherwise the task of definition is too demanding. This leads to novelty-suppression: community members just ignore some interesting concepts and even attempts at definition. In this situation, novelty-suppression is caused by the paradigm (and what is a rational research strategy given it) but there is no reason to assume that every paradigm available to this community would cause novelty-suppression; or the same level of novelty-suppression. (By the way, I adapted this term "novelty-suppression" from the experiments of psychiatrists on novelty-suppressed feeding of rodents.). (shrink)

Head direction (HD) cells, abundant in the rat postsubiculum and anterior thalamic nuclei, fire maximally when the rat’s head is facing a particular direction. The activity of a population of these cells forms a distributed representation of the animal’s current heading. We describe a neural network model that creates a stable, distributed representation of head direction and updates that representation in response to angular velocity information. In contrast to earlier models, our model of the head direction system accurately tracks a (...) series of actual rat head rotations, and, using biologically plausible neurons, it fits the single-cell tuning curves of real HD cells recorded from rats executing those same rotations. The model makes neurophysiological predictions that can be tested using current technologies. (shrink)

The main function of vision in many animals is to control movement. In rodents, some visuomotor acts require the construction of models of the external world while others rely on Gibsonian invariants. Such findings support Norman's dual processing approach but it is not clear that the two types of processing rely on homologs of visual processing streams described in primates.