This book deals with embryology although it is not a book on embryology. It is in itself like a developing embryo and at a difference of textbooks it does not pretend to be an introduction to any particular scientific discipline. This work was born from a fascination about forms and it is the draft of a morphological process: the account of a form coming into being, the form of an as yet unnamed but emerging science. A new science of qualities (...) in which the natural phenomena are understood as wholes, as complex entities, possessing integral properties that are non-reducible to discrete or quantifiable magnitudes. This book is like a jump into the future of science but also it is a return in time in order to find the founder of science. The first thinker that blended speculative thought with the direct observation of facts. This book is a return to the organism, to purpose and meaning, a return to Aristotle. (shrink)

In my continuing efforts to build a bridge between psychoanalytic findings and biosemiotics here, as in previous works, ‘biosemiotic’ refers to the hierarchy of meaning-forms (from biological to semiotic-organizations) underlying an updated psychoanalytic model of mind. Within this framework I present a broad range of bio-semiotic phenomena, processes, dynamics, defenses, and universal and unique internalized interpersonal patterns, that in psychoanalysis all commonly fall under the broad heading of the “Unconscious.” Reconceptualized as interpretive data within the purview of a psychoanalytic discourse-semantic (...) this biosemiotic framework posits an epigenetic continuum of human meaning-organizations originating at basic organic levels, moving upward through biological, psycho-somatic and affective expression, proto-semiotic transmissions, represented forms, and finally to explicit linguistic signs and complex symbol systems. In addition to assuming an uninterrupted epigenetic continuum crystallizing in hierarchic organization, this framework accentuates the multilayered and increasingly condensed quality of higher more elaborate organizations of meaning in human communication, drawing attention to persisting biological undercurrents in implied sense, intent, and motivation, all of which impact on repressive/defensive mechanisms. Drawing from previous works (Aragno 1997, 2005, 2008a, b, Psychoanalytic Inquiry 29(1):30–47, 2009, Biosemiotics 3:57–77, 2010, 2011a, Signs 5:71–74, 2011b, Journal of the American Psychoanalytic Association, Centennial Paper, Special Centennial Issue 59(2):239–288, 2011b, Signs 5:29–70, 2011c) in which I labored to update and revise Freud’s first topographical theory of mind, this paper presents the phenomenology of unconscious ‘data’ for the purpose of introducing a diverse range of non-linguistic signifying forms from which psychoanalysts infer mental processes and ‘interpret’ meanings. An important underlying premise regarding psychoanalytic data and its relation to the basic biosemiotic ‘agenda’ is that until grounded in an updated developmental theory of mind inclusive of pre- and proto-semiotic-forms, that is evolutionarily plausible, epistemologically based, and correlates with contemporary neuroscience, the term “sign” is merely an abstract linguistic ‘label’ rather than a mental act with antecedent developmental stages manifesting meanings through different forms and modes of expression. Drawn from the yields of the psychoanalytic method and semantic this revised metatheoretical approach provides insights into the sensory-emotive, bodily origins of unconscious layers of non-linguistic signification thereby expanding our understanding of the formative stages of the ‘semiotic function’ in human evolution. This being the third in a series of papers integrating the yields of psychoanalytic methodology with the underlying premises of ‘Biosemiotics,’ some familiarity with the background knowledge provided in the previous two is strongly recommended. (shrink)

Quantum–mechanical systems may be understood in terms of information. When they interact, they modify the information they carry or represent in two, and only two, ways: by selecting a part of the initial amount of (potential) information and by sharing information with other systems. As a consequence, quantum systems are informationally shielded. These features are shown to be general features of nature. In particular, it is shown that matter arises from quantum–mechanical processes through the constitution of larger ensembles that share (...) some information while living organisms make use of a special form of information selection. (shrink)

This article seeks to address what the work of Catherine Malabou can offer to the thinking and understanding of history. Characterizing Malabou’s intellectual project as a meditation on the relation between history and possible knowledge, it situates the philosopher’s work in the tradition of historical epistemology. It will be argued that, in its engagement with philosophical and (neuro)biological theories of plasticity and epigenesis, the historical constitution of Malabou’s philosophical system problematizes the practical and ontological difficulty behind any commitment to (...) a historically bounded knowledge of what here will be called, following Heidegger and Foucault, ‘pure finitude’. The article concludes by suggesting that, if placed alongside the work of intellectual historian Quentin Skinner, Malabou’s historical epistemology makes a decisive and useful contribution to contemporary debates regarding historical method by underscoring the (neuro)biological rooting of persistent epistemic gaps between historical understanding and experience. (shrink)

The genetic code appeared on Earth with the first cells. The codes of cultural evolution arrived almost four billion years later. These are the only codes that are recognized by modern biology. In this book, however, Marcello Barbieri explains that there are many more organic codes in nature, and their appearance not only took place throughout the history of life but marked the major steps of that history. A code establishes a correspondence between two independent 'worlds', and the codemaker is (...) a third party between those 'worlds'. Therefore the cell can be thought of as a trinity of genotype, phenotype and ribotype. The ancestral ribotypes were the agents which gave rise to the first cells. The book goes on to explain how organic codes and organic memories can be used to shed new light on the problems encountered in cell signalling, epigenesis, embryonic development, and the evolution of language. (shrink)

This article examines the conflicting representations of plasticity and epigenetics in the work of philosopher Catherine Malabou and evolutionary theorists Mary Jane West-Eberhard and Eva Jablonka. In order to speak of a new biological ‘paradigm’ and to attribute values of novelty or inventiveness to life itself, Malabou has to suppress the unsettled debates within the life sciences. The aporias of evolutionary narrative and causality reveal a necessary differentiality and textuality that belongs neither to life nor science itself, but leaves a (...) haunting remanence within every corpus. New materialism resists this necessity of life-science, which calls for a deconstructive reading. (shrink)

The text situates Malabou’s work in a history of what she calls ‘ultrametaphysics’. She presents it as being both genuinely historical and to a great extent inserted in the Western philosophical tradition. This history is presented from a thread, not necessarily the only one possible, that begins with Heidegger, passes through Levinas, Derrida and Ludueña. Malabou's ultrametaphysical position is then presented in comparison with these previous formulations, which makes it possible to elaborate, in this perspective, some of her concepts such (...) as plasticity, transformation and epigenesis as well as consider their relationship with both speculative realism and with the reception of the Kantian notion of transcendental. (shrink)

In the field of germline development in amniote vertebrates, primordial germ cell (PGC) specification in birds and reptiles remains controversial. Avians are believed to adopt a predetermination or maternal specification mode of PGC formation, contrary to an inductive mode employed by mammals and, supposedly, reptiles. Here, we revisit and review some key aspects of PGC development that channelled the current subdivision, and challenge the position of birds and reptiles as well as the ‘binary’ evolutionary model of PGC development in vertebrates. (...) We propose an alternative view on PGC specification where germ plasm plays a role in laying the foundation for the formation of PGC precursors (pPGC), but not necessarily of PGCs. Moreover, inductive mechanisms may be necessary for the transition from pPGCs to PGCs. Within this framework, the implementation of data from birds and reptiles could provide new insights on the evolution of PGC specification in amniotes. (shrink)

Context: Radical Constructivism is an issue that deeply divides the cognitive science community: most researchers reject it, but an increasing number do not. Problem: Constructivists stress that our knowledge starts from experience. Some (“ontic” constructivists) deny the existence of a mind-independent world, while others (“radical” constructivists) claim merely that, if such a world exists, we can know nothing about it. Both positions conflict with scientific realism. It is not clear that the conflict can be resolved. Method: This paper uses philosophical (...) argument to ask whether constructivism can be rationally preferred over realism in science. Results: Ontic constructivism cannot be disproved by any knock-down argument. Nevertheless, it is irrational to accept it, because it ignores the strategy of “inference to the best explanation”: realism is the best explanation of the successes of science. Radical constructivism, too, fails to explain these successes. Some radical constructivists have tried to offer theories more sympathetic to realism. For instance, Ernst von Glasersfeld sees science as a coherent ordering of experience, and appeals to Piagetian psychology as support. There are close similarities. But Piaget was also caught in a constructivist anti-realism, despite his attempt to evade it. Implications: The constructivist’s claim that scientific concepts and theories are generated by human minds is correct. But this important insight should not be used to deny realism, which is the best explanation of the many undeniable successes of science and engineering. (shrink)

Philosophy of biology before biology Edited by Cécilia Bognon-Küss & Charles T. Wolfe Table of contents Cécilia Bognon-Küss & Charles T. Wolfe. Introduction 1. Cécilia Bognon-Küss & Charles T. Wolfe. The idea of “philosophy of biology before biology”: a methodological provocation Part I. FORM AND DEVELOPMENT 2. Stéphane Schmitt. Buffon’s theories of generation and the changing dialectics of molds and molecules 3. Phillip Sloan. Metaphysics and “Vital” Materialism: The Gabrielle Du Châtelet Circle and French Vitalism 4. John Zammito. The Philosophical (...) Reception of C. F. Wolff’s Epigenesis in Germany, 1770-1790: Herder, Tetens and Kant Part II. ORGANISM & ORGANIZATION 5. François Duchesneau. Senebier and the Advent of General Physiology 6. Tobias Cheung. Organization and Process. Living Systems Between Inner and Outer Worlds: Cuvier, Hufeland, Cabanis. Part III. SYSTEMS 7. Georg Toepfer. Philosophy of Ecology Long Before Ecology: Kant’s Idea of an Organized System of Organized Beings 8. Ina Goy. "All is leaf". Goethe's plant philosophy and poetry 9. Snait Gissis. ‘Biology’, Lamarck, Lamarckisms POSTSCRIPTS 1. Lynn Nyhart. A Historical Proposal Around Prepositions 2. Philippe Huneman. Philosophy after Philosophy of Biology before Biology Cécilia Bognon-Küss and Charles T. Wolfe. Conclusion. (shrink)

Le but de cet ouvrage est de démontrer, à travers une reconstruction rationnelle des étapes historiques fondatrices de l'embryologie expérimentale, l'importance des concepts de préformation et d'épigenèse aux origines de cette discipline. L'analyse porte sur trois périodes charnières de l'histoire de l'embryologie : (1) la réforme mécaniste et darwinienne de l'embryologie descriptive par Ernst Haeckel (1866); (2) l'avènement d'une physiologie réductionniste du développement menée par Wilhelm His (1874); (3) la création d'une "mécanique du développement" par Wilhelm Roux (1885) et les (...) interprétations néo-darwinienne (A. Weismann), néo-vitaliste (H. Driesch) et organiciste (O. Hertwig) de ses résultats les plus significatifs (1888-1908). J'y défends qu'une logique de la découverte structurait ces développements, où les modèles mécaniques d'explication devaient constamment être renouvelés lorsque leur examen empirique engendrait la découverte de phénomènes épigénétiques inédits. L'étude réalisée traite d'un enjeu fondamental de la philosophie des sciences : le rapport entre la rationalité scientifique et la découverte. Elle offre aussi un éclairage sur une question très actuelle de la philosophie de la biologie, soit les transformations de la notion d'épigenèse en rapport avec les théories épigénétiques contemporaines. La méthodologie adoptée s'inscrit dans la tradition de l'épistémologie historique, consacrée à l'étude du développement des structures du savoir scientifique. Cette tâche exige l'analyse historique de diverses sources documentaires; mais un éclairage théorique constitué tant de modèles provenant de la philosophie des sciences que de connaissances scientifiques demeure indispensable. Ici le modèle d'Imre Lakatos, centré sur la notion de programme de recherche, est entre autres privilégié."--provided by publisher. (shrink)

Post-Kantian philosophers historicize the world soul, reconceiving it as an implicitly rational, progressive, yet impersonal agency, at work throughout nature as a formative principle, more especially, however, in the progressive liberation and self-determination of spirit in human history. This chapter outlines the concept’s career in the thought of Kant, Maimon, Schelling, and Hegel, focusing especially on the overlapping functions they accord to the world soul. On the one side, it serves to mediate within nature between the opposing spheres of mechanism (...) and organic life; on the other, between those of unconscious currents of historical development and self-consciously free human action. In thus tasking the world soul with mediating between nature and the history of human freedom, German idealists are faithful to their Platonic source of inspiration, even as they refashion the concept in a distinctively modern, post-Enlightenment spirit. (shrink)

It is beyond the scope of this paper to describe in detail the rise to popularity of the emboîtement theories during the last decades of the seventeenth century.51 Eventually the theories did gain great influence, but some points emerging from the above discussion indicate that the rise to popularity was not, perhaps, quite as rapid as has sometimes been assumed.52 Although the earlier preformation theories were sometimes regarded as the ancestors of the later ideas,53 there was little intellectual continuity between (...) the two movements, based as they were upon such divergent motivations. Nor can the preformation theories be regarded as the origin of the belief that a miniature can actually be seen within the egg, since the existence of metamorphosis as a perfectly valid alternative to epigenesis meant that the work of Malpighi and others, usually described as “preformationist,” was not always taken in this latter sense at the time it was published. The pre-existence theories developed in response to particular philosophical problems, and were themselves responsible for the reinterpretation of the observations. In France, the thoughts of Malebranche and Perrault were probably already exerting influence before their written support for pre-existence appeared, but elsewhere the idea was not taken up so rapidly, and ovism, for instance, could develop without associating itself with emboîtement. Malpighi always seems to have remained opposed to pre-existence,54 but by the last decade of the century, the idea had become sufficiently powerful to influence Ray and Garden in Britain, and was receiving support from as influential a thinker as Leibniz.55 But Garden and Hartsoeker were responsible for dividing emboîtement between two schools, just as the concept itself was becoming popular. The work of both Malpighi and Leeuwenhoek served as the basis of the animalculist version, illustrating how the microscopic discoveries served as much to disrupt the intellectual development of the emboîtement concept as they did to promote it. *** DIRECT SUPPORT *** A8402051 00002. (shrink)

Richard Owen has been condemned by Darwinians as an anti-evolutionist and an essentialist. In recent years he has been the object of a revisionist analysis intended to uncover evolutionary elements in his scientific enterprise. In this paper I will examine Owen's evolutionary hypothesis and its connections with von Baer's idea of divergent development. To give appropriate importance to Owen's evolutionism is the first condition to develop an up-to-date understanding of his scientific enterprise, that is to disentagle Owen's contribution to the (...) modernization of typology and morphology. I will argue that Owen's Platonic essentialism is rhetorical and incongruous. On the contrary, an interpretation of the archetype based on Aristotle's biological works makes possible a new conception of type, based on a homeostatic mechanism of stability. The renewal of morphology hinges on homological correspondences and a homeostatic process is also the origin of serial and special homology. I will argue that special homology shows an evolutionary orientation insofar as it is a typically inter-specific character while serial homology is determined through an elementary usage of the categories of developmental morphology. (shrink)

The 17th and 18th centuries were the theatre of the fight between two main theories concerning the development of organisms: preformationism (or preformism) and epigeneticism (or epigenesis). According to the first, the formation of new features during organisms’ development can be seen as the result of a mere unfolding of features that were preformed in the sperm, the egg, or the zygote. According to epigeneticism, there is no pre-existing form, and development is a process where genuinely new characters emerge (...) from formless matter. The debate involved naturalists, anatomists, physiologists, microscopists, medical doctors, and philosophers as well. Current developmental biology is, according to some, still inspired (or haunted) by the age-old controversy. The aim of this contribution is twofold. First, to discuss in which guise, if any, the old controversy is still shaping the contemporary debate in biology and philosophy of biology; and, second, to sketch Schelling’s position on that debate, suggesting that it may contain some still valuable philosophical insight. (shrink)

A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of the (...) neuromuscular junction is proposed and the basic selective aspect of learning emphasized. (shrink)

The aim of this paper is to show that for Kant, a combination of epigenesis and monogenesis is the condition of possibility of anthropology as he conceives of it and that moreover, this has crucial implications for the biological dimension of his account of human nature. More precisely, I begin by arguing that Kant’s conception of mankind as a natural species is based on two premises: firstly the biological unity of the human species (monogenesis of the human races); and (...) secondly the existence of ‘seeds’ which may or may not develop depending on the environment (epigenesis of human natural predispositions). I then turn to Kant’s account of man’s natural predispositions and show that far from being limited to the issue of races, it encompasses unexpected human features such as gender, temperaments and nations. These predispositions, I argue, are means to the realisation of Nature’s overall purpose for the human species. This allows me to conclude that man’s biological determinism leads to the species’ preservation, cultivation and civilisation. (shrink)

Contemporary debate on Kant’s practical philosophy has focused on racial claims appearing primarily in transcripts of students’ notes taken during his lectures. But was Kant – the champion of world citizenship – really a racist? It is certainly hard to defend him from the charge of racial prejudices. However, a universally exclusivist standard of rationality such as the one he promoted leads at worst to cultural imperialism. It is more doubtful whether this amounted also to a full racist theory, as (...) this would have implied seeing some races as inherently incapable of full rationality. Kant’s biological theory of races – the investigation of race being a theoretical rather than practical task – did not serve such a racist purpose. This article argues that Kant was ultimately interested in scientific distinctions, assuming the point of view of a naturalist researcher (Naturforscher). Accordingly, he cannot be said to be a biological racist. (shrink)

The paper aims at proposing an extended notion of epigenesis acknowledging an actual causal import to the phenotypic dimension for the evolutionary diversification of life forms. “Introductory remarks” section offers introductory remarks on the issue of epigenesis contrasting it with ancient and modern preformationist views. In “Transmutation of forms: phenotypic variation, diversification, and complexification” section we propose to intend epigenesis as a process of phenotypic formation and diversification dependent on environmental influences, independent of changes in the genomic (...) nucleotide sequence, and occurring during the whole life span. Then, “Evolvability and phenotypic evolution” section focuses on phenotypic plasticity and offers an overview of basic properties that allows biological systems to be evolvable—i.e. to have the potentiality of producing phenotypic variation. Successively, the emphasis is put on environmentally-induced modifications in the regulation of gene expression giving rise to phenotypic variation and diversification. After some brief considerations on the debated issue of epigenetic inheritance, the issue of culture is considered. The key point is that, in the case of humans and of the evolutionary history of the genus Homo at least, the environment is also, importantly, the cultural environment. Thus, “Bio-cultural feedback” section argues that a bio-cultural feedback should be acknowledged in the “epigenic” processes leading to phenotypic diversification and innovation in Homo evolution. Finally, “Brain plasticity and cultural neural reuse” section introduces the notion of “cultural neural reuse”, which refers to phenotypic/neural modifications induced by specific features of the cultural environment that are effective in human cultural evolution without involving genetic changes. Therefore, cultural neural reuse may be regarded as a key instance of the bio-cultural feedback and ultimately of the extended notion of epigenesis proposed in this work. (shrink)

The discovery of the concrete basis for genes, and especially the clarification of mechanisms regulating gene expressions (in particular those that bear on the stepwise processing of hereditary information from the sequences of DNA nucleotides to the proteins) was to give flesh to the concept of a genetic program, for these regulations introduce relationships of order between the various elements of information contained in the genes. These order relations are then revealed during the time-dependent expression of the genetic program. They (...) can lead, in the case of a given program, to a plethora of particular outcomes, because the number of possible combinations rapidly becomes enormous. Since the discoveries of Jacob and Monod, it is clear that the genes specifying the regulatory functions will be responsible for phenotypic variability, especially for the apparently ideal adaptation of a living organism to its environment, and more generally for all the genotype-bound manifestations as they unfold in time. Thus we are led to consider three particular characteristics that allow for the representation of living beings: a program, which summarizes the hereditary constraints and is, in fact, the abstract notion underlying the definition of all individuals in a given class (species); an initial state of the system that represents the context in which the program must express itself at the time of the individual's birth; and a particular outcome of each program, which coincides with individual development. The set of all outcomes constitutes the genetic envelope and allows the essential characteristics of the program to be obtained by induction. Theoretically, a structured set equivalent to the aforementioned one could be reconstructed by providing the program, the initial state, and the totality of the events of the external environment, producing any interaction whatever with the individual. As a consequence, the observation of a phenotype does not tell in any straightforward way, what is the direct consequence of the expression of a particular gene, or of a specific feature of the environment. A phenocopy is a particular example of a phenotype that is the result of a gene expression mimicking a particular gene-directed phenotype, without however corresponding to a pparticular mutation of a known gene. (shrink)

In this paper, we reflect on the connection between the notions of organism and organisation, with a specific interest in how this bears upon the issue of the reality of the organism. We do this by presenting the case of Buffon, who developed complex views about the relation between the notions of “organised” and “organic” matter. We argue that, contrary to what some interpreters have suggested, these notions are not orthogonal in his thought. Also, we argue that Buffon has a (...) view in which organisation is not just ubiquitous, but basic and fundamental in nature, and hence also fully natural. We suggest that he can hold this view because of his anti-mathematicism. Buffon’s case is interesting, in our view, because he can regard organisation, and organisms, as perfectly natural, and can admit their reality without invoking problematic supernaturalist views, and because he allows organisation and the organismal to come in kinds and degrees. Thus, his view tries to do justice to two cautionary notes for the debate on the reality of the organism: the need for a commitment to a broadly naturalist perspective, and the need to acknowledge the interesting features of organisms through which we make sense of them. (shrink)

Can we properly define and explain the human mind an aesthetic mind? The purpose of the paper is to answer this and the related questions that it implies. How do we understand the conceptual field of the aesthetic? What do we mean when we speak about an aesthetic experience or when we express an aesthetic judgement? The first move consists in shaping the outlines of the «aesthetic» as a cluster-concept. Having identified the conceptual core of aesthetic as an expressive synthesis (...) between the emotional and cognitive layers of the experience, I try to develop a theoretical paradigm consistent with it and, consequentially, a mental mechanism of the aesthetic. The next step consists, therefore, in replacing the causal monism involved in the adaptationist paradigm by a plurality of factors. Consequently, I claim that at the origin of the aesthetic mechanism there are four factors. These factors are: 1) the mimetic assimilation of the real; 2) the "seeking" or the pleasure of exploration; 3) the pleasure of exercising preferences as a degree of freedom and an advantage in the conduct of life; 4) the impulse to play. All these factors are dispositions rooted in the system of primary emotions and represent the preconditions for the epigenetic emergence of the aesthetic mechanism. Conclusively, this mechanism is considered a dynamic activity of the brain that integrates into a single space of mutual resonance and harmonization neocortical and subcortical neural circuits: aspects of mental life emotionally attuned and aspects that are specific of cognitive processing of information. (shrink)

What is the origin and meaning of our aesthetic sense? Is it genetically encoded or is it culturally inherited? The aim of the essay is to answer to such issues by defining the emergent and meta-functional character of the aesthetic attitude. First, I propose to include the faculty of desire in the free play of the cognitive faculties at the center of Kant’s Critique of Judgment. The following step is given by a brief analysis of Darwin’s controversial remarks on the (...) pre-human birth of aesthetics and its relationship with sexual selection (§§ 1-2). The point of discontinuity between a mere animal aesthetic sense and a proto-human one is then found to become indeterminate of desire in the correlative diversification of aesthetic attractors (§§ 3-4). Successively, I deal with the supervenience character of the aesthetic and its anticipatory value. After a short genealogy of the notion of supervenience, I then develop its affinity with that of epigenesis (§§ 5-6). Afterwhich follows a review of two contemporary evolutionary perspectives on aesthetics: T. Deacon’s essay on the “aesthetic faculty” and J. Tooby and L. Cosmides thesis on the evolutionary meaning of the aesthetic-fictional activities (§§ 7-8). Conclusively, the epigenesis of an aesthetic mind is considered as the unity between the breath of aísthesis and the breath of linguistic sign (§§ 9-10). (shrink)

The theories of pre-existence and epigenesis are typically taken to be opposing theories of generation in the seventeenth and eighteenth centuries. One can be a pre-existence theorist only if one does not espouse epigenesis and vice versa. It has also been recognized, however, that the line between pre-existence and epigenesis in the nineteenth century, at least, is considerably less sharp and clear than it was in earlier centuries. The debate (1759-1777) between Albrecht von Haller and Caspar Friedrich (...) Wolff on their theories of generation is usually taken to be a debate between a pre-existence theorist and an epigeneticist, and the supposed fact that these two theories of generation are mutually exclusive explains (so the story goes) the divide between Haller and Wolff. However, it’s not clear that Haller endorsed an especially robust form of pre-existence, and nor is it clear that Wolff’s theory of generation -- once he considered it carefully -- is clear epigenetic. Rather, Haller’s theory of generation is marked by traces of epigensis and Wolff’s theory has elements of pre-existence theory. This is not to say that their theories of generation are basically the same, but the debate between the two ought not to be framed in terms of pre-existence versus epigenesis. Their points of difference must be explained in some other way. In this way, their controversy bears characteristics of similar disputes over generation in the nineteenth century more than it resembles those in the seventeenth century. In this paper, I argue that (a) Haller’s and Wolff’s theories both blend elements from pre-existence and epigenesis; (b) but there are still deeply-rooted differences between the two generation theories; (c) one source of these differences is that Haller and Wolff have divergent conceptions of what an adequate explanation is; (d) we can see that they have different conceptions of what constitutes an adequate explanation by paying heed to their evaluations of Descartes’ epistemology and methodology in his theory of generation (such as it is); and (e) this shows that one of the main differences between Haller’s generation theory and that of Wolff is the degree to which each thinks we need to (and indeed can) explain the nature of the causes -- both efficient and final -- at play during the formation of organic beings. (shrink)

Dean Falk has strategically explored “mother-infant gestural and vocal interactions... in chimpanzees and humans” in order to offer hypotheses “about the evolutionary underpinnings that preceded the first glimmerings of language.” Though she offers compelling evidence for many interesting hypotheses as to the epigenesis of language, other possibilities have yet to be explored. Here we explore the role of gestural communication among deaf signers and the neural correlates associated with this type of communication.

At the end of the nineteenth century, approaches from experimental physiology made inroads into embryological research. A new generation of embryologists felt urged to study the mechanisms of organ formation. This new program, most prominently defended by Wilhelm Roux, was called Entwicklungsmechanik. Named variously as “causal embryology”, “physiological embryology” or “developmental mechanics”, it catalyzed the movement of embryology from a descriptive science to one exploring causal mechanisms. This article examines the specific scientific and epistemological meaning of the mechanistic approaches of (...) embryological development by focusing on Wilhelm His’ histogenetic work. Roux was neither the first, nor the only one to argue for an experimental exploration of causes in embryology. At the time of Roux, physiological explanations of the genesis of the anatomical forms were developing in parallel, not only in German-speaking countries, but in France, Switzerland and English-speaking countries as well. The experimental approach and the cellular descriptions of embryogenesis were already omni-present when Roux proposed his Entwicklungsmechanik. However, these approaches remained disjointed. It appears that it was Wilhelm His who first succeeded in combining the question of the causal factors determining epigenesis, which was closely connected with experimentation on, and cellular descriptions of, development, in a coherent and concrete synthesis, making him one of the true initiators of the developmental mechanics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.2 (2001) 251-277 [Access article in PDF] Hans Christian Andersen's Fish Out of Water Nancy Easterlin I Now that Darwinian literary criticism is on the horizon, the natural human tendency to codify manifests itself in calls to summarize succinctly what such an approach entails. Though clarity is always to be praised, bioevolutionary critics need to guard against the reductiveness that has beleaguered attempts at a scientifically (...) grounded literary criticism since the early twentieth century; most especially, we should think twice about limiting the interpretation of complex and varied works to selected sociobiological themes divorced from other biocultural considerations. David Sloan Wilson makes much the same point to students of evolution when he quotes Celia Heyes in a recent review of Evolutionary Psychology, David Buss's new textbook: "When I first encountered the term 'evolutionary psychology,' I thought it referred to the study of how mind and behavior evolved. But I was mistaken. In current usage, 'evolutionary psychology' refers exclusively to research on human mentality and behavior, motivated by a very specific, nativist-adaptationist interpretation of how evolution operates." 1If, as D. S. Wilson suggests, evolutionary psychology thus narrowly defined threatens to produce a limited understanding of human mind and behavior and, in the process, fragment the discipline of psychology further, how much less potentially productive is such an approach for those of us whose central objects of study, cultural artifacts, are as the products of behavior even further removed from the study of mind? Leda Cosmides and John Tooby are most explicit about the falsity of assuming that psychological adaptations determine behavior. This being so, it seems impossible that such adaptations could determine the [End Page 251] meaning of artworks, which are themselves the products of complex human behaviors. As I hope this discussion of Hans Christian Andersen's "Little Mermaid" will demonstrate, an approach to aesthetics strictly following the lead of evolutionary psychology as currently defined, while supplying valuable general insights about the motives for artistic behaviors and the cognitive processes engaged in them, cannot by itself inform us about the meaning of individual artworks. This is a crucial issue, since interpretation is the fundamental pursuit of scholars in fields like mine, literary studies.Putting the question of interpretive frutifulness aside for the moment, it can be said unequivocally that criticism that fails to be sensitive to mutation and change is not properly Darwinian. Evolutionary psychology and sociobiology themselves maintain that our psychic architecture is comprised of domain-specific competences; the result, as E. O. Wilson points out, is that the human mind is not designed to understand reality but is instead an instrument for survival and reproduction. 2 "Natural selection," says Michael Ruse, "works in a gerry-building fashion, making do with what it has at hand." 3 Though our various evolved competences cannot be radically dissonant if the organism is to survive, neither are they logically integrated, neatly interlocking "modules." Under some environmental conditions, specific adaptations or epigenetic rules are not likely to produce a competitive advantage while other very different adaptations certainly will, and hence the flexibility of the organism ensures its survival. If, for instance, I place my coffee mug down on my desk and at that exact moment two cars collide on the street outside, familiarity with my environment militates against invocation of the causal rule, even though such a rule is incontrovertibly part of our adapted psychology. 4 Knowing, then, that we share an evolved psychic architecture whose patient excavation, so to speak, will result in a progressively better defined concept of human nature, and knowing too that the behavior of human beings as writers as well as other kinds of agents varies under divergent environmental conditions, Darwinian criticism should be sensitive to the complex relationship between individual adaptations, the total array of adaptations, subjective cognitive processes, and environmental circumstances that give literary works enduring significance. In contemplating literary meaning, as with aesthetics, we should be mindful that epigenesis is not simply the instantiation of epigenetic rules. 5 Ideally, literary interpretation should be informed by the evolution of mind, behavior, and... (shrink)

Harvey and Highmore experimented together on chick fetuses at Oxford in the early 1640s, yet in 1651 published significantly different treatises on generation that emphasize their reliance on observations and dissections of fetal chicks at different stages of incubation. The key differences follow from their views on matter and souls. Harvey conceives of living bodies as governed by Aristotelian souls and faculties. Highmore views matter as made of corpuscles and describes organs as involved in chemical procedures. Highmore's treatise is a (...) response to Digby's claim that heat, moisture, and pressure could explain generation. Although Digby's treatment lacks Harvey's and Highmore's attention to detail, it offers a point of comparison that leads to a more nuanced understanding of their explanation. Moreover, Highmore's dedication of his work to Boyle provides a new perspective on both men's intellectual evolution from the latter part of the 1640s to 1651. (shrink)

This paper takes an organicist perspective of W. Harvey’s conception of epigenesis in his work Exercitationes de generatione animalium (1651). In line with this reading, I provide a critical assessment of the different interpretations (mechanistic or vitalist) of Harvey’s idea of epigenesis. The English physician develops his conception of embryogenesis as a process that cannot be understood from the categories of human art, as is apparent in his criticisms towards his teacher, Fabricius. Nor is it accurate to say (...) that his position is animistic. An immersion in this last question will show us his organic conception of the soul, as an extension of the Aristotelian-Galenic tradition. (shrink)

Progress in neuroscience – notably, on the dynamic functions of neural networks – has deepened our understanding of decision‐making, acquisition of character and temperament, and the development of moral dispositions. The evolution of our cerebral architecture is both genetic and epigenetic: the nervous system develops in continuous interaction with the immediate physical and socio‐cultural environments. Each individual has a unique cerebral identity even in the relative absence of genetic distinction, and the development of this identity is strongly influenced by social (...) and cultural environments leaving major traces in the connectivity of the brain. This interaction introduces important elements of variability and plasticity. Synaptic epigenetic theories of cultural and social imprinting on our brain architecture suggest the possibility that we can be “epigenetically proactive” and adapt our social structures, in both the short and the long term, to benefit and constructively interact with the ever‐developing neuronal architecture of our brains. Epigenetic proaction can be described as a way to socially steer evolution by influencing the cultural imprints to be stored in our brains. The purpose of this article is to present, in a historical and ideological light, the idea that we may culturally shape the developing brain, and discuss some key risks and benefits of this endeavour. The article is a contribution to neuroethics. (shrink)

Catherine Malabou's work is not only positioned within recent trends in philosophy that self-declare as 'turns', but is also capable of exposing some of the generative/genetic vectors of these movements. In the first part of this article, we will try to expose some pertinent questions on the subject of the epigenesis of reason (or thought) for Malabou. Malabou's particular formulation of such epigenetics, which we will briefly explore, will serve as a point of departure for the second part, where (...) we will present the notion of a threefold turn in contemporary philosophy/theory/critique. In this second part, our intention is to show that there are (at least) three tendencies that specify some of these contemporary turns: the material turn; the ontological turn; and the speculative turn. We also intend to show, however, that all three are part of a larger movement, identified by the same transcendental (epi)genetic vector that we find in Malabou's work. In this threefold turn, we find three ways of responding to the same desire to de-/re-stabilise the transcendental, to de-/re-construct a foundation for the continuation of the critical-philosophical mission. The epigenesis of the transcendental is thus revealed as a contemporary strategy for continuing to re-generate philosophy, which today seems to depend on negotiating with the legacy of this materialist-ontological-speculative triple turn. (shrink)

According to a classic periodization in the history of science, biological thought as it emerged in France from the last decades of the seventeenth century to the 1740s was strongly committed to the doctrine of the preexistence of germs. Nicolas Malebranche’s role in disseminating this paradigm, particularly in the milieu of the Académie Royale des Sciences during the years when Bernard Le Bouyer de Fontenelle was its secretary, has been studied in detail, especially by Jacques Roger. However, much less has (...) been said about the authors who argued against this doctrine prior to the appearance of the relevant pieces by Pierre-Louis Moreau de Maupertuis, Georges-Louis Leclerc, Comte de Buffon, and Denis Diderot. I aim to examine a series of French medical treatises and clandestine manuscripts that outlined a mechanist theory of epigenesis, between the end of the seventeenth century and the 1720s, to bring to light the strategies—often quite original—that allowed them to achieve this result. One interesting case is the heterodox readers of Malebranche, which use some of his own arguments (notably on the physiology of brain traces and the laws of nature) both against preexistence and to support epigenesis. I inquire into the historical worth of the positions defended by these authors as well as into the connections existing between the history of epigenesis and that of materialism in the early modern era. (shrink)

In the 1787 Transcendental Deduction of the Categories Kant indicates the only possible ways by which one can account for a necessary agreement of experience with the concepts of its objects (B166), using analogies between modes of explanation and biological theories about the origin of life. He endorses epigenesis as a model for his system of pure reason (B167). This paper examines various interpretive claims about the meaning of this theory of generation and its significance for Kant’s philosophy (Section (...) 1), showing that, after his Critical shift in perspective, in 1775/77 Kant already combined preformed elements and their purposively oriented formation by natural forces (Section 2). Contrary to the standard view, Kant’s theory of race appears to constitute the background to assess Blumenbach’s later (1799/1781) shift to epigenesis after supporting Haller’s preformism (Section 3). In Section 4, I argue that the ground of affinity between epigenesis and formal idealism rests in tracing the first origin of these conformities: externala posterioriclimate conditions and predisposed germs and dispositions within the generative power of the human body; and externala posterioriexperience and spontaneousa prioriconcepts of its objects, within pure sensory intuiting and pure thinking. In both cases the external empirical conditions would function as occasioning propelling factors affecting internal pre-established forms of generation. (shrink)

Mealey distinguishes two types of sociopathy: (1) or obligate, and (2) or facultative. Either sociopathy evolved twice, or one form is derived from the other, e.g., through: (1) genetic assimilation generating polymorphism in the relative strength of biases favoring the development of otherwise facultative strategies, or (2) independently heritable but strategically relevant characteristics biasing the optimal selection of facultative strategies.

A compendium of the history and philosophy of wildlife from ancient mythology to scientific ideas of the XIX-XX centuries. Content: 1.1 Knowledge of wildlife: a long way from myths to science. 1.2 The evolution of pre-Darwinian ideas about the constancy and variability of species of living organisms. 1.3 The driving forces of wildlife development. Classical Darwinism: the struggle for existence, natural selection, inheritance of variability. 1.4 Genetic views on the hereditary transmission of species characteristics (preformism, epigenesis, pangenesis, neo-Darwinism). Literature.

In Insight, Bernard Lonergan provides, albeit schematically, a unique philosophy of biology which he takes as having “profound differences” with the world view presented by Darwin. These turn on Lonergan's idea of “schemes of recurrence” and of organisms as “solutions to the problem of living in an environment.” His lapidary prose requires some deciphering. I present the broad lines of his philosophy of biology and argue that Jean Piaget's structuralism can shed light on Lonergan's intentions in virtue of his use (...) of cybernetics and the isomorphism between biology and knowledge. In turn, Piaget draws on Waddington's restatement of epigenesis and I suggest that the result, “process structuralism,” is a viable alternative to the modern Darwinian synthesis. (shrink)

Johann Friedrich Blumenbach is widely known as the father of German vitalism and his notion of Bildungstrieb, or nisus formativus, has been recognized as playing a key role in the debates about generation in German-speaking countries around 1800. On the other hand, Caspar Friedrich Wolff was the first to employ a vitalist notion, namely that of vis essentialis, in the explanatory framework of epigenetic development. Is there a difference between Wolff’s vis essentialis and Blumenbach’s nisus formativus? How does this difference (...) influence their overall understanding of the epigenetic process? The paper aims to provide an answer to these questions through the analysis of a little-known document, which contributes to shed light on a crucial chapter of the German life sciences in the late eighteenth-century, namely the decisive phase of the process that led to the formalization of biology as a unified field of inquiry at the beginning of the nineteenth century. (shrink)