The concept of the future is re-emerging as an urgent topic on the academic agenda. In this article, we focus on the ‘politics of the future’: the social processes and practices that allow particular imagined futures to become socially performative. Acknowledging that the performativity of such imagined futures is well-understood, we argue that how particular visions come about and why they become performative is underexplained. Drawing on constructivist sociological theory, this article aims to fill (part of) this gap by exploring (...) the question ‘how do imagined futures become socially performative’? In doing so, the article has three aims to (1) identify the leading social–theoretical work on the future; (2) conceptualize the relationship of the imagination of the future with social practices and the performance of reality; (3) provide a theoretical framework explaining how images of the future become performative, using the concepts ‘techniques of futuring’ and ‘dramaturgical regime’. (shrink)

First published in 2010, Cornelia Vismann’s article has already attained the status of a classic. In a formulation inspired by linguistic theory, the author argues that the relation between cultural techniques and media can be understood in analogy to grammatical operations. Thus, cultural techniques define the agency of media and execute the procedural rules which the latter set in place. Together, they articulate a critique of subjectivity and sovereignty that proceeds by re-examining the notion of ‘culture’ via its (...) agricultural origins to the current moment when the ‘preservation of cultural techniques’ has entered legal and academic discourse. Ultimately, despite their apparent separation from praxis, cultural techniques continue to proliferate through axes of substitution and displacement. (shrink)

These introductory remarks outline the German concept of Kulturtechniken (cultural techniques) by tracing its various overlapping meanings from the late 19th century to today and linking it to developments in recent German theory. Originally related to the agricultural domain, the notion of cultural techniques was later employed to describe the interactions between humans and media, and, most recently, to account for basic operations and differentiations that give rise to an array of conceptual and ontological entities which are said (...) to constitute culture. In the second part of the essay, cultural techniques are analyzed as a concept that allows theorists to overcome certain biases and impasses characteristic of that domain of German media theory associated with the work of the late Friedrich Kittler. (shrink)

Logic: Techniques of Formal Reasoning, 2/e is an introductory volume that teaches students to recognize and construct correct deductions. It takes students through all logical steps--from premise to conclusion--and presents appropriate symbols and terms, while giving examples to clarify principles. Logic, 2/e uses models to establish the invalidity of arguments, and includes exercise sets throughout, ranging from easy to challenging. Solutions are provided to selected exercises, and historical remarks discuss major contributions to the theories covered.

This paper seeks to introduce cultural techniques to an Anglophone readership. Specifically geared towards an Anglophone readership, the paper relates the re-emergence of cultural techniques (a concept first employed in the 19th century in an agricultural context) to the changing intellectual constellation of postwar Germany. More specifically, it traces how the concept evolved from – and reacted against – so-called German media theory, a decidedly anti-hermeneutic and anti-humanist current of thought frequently associated with the work of Friedrich Kittler. (...) Post-hermeneutic rather than anti-hermeneutic in its outlook, the reconceptualization of cultural techniques aims at presenting them as chains of operations that link humans, things, media and even animals. To investigate cultural techniques is to shift the analytic gaze from ontological distinctions to the ontic operations that gave rise to the former in the first place. As Siegert points out, this shift recalls certain concurrent developments within the North American posthumanities; the paper therefore also includes a discussion of the similarities and differences between German and North American posthumanism. (shrink)

Contrary to the general belief that modernist art and architecture reflect the technological society, Jacques Ellul maintains in his L’empire du non-sens that they are justifications for the integration of humankind into what he called the technicist complex. Modernism in art and architecture meant that every product must be qualified by a technological character. This unassailable belief exerted some far-reaching influences on symbolic thought, on artistic expression, on architectural character. If imitation and invention were the two inseparable concepts through which (...) art and architecture were produced and symbolized, it is because they operate on a certain transparency between an exemplar and a work of art. By contrast, in the mentality of technique, artistic production operates based on a certain opacity to meanings outside of itself. Imitation and invention were separated. Thus, one of the principal beliefs in modernism, that art and architecture symbolize the technological society is actually one of its weakest. In considering technology as both the symbol and the product, the artistic idea and its representation collapsed into each other. (shrink)

Nous sommes dans une société où se multiplient les techniques de communication. Quelles sont-elles? Quelles nouvelles formes de lien social accompagnent-elles? Comment penser le rapport entre techniques et société? Telles sont les interrogations avancées et qui s’appuient sur la demande sociale latente propre à nos sociétés et qui est à la source des progrès techniques, ceux-ci, ensuite, imposant leur propre logique.In our society, techniques of communication increase in number. What are they? What new forms of social (...) link go with them? How are we supposed to think the relationship between techniques and society? Such are the questions we have to ask. They imply a social unconscious characteristic of modern societies and, in feed-back, the effects of the technical logic. (shrink)

The paper seeks to analyze children’s bodily vulnerability as grounded in generational order. The thesis is put forward, that the generational order is embodied via body techniques of vulnerability, deployed both by adults and children. In presenting results from research on professional responses to child maltreatment and neglect, three sets of age related body techniques of vulnerability are identified, concerning caregivers, professionals and the children itself.

Humanity is made of technical objects. Despite of this fact, technique is not considered as a cultural matter especially in engineering schools where it should be taught. As teachers and searchers at the INSA Lyon, we have experienced the way and the difficulties to develop this technical culture.

Mitochondrial replacement techniques (MRTs) usually aim to prevent the genetic transmission of maternally inherited mitochondrial diseases. Until now, only the UK and Australia have implemented specific legal regulations of MRTs. In both countries, clinical trials on these techniques are only permissible for cases with a high risk of severe mitochondrial disease in the offspring. However, these techniques can also be applied to treat infertility, especially for older women with impaired oocyte quality. In some countries without legal regulation (...) of these techniques, MRTs are already offered for this purpose. Yet, this application of MRTs has received insufficient attention in the bioethical literature so far. In this paper, I examine whether there are ethical reasons to prohibit trials on MRTs in the context of infertility when they are permitted for preventing mitochondrial disease. Allowing MRTs in one context but not the other might be justified either because their application in the context of mitochondrial disease (1) is supported by a more convincing evidence base, (2) has a higher potential benefit or (3) has a lower risk. I compare both applications of MRTs with respect to these three factors. I conclude that there is no convincing reason to prohibit clinical trials on MRTs for infertility when they are permitted in the context of mitochondrial disease. (shrink)

Research on perception without awareness has provoked strong emotional responses from individuals within and outside the scientific community, due in part to the perceived potential for abuse of subliminal techniques. In this paper, four basic issues regarding the use of subliminal techniques for propaganda purposes are discussed: whether exposure to subliminal stimuli can produce significant, predictable changes in affect, cognition and behavior; whether these effects are robust and powerful enough to make the use of subliminal techniques for (...) propaganda purposes feasible; whether the effects of subliminal stimulation are stable over time; and whether subliminal influences can be resisted by unwilling subjects. Research suggests that exposure to simple drive-or affect-related subliminal stimuli can produce ecologically significant, temporally stable changes in attitudes and behavior, and therefore may have potential for use as propaganda tools. Implications of these findings for our understanding of the mechanisms underlying subliminal perception are discussed. Technical problems which would need to be addressed before subliminal propaganda techniques could be employed are also discussed. Ethical issues raised by the use of covert attitude and behavior manipulation techniques are addressed. (shrink)

One of the clearest examples of a technological system, in the sense that Ellul discussed it, is contemporary biomedical health care. The foundation of technological systems is technique: efficient methods for achieving isolated goals. However, the goal of health care should be to achieve health in the full sense of wholeness. Traditional healing systems addressed heath in this sense, but biomedicine cannot; attempting to use the techniques of traditional systems without the accompanying culture ruptures those systems. Using the contemporary (...) epidemic of chronic noncommunicable diseases as an example, this article attempts to exposes the limitations of a technical approach, as well as the limitations of the methodology of risk analysis. (shrink)

Neoliberal Techniques of Social Suffering: Political Resistance and Critical Theory from Latin America and Spain is the result of the critical and political commitment of various Latin American and Spanish philosophers who share a critical approach to the global “stealth revolution” in recent decades, where neoliberalism has forced the well-being and reproduction of life to adapt to a system devastating for both humans and non-humans. The authors voice the shared concern of contemporary Spanish and Latin American societies to build (...) new conceptions of the public and the common through mobilizing affects usually disavowed in political theory. If, in Ancient Greece, the idea of strengthening the most vulnerable and weakest was deplored as the art of sophists, this collection edited by Laura Quintana and Nuria Sánchez Madrid explores the other side of our social world to revive grassroots strategies of resistance and emancipation, which are able to bring about new distributions of power, welfare, and discursive legitimation and to extend our goal of creating a radically democratic world. (shrink)

This article reevaluates the mystical techniques and experiences peculiar to Abraham Abulafia’s Kabbalah and attempts to offer an alternative approach to their dominant understanding, which largely depends on Moshe Idel’s work. Current scholars of Jewish mysticism have a habit of highlighting the “unique character” of Abulafia’s mystical practices while asserting that they cannot be compared with the induction techniques and the psychophysical phenomena typical of hypnosis. While generally agreeing with the scholars discussed that the hyperactivation of the mind (...) found in Abulafian Kabbalah contrasts sharply with the mental relaxation attained through the mystical practices of other religious traditions, the present study takes issue with the current view of Abulafian Kabbalah’s relation to hypnotic procedures, processes, and states. This work addresses the issues present with the current view and offers a more inclusive model for interpreting Abulafia’s Kabbalah, drawing from psychiatrist Roland Fischer. (shrink)

Many historical studies tend to underline two central Kantian themes frequently emerging in Georges Canguilhem’s works: (1) a conception of activity, primarily stemming from the Critique of Pure Reason, as a mental and abstract synthesis of judgment; and (2) a notion of organism, inspired by the Critique of Judgment, as an integral totality of parts. Canguilhem was particularly faithful to the first theme from the 1920s to the first half of the 1930s, whereas the second theme became important in the (...) early 1940s. With this article, I will attempt to show that a third important theme of technique arose in the second half of the 30s also in the wake of Kant’s philosophy, especially Sect. 43 of the Critique of Judgment. This section, which states that technical ability is distinguished from a theoretical faculty, led Canguilhem to a more concrete and practical conception of activity. I will then suggest that it was by considering technique that the concept of normativity, which characterizes Georges Canguilhem’s philosophy of life, also took shape. (shrink)

Avec l’identification biométrique, nous passons imperceptiblement du contrôle à distance des populations pratiqué par les États modernes à des macro-systèmes techniques qui imposent de plus en plus leur propre logique. Du point de vue anthropologique ce déplacement de paradigme met en jeu la définition même de l’identité en renforçant le divorce entre l’identité civile et l’identité personnelle ou sociale. La frontière est désormais inscrite à même le corps biologique des individus au sein de l’espace géré depuis les terminaux du (...) grand réseau mondial de gestion des flux disséminés sur la planète. Elle tend donc à se confondre avec les limites fonctionnelles du Macro-Système technique. Du point de vue du droit, la mise en place par les États de dispositifs d’identification biométriques s’exprime principalement par la restriction de la liberté de circuler accordée aux individus. L’un des constats apporté par la revue des législations nationales montre pourtant que le droit s’adapte globalement à cette nouvelle situation. Cet article interroge en conclusion quelques-unes des raisons permettant d’expliquer ces reculs successifs et propose, parmi elles, la définition implicite de l’individu sur laquelle fait fond le droit moderne.With biometric identification we are imperceptibly moving from the remote control of the population practised by the modern States on to large technical systems which increasingly impose their own logic on people. From an anthropological viewpoint, this paradigm shift calls into question the very definition of « identity » by broadening the divide between civil identity and personal or social identity. The frontier is now inscribed on the biological body of the individual within the space that is managed from the terminals of the global flow management networks scattered the world over. The frontier thus tends increasingly to coincide with the functional limits of the large technical system. From a legal viewpoint, the introduction by States of biometric identification systems results primarily in a restriction of the freedom of circulation granted to individuals. One of the findings which emerge from a review of national legislations is however that law is globally adapting to this new situation. In the conclusion, the article considers some of the reasons behind these successive backward steps, and proposes, amongst them, an implicit definition of the individual on which modern law is founded. (shrink)

In accordance with societal norms and values, consumers readily indicate their positive attitudes toward sustainability. However, they hardly take sustainability into account when engaging in exchange relationships with companies. To shed light on this paradox, this paper investigates whether defense mechanisms and the more specific concept of neutralization techniques can explain the discrepancy between societal norms and actual behavior. A multi-method qualitative research design provides rich insights into consumers’ underlying cognitive processes and how they make sense of their attitude–behavior (...) divergences. Drawing on the Ways Model of account-taking, which is advanced to a Cycle Model, the findings illustrate how neutralization strategies are used to legitimize inconsistencies between norm-conforming attitudes and actual behavior. Furthermore, the paper discusses how the repetitive reinforcement of neutralizing patterns and feedback loops between individuals and society are linked to the rise of anomic consumer behavior. (shrink)

For Ricœur any study of Freud, or of psychoanalysis more generally, needs to take into account the crucial dimension of the analytic experience itself. Psychoanalysis, as a “mixed discourse,” aims to anticipate questions of meaning and explication alongside technical questions of energies, repression, displacement, and so on. The analytic experience is one which is practical and intersubjective, but which is also guided by various techniques or methods. These techniques, I will argue, should be understood as a type of (...) techne, one which is less concerned with hermeneutic questions of meaning than with quasi-scientific questions of force, feedback, struggle, and process. The practice of psychoanalysis, on the other hand, deals with the ways in which these forces or drives become meaningful for a particular subject, and within a singular context or history. This article will aim to draw out both the interrelationship between techniques and practical understanding, and also the productive incommensurability between the two. (shrink)

Les réseaux socionumériques constituent des supports identitaires ambivalents pour leurs utilisateurs. À de nombreux égards, ils entretiennent des proximités avec les techniques de soi développées depuis l'antiquité dans la société occidentale. Cette similarité explique certainement leur adoption si enthousiaste. Cependant, ces plateformes possèdent des caractéristiques particulières qui les éloignent des objectifs usuels des techniques de soi, destinées au développement de l'autoréflexivité et au soin de soi. Elles constituent davantage des outils d'expression de soi que des techniques de (...) soi. Leur compréhension nécessite aussi de sortir d'une vision egocentrée de l'individu pour envisager la dimension fondamentalement co-construite de notre identité. (shrink)

There is considerable interest in the use of neuroimaging techniques for forensic purposes. Memory detection techniques, including the well-publicized Brain Fingerprinting technique (Brain Fingerprinting Laboratories, Inc., Seattle WA), exploit the fact that the brain responds differently to sensory stimuli to which it has been exposed before. When a stimulus is specifically associated with a crime, the resulting brain activity should differentiate between someone who was present at the crime and someone who was not. This article reviews the scientific (...) literature on three such techniques: priming, old/new, and P300 effects. The forensic potential of these techniques is evaluated based on four criteria: specificity, automaticity, encoding flexibility, and longevity. This article concludes that none of the techniques are devoid of forensic potential, although much research is yet to be done. Ethical issues, including rights to privacy and against self-incrimination, are discussed. A discussion of legal issues concludes that current memory detection techniques do not yet meet United States standards of legal admissibility. (shrink)

Building and expanding on Foucault’s work, this essay interprets pastoral power as a turning point within the long-term history of the care of the self. Through an analysis of early Christian monasticism, it claims that the pastorate emerged out of a re-conceptualization of ancient understandings of human finitude and a correlative transformation of the techniques revolving around it. Pastoral power instantiates a specific way of framing institutionally the subject’s opening to the limits. The argument thus suggests how, and to (...) what extent, this matrix of government still determines, albeit under a different guise, the current political phase, especially in as far as economic governmentality and its call to the indefinite self-enhancement of subjectivity are concerned. (shrink)

Clinical ethics consultation (CEC) has become all about right technique. When we encounter a case of conflict or confusion, clinical ethicists are expected to deploy a standardized, repeatable, and rationally defensible method for working toward a recommendation and/or consensus. While it has been noted previously that our techniques of CEC often foreclose on its internal goods, there remains an assumption that we must just find the _right_ efficient technique and the problem would be solved. In this paper, I question (...) that assumption, arguing that any standardized, identically repeatable model of CEC will pull us counterproductively away from ethical reflection, and toward the values of modern _techne_: primarily efficiency, efficacy, and repeatability. This is because standardized techniques of CEC pull the dynamism of being into what Catherine Pickstock calls “identical repetition,” a technologized ontology, which is fundamentally at odds with what being is. And, since ethics is a search for the good of being, avoiding the ontological heart of being severely restricts ethics. (shrink)

Collecting data using an appropriate sampling technique is a challenging task for a researcher to do. The researchers will be unable to collect data from all possible situations, which will preclude them from answering the study’s research questions in their current form. In light of the enormous number and variety of sampling techniques/methods available, the researcher must be knowledgeable about the differences to select the most appropriate sampling technique/method for the specific study under consideration. In this context, this study (...) also looks into the basic concepts in probability sampling, kinds of probability sampling techniques with their advantages and disadvantages. Social science researchers will benefit from this study since it will assist them in choosing the most suitable probability sampling technique(s) for completing their research smoothly and successfully. (shrink)

Many sentences like ‘Some chairs are heavier than some tables’ seem both to be true and to imply the existence of composite objects. Some nihilists response to the challenge such sentences present by replacing them with “nihilistically acceptable paraphrases,” sentences that serve the same practical ends but do not even seem to imply the existence of composite objects. The chairs/tables sentence has been given the paraphrase ‘There are _x_s that are arranged chairwise and there are _y_s that are arranged tablewise, (...) and the _x_s are heavier than the _y_s’. But Gabriel Uzquiano has given examples of apparently true sentences that apparently imply the existence of composite objects and which cannot be given nihilistically acceptable paraphrases using only the devices displayed in the chairwise/tablewise paraphrase. This chapter presents techniques that enable one to provide nihilistically acceptable paraphrases of Uzquiano’s “challenge” sentences and proceeds to discuss some possible limitations of these techniques. (shrink)

News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In this paper, we explore (...) Mexico's rule of law in relation to mitochondrial replacement techniques and show that, in fact, certain instances of MRTs are prohibited at the federal level and others are prohibited at the state level. According to our interpretation of the law, the scientists behind this first successful MRT procedure broke federal regulations regarding assisted fertilization research. (shrink)

Mitochondrial replacement techniques, known in the popular media as 'three-parent' or 'three-person' IVFs, have the potential to enable women with mitochondrial diseases to have children who are genetically related to them but without such diseases. In the debate regarding whether MRTs should be made available, an issue that has garnered considerable attention is whether MRTs affect the characteristics of an existing individual or whether they result in the creation of a new individual, given that MRTs involve the genetic manipulation (...) of the germline. In other words, do MRTs affect the qualitative identity or the numerical identity of the resulting child? For instance, a group of panelists on behalf of the UK Human Fertilisation and Embryology Authority has claimed that MRTs affect only the qualitative identity of the resulting child, while the Working Group of the Nuffield Council on Bioethics has argued that MRTs would create a numerically distinct individual. In this article, I shall argue that MRTs do create a new and numerically distinct individual. Since my explanation is different from the NCOB's explanation, I shall also offer reasons why my explanation is preferable to the NCOB's explanation. (shrink)

This paper proposes an account of accurate scientific representation in terms of techniques that produce data from a target phenomenon. I consider an approach to accurate representation that abstracts from such epistemic factors, justified by a thesis I call Ontic Priority. This holds that criteria for representational accuracy depend on a pre-established account of the nature of the relation between a model and its target phenomenon. I challenge Ontic Priority, drawing on the observation that many working scientists do not (...) have access to information allowing them to describe this relation between model and target or compare them accordingly. I critique the ability of an ontic-first approach to provide accuracy criteria in such cases and present historical support for an alternative according to which a model is accurate if and only if integrating the model into a theory of the data acquisition process yields well-fitting predictions of patterns in the data. (shrink)

The Technique of Islamic Bookbinding: Methods, Materials and Regional Varieties. By Karin Scheper. Islamic Manuscripts and Books, vol 8. Leiden: Brill, 2015. Pp. xii + 428, illus. $181, €140.

Casting Techniques in Minoan and Mycenaean Crete. I. The casting tools Studies on copper and bronze metallurgy in the prehistoric Aegean area generally focus on metal objects but neglect the bronzesmith tools : crucibles, molds and ventilation systems (“ tuyères”, bellows…). However, their study provides new information on both the technical processes of making a metal object and their evolution, and the existence of technical traditions and “ savoir-faire” of these bronzesmiths. The first part of this study is devoted (...) to the examination of the corpus of Cretan tools from the EBA to the LBA highlighting their specific features and functions, while the resulting synthesis— forthcoming in a future issue— will focus on the technical process and changes in casting activities and the “ savoir-faire” of the Cretan bronzesmiths. (shrink)

Mitochondrial replacement techniques (MRTs) are a new group of biotechnologies that aim to aid women whose eggs have disease-causing deleteriously mutated mitochondria to have genetically related healthy children. These techniques have also been used to aid women with poor oocyte quality and poor embryonic development, to have genetically related children. Remarkably, MRTs create humans with DNA from three sources: nuclear DNA from the intending mother and father, and mitochondrial DNA from the egg donor. In a recent publication Françoise (...) Baylis argued that MRTs are detrimental for genealogical research via mitochondrial DNA because they would obscure the lines of individual descent. In this paper, I argue that MRTs do not obscure genealogical research, but rather that MRT-conceived children can have two mitochondrial lineages. I argue for this position by showing that MRTs are reproductive in nature and, thus, they create genealogy. (shrink)

Since mitochondrial replacement techniques were developed and clinically introduced in the United Kingdom, there has been much discussion of whether these lead to children borne of three parents. In the UK, the regulation of MRT has dealt with this by stipulating that egg donors for the purposes of MRT are not genetic parents even though they contribute mitochondrial DNA to offspring. In this paper, I examine the way that the Human Fertilisation and Embryology Act in the UK manages the (...) question of parentage. I argue that the Act breaks the link typically made between genetic causation and genetic parenthood by redefining genetic causation solely in terms of nuclear genetics. Along with this, mtDNA is construed as a kind of supplement to the nuclear family. Drawing on the account of the supplement developed by Jacques Derrida, I argue that mtDNA and the women who donate it are seen as both essential to establishing the nuclear family but also exterior to and insignificant for it. (shrink)

Several objections against the morality of researching or employing mitochondrial replacement techniques have been advanced recently. In this paper, I examine three of these objections and show that they are found wanting. First I examine whether mitochondrial replacement techniques, research and clinical practice, should not be carried out because of possible harms to egg donors. Next I assess whether mitochondrial replacement techniques should be banned because they could affect the study of genealogical ancestry. Finally, I examine the (...) claim that mitochondrial replacement techniques are not transferring mitochondrial DNA but nuclear DNA, and that this should be prohibited on ethical grounds. (shrink)

The need for conceptual work in marketing ethics is addressed by examining the five techniques of neutralization as a means for partially explaining unethical behaviors by marketing practitioners. These techniques are often used by individuals to lessen the possible impact of norm-violating behaviors upon their self-concept and their social relationships. Borrowed from the social disorganization and deviance literature, the five techniques of neutralization are: (1) denial of responsibility, (2) denial of injury, (3) denial of victim, (4) condemning (...) the condemners and (5) appeal to higher loyalties. Examples of marketing professionals using each of the five techniques are given, and a conceptual model linking the techniques of neutralization with unethical behavior is presented. Finally, relevant research questions are offered for consideration. (shrink)

The need to align multiple experimental procedures and produce converging results so as to demonstrate that the phenomenon under investigation is real and not an artifact is a commonplace both in scientific practice and discussions of scientific methodology (Campbell and Stanley 1963; Wimsatt 1981). Although sometimes this is the purpose of aligning techniques, often there is a different purpose—multiple techniques are sought to supply different perspectives on the phenomena under investigation that need to be integrated to answer the (...) questions scientists are asking. After introducing this function, I will illustrate it by considering three of the major techniques in cognitive neuroscience for linking cognitive function with neural structure. (shrink)

Innovative loss‐of‐function techniques developed in recent years have made it much easier to target specific genomic loci at transcriptional levels. CRISPR interference (CRISPRi) has been proven to be the most effective and specific tool to knock down any gene of interest in mammalian cells. The catalytically deactivated Cas9 (dCas9) can be fused with transcription repressors to downregulate gene expression specified by sgRNA complementary to target genomic sequence. Although CRISPRi has huge potential for gene knockdown, there is still a lack (...) of systematic guidelines for efficient and widespread use. Here we describe the working mechanism and development of CRISPRi, designing principles of sgRNA, delivery methods and applications in mammalian cells in detail. Finally, we propose possible solutions and future directions with regard to current challenges. (shrink)

Mediators utilize a wide range of skills in the process of facilitating dialogue and resolving conflicts. Among the most useful techniques for clinical ethics consultants (CECs)—and surely the least discussed—are those employed in acrimonious, hostile conversations between stakeholders. In the context of clinical ethics disputes or other bedside conflicts, good mediation skills can reverse the negative interactions that have prevented the creation of workable treatment plans or ethical consensus. This essay lays out the central framework mediators use in distinguishing (...) positions from interests and describes a set of strategies for managing contentious ethics consultations or working with “difficult” patients, families, or patient-careprovider interactions. (shrink)

“Dialectic” has been a matter of growing interest in contemporary philosophy. The present article analyzes dialectical methods and positions them by reference to two paradigmatic texts of German idealism and analytic philosophy, i.e. J.G. Fichte’s Science of Knowing (1804) and J. McDowell’s Mind and World. Both dialectical approaches will be interpreted with regard to their contribution in the debate on reductionism and anti-reductionism: both Fichte and McDowell claim that philosophical positions and logical terms stand in a dualistic relationship to one (...) another, on the one hand, but are separated by a gulf, on the other. I will argue that for McDowell dialectic seems to be an alternative to one-sided reductionisms as well as to normal anti-reductionistic holism. Furthermore, for Fichte dialectic is an adequate method for describing the relationship of reductionism and anti-reductionism itself. Both see in dialectic a technique for bridging the gulf between binary opposite terms of logic as well as mutually exclusive positions, such as mind and world, subject and object, or idealism and realism. (shrink)

Faut-il craindre la technique comme un monstre qui dévorerait notre être et qui nous éloignerait du souci de nous-mêmes, en nous réduisant à ne plus être que ses objets? Faut-il la craindre tout particulièrement pour la médecine qui se donne en confiance aux appareils et aux calculs, sans toujours imaginer à quelle opération de réduction, elle risque, ce faisant, de livrer malades et maladies? Mais la technique n’est-elle pas d’abord un geste de notre part, un geste provisoire que nous faisons (...) vers nous-mêmes, aussi maladroit puisse-t-il paraître? Ce geste, l’avons-nous achevé? Sommes-nous sûrs du sens et de la suite que nous voulons lui donner? Parmi tous les lieux de technique en médecine qui appellent à réenvisager ces questions, il y en a un emblématique, celui de l’imagerie cérébrale, avec sa prétention à dire notre intimité, sa réalité de faiseuse d’images et notre jouissance à en nourrir notre imaginaire. Devons-nous être dupes? Ne pouvons-nous voir la technique comme un moyen, non de nous figer, mais de nous chercher et de nous dépasser? Un moyen de nous révéler, une confiance que nous nous donnons pour cette entreprise? (shrink)

In February 2015 the UK became the first country to legalise high-profile mitochondrial replacement techniques, which involve the creation of offspring using genetic material from three individuals. The aim of these new cell reconstruction techniques is to prevent the transmission of maternally inherited mitochondrial disorders to biological offspring. During the UK debates, MRTs were often positioned as a straightforward and unique solution for the ‘eradication’ of mitochondrial disorders, enabling hundreds of women to have a healthy, biologically-related child. However, (...) many questions regarding future applications and potential users remain. Drawing on a current qualitative study on reproductive choices in the context of mitochondrial disorders, this article illustrates how the potential limitations of MRTs have been obscured in public debates by contrasting the claims made about the future beneficiaries with insights from families affected by mitochondrial disorders and medical experts. The analysis illuminates the complex choices with which families and individuals affected by mitochondrial disorders are faced, which have thus far remained invisible. An argument is presented for improved information for the public as well as an intensification of critical empirical research around the complex and specific needs of future beneficiaries of new reproductive biotechnologies. (shrink)

Les sciences et les techniques sont au coeur de nos vies quotidiennes et constituent les piliers de notre modernité. Elles ont transformé les modes de vie, les relations de pouvoir, nos identités et nos imaginaires. Controverses sur les OGM, enjeux du changement climatique et de sa prévision, nouveaux imaginaires véhiculés par Internet ou les jeux vidéo... Comment analyser dans ces cas qui font l'actualité les liens inextricables entre ce que l'on sait du monde, ce que l'on souhaite y faire (...) et la façon dont on le gouverne? Les théories et approches dominantes de l'économie, de la sociologie, de l'histoire ou de la science politique ont souvent ignoré ces enchevêtrements complexes. Cet ouvrage propose un panorama du champ "sciences, techniques et société", très interdisciplinaire, qui s'est justement donné pour objet l'étude des transformations récentes et conjointes des façons de savoir, des formes d'expertise, des marchés, des espaces publics et des formes de gouvernement. (shrink)

The Manufacturing Techniques of Myrtos-Pyrgos Stone Vessels The Minoan site of Myrtos-Pyrgos has produced a wide range of Proto-and Neopalatial objects (faience, pottery, stone vessels, sealstones, etc.) that demonstrate a high level of craftsmanship and also the existence of an elite to consume them. Among the finds, the Protopalatial stone vessels show great skill in production and appear very similar to those of Quartier Mu at Malia. While the repertoire of forms is largely common to the two centres, study (...) of the techniques used reveals particularly close links — which may suggest a regional distribution of techniques in the Cretan workshops of the time. Among the later material, the presence of fragments of Egyptian vessels (and vessels of Egyptian stone) points to likely exchanges with Egypt. (shrink)

Contract cheating is a major problem in Higher Education because it is very difficult to detect using traditional plagiarism detection tools. Digital forensics techniques are already used in law to determine ownership of documents, and also in criminal cases, where it is not uncommon to hide information and images within an ordinary looking document using steganography techniques. These digital forensic techniques were used to investigate a known case of contract cheating where the contract author has notified the (...) university and the student subsequently confirmed that they had contracted the work out. Microsoft Word documents use a format known as Office Open XML Format, and as such, it is possible to review the editing process of a document. A student submission known to have been contracted out was analysed using the revision identifiers within the document, and a tool was developed to review these identifiers. Using visualisation techniques it is possible to see a pattern of editing that is inconsistent with the pattern seen in an authentic document. (shrink)

Satisfaction systems and reductions between them are presented as an appropriate context for analyzing the satisfiability and the validity problems. The notion of reduction is generalized in order to cope with the meet-combination of logics. Reductions between satisfaction systems induce reductions between the respective satisfiability problems and (under mild conditions) also between their validity problems. Sufficient conditions are provided for relating satisfiability problems to validity problems. Reflection results for decidability in the presence of reductions are established. The validity problem in (...) the meet-combination is proved to be decidable whenever the validity problem for the components are decidable. Several examples are discussed, namely, involving modal and intuitionistic logics, as well as the meet-combination of modal logic and intuitionistic logic. (shrink)

La distinction qu’Aristote propose de la connaissance pratique et de la connaissance théorique semble laisser le statut de la technique problématique : présentée comme une étape vers la science en Métaphysique A 1, la technique est rapprochée de la prudence en Éthique à Nicomaque VI 1, en ce qu’elles relèvent toutes deux de la même « raison délibérative ». Cette indétermination semble légitimer la critique célèbre adressée par Kant à la distinction aristotélicienne, ainsi que la conclusion radicale qu’il en tire (...) de rapatrier l’ensemble de la technique et des maximes de la prudence dans le domaine de la connaissance théorique. Le commentaire aristotélicien lui-même reste divisé sur cette question. Dans cet article, nous souhaitons proposer une interprétation nouvelle de la place qu’assigne Aristote à la technique dans le domaine du savoir, et notamment de son autonomie vis-à-vis des sciences théoriques. Cette interprétation se fonde sur l’analyse par Aristote de la délibération pratique comme d’une forme de recherche (ζήτησις), qui s’oppose fondamentalement à l’ἐπιστήμη comme savoir constitué et achevé dans sa présentation déductive. La technique apparaît alors comme le savoir positif qui permet de guider la délibération, et qui a donc trait aux méthodes. L’intérêt de cette lecture est de suggérer l’existence d’un lien profond entre la technique et la logique de l’ Organon, qui pointe vers notre concept moderne de « procédure », dont le rôle est central dans la théorie moderne de la calculabilité et en informatique. (shrink)

An analysis of Jonas' thought, focusing on three major themes: technique, vulnerability and ontology of life. Hans Jonas proposes a critique of traditional ethical approaches, which have proven incapable of dealing with the complex long-term effects of technological innovations. He suggests the "Responsibility Principle" as a new ethical paradigm, centered on considering the future consequences of human actions. In this sense, Jonas emphasizes the need for future-oriented ethics, which includes the preservation of life and the environment, ensuring that technological development (...) does not compromise future generations. The relevance of the "Responsibility Principle" lies in its ability to offer an adequate response to technological transformations and the threats they pose to planetary sustainability. Jonas highlights that the power acquired by humanity over nature, due to technological advances, requires ethical reflection that goes beyond classical paradigms such as utilitarianism and Kantian ethics. He criticizes the lack of guidance in previous approaches to dealing with long-term implications, proposing an ethics that considers the impact of current actions on future generations. (shrink)

Argument This essay studies the convergence of brain research with the physiology of emotions during the early twentieth century. It argues that the brain entered the laboratory of emotions not as an object of knowledge, but as a technique for producing emotions, in spite of the laboratory. The new brain-generated emotion signaled an epistemic break in the nature of studied emotion. It restructured the relationships between physiological and psychological forms of knowledge. It embodied the historical and political concerns of physiologists (...) with pain. And it excluded the affectively experiencing subject from the study of “emotion.” The essay also suggests that the brain-generated emotion was an object suspended in time and abstracted from history. Its unique a-temporal and de-contextualized characteristic transformed emotion into a product of a laboratory whose mode of production mimicked the modern factory. The constitutive elements that were assembled in creating the brain as emotion-generator were instrumental for the important studies of James Papez, Paul MacLean, and for the modern concept of Limbic System. The time has come [to]…begin the vivisection of the human heart according to scientific methods. Angelo Mosso, 1896. (shrink)

Legal text retrieval traditionally relies upon external knowledge sources such as thesauri and classification schemes, and an accurate indexing of the documents is often manually done. As a result not all legal documents can be effectively retrieved. However a number of current artificial intelligence techniques are promising for legal text retrieval. They sustain the acquisition of knowledge and the knowledge-rich processing of the content of document texts and information need, and of their matching. Currently, techniques for learning information (...) needs, learning concept attributes of texts, information extraction, text classification and clustering, and text summarization need to be studied in legal text retrieval because of their potential for improving retrieval and decreasing the cost of manual indexing. The resulting query and text representations are semantically much richer than a set of key terms. Their use allows for more refined retrieval models in which some reasoning can be applied. This paper gives an overview of the state of the art of these innovativetechniques and their potential for legal text retrieval. (shrink)

This article explores the carnal dimensions of existence through ethnographic research in a mixed martial arts club. Mixed martial arts (MMA) is an emergent sport where competitors in a ring or cage utilize strikes (punches, kicks, elbows and knees) as well as submission techniques to defeat opponents. Through data gathered from in-depth interviews with MMA practitioners and participant observation in an MMA club, I elucidate the social processes that are integral to the production of an MMA fighter habitus. I (...) examine how body techniques are learned and become attached to the identity of mixed martial arts fighters. Using Crossley’s concept of reflexive body techniques, I examine how MMA fighters engage in body callusing through use of reflexive body techniques thereby allowing them to withstand the rigors of the sport. (shrink)

[ENGLISH] This article discusses the potential of synthetic biology to address fundamental questions in the philosophy of biology regarding the nature of life and biological functions. Synthetic biology aims to reduce living organisms to their simplest forms by identifying the minimal components of a cell and also to create novel life forms through genetic reprogramming, biobrick assembly, or novel proteins. However, the technical success of these endeavors does not guarantee their conceptual success in defining life. There is a lack of (...) consensus among researchers on how to define and classify the entities produced in the lab, whether they should be considered living or categorized differently. The criteria for minimal cells and minimal life are subject to arbitrary choices and varying interpretations. The concept of function, crucial to synthetic biology, is also difficult to define. The article highlights the need to consider the minimal set of functions that characterize life before determining the smallest genomes that code for those functions. The arbitrary nature of defining both life and function complicates the understanding and classification of these entities. The article suggests that the traditional dichotomy between the living and the non-living may no longer be valid and that the concept of life itself may not require precise scientific definition. As synthetic biology advances, the article emphasizes the importance of redefining or constructing new categories to encompass the expanding possibilities and creations in the field. The ability to create new life forms raises questions about recognition, identification, and ethical implications, requiring a conceptual and philosophical engagement beyond the technical achievements of synthetic biology. -/- [FRENCH] L'article aborde le potentiel de la biologie synthétique pour répondre à des questions fondamentales de la philosophie de la biologie concernant la nature de la vie et des fonctions biologiques. La biologie synthétique vise à réduire les organismes vivants à leurs formes les plus simples en identifiant les composants minimaux d'une cellule et à créer de nouvelles formes de vie grâce à la reprogrammation génétique, à l'assemblage de biobriques ou à des protéines nouvelles. Cependant, le succès technique de ces approches ne garantit pas leur réussite conceptuelle dans la définition de la vie. Il n'y a pas de consensus parmi les chercheurs sur la façon de définir et de classer les entités produites en laboratoire, qu'elles doivent être considérées comme vivantes ou catégorisées différemment. Les critères des cellules minimales et de la vie minimale sont soumis à des choix arbitraires et à des interprétations variables. La notion de fonction, essentielle en biologie synthétique, est également difficile à définir. L'article met en évidence la nécessité de prendre en compte l'ensemble minimal de fonctions qui caractérisent la vie avant de déterminer les plus petits génomes qui codent ces fonctions. La nature arbitraire de la définition de la vie et de la fonction complique la compréhension et la classification de ces entités. L'article suggère que la dichotomie traditionnelle entre le vivant et le non-vivant pourrait ne plus être valable et que le concept même de vie ne nécessite pas une définition scientifique précise. À mesure que la biologie synthétique progresse, l'article souligne l'importance de redéfinir ou de construire de nouvelles catégories pour englober les possibilités et créations croissantes dans le domaine. La capacité à créer de nouvelles formes de vie soulève des questions de reconnaissance, d'identification et d'implications éthiques, nécessitant une réflexion conceptuelle et philosophique au-delà des avancées techniques de la biologie synthétique. (shrink)