Schizophrenia is a serious mental illness characterized by a disconnection between brain regions. Transcranial magnetic stimulation is a non-invasive brain intervention technique that can be used as a new and safe treatment option for patients with schizophrenia with drug-refractory symptoms, such as negative symptoms and cognitive impairment. However, the therapeutic effects of transcranial magnetic stimulation remain unclear and would be investigated using non-invasive tools, such as functional connectivity. A longitudinal design was adopted to investigate the alteration in FC dynamics using (...) a dynamic functional connectivity approach in patients with schizophrenia following high-frequency repeated transcranial magnetic stimulation with the target at the left dorsolateral prefrontal cortex. Two groups of schizophrenia inpatients were recruited. One group received a 4-week high-frequency rTMS together with antipsychotic drugs, while the other group only received antipsychotic drugs. Resting-state functional magnetic resonance imaging and psychiatric symptoms were obtained from the patients with schizophrenia twice at baseline and after 4-week treatment. The dynamics was evaluated using voxel- and region-wise FC temporal variability resulting from fMRI data. The pattern classification technique was used to verify the clinical application value of FC temporal variability. For the voxel-wise FC temporary variability, the repeated measures ANCOVA analysis showed significant treatment × time interaction effects on the FC temporary variability between the left DLPFC and several regions, including the thalamus, cerebellum, precuneus, and precentral gyrus, which are mainly located within the cortico-thalamo-cerebellar circuit. For the ROI-wise FC temporary variability, our results found a significant interaction effect on the FC among CTCC. rTMS intervention led to a reduced FC temporary variability. In addition, higher alteration in FC temporal variability between left DLPFC and right posterior parietal thalamus predicted a higher remission ratio of negative symptom scores, indicating that the decrease of FC temporal variability between the brain regions was associated with the remission of schizophrenia severity. The support vector regression results suggested that the baseline pattern of FC temporary variability between the regions in CTCC could predict the efficacy of high-frequency rTMS intervention on negative symptoms in schizophrenia. These findings confirm the potential relationship between the reduction in whole-brain functional dynamics induced by high-frequency rTMS and the improvement in psychiatric scores, suggesting that high-frequency rTMS affects psychiatric symptoms by coordinating the heterogeneity of activity between the brain regions. Future studies would examine the clinical utility of using functional dynamics patterns between specific brain regions as a biomarker to predict the treatment response of high-frequency rTMS. (shrink)

This paper recounts the efforts of a Bioethics student to understand the experience of human subjects of medical research in Kenya. Although the endeavor resulted in more questions than answers, it served to highlight areas where the current system of protections has failed to secure the well-being of those involved. It concludes that, in addition to existing considerations, ethical review ought to include another kind of information: that which can be gained only from listening to the feelings and experiences related (...) by subjects themselves. (shrink)

A major controversy in the study of the "Analects" has been over the relation between two central concepts, ren (humanity, human excellence) and li (rites, rituals of propriety). Confucius seems to have said inconsistent things about this relation. Some passages appear to suggest that ren is more fundamental than li, while others seem to imply the contrary. It is therefore not surprising that there have been different interpretations and characterizations of this relation. Using the analogy of language grammar and mastery (...) of a language, it is proposed here that we should understand li as a cultural grammar and ren as the mastery of a culture. In this account, society cultivates its members through li toward the goal of ren, and persons of ren manifest their human excellence through their practice of li. (shrink)

Presents Li Zehou's culminating views on ethics in a series of works that highlight the importance of Confucian philosophy today.

Professor Li Bocong's philosophical works embody Chinese society's intellectual reflection on its technological, economic and social modernisation. Drawing on classical Chinese philosophy, the Chinese interpretation of Marxism and dialogue with other Western philosophical traditions, he has formulated a research programme in the philosophy of engineering and stimulated the emergence of an independent national school of thought. In the past decades, generations of Chinese philosophers and social scientists have further developed his approach and understanding of engineering as a special field of (...) human practice that is of central importance to today's societies. In the interview conducted with Professor Li Bocong in May 2025, we discuss his personal and intellectual biography, his inspirations from traditional Chinese culture, his reflections on the concepts of science, technology and engineering in the East and West and their intellectual exchange, his understanding of human action, creativity and rationality and their manifestations in engineering; the socio-technical transformations in today's China, the dialectic of the global and the local in socio-technical development, and the principles of philosophical life. (shrink)

Li Shicen jiang yan ji -- Li Shicen lun wen ji.

本书内容包括:从康德的“道德宗教”论儒家的宗教性、重评张载由“气化论”证立的成德论、从历史中提取智慧、当今越南的宗教与社会等。.

本书主要记述作者赴欧盟国家考察法律制度的感受心得,收《权利,权利》、《丹麦的平民政治》、《风雨柏林墙》等40多篇文章。.

书中介绍了国内外护理伦理学的历史与现状,阐述了护理道德的基本原则、规范和范畴及护理道德、教育、评价的意义及方法等。.

本书包括一个思想者、一个建筑者、一个教育者等三大部分,收入了《古为今用,洋为中用,推陈出新》、《空间的平断面形状》、《美国购物中心的发展趋势》等文章。.

本书力图在哲学诠释学与文学诠释学之间建立一种逻辑中介,并系统地阐述文学诠释学的重要问题,以文本、理解与意义为核心概念,在诠释学理解事件中系统地阐释文本与意义之间的内在关系,是本书的中心主题。.

本书共收入论文41篇,分为:社会主义伦理思想与道德实践研究、青年修养、职业道德等5部分。.

本书收录了著名学者李石岑先生的15篇讲演,涉及怀疑与信仰、哲学与人生、佛学与人生、教育与人生等哲学与生命论题。.

shang juan. Shi dai jing shen di zhe xue fan si -- xia juan. Zhongguo xian dai hua zhi zhe xue tan tao.

智慧啟發的關鍵在於「心」! 學會用平常心來享受人生的無常變化！ 學會捨棄不必要的繁瑣，讓生活回歸於簡單狀態！ 一百二十八則小品分享，讓你從「心」學會啟發智慧！ 玄學與儒學為中華文化的主要思想，儒學以四書五經為主，主要用於生活；玄學則以老子《道德經》為主，主要用於自性。李憲鳴（雲子），師承老子思想，融合玄學與儒學，並將兩者學說合而為一。期盼藉由自然的玄學定律， 教導讀者依循培德、修道的心，將人的生活意識裡一切印象拋棄，回歸重拾自性的清靜，不再受限於人性思維，而沉淪於人生苦海之中。 本書以作者自身所悟，透過淺顯易懂的經典之理與讀者分享，包含仁心、善念、崇尚自然、無私無欲、知足等結合知識與常識的經驗短文分享，期許讀者從心開始播下智慧的種子，從新學會生活的藝術，讓忙碌於生活的現代人開 始簡單生活。.

本书收《论小农社会主义对我国社会主义事业的影响》、《论人的目的》、《论共产主义运动的失败》等20多篇文章。.