Medication-related osteonecrosis of the Jaw (MRONJ) is a serious adverse drug reaction that can seriously affect the quality of life of patients if not promptly diagnosed and treated. To date, preventive measures have been the most effective strategy for reducing the incidence of MRONJ. The role of dental practitioners in managing patients treated with Bone Modifying Agents (BMAs) varies across countries, with some healthcare systems providing a more structured approach than others. This systematic review aims to investigate the knowledge and (...) awareness of MRONJ among dentists, interpreting the findings from a medical and bioethical perspective. The protocol for this study was designed following the PRISMA guideline and registered on PROSPERO (CRD420251015032). A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICo question: Are dentists well-informed and aware of the risk of MRONJ in patients receiving BMAs? Furthermore, to address potential geographic differences, a country-specific literature review was conducted to compare the level of MRONJ awareness between patients receiving BMAs and dental professionals within the same country. Studies published up to March 2025 were screened. Twenty-two studies were included in this systematic review. Among the 10,536 dentists involved, 62.8% were well-informed about MRONJ, but only 9.7% were aware of its risk factors. The most common sources of information were university education, followed by scientific journals and specific training courses or conferences. Studies performed in the same countries investigating MRONJ awareness among patients taking BMAs were analyzed. Country-based analysis revealed significant discrepancies between dentists’ (68.5%) and patients’ (19.5%) knowledge and awareness of MRONJ in the USA, Saudi Arabia, Bulgaria, and Brazil. Finally, a bioethical analysis of European legal frameworks on informed consent for pharmacological therapies revealed that adequately informing patients about treatment risks is both an ethical obligation and a legal duty, rooted in constitutional and legislative principles. This systematic review reveals a low level of awareness despite an acceptable level of knowledge among dentists, highlighting an alarming discrepancy. Beyond knowledge of the disease, awareness of its risk factors and preventive strategies is essential for dentists to adopt a personalized and safe workflow for these patient groups. Ensuring personalized therapy requires a structured and collaborative approach based on ethical principles and shared knowledge. Strengthening interprofessional training and teamwork is essential to improving prevention and patient empowerment. CRD420251015032. (shrink)

The mortality rate of patients affected with oral squamous cell carcinoma has been stable in recent decades due to several factors, especially diagnostic delay, which is often associated with a late stage diagnosis and poor prognosis. The aims of this paper were to: analyze diagnostic delay in OSCC and to discuss the various psychological factors of patients with OSCC, with particular attention to the patient’s fear of receiving news regarding their health; and the professional dynamics related to the decision-making processes (...) in cases of suspected OSCC. A preliminary review of literature focusing on OSCC diagnostic delay was performed. Seven articles were included with the diagnostic delay ranging from 45 days to approximately 6 months. Patients’ fears and, to a lesser degree, the concerns of dentists, were found to be still poorly investigated. On the basis of the authors’ professional experience, the development of oral lesions of unknown origin may generate different behaviors in the decision-making processes by patients and clinicians, and fear may play a key role in the distinct steps of this process. It is crucial to increase awareness and inform patients about the onset of OSCC, and contemporaneously encourage experimental studies on patients’ fear and professional behaviors with respect to communication regarding OSCC. (shrink)

An appropriate kind of curved Hilbert space is developed in such a manner that it admits operators of $\mathcal{C}$ - and $\mathfrak{D}$ -differentiation, which are the analogues of the familiar covariant and D-differentiation available in a manifold. These tools are then employed to shed light on the space-time structure of Quantum Mechanics, from the points of view of the Feynman ‘path integral’ and of canonical quantisation. (The latter contains, as a special case, quantisation in arbitrary curvilinear coordinates when space is (...) flat.) The influence of curvature is emphasised throughout, with an illustration provided by the Aharonov-Bohm effect. (shrink)

A brief statement of medieval linguistic analysis as found chiefly in the works of Thomas Aquinas. A thin survey of contemporary analysis is offered in order to contrast the purported acceptance of analysis as the end of philosophy with Thomas' use of analysis as method. Unfortunately, most of the constructive work in language analysis during the past ten years is not considered. The brevity of the text precludes persuasive treatment; yet the book succeeds in its expressed purpose of sketching some (...) chief differences between the medieval and contemporary approaches in the hope that the confrontation of these currents will bring to the fore the analytic work of Aquinas himself.--D. P. B. (shrink)

[D. H. Mellor] Kant's claim that our knowledge of time is transcendental in his sense, while false of time itself, is true of tenses, i.e. of the locations of events and other temporal entities in McTaggart's A series. This fact can easily, and I think only, be explained by taking time itself to be real but tenseless. /// [J. R. Lucas] Mellor's argument from Kant fails. The difficulties in his first Antinomy are due to topological confusions, not the tensed nature (...) of time. Nor are McTaggart' s difficulties due to the tensed nature of time. The ego-centricity of tensed discourse is an essential feature of communication between selves, each of whom refers himself as 'I', and is required for talking about time as well as experience and agency. Arguments based on the Special Theory are misconceived. Some rest on a confused notion of 'topological simultaneity'. In the General Theory a cosmic time is defined, as also in quantum mechanics, where a natural present is defined by a unique hyperplane of collapse into eigen-ness. (shrink)

This paper analyzes several properties of infima in Dn, the n-r.e. degrees. We first show that, for every n> 1, there are n-r.e. degrees a, b, and c, and an -r.e. degree x such that a < x < b, c and, in Dn, b c = a. We also prove a related result, namely that there are two d.r.e. degrees that form a minimal pair in Dn, for each n < ω, but that do not form a minimal pair (...) in Dω. Next, we show that every low r.e. degree branches in the d.r.e. degrees. This result does not extend to the low2 r.e. degrees. We also construct a non-low r.e. degree a such that every r.e. degree b a branches in the d.r.e. degrees. Finally we prove that the nonbranching degrees are downward dense in the d.r.e. degrees. (shrink)

Das »Richtige und das Gute« (1930), das ethische Hauptwerk W. D. Ross’, enthält eine Vielzahl wichtiger moralphilosophischer Thesen und Argumente, die bis in die Gegenwart kontrovers diskutiert werden. Im Mittelpunkt steht seine pluralistische Deontologie, der zufolge sich die richtige Handlung aus einer Abwägung der in der jeweiligen Situation relevanten und unableitbaren Prima-facie-Pflichten ergibt, von denen nur ein Teil auf die Optimierung der Handlungsfolgen bezogen ist. Diese Deontologie wurde zu einem modernen Klassiker unter den normativen ethischen Theorien. Darüber hinaus stellt Ross’ (...) These, dass moralische Intuitionen eine Quelle selbstevidenten Wissens sein können, einen wichtigen Referenzpunkt in Debatten um den erkenntnistheoretischen Fundamentalismus dar. Auch für die Handlungstheorie liefert Ross einflussreiche Argumente, wenn er die Ansicht vertritt, dass Pflichten nie ein bestimmtes Motiv des Handelnden zum Gegenstand haben können. Eine zentrale Stellung nimmt für Ross die Güterlehre ein, in welcher er von vier Grundgütern, Tugend, Wissen, Lust und Gerechtigkeit, ausgeht. Wurde Ross in den ersten Jahrzehnten des 20. Jahrhunderts im damaligen Großbritannien als ein herausragender Ethiker – einer der bedeutendsten des Jahrhunderts, auf Augenhöhe mit G.E. Moore – angesehen, wandelte sich das Meinungsbild in den folgenden Jahrzehnten unter dem Einfluss besonders des Logischen Positivismus und der Philosophie Wittgensteins. In den letzten Jahrzehnten ist jedoch wieder ein wachsendes Interesse an Ross’ Ethik festzustellen. Dabei wird »Das Richtige und das Gute« bisweilen sogar mit der »Nikomachischen Ethik«, Kants »Grundlegung« und Humes »Untersuchung über die Prinzipien der Moral« verglichen. (shrink)

My review of Cornelius Castoriadis' book Crossroads in the Labyrinth ended with the apt reference, I now see, to the emperor being naked. In Joel Whitebook's second review, largely irrelevant to my criticisms of Castoriadis, he fears, though he doesn't know me personally, that only the lack of psychological counseling can explain my uncontrolled anger against Castoriadis. Let me dignify his long distance psychoanalysis by passing over it in silence. Silence is also the best remedy for Whitebook's transcendental deduction that (...) I have a “pluralistic, localistic, discontinuous ontology.” Even if I knew what that was I find it amazing that he located it in a 10 page review. Perhaps Whitebook just “feels” the presence of this ontology along with evidence of my mental problems. (shrink)

The group of Dialectical Theology (also known as Neo-Orthodoxy) included some of the most well-known theologians of the 20th century – Karl Barth, Rudolf Bultmann, Friedrich Gogarten, Eduard Thurneysen, Georg Merz und Emil Brunner. In the summer of 1922 they founded the journal Zwischen den Zeiten, which launched Dialectical Theology as the most influential avant-garde movement in Protestantism during the Weimar Republic. Due to internal strife and theological disagreements, the group began to lose strength in the early 1930s and eventually (...) split up and ceased publishing Zwischen den Zeiten in 1933. The individual members later became fierce critics of each other’s theological works. Gogarten and Barth became arch enemies during the so-called “church struggle” (Kirchenkampf), and Bultmann and Barth became each other’s nemesis in the Federal Republic of Germany.In this article I examine the rise and fall of this movement. I argue that the concept “generation” was central to the early self-understanding and selfjustification of the group. It allowed the group to forge an alliance and oppose an antagonistic group of influential theologians. The claim to speak up for a young generation of theologians and pastors – in opposition to an older, liberal generation – became the rallying cry for Dialectical Theology. Further, I argue that conferences, not only the theological writings, played a central, constitutive role in establishing the group as a theological movement. It was at conferences that the members of Dialectical Theology could challenge the older generation and assert their own theological stance. Instead of merely concentrating on the published theological writings of each of the members, I thus argue that one must additionally focus on the applied concepts and the role of conferences to understand the history of Dialectical Theology. It is only when we include these additional contexts that we understand how Dialectical Theology was able to be launched and sustained as a theological movement despite the irreconcilable differences amongst the members. (shrink)

Le P. D. M. De Petter, o.p., fondateur de cette revue dont il assuma la direction jusqu'à sa mort, survenue le 6 avril 1971, publia pendant sa vie divers articles qui ont suscité, à bon droit, l'intérêt du public philosophique. Ces études demeurent cependant fragmentaires par rapport à sa vision philosophique globale, telle qu'elle est exprimée dans ses cours non publiés. Elles ne reçoivent d'ailleurs leur pleine signification qu'à partir de cette vue d'ensemble. Le présent exposé a pour objectif d'initier (...) les lecteurs aux idées maîtresses de cette œuvre. Il n'a par conséquent d'autre prétention que de rendre fidèlement la pensée du P. De Petter. Il s'agit surtout de deux cours, qui sont étroitement liés : l'un d'anthropologie, l'autre de métaphysique. Le premier constitue le fondement du deuxième lequel, à son tour, complète le premier, en sorte que les deux forment une parfaite unité. De Petter révèle à travers ses cours une ligne de pensée très personnelle et originale. Sans doute en était-il conscient et il n'hésita pas à remettre en question toute la philosophie occidentale. Il y décelait une double erreur : d'une part une vision défectueuse et unilatérale de l'unité complexe de l'homme, d'autre part une interprétation insuffisante de l'ouverture humaine sur la réalité en soi et indépendante. En ce qui concerne le premier point, De Petter insiste sur le dualisme qui domine, quasiment sans contestation, toute la philosophie occidentale, et qui n'est contredit que par l'antidualisme des phénoménologues ; d'autre part il souligne les déficiences de cet antidualisme. Le dualisme n'a pas su rendre compte de l'unité humaine, tandis que l'antidualisme l'exagérait au point d'oublier la complexité de l'homme. En ce qui concerne le second point – l'ouverture humaine sur la réalité en soi – De Petter insiste sur le conceptualisme de toute la philosophie jusqu'à Kant. L'erreur de celui-ci consistait à considérer les concepts comme l'expression adéquate de la réalité elle-même, qu'ils tendaient à supplanter. Ensuite, il signale la réduction de l'être à l'être-pour-moi, prônée depuis Kant. Sur ce point également, la position de De Petter consiste à refuser les deux erreurs mentionnées. Aux phénoménologues, il imprunta tous les facteurs qui relativisent la connaissance humaine, mais à son avis l'affirmation de tout relativisme reste en deça de sa propre implication. Cette affirmation, en effet, prouve l'intentionalité foncière de la conscience sur la réalité même. C'est par cette intentionalité que la métaphysique devient possible. Celle-ci pourtant devra s'accorder au réalisme tel que De Petter le conçoit. Par ce réalisme il faut comprendre que la conscience humaine, à travers toutes les formes de relativité, vise l'absolu sans pouvoir y accéder. Dans cette ligne de pensée, la métaphysique ne fera que se rapprocher du mystère de la réalité toujours inaccessible. Sera-t-elle pour autant une métaphysique du silence ? Non pas. De Petter estime que le mystère de Dieu se montre – en tant que profondeur insondable – à travers l'insuffisance, la contingence ou le vide intérieur de notre monde. Signalons, pour terminer, que De Petter avance dans ses cours, une critique perspicace et profonde des thèses principales de l'anthropologie et de la métaphysique scolastiques. (shrink)

An examination of the contemporary Italian movement associated with M. P. Sciacca, and the serious application of dialectical and phenomenological methods to unveil the structure of "intentionality" or "spirit." An appraisal of Sciacca together with a sample critique of Dante follows a competent summary of the prevailing positions.--D. B. B.

The problem the author sets himself in this historico-critical study of the post-Kantian development of the a priori is: Can one understand the nature of the a priori as part of the explanation of knowledge, without assigning it exclusively to the subject and without radically identifying the a priori and the a posteriori? Dufrenne thinks this can be done by retaining a dualism of subject and object. Well-written and scholarly. An index would have been helpful.--D. D. O.

This article is the text of an interview with D. H. Mellor conducted by Andrew Pyle and first published in the Spring 1993 issue of the philosophical journal Cogito.

The Russian philosopher Victor D. Kudryavtsev-Platonov was introduced to Kant’s ideas through the works of his older contemporaries, one of whom was Wilhelm Traugott Krug, the author of the concept of transcendental synthetism. However, the degree and character of the influence of his philosophical ideas on Kudryavtsev-Platonov’s epistemology remain unexplored to this day. To fill this gap I have examine the main features of transcendental synthetism and the basic tenets of Krug’s theory of cognition as well as their specific relation (...) to Kant’s transcendentalism. I then describe the character of Kudryavtsev-Platonov’s acquaintance with the works of Krug and compare the views of these two philosophers. I demonstrate that Krug’s theoretical philosophy is a mix of Kantian transcendentalism and common sense convictions. I establish that Kudryavtsev-Platonov became acquainted with Krug’s Fundamental Philosophy and The System of Theoretical Philosophy quite early on. He was an opponent of the philosophy of common sense although, like Krug, he derived the being of the real and ideal world from the fact of self-consciousness. Unlike Krug, Kudryavtsev-Platonov ascribes to a priori forms of cognition not only subjective but also objective meaning. I conclude that Kudryavtsev-Platonov’s transcendental monism is genetically connected with Krug’s transcendental synthetism, i.e. its modification with a metaphysical slant. Krug’s ideas show themselves in a peculiar way in the Russian philosopher’s epistemological ideas: in the methodology of deriving the main principles of philosophy, in the structure of cognition and in the place the latter assigns to it in the system of philosophical knowledge. (shrink)