Understanding life through its origins reveals the groundwork underlying the differentiations of its autonomous generative matrixes. Following the primogenital matrix of generation, the three generative matrixes of the specifically human sense of life establish humanness within the creative human condition as the existential sphere of sharing-in-life.

Origin of life on earth transpired once and from then on, it emerges as an endless eternal process. Matter and energy are constants of the cosmos and the hypothesis is that the origin of life is a moment when these constants intertwined or interacted. Energy from the cosmos interacted with inorganic matter to support matter with retention of this riveted energy, as energy to be circulated within the primitive channelized structures to conserve energy by the materialization (...) of the proton homeostasis mechanisms developed from the obtainable inorganic matter. The driver for these processes as we now confirm, exists in the quantum world and through quantum phenomenal processes could have combined these constants to create the magic of life. Primitive earth was a chemical reactive system that triggered a macromolecular evolution by means of open thermodynamic systems, driven by cyclic gradients of temperature, electromagnetic radiation and chemical potentials which sustained life and proto-consciousness in the first life forms driven by the quantum processes. The origin of life is always an intriguing topic but the purpose for finding the cause should never be inclined towards obliterating it; for if that is the case, the further we seek, the farther it will go. (shrink)

This essay accomplishes two goals. First, I explore Husserl’s study of “tension” from his 1893 manuscript, “Notes Towards a Theory of Attention and Interest,” to reveal that it comprises his de facto first analysis of instinct. Husserl there describes tension as the innate pull to execute ever new objectifications. He clarifies this pull of objectification by contrasting it to affective and volitional experiences. This analysis surprisingly prefigures a theory of drive-feelings and anticipates the idea that consciousness is both teleological and (...) autotelic. Second, I show how Husserl’s de facto account of instincts from 1893 inspires his robust philosophy of instincts from Studies concerning the Structures of Consciousness and other late manuscripts. While Husserl maintains many 1893 insights, he now claims that the instinct towards objectification comprises affective and volitional moments. Finally, I demonstrate that Husserl’s analyses of instincts throughout his life are united by the idea that consciousness possesses an essential structural lack. (shrink)

This text builds upon the over 1500 papers published in peer-reviewed journals revealing that there are more than 200 biological codes in living systems. The author claims this experimental fact is bound to change biology forever. This book shows how this very discovery reveals that coding is a new mechanism of life, just as the discovery of electromagnetism revealed the existence of a new physical force in the universe. The existence of many biological codes, furthermore, Barbieri argues, is one (...) of those experimental facts that have extraordinary theoretical consequences. It implies that coding is not only a mechanism that constantly operates in all living systems, but also a mechanism of evolution, more precisely a mechanism that gave origin to the absolute novelties of the history of life. This amounts to saying that evolution took place by two distinct mechanisms, by natural selection and by natural conventions, two mechanisms that are fundamentally different because natural selection is the result of copying and deals with information whereas natural conventions are the result of coding and deal with meaning. This volume appeals to students and researchers working in the fields of semiotics, philosophy, biology and mathematics. (shrink)

I defend origins of life research against an argument, given by Roger White in 2007, that it rests on a mistake. I show how the Bayesian machinery can illuminate the rational search for alternative explanations of currently inexplicable, improbable data, and in particular how it can illuminate the rational search for a secular explanation of the origins of life and of the fine-tuning of the universe.

The ‘managed-metabolism’ hypothesis suggests that a ‘cooperation barrier’ must be overcome if self-producing chemical organizations are to undergo the transition from non-life to life. This dynamical barrier prevents un-managed autocatalytic networks of molecular species from individuating into complex, cooperative organizations. The barrier arises because molecular species that could otherwise make significant cooperative contributions to the success of an organization will often not be supported within the organization, and because side reactions and other ‘free-riding’ processes will undermine cooperation. As (...) a result, the barrier seriously impedes the emergence of individuality, complex functionality and the transition to life. This barrier is analogous to the cooperation barrier that also impedes the emergence of complex cooperation at all levels of living organization. As has been shown at other levels of organization, the barrier can be overcome comprehensively by appropriate ‘management’. Management implements a system of evolvable constraints that can overcome the cooperation barrier by ensuring that beneficial co-operators are supported within the organization and by suppressing free-riders. In this way, management can control and manipulate the chemical processes of a collectively autocatalytic organization, producing novel processes that serve the interests of the organization as a whole and that could not arise and persist in an un-managed chemical organization. Management self-organizes because it is able to capture some of the benefits that are produced when its interventions promote cooperation, thereby enhancing productivity. Selection will therefore favour the emergence of managers that take over and manage chemical organizations so as to overcome the cooperation barrier. The managed-metabolism hypothesis demonstrates that if management is to overcome the cooperation barrier comprehensively, its interventions must be digitally coded. In this way, the hypothesis accounts for the two-tiered structure of all living cells in which a digitally-coded genetic apparatus manages an analogically-informed metabolism.GraphicalOpen image in new window. (shrink)

Time plays a central role in evolutionary theory. In this paper, we examine the language Darwin used to describe time in his work On the Origin of Species. We present the results of a computationally assisted lexical-semantic analysis of word frequencies, variations, and contextual meanings of time-related lexical items across the six editions of the Origin. Focusing on terms such as cycle, circle, chain, scale, line, tree (of life), progress, succession, and time, we analyse how Darwin represents (...) temporality through recurrent patterns of usage. Our findings show that Darwin describes species as forming “chains of affinities” connected through “blood relationships,” which unfold as “successive” “lines of descent.” These expressions indicate a view of evolutionary change as a continuous process articulated through lineages of descent. Our analysis shows that, within this set of terms, tree of life plays only a minor, locally concentrated lexical role in the Origin. Darwin’s representation of evolutionary time is primarily structured through the vocabulary of succession, line, and chain, rather than through arboreal concepts or imagery. This lexical pattern suggests that, at the level of textual articulation, key aspects of evolutionary temporality are predominantly expressed through geological successions and genealogical lineages that would later be found in tree-based models in evolutionary biology. (shrink)

For centuries the question of the origin of life had focused on the question of the spontaneous generation of life, at least primitive forms of life, from inanimate matter, an idea that had been promoted most prominently by Aristotle. The widespread belief in spontaneous generation, which had been adopted by the Church, too, was finally abandoned at the beginning of the twentieth century, when the question of the origin of life became related to that (...) of the artificial generation of life in the laboratory. This paper examines the role of social authorities, researchers’ basic beliefs, crucial experiments, and scientific advance in the controversies about spontaneous generation from the seventeenth to the nineteenth centuries and analyzes the subsequent debates about the synthesis of artificial life in the changing scientific contexts of the nineteenth and early-twentieth centuries. It shows that despite the importance of social authorities, basic beliefs, and crucial experiments scientific advances, especially those in microbiology, were the single most important factor in the stepwise abandoning of the doctrine of spontaneous generation. Research on the origin of life and the artificial synthesis of life became scientifically addressed only when it got rid of the idea of constant smooth transitions between inanimate matter and life and explored possible chemical and physical mechanisms of the specificity of basic molecules and processes of life. (shrink)

The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common Ancestor. Most likely, the Last Universal Common Ancestor was subject to Darwinian evolution, but the question remains to what extent Darwinian evolution applies to the prebiotic and protocellular phases. In this review, we reflect on the current (...) status of evolutionary theory in origins of life research by bringing together philosophy of science, evolutionary biology, and empirical research in the origins field. We explore the various ways in which evolutionary theory has been extended beyond biology; we look at how these extensions apply to the prebiotic development of (proto)metabolism; and we investigate how the terminology from evolutionary theory is currently being employed in state-of-the-art origins of life research. In doing so, we identify some of the current obstacles to an evolutionary account of the origins of life, as well as open up new avenues of research. (shrink)

This disagreement extends to the fundamental details of physical and biochemical theories. On the other hand, (2) There is almostuniversal agreementthatlife did notfirstcome aboutmerely by chance. This is not to say that all scientists think that life’s existence was inevitable. The common view is that given a fuller understanding of the physical and biological conditions and processes involved, the emergence of life should be seen to be quite likely, or at least not very surprising. The view which is (...) almost universally rejected by researchers in the field is that the numerous and prima facie improbable physical and biological requirements for life all fell together just by a fluke, like so many dice tumbling out of a bag and landing all sixes. Most importantly, for the purposes of the following discussion, (3) The conviction that life did not arise largely by chance is treated as epistem- ically prior to the development of alternative theories. C 2007, Copyright the Authors Journal compilation C 2007, Blackwell Publishing, Inc. (shrink)

This paper examines Hannah Arendt's notion of citizenship with reference to her account of loneliness in the modern age. Whereas recent scholarship has emphasized Arendt's notion of the “right to have rights” in order to advance her conception of citizenship in the context of global democratic theory, I maintain that this discourse threatens to overshadow the depth of her critical relation to the liberal tradition. By turning to loneliness, I aim to show that Arendt's understanding of citizenship guides a prescient (...) critique of the basic assumptions that underlie notions of citizenship within liberal political theory. On her view, these forms of citizenship do not secure liberty, but instead reproduce the very loneliness that has made modern individuals susceptible to totalitarian domination. With this, I argue that Arendt poses her notion of citizenship as an antidote to loneliness and, thus, to the vulnerability of modern political life to totalitarianism. (shrink)

The clash between atheism and religion has become the defining battle of the 21st century. Books on and about atheism retain high profile and popularity, and atheist movements on both sides of the Atlantic capture headlines with high-profile campaigns and adverts. However, very little has been written on the history of atheism, and this book fills that conspicuous gap. Instead of treating atheism just as a philosophical or scientific idea about the non-existence of God, Atheists: The Origin of the (...) Species places the movement in its proper social and political context. Because atheism in Europe developed in reaction to the Christianity that dominated the continent's intellectual, social and political life, it adopted, adapted and reacted against its institutions as well as its ideas. Accordingly, the history of atheism is as much about social and political movements as it is scientific or philosophical ideas."--book jacket. (shrink)

How, where, and why life first emerged are still open scientific questions. To answer them, origins-of-life (= OoL) research draws on a variety of approaches from disciplines such as chemistry, biology, geology, and even astronomy. The goal is to account for the processes that led from simple chemical components to the first forms of life on Earth more than 3.5 billion years ago. This puts OoL-research in a particularly challenging epistemic situation compared to other sciences. OoL-researchers cannot (...) expect to find substantial traces of the formation of the first forms of life. In addition, their knowledge of environmental conditions on the Earth at the time of the OoL is uncertain. And yet, for all that, OoL-research is a very active field. This sets the topic for this thesis: I study, from a philosophy-of-science perspective, the strategies OoL-researchers use to counteract and overcome their unusually difficult epistemic starting point to generate knowledge about the OoL. -/- The thesis draws on and contributes to philosophy-of-science literature in two main areas: (i) general philosophy of science, particularly discussions relating to experimentation and explanation; and (ii) the philosophy of the historical sciences, specifically debates about resources for evidential reasoning and the role of experimentation in studying phenomena in the deep past. -/- In Chapter 2, I provide an overview of OoL-research and motivate a focus on OoL-research in the context of the philosophy of the historical sciences. In Chapter 3, I analyze a case study on identifying and interpreting traces of very early life. Based on that, I challenge a common preconception in existing characterizations of ‘trace’ in the philosophy of the historical sciences and introduce a distinction between what I call ‘direct’ and ‘circumstantial’ traces to better understand situations where evidence from traces is particularly scarce or ambiguous. Chapters 4 and 5 both engage with specific case studies from prebiotic chemistry, a subfield of OoL-research that is largely experimental and draws on strategies from synthetic organic chemistry. In Chapter 4, I characterize ‘synthesis’ as its own, as yet neglected experimental strategy, and analyze the epistemic value of synthetic experiments in OoL-research. My proposal calls into question the argument that experimentation as a method to study past phenomena is either impossible or inefficient. In Chapter 5, I put forward a distinction between different functions of possibilities in scientific explanations that I call ‘elucidating’ and ‘embedding’ and illustrate their relevance to OoL-research. Furthermore, I highlight how my distinction improves upon existing debates over the nature of ‘how-possibly’ explanations. (shrink)

The central concern of this book is us human beings. The authors’ basic question is: ‘How is it that we can live in mutual care, have ethical concerns, and at the same time deny all that through the rational justification of aggression?’ The authors answer this basic question indirectly by providing a look into the fundaments of our biological constitution, concentrating on what they term emotioning, that is the flow of emotions in daily life that guides the flow of (...) the systemic conservation of a manner of living. Maturana and Verden-Zoller claim that the fundamental emotion that gave rise to humans as sapient languaging beings was love, and that this remains our fundament even when other emotions become socially prevalent. (shrink)

Of all the sciences pertaining to Man it is the science of prehistoric man which has made the most sensational progress during the last fifty years. With this in mind it seems possible to construct a synthesis of all the facts known at the present time, in spite of the risks incurred by such an attempt. It is surely necessary at certain times to be rash, and in science as well as in life one must be willing to dare (...) greatly, to act dangerously. (shrink)

This paper focuses on the consolidation of Molecular Evolution, a field originating in the 1960s at the interface of molecular biology, biochemistry, evolutionary biology, biophysics and studies on the origin of life and exobiology. The claim is made that Molecular Evolution became a discipline by integrating different sorts of scientific traditions: experimental, theoretical and comparative. The author critically incorporates Timothy Lenoir’s treatment of disciplines , as well as ideas developed by Stephen Toulmin on the same subject. On their (...) account disciplines are spaces where the social and epistemic dimensions of science are deeply and complexly interwoven. However, a more detailed account of discipline formation and the dynamics of an emerging disciplinary field is lacking in their analysis. The present essay suggests focusing on the role of scientific concepts in the double configuration of disciplines: the social/political and the epistemic order. In the case of Molecular Evolution the concepts of molecular clock and informational molecules played a central role, both in differentiating molecular from classical evolutionists, and in promoting communication between the different sorts of traditions integrated in Molecular Evolution. The paper finishes with a reflection on the historicity of disciplines, and the historicity of our concepts of disciplines. (shrink)

Contemporary nuclear physics, molecular biology, and evolutionary theory each address their domains through independent frameworks with empirical parameters and no shared derivational foundation. This paper derives the origin of life and all three core conditions of Darwinian evolution — self-replication, mutation, and selection pressure — as necessary consequences of a single algebraic structure: M₃(ℂ), the unique minimal non-commutative algebra of Cognitional Mechanics (CM). No free parameters are introduced at any stage. -/- The derivation proceeds in two stages. First, (...) the spectral position κ* = 1/6 is derived internally from CM Axioms 1–4 alone: the minimum occupied-state count generating non-commutativity is n = 2 (Axioms 1 and 4), and the unique Ad-invariant positive-definite metric scalar is A = 12 (Axioms 2 and 4), yielding κ* = 2/12 = 1/6 with no empirical input. This value determines the four-dimensional bonding space V_C on which all subsequent structure is built. -/- Second, life (Condition P) and Darwinian evolution (Condition Q) are shown to be algebraically distinct. A system satisfies Condition P if it sustains idempotent self-referential computation — the algebraic definition of life, substrate-independent in principle and realised at minimum cost by carbon. Condition Q additionally requires mutation, derived as the structural action of off-diagonal root operators forced by Axioms 1 and 3, and positive selection pressure, derived as N²-scaled relative entropy with the parameter-free coefficient 25/1296. A κ-space scan confirms κ* = 1/6 as the minimum-cost simultaneous realisation of both conditions within Z = 1–36. Biogenesis and Darwinian evolution are thermodynamic projections of M₃(ℂ) spectral structure; molecular biology is their Tier-2 image. -/- Published on April, 19 2026 DOI:10.5281/zenodo.19648298 . (shrink)

The aesthetically optimistic view of life in the last paragraph of Darwin’s On the Origin of Species contrasts with the evidence in his autobiography of a supposed perceptive colour blindness to the magnificence of nature. Accepting the theory of evolution as one of the scientific theories that has contributed to disenchantment, my aim is to delve into the Darwinian perception of natural beauty and solve this contrast of perceptions within the framework of the Weberian concept of “disenchantment of (...) the world.” To do this, I have carried out a computer-assisted study of Darwin’s language focusing on the frequency of aesthetic-emotional and religious adjectives and adverbs in the six editions of the Origin. A semantic analysis of the lexicon shows that, although disenchanted, Darwin perceives nature as aesthetically enhanced. I arrive at the conclusion that Darwin’s alleged colour blindness does not come from a loss of his capacity to aesthetically perceive nature, but from his loss of religious belief. (shrink)

Maurice Blondel's articles from 1906 on the origin of philosophy opens with the idea of whether philosophy is be spontaneous or whether it requires specific training. Behind this question lies the more fundamental issue of the relative balance of science and life and where philosophy finds its more natural home.

Condillac's Essay on the Origin of Human Knowledge, first published in French in 1746 and offered here in a new translation, represented in its time a radical departure from the dominant conception of the mind as a reservoir of innately given ideas. Descartes had held that knowledge must rest on ideas; Condillac turned this upside down by arguing that speech and words are the origin of mental life and knowledge. He argued, further, that language has its (...) class='Hi'>origin in human interaction and in our natural capacity to react spontaneously and instinctively to the expression of emotions and states of mind in others. The importance of this pointedly anti-Cartesian view, and its relevance to both aesthetics and epistemology, were quickly understood, and Condillac's work influenced many later philosophers including Herder, Rousseau, and Adam Smith. His conception also anticipated Wittgenstein's view of language, its usage, and its relation to mind and thought. (shrink)

Cognitively modern human beings have language, art, science, religion, refined tool use, advanced music and dance, fashions of dress, and mathematics. Blue jays, border collies, dolphins, and bonobos do not. Only human beings have what we have, and this discontinuity in Life, this perspicuous Grand Difference, presents us with the most abiding and compelling scientific riddle of all. In The Way We Think, Gilles FauconnieRAnd I put forward the hypothesis that The Grand Difference arose in the following way . (...) The basic mental operation of conceptual integration, also known as ‘blending’, has been present and evolving in various species foRA long time, probably since early mammals, and there is no reason to doubt that many mammalian species aside from human beings have the ability to execute rudimentary forms of conceptual integration. Human beings evolved not an entirely different kind of mind, but instead the capacity for the strongest form of conceptual integration, known as ‘double- scope’ blending. Human beings are thus on a gradient with other species, but what a difference an extra step makes. Double-scope blending is the hallmark of cognitively modern human beings, and The Grand Difference is the product of double-scope blending. What is blending and why is it so important? As an illustration, consider our perception of a seal. The eyes of a seal are remarkably like the eyes of a human being. When we see a seal at the seashore, it is impossible to resist the conclusion that we and the seal share a category. Compelling and evident analogies leap out at us, between the seal’s appearance and ours, between the seal’s motion and ours. Our human eyes align toward an object as our limbs propel our bodies toward it, and it seems to be no different for the seal. Working from such analogies, we immediately forge a mental blend of ourselves and the seal. The result is a conception of a seal that has not only all of the seal’s appearance and motion but additionally a feature we know only of ourselves the possession of a mind . . (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 26.1 (2002) 216-223 [Access article in PDF] Notes and Fragments Genre Fiction and "The Origin of the Work of Art" Nancy J. Holland I FIRST, A CONFESSION. Like, I suspect, many of my readers, I am an unpublished fiction writer. Unlike most of the closet fiction writers in academia, however, I write genre fiction. The question that immediately follows is how that writing is related (...) to the intellectual work I do in philosophy.This question, of course, is open to a broad range of answers, from the possibility that the two aren't related at all, to potential Freudian answers it might take years of therapy to unearth. Teaching informs one's life, however, as much as the reverse, and in teaching Martin Heidegger's "The Origin of the Work of Art" to my Metaphysics class last year, I began to understand at least one dimension of the appeal that writing genre fiction has for me as a philosopher.But first, let me explain what I mean by genre fiction. In what follows, I will be referring primarily to four forms of genre fiction that have clear roots in the nineteenth century in Western Europe and North America: two gender-segregated genres, the western and the romance, and two gender-marked genres, science fiction and detective novels. I will be comparing these to two other forms of "popular culture" that also developed in the nineteenth century and have, I would argue, similar relationships to the older, more "legitimate," more elite art forms which they closely resemble: photography 1 and popular music, [End Page 216] especially those forms of popular music such as ragtime, blues, jazz, and rock that are informed by the African-American experience in the United States. 2These "low brow" art forms all appear to have arisen out of the growth of the middle class in developing parts of the world during the nineteenth century and the correlative confluence of greater leisure, greater aggregate prosperity, and higher levels of education across a broader spectrum of society. Further, these art forms all combine the surface appearance of their respective "high brow" correlate arts with the reassurance of repetition that is the cornerstone of the folk arts with which they are also correlated. Each of these forms of popular culture balances itself, then, between a demand for more and more "works of art" (and/or class aspirations based on the appearance of such) and a demand for the familiar in a rapidly changing, materially challenging world.Thus, photography gives us a frozen and thereby purified visual reality, an icon of memory to which we can return at will. The truth it reveals is most often starker than that of folk painting and portraiture, but also gives the appearance of being free from the subjectivity of the artist. Great iconic photographs such as the kiss on V-E day, I have heard it said, become more real than the reality they encapsulated.Popular music similarly combines often amazing musical complexity (which is not unknown, although rarer, in western folk music) with the reassurance of a form that not only repeats itself within a song, but also between songs of the same genre. Thus, blues can be recognized by both the minor chords in its melodies and the characteristic rhyme pattern of its lyrics. Moreover, most western popular music, even to some extent free-form jazz, has a familiar and reassuring beginning-middle-end structure, both melodically and dynamically, that locates a listener immediately within the song's "story-arc." 3This same beginning-middle-end structure is one clear hallmark of genre fiction. Another is repetition. We all immediately know the plot of a detective novel or science fiction adventure: where it will begin, what the key stages of the story will be, and how it will end—not just happily, but with a specific form of reassuring outcome, be it the victory of well-intentioned intelligence over cunning evil or humanity's ability to survive even the most alien (and so most familiar) of threats. At... (shrink)

Condillac's Essay on the Origin of Human Knowledge, first published in French in 1746 and offered here in a new translation, represented in its time a radical departure from the dominant conception of the mind as a reservoir of innately given ideas. Descartes had held that knowledge must rest on ideas; Condillac turned this upside down by arguing that speech and words are the origin of mental life and knowledge. He argued, further, that language has its (...) class='Hi'>origin in human interaction and in our natural capacity to react spontaneously and instinctively to the expression of emotions and states of mind in others. The importance of this pointedly anti-Cartesian view, and its relevance to both aesthetics and epistemology, were quickly understood, and Condillac's work influenced many later philosophers including Herder, Rousseau, and Adam Smith. His conception also anticipated Wittgenstein's view of language, its usage, and its relation to mind and thought. (shrink)

Looks at the life of Charles Darwin, covers the background of the book "On the Origin of Species," presents Darwin's theories and concepts of evolution, and discusses the impact of the book.

In recent years, many in medical education have examined the question of how best to reinvigorate the doctor-patient relationship, given the increasing technological distance that has emerged between them in modern medicine. In this paper it is argued that “humanism” and caring in medicine reflect the quality of transitional relatedness in the illness condition, a significant separation-attachment phase of life. By improving our understanding of the origin of caring, educational strategies for physicians in training may improve as might (...) our abilities to provide care. (shrink)

Kant and Fichte developed the concept of a worldview as a way of reflecting on experience as a whole. But what does it mean to form a worldview? And what role did it play in the German Idealist tradition? This paper seeks to answer these questions through a detailed analysis of the form of a philosophical worldview and its historical portent, both of which remain unexplored in the literature. The dearth of attention is partially to blame on Kant’s desultory development (...) of it, as well as its place in Fichte’s understudied lectures on religion. In this paper, I first reconstruct Kant’s conception as the starting point and then trace it to Fichte who went on to evolve it further. Fichte endorses the basic conceptual shape pioneered by Kant, namely, a reflective process of positing an idea and then checking the coherence of necessary judgments relative to it. However, Fichte came to realize that its philosophical function needed expanding. Beyond recognizing the possibility for alternative worldviews, Fichte further fleshed out how worldview creation could lead to human flourishing. The common feature between both thinkers is that the formation of a worldview aims to turn philosophy into a life-orienting exercise. (shrink)

Plato placed great importance on the natural number one. Plato stated that the three properties of Plato’s one are indivisible, invariable, and equal and that an ideal one has no physical properties. If we regard differences among lives as differences among genes and gene products and life as the container of genes, then life has properties similar to Plato’s one. Furthermore, life has properties of multiplying when it survives and disappearing when it dies. These properties of (...) class='Hi'>life are prerequisites for natural selection. Natural selection makes DNA become digital information, enabling accurate copies of DNA. Furthermore, DNA bases, essential for survival, become close to Plato’s one by natural selection. In addition, the information content of life must be sufficiently large for death to be irreversible, and the irreversibility of death is a prerequisite for natural selection. (shrink)

This body of work is motivated by an apparent contradiction between, on the one hand, Darwin’s testimony in his autobiographical text about a supposed perceptual colour blindness before the aesthetic magnificence of natural landscapes, and, on the other hand, the last paragraph of On the Origin of Species, where he claims to perceive the forms of nature as beautiful and wonderful. My aim is to delve into the essence of the Darwinian perception of beauty in the context of the (...) Weberian concept of “disenchantment of the world”, assumed as a possible conceptual axis that enables the unravelling of the core of this contrast of perceptions. In acknowledging the theory of evolution as one of the most prominent scientific theories likely to have contributed to disenchantment, a number of questions arise: Is disenchantment compatible with aesthetic experience and sensibility before natural beauty? Was it Darwin’s disenchanted conception of the world that led him to believe he was colour blind? To answer these questions, a computer-assisted semantic analysis of lexical frequency and variability, most especially focused on aesthetic-emotional and religious or spiritual adverbs and adjectives, has been undertaken across the six editions of The Origin. The semantic analysis demonstrates that, although disenchanted, Darwin’s descriptions of, mainly, the adaptational excellence of living beings, reflect an aesthetically enriched perception of nature. It is concluded that Darwin’s perceptual colour blindness, then, might be based on a confusion rooted in the equation of equality between aesthetic sensibility in nature and the perception of its beauty as part of the vestigia Dei. (shrink)

According to the model presented in this paper, the beginning of life was marked by the coupling of two complementary nucleotide bases: adenine and thymine. The adenine-thymine system received photons from the sun and stored their energy in the form of a chemical high-energy bond between two phosphoric acid molecules, which were before-hand fixed by adenine from the aqueous environment. The energy of the high-energy bond was then delivered in the form of two waves of electronic excitation. These were (...) utilized to synthesize new molecules, starting from the carbonic acid and ammonia molecules, fixed from the aqueous environment by the polar groups of the nucleotide bases. In this way, a nucleotides-histone protosystem was self-synthesized, evolving step by step towards complexity, by means of some internal cybernetic and informational mechanisms. During its evolution, the NHPS synthesized a limiting membrane, produced the organizing elements of the cellular organelles and constructed microtubules and microfilaments. Subsequently, the NHPS evolved to the building of DNA-histone system and formed the cellular nucleus. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: (...) What key questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

We offer a general definition of interpretation based on a naturalized teleology. The definition tests and extends the biosemiotic paradigm by seeking to provide a philosophically robust resource for investigating the possible role of semiosis (processes of representation and interpretation) in biological systems. We show that our definition provides a way of understanding various possible kinds of misinterpretation, illustrate the definition using examples at the cellular and subcellular level, and test the definition by applying it to a potential counterexample. We (...) explain how we propose to use the definition as a way of asking new questions about what distinguishes life from non-life and of formulating testable hypotheses within the field of origin-of-life research. If the definition leads to fruitful new empirical approaches to the scientific problem of the origin of life, it will help to establish biosemiotics as a legitimate philosophical approach in theoretical biology and will thereby support a theological appropriation of the biosemiotic perspective as the basis of a new theology of nature. (shrink)

For decades most scientists assumed that life emerged billions of years ago in a “primordial soup” somewhere on the Earth’s surface. Evidence is mounting, however, that life may have begun deep beneath the surface, perhaps near a volcanic ocean vent or even inside the hot crust itself. Since there are hints that life’s history on Earth extends back through the phase of massive cosmic bombardment, it may be that life started on Mars and came here later, (...) perhaps inside rocks ejected from the Red Planet by large impacts. The traffic of intact rocks between Mars and Earth is now an established fact, and experiments confirm that microbes could survive the rigours of the journey through space if cocooned within such material. Unfortunately, this planetary cross- contamination compromises astrobiologists’ hope of finding a second genesis in the solar system. (shrink)

The problem of how a mixture of chemicals can spontaneously transform themselves into even a simple living organism remains one of the great outstanding challenges to science. Various primordial soup theories have been proposed in which chemical self- organization brings about the required level of complexity. Major conceptual obstacles remain, however, such as the emergence of the genetic code, and the “chicken-and-egg” problem concerning which came first: nucleic acids or proteins. Currently fashionable is the so-called RNA world theory, which casts (...) RNA in the role of both chicken and egg. Other theories assume that protein chemistry and even clay crystal life came before nucleic acids. To be fully successful, a theory of biogenesis has to explain not merely the emergence of molecular replication and chemical complexity, but the crucial information content and information processing capabilities of the living cell. (shrink)

Deacon develops a minimal model of a nonparasitic virus to explore how nucleotide sequences came to be characterized by a code-like informational at the origin of life. The model serves to problematize the concept of biological normativity because it highlights two common yet typically implicit assumptions: that life could consist as an inert form, were it not for extrinsic sources of physical instability, and that life could have originated as a singular self-contained individual. I propose that (...) the origin of life, the genetic code, and biological normativity more generally, lead us to reject this passive individualism. (shrink)

In this article I argue that we should understand Nietzsche’s doctrine of eternal recurrence as the ideal of life affirmation opposed to philosophical pessimism, the view that life is not worth living. I first articulate Nietzsche’s psychological account of pessimism as a vengeful focus on the past and an aversion to time understood as transience. I then consider the question of why a person with the opposite psychological orientation – a creative relation to the future and an endorsement (...) of time – would will the eternal recurrence of all things. My answer appeals to Nietzsche’s notions of will to power and the redemption of the past from its senselessness. The interpretation of eternal recurrence that emerges from this approach takes Nietzsche’s vision of a great, world-redeeming individual to be integral to his doctrine of eternal recurrence. This is just one way in which it differs from common interpretations of eternal recurrence as a cosmological theory or thought experiment. (shrink)

Many solar systems in the universe may be expected to contain rocky planets that have accreted organic compounds. These compounds are likely to be universally found. In addition, the chemistry of sulfur, phosphorus, and iron is likely to dominate energy transductions and monomer activation, leading to the eventual emergence of polymers. Proteins and polynucleotides provide living matter with function, structure, and information. The conceptual puzzle regarding their emergence is discussed. The fitness of various elements to serve various roles is analyzed (...) from the viewpoint of electron orbitals. Elements with d orbitals are of central importance. (shrink)

This article reconsiders Stiegler’s account of the emergence of the human species in light of research in the field of transgenerational epigenetics. Stiegler traces this emergence to the appearance of technical artefacts allowing for the intergenerational transmission of acquired memory that would otherwise die along with the organism. This is taken to constitute a rupture in the history of life. The argument that I develop critiques Stiegler’s account at two levels: On the empirical level I argue that emerging neo-Lamarckian (...) developments in the life sciences pose a challenge to the terms in which the specificity of the human is outlined and the notion of the rupture with life that its emergence constitutes. On the logico-transcendental level, I contend that in its account of the rupture, Stiegler’s narrative repeats the logic of the ‘dual origin’ that he ascribes to Rousseau and Leroi-Gourhan in their respective accounts of the origin of the genus Anthropos. (shrink)

Systems Biology and the Modern Synthesis are recent versions of two classical biological paradigms that are known as structuralism and functionalism, or internalism and externalism. According to functionalism (or externalism), living matter is a fundamentally passive entity that owes its organization to external forces (functions that shape organs) or to an external organizing agent (natural selection). Structuralism (or internalism), is the view that living matter is an intrinsically active entity that is capable of organizing itself from within, with purely internal (...) processes that are based on mathematical principles and physical laws. At the molecular level, the basic mechanism of the Modern Synthesis is molecular copying, the process that leads in the short run to heredity and in the long run to natural selection. The basic mechanism of Systems Biology, instead, is self-assembly, the process by which many supramolecular structures are formed by the spontaneous aggregation of their components. In addition to molecular copying and self-assembly, however, molecular biology has uncovered also a third great mechanism at the heart of life. The existence of the genetic code and of many other organic codes in Nature tells us that molecular coding is a biological reality and we need therefore a framework that accounts for it. This framework is Code biology, the study of the codes of life, a new field of research that brings to light an entirely new dimension of the living world and gives us a completely new understanding of the origin and the evolution of life. (shrink)

Life appears to be a natural property of matter, but the problem of its origin only arose after early scientists refuted continuous spontaneous generation. There is no chance of life arising ‘all at once’, we need the standard scientific incremental explanation with large numbers of small steps, an approach used in both physical and evolutionary sciences. The necessity for considering both theoretical and experimental approaches is emphasized. After describing basic principles that are available (including the Darwin-Eigen cycle), (...) the search for origins is considered under four main themes. These are the RNA-world hypothesis; potential intermediates between an RNA-world and a modern world via the evolution of protein synthesis and then of DNA; possible alternatives to an RNA-world; and finally the earliest stages from the simple prebiotic systems to RNA. The triplicase/proto-ribosome theory for the origin of the ribosome is discussed where triples of nucleotides are added to a replicating RNA, with the origin of a triplet code well-before protein synthesis begins. The length of the code is suggested to arise from the early development of a ratchet mechanism that overcomes the problem of continued processivity of an RNA-based RNA-polymerase. It is probable that there were precursor stages to RNA with simpler sugars, or just two nucleotides, but we do not yet know of any better alternatives to RNA that were likely to arise naturally. For prebiotic stages (before RNA) a flow-reactor model is suggested to solve metabolism, energy gradients, and compartmentation simultaneously – thus the intense interest in some form of flow reactor. If an autocatalytic cycle could arise in such a system we would be major steps ahead. The most likely physical conditions for the origin of life require further clarification and it is still unclear whether the origin of life is more of an entropy (information) problem (and therefore high temperatures would be detrimental), rather than a kinetic problem (where high temperatures may be advantageous). (shrink)

The building blocks and origins of life have fascinated scientists since the earliest of times. What is required for life to work in terms of building blocks? An outline of the building blocks that have to be present in living systems to allow the processes that are required for life is given. These building blocks have to be organised in a specific way to allow living processes to be functional, which are summarised in what is referred to (...) as the seven pillars of life. In essence, these are the fundamental characteristics of all living systems. Evidences of when and how living systems developed on the Earth shortly after the Earth established itself as a planet are discussed. This comes from the growing body of geological evidence of the age of rocks and rock formations in different places on the Earth. This review is concluded with the latest evidence of where on Earth living systems may have started. A large amount of uncertainty exists about these processes, but more and more consilient evidence is giving us important pointers as to the origins of life on the planet Earth.Contribution: As part of this special collection, the building blocks or origins of life give insights into the chemical principles and constituents of living organisms and how their interactions allow life to function on earth. (shrink)