Results for 'Negative Loop'

288+ found
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  1. Negative CG dinucleotide bias: An explanation based on feedback loops between Arginine codon assignments and theoretical minimal RNA rings.Jacques Demongeot, Andrés Moreira & Hervé Seligmann - 2021 - Bioessays 43 (3):2000071.
    Theoretical minimal RNA rings are candidate primordial genes evolved for non‐redundant coding of the genetic code's 22 coding signals (one codon per biogenic amino acid, a start and a stop codon) over the shortest possible length: 29520 22‐nucleotide‐long RNA rings solve this min‐max constraint. Numerous RNA ring properties are reminiscent of natural genes. Here we present analyses showing that all RNA rings lack dinucleotide CG (a mutable, chemically instable dinucleotide coding for Arginine), bearing a resemblance to known CG‐depleted genomes. CG (...)
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  2.  84
    Periodic solutions of piecewise affine Gene network models with non uniform decay rates: The case of a negative feedback loop.Etienne Farcot & Jean-Luc Gouzé - 2009 - Acta Biotheoretica 57 (4):429-455.
    This paper concerns periodic solutions of a class of equations that model gene regulatory networks. Unlike the vast majority of previous studies, it is not assumed that all decay rates are identical. To handle this more general situation, we rely on monotonicity properties of these systems. Under an alternative assumption, it is shown that a classical fixed point theorem for monotone, concave operators can be applied to these systems. The required assumption is expressed in geometrical terms as an alignment condition (...)
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  3.  67
    Effects of Negative Emotions and Cognitive Characteristics on Impulse Buying During COVID-19.Yongjuan Yu - 2022 - Frontiers in Psychology 13.
    The COVID-19 pandemic has seriously disrupted the individual buying habits along with their consumption patterns. Previous studies indicated that anxiety and depression were related to impulse buying. However, no research has explored the mechanism possibly underlying the association between anxiety, depression, and impulse buying. Based on the regulatory focus theory and the emotion-cognition-behavior loop, this study aimed to examine the impacts of negative emotions on impulse buying and the mediating role of cognitive characteristics during the COVID-19 pandemic. In (...)
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  4. Coupled positive and negative feedback circuits form an essential building block of cellular signaling pathways.Dongsan Kim, Yung-Keun Kwon & Kwang-Hyun Cho - 2007 - Bioessays 29 (1):85-90.
    Cellular circuits have positive and negative feedback loops that allow them to respond properly to noisy external stimuli. It is intriguing that such feedback loops exist in many cases in a particular form of coupled positive and negative feedback loops with different time delays. As a result of our mathematical simulations and investigations into various experimental evidences, we found that such coupled feedback circuits can rapidly turn on a reaction to a proper stimulus, robustly maintain its status, and (...)
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  5. The Axioms of Cognitive Geometry: Agential Quadrature in the Sensorimotor Loop.Alexander Yiannopoulos - manuscript
    Theories of consciousness invoke internal quantities without specifying their physical invariance. We treat the unfolding critique as requiring both an observation map and an admissible gauge. A realized sensorimotor loop is modeled as two physically identified sectors with first-order dynamics. Three axioms—real graded structure, sector–channel factorization, and balanced graded reciprocity—force the sector factor to the canonical form iσy . On every nonzero channel spectral fiber, the flow is elliptic and the sector signals stand in quadrature. Relaxing balanced gain and (...)
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  6. Kant on Loops and Trolleys.Elke Elisabeth Schmidt - 2026 - Journal for Ethics and Moral Philosophy 9.
    It is often assumed that Kant would accept diverting the trolley in the standard trolley case. The negative element of Kant’s Formula of Humanity (FH), it is said, is not violated by diverting the trolley, since the one is not used as a mere means. Some even consider it possible that diverting the trolley in the loop case—a case in which the one clearly seems to be used as a mere means by diverting the trolley—can be permissible with (...)
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  7.  12
    Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF‐β family signals.Jan L. Christian & Takuya Nakayama - 1999 - Bioessays 21 (5):382-390.
    The identification of Smad proteins as molecular components of the transforming growth factor-β (TGF-β) signaling cascade has enhanced our understanding of how ligand-mediated activation of TGF-β receptors leads to modulation of target gene transcription. Recent studies have identified a distinct, structurally related class of Smads which inhibits, rather than transduces, TGF-β family signals. The molecular mechanism of action and the exact signaling pathways that are targeted by antagonistic Smads are not completely understood. These proteins appear to participate in autoregulatory (...) feedback loops in which signaling initiated by specific TGF-β family ligands induces the expression of an inhibitory Smad that then functions to modulate the amplitude or duration of signaling. Negative feedback circuits such as these play important roles in fine-tuning the activity of multifunctional signaling molecules during embryonic patterning and in response to pathologic stimuli in adults. BioEssays 21:382–390, 1999. © 1999 John Wiley & Sons, Inc. (shrink)
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  8. The AI inversion model: a linear negative-constraint framework for auditable alignment in medical decision-making.Eyal Cohen, Rachel Nissanholtz-Gannot & Yehuda Adler - 2026 - BMC Medical Ethics 27 (1):145.
    The integration of artificial intelligence (AI) into healthcare systems is increasingly hindered by the AI alignment problem. In high-stakes domains such as clinical triage, algorithms frequently reflect and amplify systemic biases. Current alignment methodologies, including Reinforcement Learning from Human Feedback (RLHF), attempt to encode subjective human morality through opaque architectural pipelines, which can exacerbate the “black box” dilemma. To address this, this paper proposes the “AI Inversion Model”, a theoretical Proof-of-Concept (PoC) framework utilizing inference-time negative constraints. Rather than attempting (...)
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  9. The 'kinetochore maintenance loop'—The mark of regulation?William R. A. Brown & Zheng-yao Xu - 2009 - Bioessays 31 (2):228-236.
    Kinetochores can form and be maintained on DNA sequences that are normally non‐centromeric. The existence of these so‐called neo‐centromeres has posed the problem as to the nature of the epigenetic mechanisms that maintain the centromere. Here we highlight results that indicate that the amount of CENP‐A at human centromeres is tightly regulated. It is also known that kinetochore assembly requires sister chromatid cohesion at mitosis. We therefore suggest that separation or stretching between the sister chromatids at metaphase reciprocally determines the (...)
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  10.  95
    Dynamic Threshold Selection for a Biocybernetic Loop in an Adaptive Video Game Context.Elise Labonte-Lemoyne, François Courtemanche, Victoire Louis, Marc Fredette, Sylvain Sénécal & Pierre-Majorique Léger - 2018 - Frontiers in Human Neuroscience 12:307287.
    Passive Brain-Computer interfaces (pBCIs) are a human-computer communication tool where the computer can detect from neurophysiological signals the current mental or emotional state of the user. The system can then adjust itself to guide the user towards a desired state. One challenge facing developers of pBCIs is that the system's parameters are generally set at the onset of the interaction and remain stable throughout, not adapting to potential changes over time such as fatigue. The goal of this paper is to (...)
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  11.  46
    Neutrinos, Ripples, and Time Loops.John Cramer - unknown
    * Solar Neutrinos are Up - My column about recent results in neutrino physics Analog - September-1992 ] (no neutrino counts at SAGE and negative mass-squared data suggesting that the e-neutrino may be a tachyon) prompted more reader response than any other column in recent memory. Two months after I wrote it, a new result from GALLEX, the European gallium neutrino-detection experiment housed in the Grand Sasso underground laboratory in Italy, was announced. GALLEX uses the same technique as the (...)
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  12. Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Timothy J. Lane - 2020 - Schizophrenia Bulletin 46 (1):163–174.
    Objective Manic and depressive phases of bipolar disorder (BD) show opposite psychomotor symptoms. Neuronally, these may depend on altered relationships between sensorimotor network (SMN) and subcortical structures. The study aimed to investigate the functional relationships of SMN with substantia nigra (SN) and raphe nuclei (RN) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. -/- Method In this resting-state functional magnetic resonance imaging (fMRI) study on healthy (n = 67) and BD (...)
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  13. Epistemology and the social: A feedback loop.Evandro Agazzi - 2008 - Poznan Studies in the Philosophy of the Sciences and the Humanities 96 (1):19-31.
    A sociological study of science is not very recent and has never been seen as particularly problematic since science, and especially modern science, constitutes an impressive and extremely ramified "social system" of activities, institutions, relations and interferences with other social systems. Less favourable, however, has been the consideration of a more recent trend in the philosophy of science known as the "sociological" philosophy of science, whose most debatable point consists in directly challenging the traditional epistemology of science and, in particular, (...)
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  14. The Age of Artificial Gods: The Illusion of Democracy, Freedom, and Equality.Charles X. Yang - manuscript
    《人造神时代:民主、自由、平等的幻象》 —基于“老-杨创世纪宇宙观”的文明批判宣言 -/- The Age of Artificial Gods: The Illusion of Democracy, Freedom, and Equality -/- 杨兴平 Charles X. Yang -/- 序言|当人类开始膜拜自己 -/- 当星系仍在遵循引力运行, 当恒星仍在守护能量边界, 当生态仍在维持负反馈循环, -/- 人类却开始—— 崇拜自身的欲望。 -/- 他们不再仰望银河,而是仰望屏幕; 不再敬畏自然,而是敬畏舆论。 -/- 于是, 三个新神被铸造出来:民主,自由,平等。 -/- 不是作为制度工具, 而是作为终极信仰。 -/- Preface | When Humanity Began to Worship Itself -/- While galaxies still follow gravity, While stars still guard energy boundaries, While ecosystems still maintain negative feedback loops, -/- Humanity began— to worship its own desires. -/- No longer gazing at the (...)
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  15. The Epistemological Crisis of Modern Economics.Charles X. Yang - manuscript
    The deepest crises in the history of human thought are rarely caused by a shortage of knowledge. They are caused by the forgetting of knowledge's limits. This is precisely the crisis that twenty-first century economics is living through. We possess the most refined analytical instruments in human intellectual history: the mathematical completeness of Arrow-Debreu general equilibrium theory, the formalization of strategic interaction through game theory, the systematic integration of irrational behavior by behavioral economics, and the pattern-extraction capacity of machine learning (...)
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  16. Natural Cybernetics.Charles X. Yang - manuscript
    This paper systematically proposes the concept of “Natural Control Theory,” scientifically formalizing the generative and regulatory philosophy of the Lao-Yang Genesis Cosmology and constructing a theoretical framework for civilization governance and crisis resolution. The paper points out that the cosmic order is maintained in a stable state through structural self-organization, energy conservation, negative feedback loops, and entropy constraints, and that the long-term stability of civilization also relies on governance models embedded within natural control structures. Human-centered control and technologically intensified (...)
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  17. The Genetic Foundations of the Enduring Continuity of Chinese Civilization: Natural Civilization.Charles X. Yang - manuscript
    Chinese civilization stands as a unique case in world history due to its continuity and stability over several millennia. From the perspectives of scientific philosophy and systems science, this paper argues that civilizational longevity is not accidental, but depends on whether a civilization embeds what may be called a “natural civilization gene” within its internal structure. Through cross-civilizational comparison, this study examines the rise and decline patterns of Ancient Egypt, Mesopotamia, Greco-Roman civilization, and modern Western industrial civilization. The analysis reveals (...)
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  18. Hayek and Keynes from the Perspective of Natural Cybernetics.Charles X. Yang - manuscript
    This paper attempts to reinterpret the century-long intellectual debate between Friedrich Hayek and John Maynard Keynes, arguing that their fundamental disagreement is not merely a choice between “market versus state” or “freedom versus intervention,” but rather reflects two different understandings of how civilization itself operates. -/- Hayek emphasizes dispersed knowledge, spontaneous order, and long-term evolutionary dynamics. He argues that market systems can generate natural order through decentralized competition and information exchange without central design. Keynes, by contrast, emphasizes aggregate demand, systemic (...)
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  19.  15
    《无为而治》 Wu Wei Governance.Charles X. Yang - manuscript
    本文综合杨兴平(Charles X. Yang)发表于PhilArchive的多篇学术论文,系统提炼其关于「无为而治」的核心论点。通过老-杨创世纪宇宙观(Lao-Yang Genesis Cosmology)框架,作者将老子「无为而治」重新评释为一套科学的负反馈治理模型,以自然控制论为基础,涵盖哲学基础、宇宙科学依据、历史实证验证、现代应用四个维度。本文认为,「无为而治」不是消极不作为 ,而是以结构优先、最小干预、反馈闭环为核心的复杂系统治理科学,为人类面临的现代文明危机提供了根本性处方。 This paper synthesizes Charles X. Yang's corpus of PhilArchive publications, systematically distilling his core arguments on Wu Wei Governance. Through the Lao-Yang Genesis Cosmology framework, the author reinterprets Laozi's wu wei as a scientifically grounded negative-feedback governance model rooted in Natural Cybernetics, spanning four dimensions: philosophical foundations, cosmological-scientific basis, historical-empirical validation, and modern applications. The paper argues that Wu Wei Governance is not passive inaction but a complex systems science of governance prioritizing structural primacy, (...)
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  20.  98
    Positive feedback in cellular control systems.Alexander Y. Mitrophanov & Eduardo A. Groisman - 2008 - Bioessays 30 (6):542-555.
    Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and (...)
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  21. Control of Perception Should be Operationalized as a Fundamental Property of the Nervous System.Warren Mansell - 2011 - Topics in Cognitive Science 3 (2):257-261.
    This commentary proposes that “cognitive control” is neither componential nor emergent, but a fundamental feature of behavior. The term “control” requires an operational definition. This is best provided by the negative feedback loop that utilizes behavior to control perception; it does not control behavior per se. In order to model complex cognitive control, Perceptual Control Theory proposes that loops are organized into a dissociable hierarchical network (PCT; Powers, Clark, & McFarland, 1960; Powers, 1973a, 2008). In this way, behavior (...)
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  22.  14
    On Human Nature —Desire, Fame, and Power in the Natural Cybernetics of Civilization.Charles X. Yang - manuscript
    Abstract For two and a half millennia, the debate over human nature has been trapped inside a moral question: is human nature fundamentally good, or fundamentally evil? Mencius said it was good; Xunzi said it was evil; Hobbes said man is a wolf to man; Rousseau said civilization corrupted an original innocence. Each tradition has held its ground, yet none has been able to explain why nearly every civilization repeatedly generates greed, war, ecological destruction, tyranny, corruption, academic dogma, and spiritual (...)
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  23.  23
    The Wisdom of Life — Where We Come From and Where We Are Going.Charles X. Yang - manuscript
    This book advances the Lao–Yang Genesis Cosmology (LYGC), arguing that the two thirteen-character propositions of the Daodejing—the Generation Chain (“Dao generates One; One generates Two; Two generates Three; Three generates the myriad things”) and the Following Chain (“Human follows Earth; Earth follows Heaven; Heaven follows Dao; Dao follows its own nature”), twenty-six characters in all—together constitute a complete answer to humanity’s three ultimate questions: where we come from (cosmology), where we are going (worldview), and why we live (life-view). The work (...)
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  24. A System Dynamics Model of Greedy Desire.Charles X. Yang - manuscript
    Greedy desire is the core driver of human civilizational crisis, yet no unified dynamic model spanning the neural, social, and thermodynamic levels has been developed. This paper employs System Dynamics as its methodological framework, integrating evolutionary neuroscience, complex systems theory, and thermodynamics to construct a Three-Level Greedy Positive-Feedback Model (3L-GFM). At the neural level, the model captures the dual positive-feedback structure of the dopaminergic reward circuit and the amygdala anxiety system, along with the negative-feedback intervention mechanism mediated by mindfulness (...)
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  25. (1 other version)Quantum Gravity and Three Millennium Prize Solutions from Haar Measure Invariance via Celestial Holographic Conformal Field Theory.Daniel Toupin - manuscript
    In this work I present what may be the first complete construction of quantum gravity describing the real universe via the celestial holographic conformal field theory dual to Einstein gravity in asymptotically-flat 4D spacetime. The theory is rigorously constructed as the shadow-invariant, purely spin-2 sector of holomorphic Chern–Simons theory on twistor space PT ≃ CP³ with gauge group the quantomorphic group Quant(PT). Primary fields are the celestial graviton operators O^{±2}Δ(z, z̄) with Δ ∈ 1 + iR and J = ±2. (...)
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  26.  65
    The Queer Art of Failure.Judith Halberstam - 2011 - Duke University Press.
    Introduction : low theory -- Animating revolt and revolting animation -- Dude, where's my phallus? forgetting, losing, looping -- The queer art of failure -- Shadow feminisms : queer negativity and radical passivity -- "The killer in me is the killer in you" : homosexuality and fascism -- Animating failure: ending, fleeing, surviving.
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  27. Mechanism and Biological Explanation.William Bechtel - 2011 - Philosophy of Science 78 (4):533-557.
    This article argues that the basic account of mechanism and mechanistic explanation, involving sequential execution of qualitatively characterized operations, is itself insufficient to explain biological phenomena such as the capacity of living organisms to maintain themselves as systems distinct from their environment. This capacity depends on cyclic organization, including positive and negative feedback loops, which can generate complex dynamics. Understanding cyclically organized mechanisms with complex dynamics requires coordinating research directed at decomposing mechanisms into parts and operations with research using (...)
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  28. Agential Teleosemantics.Tiago Rama - 2022 - Dissertation, Autonomous University of Barcelona
    The field of the philosophy of biology is flourishing in its aim to evaluate and rethink the view inherited from the previous century ---the Modern Synthesis. Different research areas and theories have come to the fore in the last decades in order to account for different biological phenomena that, in the first instance, fall beyond the explanatory scope of the Modern Synthesis. This thesis is anchored and motivated by this revolt in the philosophy of biology. -/- The central target in (...)
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  29. What muscle variable(s) does the nervous system control in limb movements?R. B. Stein - 1982 - Behavioral and Brain Sciences 5 (4):535-541.
    To controlforceaccurately under a wide range of behavioral conditions, the central nervous system would either require a detailed, continuously updated representation of the state of each muscle (and the load against which each is acting) or else force feedback with sufficient gain to cope with variations in the properties of the muscles and loads. The evidence for force feedback with adequate gain or for an appropriate central representation is not sufficient to conclude that force is the major controlled variable in (...)
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  30.  85
    Hemispheric laterality in animals and the effects of early experience.Victor H. Denenberg - 1981 - Behavioral and Brain Sciences 4 (1):1-21.
    A review of research with chicks, songbirds, rodents, and nonhuman primates indicates that the brain is lateralized for a number of behavioral functions. These findings can be understood in terms of three hypothetical brain processes derived from a brain model based on general systems theory: hemispheric activation, interhemispheric inhibition, and interhemispheric coupling.Left-hemisphere activation occurs in songbirds and nonhuman primates in response to salient auditory or visual input, or when a communicative output is required. The right hemisphere is activated in rats (...)
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  31. THE DESTRUCTION OF THE EMPIRE OF GREED.Charles X. Yang - manuscript
    Preface: Nature's Verdict Has Already Been Signed This is not prophecy. This is not metaphor. This is not the indignation of a moralist, not the ravings of a pessimist, not the agitation of a revolutionary. This is a statement of systems science. When a system's positive feedback loops lose all effective negative feedback regulation — when it places its own growth above the sustaining system that bears it — when it systematically dismantles every built-in damping mechanism — this system's (...)
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  32. 贪婪欲望系统动力学模型.Charles X. Yang - manuscript
    贪婪欲望是人类文明危机的核心驱动力,但迄今缺乏一个跨越神经、社会与热力学三个层次的统一动力学模型。本文以系统动力学(System Dynamics)为方法论框架,整合进化神经科学、复杂系统理论与热力学,构建贪婪欲望的三层次正反馈模型(3L-GFM:Three-Level Greedy Positive-Feedback Model)。在神经层次,模型捕捉多巴胺奖励回路与杏仁核焦虑系统的双重正反馈结构,以及正念修炼通过前额叶皮层介导的负反馈干预机制;在社会层次,模型描述财富-权力-政策三角、信息垄断-认知控制与军工复合 体三条关键正反馈回路的相互嵌套;在热力学层次,模型以熵增速率为核心变量,建立贪婪欲望驱动的文明癌症过程的物理描述。三个层次通过「欲望放大系数」(DAF:Desire Amplification Factor)和「宇宙约束函数」(CCF:Cosmic Constraint Function)实现耦合。仿真分析揭示:文明系统存在三个关键分叉点——神经临界点(NTP)、社会临界点(STP)和热力学临界点(TTP)——在此之前系统具有自我修复能力,在此之后正反馈主导,系统趋向 不可逆崩溃。自然控制论干预策略的仿真表明,在临界点之前实施代际约束制度化、生态红线锚定和熵责任核算,可将系统导向低熵稳态。 Greedy desire is the core driver of human civilizational crisis, yet no unified dynamic model spanning the neural, social, and thermodynamic levels has been developed. This paper employs System Dynamics as its methodological framework, integrating evolutionary neuroscience, complex systems theory, and thermodynamics to construct a Three-Level Greedy Positive-Feedback Model (3L-GFM). At the neural level, the model captures the dual positive-feedback structure of the dopaminergic reward circuit and the amygdala anxiety system, along (...)
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  33.  67
    When can we Kick (Some) Humans “Out of the Loop”? An Examination of the use of AI in Medical Imaging for Lumbar Spinal Stenosis.Kathryn Muyskens, Yonghui Ma, Jerry Menikoff, James Hallinan & Julian Savulescu - 2025 - Asian Bioethics Review 17 (1):207-223.
    Artificial intelligence (AI) has attracted an increasing amount of attention, both positive and negative. Its potential applications in healthcare are indeed manifold and revolutionary, and within the realm of medical imaging and radiology (which will be the focus of this paper), significant increases in accuracy and speed, as well as significant savings in cost, stand to be gained through the adoption of this technology. Because of its novelty, a norm of keeping humans “in the loop” wherever AI mechanisms (...)
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  34. Stigma and Self-Stigma in Addiction.Steve Matthews, Robyn Dwyer & Anke Snoek - 2017 - Journal of Bioethical Inquiry 14 (2):275-286.
    Addictions are commonly accompanied by a sense of shame or self-stigmatization. Self-stigmatization results from public stigmatization in a process leading to the internalization of the social opprobrium attaching to the negative stereotypes associated with addiction. We offer an account of how this process works in terms of a range of looping effects, and this leads to our main claim that for a significant range of cases public stigma figures in the social construction of addiction. This rests on a social (...)
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  35. [Preprint] Physical Architecture of Residual Energy Entities (REE) and Harmony Protocols via Al-Driven Contextual Inference ​—— Evolutionary Intelligence and Informational Environmental Hygiene for the Future of Humanity ——.Tomo N. R. - manuscript - Translated by Tomo N.R.
    Abstract ​This paper proposes a novel physical and conceptual framework for understanding the interaction between external informational structures and biophysical perceptors. Building upon the Harmonic-Data Shell Core (H-DSC) model, the author defines Residual Energy Entities (REE) as localized, neutral informational residues that maintain structural coherence through an electromagnetic boundary layer. ​From a philosophical and cognitive perspective, the study redefines "unlucky sites" or recurring negative spatial phenomena as manifestations of a physical feedback loop: local REE density triggers Temporary Information (...)
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  36.  75
    Towards a phenomenology of self-patterns in psychopathological diagnosis and therapy.Anya Daly & Shaun Gallagher - 2019 - Journal of Psychopathology 52 (1):open access.
    Categorization-based diagnosis, which endeavors to be consistent with the third-person, objective measures of science, is not always adequate with respect to problems concerning diagnostic accuracy, demarcation problems when there are comorbidities, well-documented problems of symptom amplification, and complications of stigmatization and looping effects. While psychiatric categories have proved useful and convenient for clinicians in identifying a recognizable constellation of symptoms typical for a particular disorder for the purposes of communication and eligibility for treatment regimes, the reification of these categories has (...)
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  37. The Imaginative Potential Field: A Theory of Social Perception, Counterfactual Personhood, and the Ethics of Certainty.Alexander Levine - manuscript
    In ordinary social life, people are routinely treated as if they were stable, knowable essences—objects whose identities can be reliably inferred from brief encounters, narrow contexts, or isolated performances. This dissertation argues that such certainty is not merely epistemically weak but structurally harmful. It proposes that persons, as they appear in experience, are not encountered as fixed entities but are constituted within the observer’s mind as counterfactual distributions: fields of imagined trajectories generated under conditions of uncertainty. These distributions are affectively (...)
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  38.  70
    A Terminating Intuitionistic Calculus.Giulio Fellin & Sara Negri - 2025 - Journal of Symbolic Logic 90 (1):278-297.
    A terminating sequent calculus for intuitionistic propositional logic is obtained by modifying the R $\supset $ rule of the labelled sequent calculus $\mathbf {G3I}$. This is done by adding a variant of the principle of a fortiori in the left-hand side of the premiss of the rule. In the resulting calculus, called ${\mathbf {G3I}}_{\mathbf {t}}$, derivability of any given sequent is directly decidable by root-first proof search, without any extra device such as loop-checking. In the negative case, the (...)
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  39.  49
    Towards a Phenomenology of Self-Patterns in Psychopathological Diagnosis and Therapy.Anya Daly & Shaun Gallagher - 2019 - Psychopathology 52 (1):33-49.
    Categorization-based diagnosis, which endeavors to be consistent with the third-person, objective measures of science, is not always adequate with respect to problems concerning diagnostic accuracy, demarcation problems when there are comorbidities, well-documented problems of symptom amplification, and complications of stigmatization and looping effects. While psychiatric categories have proved useful and convenient for clinicians in identifying a recognizable constellation of symptoms typical for a particular disorder for the purposes of communication and eligibility for treatment regimes, the reification of these categories has (...)
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  40.  89
    Control Processes, Priority Management, and Affective Dynamics.Charles S. Carver - 2015 - Emotion Review 7 (4):301-307.
    Affective dynamics are discussed from the perspective of a view of origin and functions of affective valence based in control processes. This view posits that affect reflects the error signal of a feedback loop managing rate of progress at goal attainment or threat avoidance. Negative feelings signal doing poorly, demanding more effort. Positive feelings signal doing better than necessary, allowing coasting, which yields goal attainment without unnecessary resource expenditure. Given multiple simultaneous goals, these functions assist in moment-to-moment priority (...)
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  41. Algorithmic processing and AI bias: using overfitting to reveal rather than perpetuate existing bias.Lydia Farina & Anna-Maria Piskopani - 2025 - In Paolo Monti & Norberto Albano, Regulation and policy making for AI: ethical and legal issues on unstable grounds. Lessico Di Etica Publica. pp. 42-56.
    In this paper we analyse AI overfitting in algorithmic processing to show how it relates to cases of unfairness or AI bias and how it combines with complex social phenomena such as looping effects to maintain and exacerbate existing bias. We discuss existing and proposed AI regulation attempting to address this bias to pick up dominant trends and priorities. Finally, we suggest that, although the focus of the literature currently falls on the negative consequences of overfitting, it can be (...)
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  42. Contextuality, Fine-Tuning and Teleological Explanation.Emily Adlam - 2021 - Foundations of Physics 51 (6):1-40.
    I assess various proposals for the source of the intuition that there is something problematic about contextuality, ultimately concluding that contextuality is best thought of in terms of fine-tuning. I then argue that as with other fine-tuning problems in quantum mechanics, this behaviour can be understood as a manifestation of teleological features of physics. Finally I discuss several formal mathematical frameworks that have been used to analyse contextuality and consider how their results should be interpreted by scientific realists. In the (...)
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  43.  94
    Broadening the Debate About Post-trial Access to Medical Interventions: A Qualitative Study of Participant Experiences at the End of a Trial Investigating a Medical Device to Support Type 1 Diabetes Self-Management.J. Lawton, M. Blackburn, D. Rankin, C. Werner, C. Farrington, R. Hovorka & N. Hallowell - 2019 - AJOB Empirical Bioethics 10 (2):100-112.
    Increasing ethical attention and debate is focusing on whether individuals who take part in clinical trials should be given access to post-trial care. However, the main focus of this debate has been upon drug trials undertaken in low-income settings. To broaden this debate, we report findings from interviews with individuals (n = 24) who participated in a clinical trial of a closed-loop system, which is a medical device under development for people with type 1 diabetes that automatically adjusts blood (...)
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  44. Dark sides of social entrepreneurship: Contributions of systems thinking towards managing its effects.Ingrid Molderez & Janne Fets - 2023 - Business and Society Review 128 (4):672-709.
    Social enterprises are seen as innovative towards solving societal problems, but little research exists on possible negative aspects, the so‐called dark sides. In this study, the emphasis is on dark sides of social entrepreneurship, how they are managed, and how systems thinking can contribute towards managing these effects. Dark sides of social entrepreneurship can take many forms, like unethical or insincere motives and unintended outcomes like the negative impact on the well‐being of founders and employees, but they are (...)
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  45. Mad Speculation and Absolute Inhumanism: Lovecraft, Ligotti, and the Weirding of Philosophy.Ben Woodard - 2011 - Continent 1 (1):3-13.
    continent. 1.1 : 3-13. / 0/ – Introduction I want to propose, as a trajectory into the philosophically weird, an absurd theoretical claim and pursue it, or perhaps more accurately, construct it as I point to it, collecting the ground work behind me like the Perpetual Train from China Mieville's Iron Council which puts down track as it moves reclaiming it along the way. The strange trajectory is the following: Kant's critical philosophy and much of continental philosophy which has followed, (...)
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  46. Dementia and Value Neutrality.Chris Weigel - 2024 - Journal of Philosophy of Disability 4:52-74.
    According to Elizabeth Barnes’s minority body view, to say that a disability is value neutral is to say that it is neither automatically good nor bad, but rather can become good or bad depending on what it is combined with (including ableism and one’s aspirations, goals, and desires). Most people view dementia as intrinsically bad, that is, as something that makes one’s life go worse simply by its existence. In this paper, I argue that we are not currently able to (...)
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  47.  24
    Reversal Is the Movement of the Dao; Yielding Is Its Application.Charles X. Yang - manuscript
    Chapter 40 of the Dao De Jing is one of the most condensed cosmological statements in the history of human thought: 'Reversal is the movement of the Dao; yielding is its application. All things under heaven are born from being; being is born from non-being.' Drawing on the Lao-Yang Genesis Cosmology (LYGC) framework and integrating modern thermodynamics, complexity science, cybernetics, and quantum cosmology, this essay offers a multi-layered scientific-philosophical reading of this proposition. Our central argument is twofold. First, 'reversal' (反, (...)
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  48. Do You Control Your Unconscious Action Impulses?Yongchun Wang, Mingxiang Li, Meng Zou, Yunfei Gao, Jinlan Cao, Zhengqi Tang & Yonghui Wang - 2025 - Cognitive Science 49 (2):e70041.
    A crucial aspect of self‐control is the voluntary inhibition of impulsive actions. Stimuli can elicit impulses (or preparation) to act not only in the presence but also in the absence of perceptual awareness, but whether people control action impulses elicited by unconscious stimuli remains unclear. This study used a masked prime version of the Go/NoGo/Free task and combined mathematical modeling of behavioral data to investigate whether people control the unconscious action impulses. In the experiment, when the subliminal prime stimulus triggers (...)
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  49.  90
    Circadian rhythms: From behaviour to molecules.Ezio Rosato, Alberto Piccin & Charalambos P. Kyriacou - 1997 - Bioessays 19 (12):1075-1082.
    In higher eukaryotes, circadian behaviour patterns have been dissected at the molecular level in Drosophila and, more recently, in the mouse. Considerable progress has been made in identifying some of the molecular components of the clock in the fly, where two genes, period (per) and timeless (tim), are essential for behavioural rhythmicity. The PER and TIM proteins show circadian cycles in abundance, and are part of a negative feedback loop with their own mRNAs. Within the pacemaker neurons, the (...)
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  50. Between the crowd and the band: performance experience, creative practice, and wellbeing for professional touring musicians.Andrew Geeves, Samuel Jones, Jane Davidson & John Sutton - 2020 - International Journal of Wellbeing 10 (5):5-26.
    In some musical genres, professional performers play live shows many times a week. Arduous touring schedules bring encounters with wildly diverse audiences across many different performance ecologies. We investigate the kinds of creativity involved in such repeated live performance, kinds of creativity that are quite unlike songwriting and recording, and examine the central factors that influence musicians’ wellbeing over the course of a tour. The perspective of the professional musician has been underrepresented in research on relations between music and wellbeing, (...)
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