CRISPR-Cas immunity: beyond nonself and defence

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Biology and Philosophy 34 (1):6 (2019)
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Abstract

In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements and tolerate exogenous elements. We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.

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10.1007/s10539-018-9665-8

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Photo of Thomas Pradeu
Thomas Pradeu
CNRS & University Of Bordeaux

Citations of this work

Not by structures alone: Can the immune system recognize microbial functions?Gregor P. Greslehner - 2020 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 84 (C):101336.

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References found in this work

The Immune Self: Theory or Metaphor?Alfred I. Tauber - 1994 - Cambridge University Press.
Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question.Eugene V. Koonin & Petro Starokadomskyy - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 59:125-134.

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