FlyBase Gene Report: Dmel\Atg2

General Information

Symbol

Dmel\Atg2

Species

D. melanogaster

Name

Autophagy-related 2

Annotation Symbol

CG1241

Feature Type

protein_coding_gene

FlyBase ID

FBgn0044452

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Also Known As

Autophagy-specific gene 2

Key Links

Genomic Location

Cytogenetic map

62F3-62F4

Sequence location

3L:2,774,338..2,780,677 [+]

Recombination map

3-4

RefSeq locus

NT_037436 REGION:2774338..2780677

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables phosphatidylinositol-3-phosphate binding

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

enables protein-membrane adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

Biological Process (13 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in cellular response to starvation

inferred from mutant phenotype

(Zirin et al., 2013)

involved_in glycophagy

inferred from mutant phenotype

(Zirin et al., 2013)

involved_in larval midgut cell programmed cell death

inferred from mutant phenotype

(Xu et al., 2015, Chang et al., 2013)

involved_in larval midgut histolysis

inferred from mutant phenotype

(Denton et al., 2009)

involved_in macroautophagy

inferred from mutant phenotype

(Xu et al., 2015, Chang et al., 2013, Pircs et al., 2012, Scott et al., 2004)

involved_in mitophagy

inferred from mutant phenotype

(Xu et al., 2019)

involved_in wound healing

inferred from high throughput mutant phenotype

(Campos et al., 2010)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in autophagosome assembly

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

involved_in autophagy of mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

involved_in autophagy

inferred from electronic annotation with InterPro:IPR026849

(InterPro Project Members, 2004-)

involved_in glycophagy

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

involved_in pexophagy

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

involved_in piecemeal microautophagy of the nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

involved_in reticulophagy

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in phagophore assembly site

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

located_in phagophore assembly site

inferred from sequence or structural similarity with SGD:S000005186

(Gene Ontology Curators, 2002-)

is_active_in phagophore

inferred from biological aspect of ancestor with PANTHER:PTN000324023

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES

Protein Family (UniProt)

Protein Signatures (InterPro)

Autophagy-related protein 2

Summaries

Gene Snapshot

Autophagy-related 2 (Atg2) encodes a protein known to be required for autophagy. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

AUTOPHAGY-RELATED GENES -: The Autophagy-related genes (Atg), characterized extensively in yeast, are a set of approximately twenty evolutionarily conserved genes required for autophagy. Autophagy (specifically, macroautophagy) is the process of bulk degradation of cytoplasmic material. It takes place by the assembly of a double membrane vesicle, the autophagosome, which delivers cargo to the lysosome for recycling. (Adapted from FBrf0219844 and FBrf020902).

Summary (Interactive Fly)

a component of the Vps34 lipid kinase complex that is required for the formation of PI3P - functions in vesicle trafficking including autophagy and endocytosis - involved in stress, metabolic and immune signaling pathways - binds to Rab18 - promotes niche occupancy by bam mutant stem cells - Zonda, an Atg6 interactor, is critically required for starvation-induced autophagy - UVRAG interacts with Atg6 and together they promote autophagy - required for endolysosomal degradation and epithelial polarity during wing development

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Atg2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VZX7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Atg2-RA

FBtr0072970

NM_139491

6259

1906

Atg2-RB

FBtr0333441

NM_001274412

6266

1906

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Atg2-PA

FBpp0072840

214.9

1906

5.33

FBpp0305632

214.9

1906

5.33

Q9VZX7

NP_001261341

AGB94036

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1906 aa isoforms: Atg2-PA, Atg2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Autophagy-related protein 2

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Atg2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.57

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

salivary gland

(Lee et al., 2003)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

adult head

(Simonsen et al., 2008)

Additional Descriptive Data

qRT-PCR of adult female heads assayed at weekly intervals shows that transcript levels remain fairly constant.

(Simonsen et al., 2008)

The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.

(Lee et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Atg2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Atg2

View exonic expression by tissue for Dmel\Atg2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0044452

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38344/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044452

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044452

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044452

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1241

Flygut - An atlas of the Drosophila adult midgut

FBgn0044452

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Atg2

Transgenic constructs containing regulatory region of Atg2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)Exel6091

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of larval stage | recessive

Atg2^EP3697

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage | female, with Scer\GAL4^Mef2.PU

Atg2^KK100148

abnormal locomotor behavior | adult stage | male, with Scer\GAL4^Mef2.PU

Atg2^KK100148

abnormal neuroanatomy

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

Atg2^EP3697

abnormal size | P-stage, with Scer\GAL4^NP0001

Atg2^JF02786

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

Atg2^JF02786

decreased cell death | P-stage, with Scer\GAL4^NP0001

Atg2^JF02786

short lived, with Scer\GAL4^Act88F.PU

Atg2^KK100148

short lived, with Scer\GAL4^Mef2.PU

Atg2^KK100148

short lived, with Scer\GAL4^tin.CΔ4

Atg2^KK100148

some die during larval stage | recessive

Atg2^EP3697

Phenotype manifest in

Allele

adult heart muscle cell | day 40 of adulthood, with Scer\GAL4^Mef2.PU

Atg2^KK100148

adult heart muscle cell | progressive, with Scer\GAL4^Mef2.PU

Atg2^KK100148

anterior fascicle & synapse, with Scer\GAL4^elav-C155

Atg2^EP3697

autophagosome | :chemical conditional | nutrition conditional

Atg2^JF02786

autophagosome | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Atg2^HMS01198

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

Atg2^HMS01198

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PU

Atg2^JF02786

embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

Atg2^JF02786

embryonic/larval fat body | third instar larval stage (with Df(3L)BSC119)

Atg2^EP3697

embryonic/larval midgut

Atg2^unspecified

embryonic/larval midgut | P-stage, with Scer\GAL4^NP0001

Atg2^JF02786

embryonic/larval midgut | P-stage (with Df(3L)Exel6091)

Atg2^EP3697

gastric caecum | P-stage, with Scer\GAL4^NP0001

Atg2^JF02786

indirect flight muscle cell | day 40 of adulthood, with Scer\GAL4^Mef2.PU

Atg2^KK100148

larval intersegmental nerve, with Scer\GAL4^elav-C155

Atg2^EP3697

mitochondrion | adult stage, with Scer\GAL4^Mef2.PU

Atg2^KK100148

mitochondrion | adult stage | day 40 of adulthood, with Scer\GAL4^Mef2.PU

Atg2^KK100148

neuromuscular junction

Atg2^EP3697

neuron

Atg2^unspecified

NMJ bouton

Atg2^EP3697

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\ATG2B

14 of 14

Yes

Hsap\ATG2A

13 of 14

Yes

Hsap\VPS13A

1 of 14

Hsap\VPS13D

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Atg2a

12 of 14

Yes

Rnor\Atg2b

11 of 14

Yes

Rnor\Vps13a

1 of 14

Rnor\Vps13d

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Atg2a

13 of 14

Yes

Mmus\Atg2b

13 of 14

Yes

Mmus\Vps13d

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\atg2b

11 of 13

Yes

Xtro\atg2a

10 of 13

Yes

Xtro\abl2

1 of 13

Xtro\vps13d

1 of 13

Danio rerio (Zebrafish) (3)

Drer\atg2a

12 of 14

Yes

Drer\atg2b

7 of 14

Yes

Drer\vps13c

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\atg-2

13 of 14

Yes

Cele\T08G11.1

1 of 14

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004092

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\ATG2

8 of 13

Yes

Atha\AT1G48090

1 of 13

Atha\AT4G17140

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ATG2

8 of 13

Yes

Scer\VPS13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\atg2

7 of 12

Yes

Spom\vps13a

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Atg2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Atg2^HMS01198

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Atg2^JF02786

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Cunningham et al., 2020)

Atg2^UAS.cUa

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Bakhoum et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ATG2B; autophagy related 2B

14 of 14

616226

ATG2A; autophagy related 2A

13 of 14

616225

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Atg2 - orb

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Rojas-Ríos et al., 2015)

protein-protein

Physical Interaction

Assay

References

Atg2 - Atg18a

anti tag coimmunoprecipitation, anti tag western blot

(Nagy et al., 2014)

Atg2 - Atg18b

anti tag coimmunoprecipitation, anti tag western blot

(Nagy et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

bchs

suppressible

Atg2

(Simonsen et al., 2007)

suppressible

(Kim et al., 2010)

enhanceable

(Shen and Ganetzky, 2009)

suppressible

(Zhu et al., 2017)

suppressible

(Tian et al., 2011)

rpr

suppressible

Atg2

(Ikegawa et al., 2023)

synr

suppressible

Atg2

(Ikegawa et al., 2023)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0044452

MIST (protein-protein) - An integrated Molecular Interaction Database

38344

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-4

Cytogenetic map

62F3-62F4

Sequence location

3L:2,774,338..2,780,677 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62F3-62F4

Limits computationally determined from genome sequence between P{PZ}Spn⁰⁶⁹¹¹ and P{PZ}l(3)06803⁰⁶⁸⁰³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-4

(FlyBase, 2016)

3-5.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27706

y¹ v¹; P{TRiP.JF02786}attP2

80827

y¹, v¹; P{TKO.GS04634}attP40

17156

w¹¹¹⁸; P{EP}Atg2^EP3697/TM6B, Tb¹

34719

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01198}attP2

605515

y¹ w^*; TI{KozakGAL4}Atg2^{CR71440-KO-kG4}/TM3, Sb¹ Ser¹

Kyoto

105468

y^* w^*; P{GawB}Atg2^NP7457 / TM6, P{UAS-lacZ.UW23-1}UW23-1

NIG-Fly

1241R-1

P{NIG.1241R}1

1241R-3

P{NIG.1241R}3

HMS01198

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01198}attP2

VDRC

v330026

P{VSH330026}attP40

v108447

P{KK100148}VIE-260B

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (27)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0044452

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0044452

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG1241 EP3697

(Scott et al., 2004)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Atg2 CG1241

(Scott, 2005.3.2, Scott et al., 2004)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

ATG2

(Wang et al., 2025, Song et al., 2020, Yang et al., 2020, Kamalesh et al., 2017, Bakhoum et al., 2014, Shen and Codogno, 2011, Kourtis and Tavernarakis, 2009, Scott, 2005.3.2)

Atg2

(Bradic and Rewitz, 2025, Qin et al., 2025, Zhang et al., 2025, Isaacson et al., 2024, Xu et al., 2024, Bland, 2023, Demir and Kacew, 2023, Ikegawa et al., 2023, Wang et al., 2023, Ciesielski et al., 2022, Huang et al., 2022, Marshall and Dionne, 2022, Varga et al., 2022, Xu et al., 2022, Bonfini et al., 2021, Gerenu et al., 2021, Laczkó-Dobos et al., 2021, Rosendo Machado et al., 2021, Barthez et al., 2020, Cunningham et al., 2020, Funikov et al., 2020, Gohel et al., 2020, Rodriguez-Fernandez et al., 2020, Xu et al., 2020, Aparicio et al., 2019, Meltzer et al., 2019, Xu et al., 2019, Billes et al., 2018, Clark et al., 2018, Gene Disruption Project members, 2018-, O'Keefe and Denton, 2018, Pandey et al., 2018, Bali and Shravage, 2017, Galluzzi et al., 2017, Kim et al., 2017, Lei et al., 2017, Manent et al., 2017, Péan et al., 2017, Transgenic RNAi Project members, 2017-, Kuleesha et al., 2016, Zheng et al., 2016, Denton et al., 2015, Kim et al., 2015, Kuhn et al., 2015, Nagy et al., 2015, Rodriguez-Fernandez and Dell'Angelica, 2015, Rojas-Ríos et al., 2015, Xu et al., 2015, Zang et al., 2015, Zhang and Baehrecke, 2015, Zirin et al., 2015, Banreti et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Chang et al., 2013, Denton et al., 2013, Takáts et al., 2013, Zirin et al., 2013, Denton et al., 2012, Érdi et al., 2012, Garcia et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Pircs et al., 2012, Qin et al., 2011, Tian et al., 2011, Chang and Neufeld, 2010, Kim et al., 2010, Denton et al., 2009, Liu and Lehmann, 2008, Simonsen et al., 2008, Martin et al., 2007, Zeitouni et al., 2007)

CG1241

(El Fissi et al., 2024, Meadows, 2017.1.11, Érdi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Lee et al., 2003)

EP3697

atg2

(Zhao et al., 2023, Joy et al., 2021, Singh and Chowdhuri, 2018, Zhang et al., 2016, Kwon et al., 2013, Campos et al., 2010, Shelly et al., 2009, Shen and Ganetzky, 2009, Simonsen et al., 2007)

Name Synonyms

Autophagy-related 2

Autophagy-specific gene 2

(Scott, 2005.3.2, Scott et al., 2004, Scott et al., 2004)

Secondary FlyBase IDs

FBgn0035373

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38344

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VZX7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VZX7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0044452

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38344/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0044452

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0044452

FlyMine - An integrated database for Drosophila genomics

FBgn0044452

InterPro - A database of protein families, domains and functional sites

Autophagy-related protein 2

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1241

MARRVEL_MODEL - MARRVEL (model organism gene)

38344

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0044452

DroID - A comprehensive database of gene and protein interactions.

FBgn0044452

DRSC - Results frm RNAi screens

FBgn0044452

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Atg2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0044452

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0044452

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1241

Flygut - An atlas of the Drosophila adult midgut

FBgn0044452

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC016380

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

38344

References (131)

The following external sites may use different assemblies or annotations than FlyBase.

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