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Philosophy of CRISPR-Cas: Introduction to Eugene Koonin’s target paper and commentaries
Biology and Philosophy 34 (1):16 (2019)
Abstract
In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements and tolerate exogenous elements. We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.Author's Profile
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Citations of this work
What Counts as an Immune Response? On the Role of Abiotic Stress in Immunology.Sophie Juliane Veigl - 2023 - Biological Theory 18 (3):210-224.
References found in this work
Transformations of Lamarckism: From Subtle Fluids to Molecular Biology.Eva Jablonka & Snait Gissis (eds.) - 2011 - MIT Press.
Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question.Eugene V. Koonin & Petro Starokadomskyy - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 59:125-134.
Darwin's Struggle for Survival: Heredity and the Hypothesis of Natural Selection.Jean Gayon & Matthew Cobb - 1999 - Journal of the History of Biology 32 (2):413-415.
CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology.Eugene V. Koonin - 2019 - Biology and Philosophy 34 (1):9.
The Creativity of Natural Selection? Part I: Darwin, Darwinism, and the Mutationists.John Beatty - 2016 - Journal of the History of Biology 49 (4):659-684.
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