Alley's Hepatitis C

I apologize for the adult material appearing on this list. I'll try to remove it.

Alley

В США успешно завершились исследования принципиально новых препаратов от гепатита С, сообщает Nature. Фармацевтические компании Merck и Vertex Pharmaceuticals заявили об окончании поздней фазы клинических испытаний боцепревира и телапревира соответственно.

В настоящее время для лечения гепатита С используются неспецифические противовирусные лекарства в комбинации с интерфероном-α. Несмотря на то, что большинство больных выздоравливает после годичного курса этих лекарств, используемые препараты вызывают ряд серьезных побочных эффектов, в том числе анемию, простудные заболевания, депрессию.

Оба новых препарата относятся к группе ингибиторов протеазы. Они блокируют действие этого фермента, в результате чего нарушается процесс синтеза вирусных белков. По результатам клинических испытаний, у двух третей больных гепатитом С после 48 недель приема боцепревира в комбинации с традиционной схемой лечения концентрации вирусной РНК в крови снизилась до лабораторно неопределяемого уровня. При этом некоторые пациенты успешно завершили курс через 28-36 недель после начала лечения.

Телапревир также испытывался в комбинации со стандартной схемой лечения. По результатам исследований, значительное снижение концентрации вирусной РНК наблюдалось у 72 процентов участников после 24 недель использования нового препарата. Наиболее высокие шансы выздоровления были зафиксированы в группе пациентов, действие нового лекарства у которых начало проявляться на 4-12 неделе лечения.

Merck и Vertex планируют подать документы на регистрацию разработанных препаратов от гепатита С в Управление по контролю за продуктами и лекарствами США (FDA) до конца 2010 года. Фармкомпании рассчитывают получить одобрение надзорных органов к середине 2011 года. По словам экспертов, в случае выхода на рынок объем продаж новых лекарств может достигнуть 15 миллиардов долларов к 2017 году.
http://www.headlines.ru/gorss.php?http://medportal.ru/mednovosti/news/2010/08/16/hepcdrugs/

I am feeling lazy today. We were supposed to have a young man come rake leaves today and he didn't show up - can't blame him because it is drizzly and cold. He knocked on our door yesterday afternoon and offered.. Jim said he was about 10 years old and his parent/adult was driving him in a mini-van... $25.00 for our front yard(worth it). Jim said okay... he is probably needing Christmas money. Said he'd be back today about the same time. A no show LOL. WE HAVE A LOT OF LEAVES TOO! But like I said it is cold and wet.

We'll give him another chance before we rake our leaves. (we? LOL I mean Jim)

I'm sure our neighbors to the right of us would really like us to rake... they have raked several times already. Why? Let them all fall first. I personally love them. I love walking in them.

Didn't get the boys this weekend and Tonya was supposed to bring Shelby by for her birthday present... but didn't show either.

I think tonight will be a early to bed... I am cold and sleepy. I am dreading work tomorrow... yuck!

Friday is my liver doc appt... I was supposed to take my last shot this past Friday and skipped it. I am done for awhile... I need a break!

Well gonna close and check e-mail.

(I know this was a boring post but just felt I needed to post something)

http://www.hepatitis-central.com/m…

An interesting development with the new alpha-interferon they've been testing.

I have read about this drug a few times, but I can't remember if any of the studies are with HCV1's. I know one of them was a HCV2 group and they were like SVR'd for ever.

Just thought you might appreciate it. Read carefully cause it can get a little confusing.

I'm not quite sure what to think of this abstract, but I just thought some of you would want to know, they are wondering about it.

http://www.hepatitis-central.com/m…

Please don't flame the messenger ;-). I just like to try to keep people informed, and as with anything in science and medicine, nothing is definite.

Have any of you had a problem with headaches during treatment? I've been having migraine-like headaches for about a week.

I talked to my gastro doc; he says if they don't abate, he may discontinue treatment and that severe headaches are not common side effects. He also suggested talking to my regular doc, so I have an appointment with her on Monday.

Any help would be appreciated.

Thanks!

Hey gang,
Just wanted to take a moment to introduce myself. I'm 32, Hep C type 1 positive, currently in my second attempt at treatment.
things are going okay, and at the moment, I'm at zero load, though who knows if that will continue (we all know what this virus is like).
Looking forward to getting to know you guys. I don't know why it took me so long to search for group with this topic, duh!

if there is an auto-injector available for any of the hcv injectables? Like an Epi Pen??

Thanks

Hi all. My name is Tess and I'm 22. Just a few days ago, I was told that my third annual STD blood tests came back Hep C positive (the qualitative/antibodies test if I understand this right). My gyno (who recently added HCV to her testing) referred me to get more extensive testing (the quantitative one I believe) to see where the disease is. My appointment with my GP is next week.

This news is completely crushing for me, as another health problem is the polar opposite of what I need right now. The past three months I have been recovering well from a surgery to cure Conn's Syndrome (caused by a tumorous, cyst-producing, hemmoraging left adrenal gland, which is now gone). In addition, I have two autoimmune diseases that have developed over the past 5 or 6 years - Hashimoto's Thyroiditis and lichen planus (in my gums). I was tired of these problems already... now there's more on my plate.

Previous to this week's news, I had been trying to figure out a connection between my various medical conditions. I see an endocrinologist, and she has been great in helping me get my thyroid back on track and she helped me find a surgeon who was willing to remove my adrenal gland. But neither she nor my other doctors have ever sought to put what I'm convinced is a puzzle together. Has anyone here had autoimmune problems with their HCV? Is anyone familiar with evidence supporting these ideas?

In addition, I have been trying to deal with the feelings of anger I have been experiencing - toward myself for putting loved ones at risk because I didn't know and toward the universe. I also feel ashamed, and I don't want many people to know. I know that sharing health issues is a very personal decision, but any advice on breaking news such as "I have HCV" would be appreciated. I am also terrified of future relationships, as I don't want to break news to someone that I have something they could catch potentially.

Hey everyone

Hopefully this won’t come across as advertising, but I was invited to beta test this site you all might want to check out. It’s called www.lovehealz.com and is basically a mix between Myspace and eHarmony specifically for people with Hepatitis C and other illnesses. They said they are going to be donating millions of dollars to charities like the International AIDS Vaccine Initiative and the American Social Health Association! That’s really why I wanted to post here.

It seems like they’re supporting a really great cause and could really use some additional opinions to make it work.


Here’s the beta code to sign up: RFBETA06
Hope to see you there!

-Jason