Privacy

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Whoever said that technology will make our lives so much simpler was sorely mistaken. In as much as technology does make our day to day existence more convenient, it also has a tendency to create complicated problems.

Take the issue of privacy. Before the digital age, protecting once privacy meant not giving out information to people you do not know. And by then information that one gives has a relatively small chance of landing in the hands of other people. However, now, we give our information to a site to avail of their services only to be surprised that we are being offered viagra via the previous site that we gave our information to. And Facebook has not been immune to this type of problem.

One problem that has been seen in the Facebook privacy setting debacle is the fact that a significant number of its users are from countries outside of the United States. That being said the issue of conflicting laws and sovereignty, and other legal problem arises in the regulation of the right to privacy. So, so much for technology simplifying our lives.


- Gino Paulo O. Uy, Entry #5

Inhaled PDE5's treat CF

Never realized the plan was to nebulize cheap cialis or levitra - always thought we would just take them as a pill. So interesting....




Expert Opin Investig Drugs. 2011 Mar 24. [Epub ahead of print]


Inhaled phosphodiesterase type 5 inhibitors for cystic fibrosis: a new therapy for systemic disease?



University of Medicine and Pharmacy "Gr.T.Popa" Iasi, Department of Internal Medicine II-Pulmonary Disease, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, 700115 Iasi, Romania +40 232 
239408 ; +40 232 270918 ; sabina.antonela.antoniu@pneum.umfiasi.ro.

Abstract



Cystic fibrosis is a rare disease characterized by abnormalities in chloride and sodium transmembrane transportation due to various mutations in the cystic fibrosis transmembrane regulator (CFTR) gene, F508del being the most commonly found. Corrective therapies for this defect are currently under investigation and PDE5 inhibitors such as sildenafil or vardenafil were found to improve CFTR activity in vitro as well as in vivo. This paper evaluates a study investigating the effects of inhaled PDE5 inhibitors in an animal model of F508del cystic fibrosis, demonstrating that in this new formulation, such compounds are also able to improve CFTR function. Such results support the further development of this therapy for a systemic disease such as cystic fibrosis, provided several issues are addressed.
PMID: 21434839 [PubMed - as supplied by publisher

How We Know What Isn't So by Thomas Gilovich

A break from fiction this week, to consider Gilovich's important book, subtitled 'The Fallibility of Human Reason in Everyday Life'. As this suggests it is a study of why we tend to believe certain things (with lots of examples of popular misconceptions from everyday life), despite the lack of evidence for them or, in many cases, solid evidence that they are not true. A couple of points to clarify before anyone starts getting defensive: the book doesn't belittle people for what they believe, it just analyses the basis for such beliefs; and little is said about religion.

A common problem is the misunderstanding of statistics, especially probability theory, which can sometimes produce counter-intuitive results. A well-known example of this is the answer to the question "how many people do you need in a room in order to get a 50% chance that two of them will have the same birthday?" The answer is 23; and what's more, you only need 35 for the probability to rise to 85%. Most people find this amazing (I did too, despite some limited experience of probability theory). One reason for misunderstanding statistics is the clustering tendency of random events. If you toss a coin and it comes up heads five times in succession, you might think this is remarkable, but it is in fact inevitable if you keep tossing the coin long enough: the "50/50" rule only applies over a long series.

As a result of this lack of understanding, people experience coincidences which are well within normal probabilities and wrongly believe that something remarkable has happened, or even that they can't really be coincidences at all but must have some greater significance. This is exacerbated by the fact that humans have an inbuilt tendency to seek patterns in events, to the extent of seeing them where they don't exist.

A lack of contrary information can lead to unwarranted beliefs. For example, a selection board which interviews candidates for an academic or training scheme may believe that they are doing a good job, because the majority of their choices perform well. But they have no way of knowing how well the people they rejected would have performed, given the chance. In fact, research into the selection process has shown that "decisions based on objective criteria alone are at least as effective as those influenced by subjective impressions formed in an interview".

We are often misled by information we receive second hand, because of the tendency to "sharpen and level", as the author puts it. By this he means that in relaying a news item, for instance, we tend to emphasise the points which we consider to be important (or which we believe) and downplay or omit other aspects. So if a carefully-written report comes to a tentative conclusion which we agree with, but wraps this around with qualifications and caveats, we tend just to relay the conclusions, making the results appear far more definite than the report's authors intended. As people "sharpen" different aspects of information to suit their beliefs, so we get a rapid polarisation of opinions on controversial issues. Even worse, some organisations deliberately "sharpen and level" because they want to turn public opinion in their favour [popular news media and politicians are of course notorious for presenting such selectively slanted information, especially during election campaigns, but so do many organisations with agendas]. Most "urban legends" probably develop as a result of an extreme version of this, with the key points pulled out and exaggerated.

This sharpening effect is exacerbated by the fact that if we hold certain beliefs, we are likely to discuss them only with people who agree with us, and only to read supportive publications. Our beliefs are thereby rarely challenged but instead are constantly reinforced, so we tend to end up with the view that our beliefs are naturally and obviously right. Anyone who disagrees with them must therefore be entirely mistaken and possibly downright stupid if not malevolent. This polarisation is obvious today in politics and in debates about other controversial issues. In reality, of course, situations are rarely as polarised as this: we exaggerate differences.

A major reason for many misplaced beliefs is that notable events stick in our minds, whereas we are much less likely to remember when something did not happen. This can distort our understanding of the likelihood of particular events. For example, it is commonly believed that a previously infertile couple is much more likely to conceive after they have adopted a child. A careful analysis of a mass of birth and adoption statistics shows that there is no truth in this at all; there is no such effect. People believe that there is because if a couple does conceive after adoption it is a notable event likely to be commented on and remembered. Conversely, no-one remembers the couples who did not conceive after adoption, or those who eventually conceived without adoption (who may well not have publicised their fertility problems).

A related issue is that if we hold certain beliefs, we are much more likely to seize on and remember any events which appear to confirm those beliefs, while dismissing and quickly forgetting any contrary evidence. Even if we do spend time examining contrary evidence, it is usually only to attack it aggressively and try to find fault with it, while we accept at face value anything which appears to support our beliefs.

A major explanation for our beliefs is that we tend to believe what we would like to be true. An obvious example is life after death. It would be wonderful if our personalities and intelligence survived in some way after death, which accounts for some of the most powerfully-held human beliefs: most people really want to believe this. More generally, there is a yearning for order and purpose in life, a wish to believe that there is more to it than meets the eye. Many find the concept that we are here (individually and collectively) only by random chance in a vast and uncaring universe simply unacceptable. They feel that it makes them, and life itself, pointless and worthless, so they instinctively reject it, leading them to dismiss, for instance, the overwhelming evidence for evolution in favour of beliefs which have no evidential support at all.

A belief in extra-sensory perception is also widespread (and a very common theme of SFF) but, as the author points out, no evidence for it has ever survived any objective analysis. Some promoters of the idea claim that trying to measure it prevents it from working, which sceptics might regard as a self-serving way of avoiding the need to provide any proof. There are various reasons for a belief in ESP, including a long history of plausible fraudsters and a very biased coverage in relevant news media, books and magazines (the vast majority of which uncritically support the idea), but the basic reason is probably that it's something that we would love to be true – for us to have such impressive and useful powers. I suspect that a belief in an alien origin of UFOs falls into the same category.

A similar example concerns alternative medicine in general, and faith healing in particular. For people (especially if seriously ill) who have not been helped by conventional medicine, there is a powerful motivation to believe anyone who offers a potential cure. Examples of "cures" are seized upon as proof, ignoring the fact that the body has a potent self-repairing system and that many ailments clear up by themselves given time. Alternative medicine also often relies on plausible (but false) similarities. The classic case is the enthusiasm in some parts of the world for medicines incorporating ground-up rhino horn to use as a kind of alternative cheap cialis – simply because it's long and hard and stands up all the time. More controversially (because it concerns our culture's popular beliefs rather than another's) the author points out that homeopathy falls into the same category; there is no validated evidence that it works, and no logical reason why it should [it makes the rhino horn notion look relatively sensible].

We have a remarkable capacity for self-delusion when it suits us. A survey of one million US high school seniors showed that 70% believed that they were above average in leadership ability, and only 2% that they were below average [much the same results occur in surveys which invite people to rate their own driving ability].

A final point: the perception of human fallibility in understanding is not exactly new. The book includes a couple of quotes from Francis Bacon, the 16th/17th century philosopher:

"The human understanding supposes a greater degree of order and equality in things than it really finds; and although many things in nature be sui generis and most irregular, will yet invest parallels and conjugates and relatives where no such thing is." Which is to say in simpler modern language, that we tend to see patterns and relationships where none exist.

and:

"…all superstition is much the same whether it be that of astrology, dreams, omens, retributive judgment, or the like…[in that] the deluded believers observe events which are fulfilled, but neglect or pass over their failure, though it be much more common."

In this review I have only had space to provide a very superficial summary of a few highlights, but Gilovich's book is packed full of examples and detailed explanations, so if this kind of thing intrigues you, go and find a copy!

Watermelon is nature's Viagra

Watermelon is nature's Viagra



If you thought watermelon is just a fruit that refreshes parched throats, here’s something you should know - the juicy fruit has ingredients that deliver Viagra-like effects to the body’s blood vessels and may even increase libido.

The finding results from a study led by an Indian researcher in US. “The more we study watermelons, the more we realize just how amazing a fruit it is in providing natural enhancers to the human body,” said Dr. Bhimu Patil, director of Texas A&M’s Fruit and Vegetable Improvement Center. "We’ve always known that watermelon is good for you, but the list of its very important health benefits grows longer with each study,” he added.

Beneficial ingredients in watermelon and other fruits and vegetables are known as phyto-nutrients, naturally occurring compounds that are bioactive, or able to react with the human body to trigger healthy reactions, Patil said. In watermelons, these include lycopene, beta carotene and the rising star among its phyto-nutrients – citrulline, whose beneficial functions are now being unraveled. It has the ability to relax blood vessels, much like cheap cialis does.

Scientists know that when watermelon is consumed, citrulline is converted to arginine through certain enzymes. Arginine is an amino acid that works wonders on the heart and circulation system and maintains a good immune system, Patil said. “The citrulline-arginine relationship helps heart health, the immune system and may prove to be very helpful for those who suffer from obesity and type 2 diabetes,” said Patil. “Arginine boosts nitric oxide, which relaxes blood vessels, the same basic effect that cialis has, to treat erectile dysfunction and maybe even prevent it,” he added.

While there are many psychological and physiological problems that can cause impotence, extra nitric oxide could help those who need increased blood flow, which would also help treat angina, high blood pressure and other cardiovascular problems.
“Watermelon may not be as organ specific as Viagra, but it’s a great way to relax blood vessels without any drug side-effects,” Patil said.

The benefits of watermelon don’t end there, he said. Arginine also helps the urea cycle by removing ammonia and other toxic compounds from our bodies. Citrulline, the precursor to arginine, is found in higher concentrations in the rind of watermelons than the flesh.

- Times of India.

Pubmed indexed 637 research articles on watermelon. Below are latest 20 articles.

1: Tarachiwin L, Masako O, Fukusaki E.
Quality Evaluation and Prediction of Citrullus lanatus by (1)H NMR-Based
Metabolomics and Multivariate Analysis.
J Agric Food Chem. 2008 Jun 28. [Epub ahead of print]
PMID: 18588311

2: van Breemen RB, Pajkovic N.
Multitargeted therapy of cancer by lycopene.
Cancer Lett. 2008 Jun 26. [Epub ahead of print]
PMID: 18585855

3: Bangalore DV, McGlynn WG, Scott DD.
Effects of fruit maturity on watermelon ultrastructure and intracellular lycopene
distribution.
J Food Sci. 2008 Jun;73(5):S222-8.
PMID: 18577014

4: Gholamalizadeh R, Vahdat A, Keshavarz T, Elahinia A, Bananej K.
Occurrence and distribution of ten viruses infecting cucurbit plants in guilan
province, iran.
Acta Virol. 2008;52(2):113-8.
PMID: 18564898

5: Wechter WP, Levi A, Harris KR, Davis AR, Fei Z, Katzir N, Giovannoni JJ,
Salman-Minkov A, Hernandez A, Thimmapuram J, Tadmor Y, Portnoy V, Trebitsh T.
Gene expression in developing watermelon fruit.
BMC Genomics. 2008 Jun 5;9:275.
PMID: 18534026

6: Wells CD, Harrison ME, Gurudu SR, Crowell MD, Byrne TJ, Depetris G, Sharma VK.
Treatment of gastic antral vascular ectasia (watermelon stomach) with endoscopic
band ligation.
Gastrointest Endosc. 2008 Jun 2. [Epub ahead of print]
PMID: 18533150

7: Farooq Z, Iqbal Z, Mushtaq S, Muhammad G, Iqbal MZ, Arshad M.
Ethnoveterinary practices for the treatment of parasitic diseases in livestock in
Cholistan desert (Pakistan).
J Ethnopharmacol. 2008 Jul 23;118(2):213-9. Epub 2008 Mar 29.
PMID: 18524514

8: Kumar S, Kumar D, Jusha M, Saroha K, Singh N, Vashishta B.
Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.)
Schrad. methanolic fruit extract.
Acta Pharm. 2008 Jun 1;58(2):215-221.
PMID: 18515231

9: Marie I, Ducrotte P, Antonietti M, Herve S, Levesque H.
Watermelon stomach in systemic sclerosis: its incidence and management.
Aliment Pharmacol Ther. 2008 May 21. [Epub ahead of print]
PMID: 18498445

10: Asero R, Monsalve R, Barber D.
Profilin sensitization detected in the office by skin prick test: a study of
prevalence and clinical relevance of profilin as a plant food allergen.
Clin Exp Allergy. 2008 Jun;38(6):1033-7. Epub 2008 Apr 13.
PMID: 18489029

11: Yakoubi S, Lecoq H, Desbiez C.
Algerian watermelon mosaic virus (AWMV): a new potyvirus species in the PRSV
cluster.
Virus Genes. 2008 Aug;37(1):103-9. Epub 2008 May 17.
PMID: 18484176

12: Hoelmer KA, Simmons AM.
Yellow sticky trap catches of parasitoids of Bemisia tabaci (Hemiptera:
Aleyrodidae) in vegetable crops and their relationship to in-field populations.
Environ Entomol. 2008 Apr;37(2):391-9.
PMID: 18419911

13: Vonderheide AP, Bernard CE, Hieber TE, Kauffman PE, Morgan JN, Melnyk LJ.
Surface-to-food pesticide transfer as a function of moisture and fat content.
J Expo Sci Environ Epidemiol. 2008 Apr 16. [Epub ahead of print]
PMID: 18414514

14: Mullai K, Jebanesan A, Pushpanathan T.
Mosquitocidal and repellent activity of the leaf extract of Citrullus vulgaris
(cucurbitaceae) against the malarial vector, Anopheles stephensi liston (diptera
culicidae).
Eur Rev Med Pharmacol Sci. 2008 Jan-Feb;12(1):1-7.
PMID: 18401966 [PubMed - indexed for MEDLINE]

15: Mort A, Zheng Y, Qiu F, Nimtz M, Bell-Eunice G.
Structure of xylogalacturonan fragments from watermelon cell-wall pectin.
Endopolygalacturonase can accommodate a xylosyl residue on the galacturonic acid
just following the hydrolysis site.
Carbohydr Res. 2008 May 19;343(7):1212-21. Epub 2008 Mar 20.
PMID: 18394594

16: Pieroni A, Gray C.
Herbal and food folk medicines of the Russlanddeutschen living in
Künzelsau/Taläcker, South-Western Germany.
Phytother Res. 2008 Jul;22(7):889-901.
PMID: 18384192

17: Vaughn Katherine LS, Clausen Edgar C, King Jerry W, Howard Luke R, Julie CD.
Extraction conditions affecting supercritical fluid extraction (SFE) of lycopene
from watermelon.
Bioresour Technol. 2008 Nov;99(16):7835-41. Epub 2008 Apr 2.
PMID: 18378137

18: Bailey SL, Chang SC, Griffiths B, Graham AN, Saffery R, Earle E, Choo KH,
Kalitsis P.
ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger,
mammalian centromere protein.
Chromosoma. 2008 Mar 28. [Epub ahead of print]
PMID: 18369653

19: Sreenath K, Venkatesh YP.
Analysis of erythritol in foods by polyclonal antibody-based indirect competitive
ELISA.
Anal Bioanal Chem. 2008 Mar 28. [Epub ahead of print]
PMID: 18369603

20: Salman-Minkov A, Levi A, Wolf S, Trebitsh T.
ACC synthase genes are polymorphic in watermelon (Citrullus spp.) and
differentially expressed in flowers and in response to auxin and gibberellin.
Plant Cell Physiol. 2008 May;49(5):740-50. Epub 2008 Mar 26.
PMID: 18367517

Watermelon is nature's Viagra

Watermelon is nature's Viagra



If you thought watermelon is just a fruit that refreshes parched throats, here’s something you should know - the juicy fruit has ingredients that deliver Viagra-like effects to the body’s blood vessels and may even increase libido.

The finding results from a study led by an Indian researcher in US. “The more we study watermelons, the more we realize just how amazing a fruit it is in providing natural enhancers to the human body,” said Dr. Bhimu Patil, director of Texas A&M’s Fruit and Vegetable Improvement Center. "We’ve always known that watermelon is good for you, but the list of its very important health benefits grows longer with each study,” he added.

Beneficial ingredients in watermelon and other fruits and vegetables are known as phyto-nutrients, naturally occurring compounds that are bioactive, or able to react with the human body to trigger healthy reactions, Patil said. In watermelons, these include lycopene, beta carotene and the rising star among its phyto-nutrients – citrulline, whose beneficial functions are now being unraveled. It has the ability to relax blood vessels, much like order cialis does.

Scientists know that when watermelon is consumed, citrulline is converted to arginine through certain enzymes. Arginine is an amino acid that works wonders on the heart and circulation system and maintains a good immune system, Patil said. “The citrulline-arginine relationship helps heart health, the immune system and may prove to be very helpful for those who suffer from obesity and type 2 diabetes,” said Patil. “Arginine boosts nitric oxide, which relaxes blood vessels, the same basic effect that cheap cialis has, to treat erectile dysfunction and maybe even prevent it,” he added.

While there are many psychological and physiological problems that can cause impotence, extra nitric oxide could help those who need increased blood flow, which would also help treat angina, high blood pressure and other cardiovascular problems.
“Watermelon may not be as organ specific as Viagra, but it’s a great way to relax blood vessels without any drug side-effects,” Patil said.

The benefits of watermelon don’t end there, he said. Arginine also helps the urea cycle by removing ammonia and other toxic compounds from our bodies. Citrulline, the precursor to arginine, is found in higher concentrations in the rind of watermelons than the flesh.

- Times of India.

Pubmed indexed 637 research articles on watermelon. Below are latest 20 articles.

1: Tarachiwin L, Masako O, Fukusaki E.
Quality Evaluation and Prediction of Citrullus lanatus by (1)H NMR-Based
Metabolomics and Multivariate Analysis.
J Agric Food Chem. 2008 Jun 28. [Epub ahead of print]
PMID: 18588311

2: van Breemen RB, Pajkovic N.
Multitargeted therapy of cancer by lycopene.
Cancer Lett. 2008 Jun 26. [Epub ahead of print]
PMID: 18585855

3: Bangalore DV, McGlynn WG, Scott DD.
Effects of fruit maturity on watermelon ultrastructure and intracellular lycopene
distribution.
J Food Sci. 2008 Jun;73(5):S222-8.
PMID: 18577014

4: Gholamalizadeh R, Vahdat A, Keshavarz T, Elahinia A, Bananej K.
Occurrence and distribution of ten viruses infecting cucurbit plants in guilan
province, iran.
Acta Virol. 2008;52(2):113-8.
PMID: 18564898

5: Wechter WP, Levi A, Harris KR, Davis AR, Fei Z, Katzir N, Giovannoni JJ,
Salman-Minkov A, Hernandez A, Thimmapuram J, Tadmor Y, Portnoy V, Trebitsh T.
Gene expression in developing watermelon fruit.
BMC Genomics. 2008 Jun 5;9:275.
PMID: 18534026

6: Wells CD, Harrison ME, Gurudu SR, Crowell MD, Byrne TJ, Depetris G, Sharma VK.
Treatment of gastic antral vascular ectasia (watermelon stomach) with endoscopic
band ligation.
Gastrointest Endosc. 2008 Jun 2. [Epub ahead of print]
PMID: 18533150

7: Farooq Z, Iqbal Z, Mushtaq S, Muhammad G, Iqbal MZ, Arshad M.
Ethnoveterinary practices for the treatment of parasitic diseases in livestock in
Cholistan desert (Pakistan).
J Ethnopharmacol. 2008 Jul 23;118(2):213-9. Epub 2008 Mar 29.
PMID: 18524514

8: Kumar S, Kumar D, Jusha M, Saroha K, Singh N, Vashishta B.
Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.)
Schrad. methanolic fruit extract.
Acta Pharm. 2008 Jun 1;58(2):215-221.
PMID: 18515231

9: Marie I, Ducrotte P, Antonietti M, Herve S, Levesque H.
Watermelon stomach in systemic sclerosis: its incidence and management.
Aliment Pharmacol Ther. 2008 May 21. [Epub ahead of print]
PMID: 18498445

10: Asero R, Monsalve R, Barber D.
Profilin sensitization detected in the office by skin prick test: a study of
prevalence and clinical relevance of profilin as a plant food allergen.
Clin Exp Allergy. 2008 Jun;38(6):1033-7. Epub 2008 Apr 13.
PMID: 18489029

11: Yakoubi S, Lecoq H, Desbiez C.
Algerian watermelon mosaic virus (AWMV): a new potyvirus species in the PRSV
cluster.
Virus Genes. 2008 Aug;37(1):103-9. Epub 2008 May 17.
PMID: 18484176

12: Hoelmer KA, Simmons AM.
Yellow sticky trap catches of parasitoids of Bemisia tabaci (Hemiptera:
Aleyrodidae) in vegetable crops and their relationship to in-field populations.
Environ Entomol. 2008 Apr;37(2):391-9.
PMID: 18419911

13: Vonderheide AP, Bernard CE, Hieber TE, Kauffman PE, Morgan JN, Melnyk LJ.
Surface-to-food pesticide transfer as a function of moisture and fat content.
J Expo Sci Environ Epidemiol. 2008 Apr 16. [Epub ahead of print]
PMID: 18414514

14: Mullai K, Jebanesan A, Pushpanathan T.
Mosquitocidal and repellent activity of the leaf extract of Citrullus vulgaris
(cucurbitaceae) against the malarial vector, Anopheles stephensi liston (diptera
culicidae).
Eur Rev Med Pharmacol Sci. 2008 Jan-Feb;12(1):1-7.
PMID: 18401966 [PubMed - indexed for MEDLINE]

15: Mort A, Zheng Y, Qiu F, Nimtz M, Bell-Eunice G.
Structure of xylogalacturonan fragments from watermelon cell-wall pectin.
Endopolygalacturonase can accommodate a xylosyl residue on the galacturonic acid
just following the hydrolysis site.
Carbohydr Res. 2008 May 19;343(7):1212-21. Epub 2008 Mar 20.
PMID: 18394594

16: Pieroni A, Gray C.
Herbal and food folk medicines of the Russlanddeutschen living in
Künzelsau/Taläcker, South-Western Germany.
Phytother Res. 2008 Jul;22(7):889-901.
PMID: 18384192

17: Vaughn Katherine LS, Clausen Edgar C, King Jerry W, Howard Luke R, Julie CD.
Extraction conditions affecting supercritical fluid extraction (SFE) of lycopene
from watermelon.
Bioresour Technol. 2008 Nov;99(16):7835-41. Epub 2008 Apr 2.
PMID: 18378137

18: Bailey SL, Chang SC, Griffiths B, Graham AN, Saffery R, Earle E, Choo KH,
Kalitsis P.
ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger,
mammalian centromere protein.
Chromosoma. 2008 Mar 28. [Epub ahead of print]
PMID: 18369653

19: Sreenath K, Venkatesh YP.
Analysis of erythritol in foods by polyclonal antibody-based indirect competitive
ELISA.
Anal Bioanal Chem. 2008 Mar 28. [Epub ahead of print]
PMID: 18369603

20: Salman-Minkov A, Levi A, Wolf S, Trebitsh T.
ACC synthase genes are polymorphic in watermelon (Citrullus spp.) and
differentially expressed in flowers and in response to auxin and gibberellin.
Plant Cell Physiol. 2008 May;49(5):740-50. Epub 2008 Mar 26.
PMID: 18367517