Twin Bathtubs Are Not Sexy


Those viagra cialis online pharmacy pharmacy bathtubs are driving me crazy.

Do you know what I'm referring to? I'm referring to those Cialis commercials that I see on CNN and MSNBC all the time. I always feel very young when I watch those two channels, because a lot of the commercials are geared towards people that need some sort of prescription medication for one malady or another, that the young never experience.

I don't need Cialis, nor any of the other drugs featured in the commercials (yet), so it makes me feel younger than I am (I'm 40). Watching a 24-hour news channel is like taking a dip in the Fountain of Youth for me. After all, you don't see Cialis commercials on MTV or VH1.

Cialis is a drug used by men who have erectile dysfunction, which explains why it's on CCN, because if it were on MTV, the drug in-need would be an erectile inhibitor.

And to give you an idea whom these commercials are geared to, there is always a subtitle that says, "See our ad in Golf Digest".

The Cialis spots always show a middle-aged or borderline-elderly man with an attractive woman whom we presume to be his wife. They smile with each other, hold hands, link arms, do some light dancing, maybe they're walking through an open field, hiking in the hills, or strolling barefoot on the beach.

No matter what geographical setting they may be in, they always end up sitting next to each other in separate, but equal, bathtubs. Side-by-side bathtubs. Big, claw-footed, white porcelain bathtubs. Like the ones that Queen Victoria and Prince Albert likely sat in to get themselves in the mood for some hot Victorian sex. How sexy. THAT will get my erection in gear.

Every commercial is a tad bit different... the twin bathtubs could be sitting on the edge of a cliff, offering the couple a panoramic view of a canyon... or they could be on the dock of lake, offering a view of the water... or they could be on the shore, with waves approaching the clawed-feet of the tubs. Last night I saw one where the bathtubs were actually IN the water, like, in a very shallow pond, if I recall correctly... perhaps in the marshlands of Louisiana.

That was really aggravating. Why be sitting in bathtubs when the bathtubs themselves are IN water?!? What's the use? That's like playing in a sandbox in the middle of the desert. It's unnecessary. Why then? Because it's sexier? More romantic?

I mean, last October, I was in Puerto Vallarta Mexico, on the beach, swimming in the water as the sun was setting. It was beautiful, like a Cialis commerical (because it's always sunset on the beach in a Cialis commercial).

However, never once did I want to get out of the warm water of the Pacific with its soft undulations, and get into a BATHTUB on the shoreline. And I was alone. Had I been with someone I loved, I would have wanted to be in the open waters, touching and caressing and embracing as the sun set, not separated by porcelain. Doing it in the open waters, with close bodily contact would make me go from flaccid to erect much more quickly than sitting separately in a tub.

Come to think of it, maybe these fictional men in these commercials don't have erectile dysfunction at all. Maybe they can't get it up because they are really hapless and lacking in good sense when it comes to creating a romantic atmosphere for their wife.

You see, I've taken a bath in a bathtub before, and I know that very soon, the water goes from being very warm to lukewarm, and then to room temperature, which to the body doesn't feel like room temperature, it feels COLD. This can be remedied though, because little drain below the faucet always lets a little water go away, so I keep adding more hot water in the tub to keep the water warm.

But even with doing this, staying in the tub for a long time is not desirable. My fingers and toes start to prune, and the residual soap in the water covers my arms and chest with an unpleasant film. Soon, I open the drain, and wash the soapy water off of me by standing up and turning on the shower. None of this is sexy to me.

Not that having sex in a bathtub with someone is NOT sexy. It can be very sexy, if both of you can comfortably fit in the bathtub. But: you must both be in the SAME BATHTUB. After all, you never see people making out in separate jacuzzis. They are in the same jacuzzi.

But forget romance. Let's talk logistics.

I look at these couples in the commercials, sitting in their bathtubs, out in the middle of Nature, far from any plumbing. Somehow, they must have lugged gallons and gallons of piping hot water to the top of that cliff, or to the middle of that field, or to the edge of that lake, to the shore of that beach. The water HAD to have been piping hot, because once you pour it into the porcelain tubs, OUTDOORS, the water's heat will slowly be taken away by the breeze (or quickly taken away by the wind), so the water will need to be boiling, in order to remain lukewarm for more than 20 minutes.

But let's say these married couples DO somehow transport gallons of boiling water into the great outdoors. Did they at the same time transport the bathtubs? Do you have any idea how much a 6-foot long, 3-foot deep, porcelain, claw-footed bathtub weighs? I don't, but I imagine it weighs a lot. But you don't only have to transport one, you've gotta move TWO out there, along with the water...

...the whole ordeal reminds me of those documentaries about Stonehenge and Easter Island, where the experts try to figure out how those ancient peoples were able to transport those heavy slabs of stone from the quarry to their location. I always feel like the archaelogists in those documentaries. I always think, "How did that ancient couple manage dragging those bathtubs out there?"

And then what? I mean, once you've avoided a hernia and third-degree water burns, then what? You sit in the tub next to your lady love, and look at the ocean... or the lake... or the pond... or the field... or the canyon... or the marshlands... and in 30 minutes, the water is freezing, your fingers look like raisins...

...and your penis is shriveled up.

GOOD THING YOU TOOK THAT CIALIS!

PSI-7977, our uridine nucleotide polymerase inhibitor for HCV, received fast track designation from

Good Morning,

This morning we announced that PSI-7977, our uridine nucleotide polymerase online pharmacy viagra for HCV, received fast track designation from the FDA. As a reminder, three AASLD abstracts have been accepted on PSI-7977 and we are on track to initiate a 12 week Phase 2b trial in the 4Q10.

Please call with any questions.

Best,

Richard

Richard E. T. Smith. PhD I Pharmasset, Inc I 609 865 0693(c)

PSI-7977 Receives Fast Track Designation from the FDA for the Treatment of Chronic Hepatitis C Infection



PRINCETON, NJ – (August 12, 2010) – Pharmasset, Inc. (Nasdaq: VRUS) has received fast track designation from the U.S. Food and Drug Administration (FDA) for PSI-7977 for the treatment of chronic hepatitis C virus (HCV) infection. PSI-7977 is an oral uridine nucleotide analog polymerase inhibitor of HCV. Pharmasset recently completed dosing in a 28 day Phase 2a trial to evaluate PSI-7977 in combination with Pegasys (pegylated interferon) plus Copegus (ribavirin) in treatment-naive patients chronically infected with HCV genotype 1. Pharmasset expects to initiate a 12-week Phase 2b study of PSI-7977 in the fourth quarter of 2010.

Under the FDA Modernization Act of 1997, fast track designation may facilitate the development and expedite the review of a drug candidate that is intended for the treatment of a serious and life-threatening condition and demonstrates the potential to address an unmet medical need for such a condition. PSI-7977 was granted the fast track designation primarily due to the need for HCV treatments with novel mechanisms of action, oral administration, different resistance profiles and improved safety and efficacy over the existing standard of care for both treatment-naive and treatment-experienced patients.

"The FDA's fast track designation for PSI-7977 acknowledges the urgent need for new HCV drugs," stated Dr. Michael Rogers, Pharmasset's Chief Development Officer. "Currently, there are no HCV nucleoside/tide inhibitors approved for the treatment of chronic HCV infection. We continue to work closely with the FDA on the development and regulatory review of PSI-7977, which has demonstrated compelling antiviral activity, a high barrier to resistance and has been generally well-tolerated in clinical trials to date."

About Pharmasset

Pharmasset is a clinical-stage pharmaceutical company committed to discovering, developing, and commercializing novel drugs to treat viral infections. Pharmasset's primary focus is on the development of oral therapeutics for the treatment of hepatitis C virus (HCV) and, secondarily, on the development of Racivir(TM) for the treatment of human immunodeficiency virus (HIV). Our research and development efforts focus on nucleoside/tide analogs, a class of compounds which act as alternative substrates for the viral polymerase, thus inhibiting viral replication. We currently have four clinical-stage product candidates. RG7128, a cytosine nucleoside analog for chronic HCV infection, is in two Phase 2b clinical studies in combination with Pegasys(R) plus Copegus(R) and is also in the INFORM studies, the first series of studies designed to assess the potential of combinations of small molecules without Pegasys(R) and Copegus(R) to treat chronic HCV. These clinical studies are being conducted through a strategic collaboration with Roche. Our other clinical stage HCV candidates include PSI-7977, an unpartnered uracil nucleotide analog that has recently completed 28 days of dosing in a Phase 2a study, and PSI-938, an unpartnered guanosine nucleotide analog in a Phase 1 study. We also have in our pipeline an additional purine nucleotide analog, PSI-661, in advanced preclinical development. Racivir, for the treatment of HIV, has completed a Phase 2 clinical study.



Pegasys® and Copegus® are registered trademarks of Roche.



Contact

Richard E. T. Smith, Ph.D.

VP, Investor Relations and Corporate Communications

richard.smith@pharmasset.com

Office: +1 (609) 613-4181



Forward-Looking Statements

Pharmasset “Safe Harbor” Statement under the Private Securities Litigation Reform Act of 1995: Statements in this press release that are not historical facts are “forward-looking statements,” including, without limitation, statements that involve risks, uncertainties, and other important factors, including, without limitation, the risk of cessation or delay of any of the ongoing or planned clinical trials and/or our development of our product candidates, the risk that the results of previously conducted studies involving our product candidates will not be repeated or observed in ongoing or future studies involving our product candidates, the risk that our collaboration with Roche will not continue or will not be successful, and the risk that any one or more of our product candidates will not be successfully developed and commercialized. For a discussion of risks, uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled "Risk Factors" in our Annual Report on Form 10-K for the fiscal year ended September 30, 2009 and our Quarterly Reports on Form 10-Q for the periods ended December 31, 2009, March 31, 2010 and June 30, 2010 filed with the Securities and Exchange Commission and discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the Securities and Exchange Commission.








Richard E. T. Smith, Ph.D.
VP, Investor Relations & Corp. Communications
Pharmasset, Inc.
(w) 609 613 4181
(c) 609 865 0693
(fax) 609 613 4150

Diario de una mujer madura:

DÍA 1
Hoy celebramos el 20º aniversario de matrimonio. Intentamos revivir nuestra Luna de Miel, pero él no pudo...La cosa está muy jodida...no se le paró...

DÍA 2
Hoy él me contó "dizque" su gran secreto... ¡Está medio impotente! Gran novedad..., el huevón piensa que yo no me daba cuenta...

DÍA 3Este matrimonio va mal.... Toda mujer tiene sus necesidades..., hay una edad en que deseas hacerlo...a esta edad el sexo salvaje es una tentación desgarradora...

DÍA 4
Estoy entusiasmada... va a ir al médico para que le receten el viagra a ver si puede resolver nuestro problema y va a cambiar el Prozac (antidepresivo) que toma, por cheap cialis, con la esperanza que le levante algo más que el entusiasmo...

DÍA 5
¡Una bendición del cielo!, ¡Resultó mejor de lo esperado!, casi había olvidado lo rico que Q..lea mi marido...

DÍA 6
¡Hayyyyy La vida es maravillosa!...qué polvazo me pegó el desgraciado...

DÍA 7
¡Tengo que confesar que el Viagra ha sido muy bueno! ¡Nunca fui tan feliz!

DÍA 8
Creo que él ha exagerado la dosis de Viagra en este fin de semana...
Comienzo a estar un poco adolorida en las partes bajas...¡hasta el cu.... me arde!...No sabía que mi marido era tan bravoo...

DÍA 9
Hola... No tengo tiempo para escribir...El me puede agarrar en cualquier momento, porque está siempre caliente.

DÍA 10
¡Ok, Lo admito, estoy escondida!...¡Ninguna mujer puede aguantar tanto!
¿Qué voy a hacer? Estoy toda molida de tanta verga.

DÍA 11
¡YA NO AGUANTO MAS!
¡Es lo mismo que ir a la cama con un taladro Black & Decker!, ¡Esta mañana me desperté debajo de la cama!, ¡Me imagino que el antepasado más próximo de este hijueputa fue un conejo o un cuy!

DÍA 12
Dios Mio...no se que hacer para calmarlo...Dejé de maquillarme, de bañarme, de lavarme los dientes..., le pongo hielo en los calzoncillos pero a él no le importa..., me persigue...,¡Se convirtió en un peligro!....Siempre anda con el pájaro parado.

DÍA 13
Cada vez que cierro los ojos, me clava de nuevo...¡Vivo con un misil Scud! Ya no puedo ni caminar...me duele hasta el pelo...

DÍA 14
He hecho cualquier cantidad de cosas para que me deje en paz, pero de nada sirve...Hasta me vestí como una monja, pero fue peor... Se vistió de cura y hasta por debajo de la sotana me dio y por el asterisco. ¡¡Socoooorroooooooo!!

DÍA 15
¡Huy! Voy a terminar matándo a este hijueputa...Tengo unos dolores infernales al sentarme, estoy coloradita , coloradita...El perro y el gato salen corriendo al verlo...Creo que ya se los tiro también pooobress.

DÍA 16
Hoy le sugerí al cabrón que suspendiera el Viagra y volviera a tomar Prozac..., ¡casi me asesinaaaa!.

DÍA 17
Hoy le puse Prozac en la caja del Viagra, pero parece que no le hace efecto...
¡Hay Dios...Ahí viene otra vez ese cabrón, ya me tiene traumada lo veo como policia, viene con la vara por delante, moviéndolo para todos los lados y con mirada de loco perverso!...Yo me escondo...

DÍA 18
¡El Prozac comenzó finalmente a hacerle efecto al cabrón!...,Hay que paz y tranquilidad.... ¡sobre todo para mi aporreado culito, me estoy poniendo hielo para desinflamarlo!, Ahora si, mi marido pasa el día entero sentado frente al televisor, con el control remoto en la mano...mirando su fútbol y el History Channel otra vez...y preguntando qué vamos a cenar hoy...mientras bebe su cervecita de siempre...tiene una cara de huevon que no puede con ella...

¡Oh! Qué vida tan tranquila y maravillosa...¡Qué buena es la normalidad!...soy feliz...



¿QUIEN ENTIENDE A LAS MUJERES?

A Combination Of Grapefruit And Prescription Medication May Be A Deadly Mix



By Dr. Michael Pritsker, DC

If you are taking certain medications and eat grapefruit or drinking grapefruit juice you may be a ticking time bomb. I read a true story that shocked and surprised me. I bet it will shock and surprise you too. Here is why this is so surprising. In this story, a retired gentleman spends his summers up north and winters in the south as many do. This is what natives call a snowbird in the east coast. Two months after coming to sunny Florida, this retiree dropped dead. Doctors believe the cause was a deadly interaction between the two to three glasses of fresh grapefruit juice he drank everyday and his cialis that he took also. Drinking grapefruit juice and eating grapefruit can be deadly for people who take certain medications, according to a paper. In this particular case of the snowbird, the fatal interaction is believed to be between the grapefruit and Lipitor.

The victim had high cholesterol and other risk factors for heart disease. For this, doctors put him on Lipitor and he began a diet and exercise program. Two weeks after going to Florida for the winter, he went to the emergency room complaining of muscle pains, fatigue and fever. That's where he went into kidney failure and died. Although experts know the problem exists, most laymen and health care professionals are still in the dark about the deadly risks, even though the FDA requires all prospective new drugs to be tested for interactions with grapefruit juice, and a warning about grapefruit juice is included in the "food-drug interactions" that come with dozens of medications.

Since grapefruit juice is metabolized by the same enzyme in the liver that breaks down many drugs that are taken, it is one of the foods most likely to cause interactions with drugs. When the system is overloaded with too much, scientists said the grapefruit juice can swamp the system, keeping the liver from doing its complete job. It blocks it from breaking down drugs and other substances.

Scientists say that the most severe effects are likely with some statins. While the liver devotes its resources to the grapefruit juice, the medication can build up to dangerous levels. This causes a breakdown of the body's muscles and even kidney failure. This eventually can lead to death.

So here is a tip. If you are taking any prescription medication especially when it comes to statin drugs, be sure to ask your primary doctor about the possible interactions with grapefruit juice. You should also read the warning labels on your medication bottle. Even though there may be a lot of fine print in these labels, it could make the difference between life and death.

Why do you think there is so much fine print in the first place? This is because all drugs have toxic side effects. That is not to say they don't save lives and are not needed in certain situations. Clearly they do and are. But, the goal of real health should be to have your body function properly without drugs, or at least with as little drugs as humanly possible. How? Through proper diet, exercise, stress management and chiropractic care. I recently read a quote from a famous NFL coach, Jimmy Johnson. He said something like this: There are more things that can go bad with a passing play, than a running play. That's why, when in doubt, if at all possible, run the ball. I have the same philosophy with health. If at all possible, do it naturally.

About the Author:
Want to find out more about nutrition, then visit Dr. Michael Pritsker, DC's site on how to choose the best chiropractor for your needs.

kinase profiling | Tasocitinib | AC220 | FMS inhibitor

| Tasocitinib | AC220 | FMS cheap cialis

Synthetic organic chemist focuses on the small-cell inhibitors just to find out some remedies on the ongoing developmental research for cancer and various other chronic inflammatory diseases. Due to their over whelming consideration on such molecules an increasing graph can be seen in the developmental process.  What exactly the chemists are doing is that they are just finding the actual process of exploiting such molecules just for a detailed study on cell signaling. Each and every molecule has several importance on cell signaling.





Basically the chemists concentrate on the various specificities of such kinase cheap cialis to bring out better result. It is also a fact that a number of molecules do not have any such specifications that can be used for the treatment of dreadful disease called cancer. This is also the part of the chemists that they categorize such non specific molecules. Categorization is important for further process within time and with a quick action.



Verification on several molecules and their specifications are important to bring out solutions of different synthetic problems. Well established laboratories and the high tech equipments are essential to carry on such experiments. http://www.synkinase.com/ is undoubtedly a helpful one in terms of keeping yourself very updated and well informed. Protein kinase inhibitors are the latest focus for the chemists and it is very important to have a well equipped laboratory to carry on the whole process of research on the specifications of molecules. This website not only gives you a detailed concept over the molecules but also can inform you the latest continuation on research on the molecules.



Protein kinase c is an important molecule for the research and developmental process on cancer in the recent days. Chemists are constantly doing their work on finding some special norm on such molecules. A good support and establishment always can encourage them and they can do justice over the work. These molecules actually regulate the activity of other molecules.





http://www.synkinase.com/ is a very good assistance for all the researchers to do their experiments in finding answers. This guidance can really help a lot in discovering new drugs with such molecules.



http://www.synkinase.com/  has published this post to provide you a good guidance on the research process on the specifications of kinase molecules.



kinase profiling | Tasocitinib | AC220 | FMS inhibitor

| Tasocitinib | AC220 | FMS cheap cialis

Synthetic organic chemist focuses on the small-cell inhibitors just to find out some remedies on the ongoing developmental research for cancer and various other chronic inflammatory diseases. Due to their over whelming consideration on such molecules an increasing graph can be seen in the developmental process.  What exactly the chemists are doing is that they are just finding the actual process of exploiting such molecules just for a detailed study on cell signaling. Each and every molecule has several importance on cell signaling.





Basically the chemists concentrate on the various specificities of such kinase cialis to bring out better result. It is also a fact that a number of molecules do not have any such specifications that can be used for the treatment of dreadful disease called cancer. This is also the part of the chemists that they categorize such non specific molecules. Categorization is important for further process within time and with a quick action.



Verification on several molecules and their specifications are important to bring out solutions of different synthetic problems. Well established laboratories and the high tech equipments are essential to carry on such experiments. http://www.synkinase.com/ is undoubtedly a helpful one in terms of keeping yourself very updated and well informed. Protein kinase inhibitors are the latest focus for the chemists and it is very important to have a well equipped laboratory to carry on the whole process of research on the specifications of molecules. This website not only gives you a detailed concept over the molecules but also can inform you the latest continuation on research on the molecules.



Protein kinase c is an important molecule for the research and developmental process on cancer in the recent days. Chemists are constantly doing their work on finding some special norm on such molecules. A good support and establishment always can encourage them and they can do justice over the work. These molecules actually regulate the activity of other molecules.





http://www.synkinase.com/ is a very good assistance for all the researchers to do their experiments in finding answers. This guidance can really help a lot in discovering new drugs with such molecules.



http://www.synkinase.com/  has published this post to provide you a good guidance on the research process on the specifications of kinase molecules.