FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\spo
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General Information
Symbol
Dmel\spo
Species
D. melanogaster
Name
spook
Annotation Symbol
CG10594
Feature Type
protein_coding_gene
FlyBase ID
FBgn0003486
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Cyp307a1

Key Links
Genomic Location
Cytogenetic map
64D5-64D5
Sequence location
Recombination map
3-14
RefSeq locus
NT_037436 REGION:5590083..5592571
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables heme binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396
(InterPro Project Members, 2004-)
inferred from sequence model
(Ono et al., 2006)
enables iron ion binding
(InterPro Project Members, 2004-)
enables monooxygenase activity
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396
(InterPro Project Members, 2004-)
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
(InterPro Project Members, 2004-)
enables oxidoreductase activity
inferred from sequence model
(Ono et al., 2006)
Biological Process (9 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
involved_in central nervous system development
inferred from mutant phenotype
(Giesen et al., 2003)
involved_in cuticle development
inferred from mutant phenotype
(Ono et al., 2006)
involved_in dorsal closure
inferred from mutant phenotype
(Ono et al., 2006, Giesen et al., 2003)
involved_in ecdysone biosynthetic process
inferred from mutant phenotype
(Chanut-Delalande et al., 2014, Ono et al., 2006)
involved_in embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(Ono et al., 2006)
involved_in embryonic digestive tract development
inferred from mutant phenotype
(Ono et al., 2006)
involved_in head involution
inferred from mutant phenotype
(Ono et al., 2006, Giesen et al., 2003)
involved_in midgut development
inferred from mutant phenotype
(Giesen et al., 2003)
involved_in oogenesis
inferred from mutant phenotype
(Ono et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endoplasmic reticulum
inferred from direct assay
(Ono et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome P450 family. (Q9VRM7)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
spook (spo) encodes a cytochrome P450 involved in ecdysteroid biosynthesis in the embryo. spo mutants fail to undergo head involution, dorsal closure or to secrete cuticle. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
CYTOCHROME P450 - CYP2 CLAN -
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP2 clan includes D. melanogaster CYP18 and CYP303-307 family genes. CYP2 members have diverse roles and are widely considered as "environmental response genes" in mammalian species. (Adapted from FBrf0248421.)
Protein Function (UniProtKB)
Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.
(UniProt, Q9VRM7)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
spo: spook
Embryonic lethal. No differentiation of cuticle and mouthparts.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\spo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VRM7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.45

Gene model reviewed during 5.57

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
spo-RA
FBtr0077130
NM_139718
2187
543
spo-RC
FBtr0346640
NM_001300014
2489
543
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
spo-PA
FBpp0076836
62.4
543
7.74
Q9VRM7
NP_647975
AAF50766
spo-PC
FBpp0312220
62.4
543
7.74
Q9VRM7
NP_001286943
AHN57968
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

543 aa isoforms: spo-PA, spo-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.27

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 3
(Namiki et al., 2005)
embryonic stage 3 -- 6
yolk
(Chung et al., 2009)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 5
yolk nucleus
(Namiki et al., 2005)
organism | striped
(Namiki et al., 2005)
embryonic stage 7 -- 8
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012, Namiki et al., 2005)
embryonic stage 13 -- 16
amnioserosa
(Fisher et al., 2012)
oogenesis stage S14
follicle cell
(Namiki et al., 2005)
Additional Descriptive Data

spo transcript is initially detected in stage 3 embryos, and is localized to the ventral side of the embryo. By stage 5, spo transcript is localized to the yolk, and in a striped pattern in the developing epithelium. At extended germ band stage, spo transcript is expressed in the amnioserosa. Embryonic expression strongly decreases after embryonic stage 11. In adult females, spo is strongly expressed in mature follicle cells.

(Namiki et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endoplasmic reticulum
inferred from direct assay
(Ono et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\spo in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of spo
Transgenic constructs containing regulatory region of spo
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (22)
Hsap\CYP1B1
4 of 14
Yes
Yes
Hsap\CYP1A1
3 of 14
No
Yes
Hsap\CYP1A2
3 of 14
No
Yes
Hsap\CYP2A6
3 of 14
No
No
Hsap\CYP2A13
3 of 14
No
No
Hsap\CYP2B6
3 of 14
No
No
Hsap\CYP2C8
3 of 14
No
No
Hsap\CYP2C9
3 of 14
No
No
Hsap\CYP2C18
3 of 14
No
No
Hsap\CYP2C19
3 of 14
No
No
Hsap\CYP2D6
3 of 14
No
No
2  
Hsap\CYP2D7
3 of 14
No
No
Hsap\CYP2E1
3 of 14
No
No
Hsap\CYP2F1
3 of 14
No
No
Hsap\CYP2J2
3 of 14
No
No
Hsap\CYP2R1
3 of 14
No
No
Hsap\CYP2S1
3 of 14
No
No
Hsap\CYP2U1
3 of 14
No
No
Hsap\CYP2W1
3 of 14
No
No
Hsap\CYP2A7
2 of 14
No
No
Hsap\CYP17A1
2 of 14
No
Yes
Hsap\CYP21A2
2 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (47)
Rnor\Cyp1b1
4 of 14
Yes
Yes
Rnor\Cyp1a1
3 of 14
No
Yes
Rnor\Cyp2a1
3 of 14
No
No
Rnor\Cyp2a2
3 of 14
No
No
Rnor\Cyp2ac1
3 of 14
No
No
Rnor\Cyp2c7
3 of 14
No
No
Rnor\Cyp2c11
3 of 14
No
No
Rnor\Cyp2c13
3 of 14
No
No
Rnor\Cyp2c24
3 of 14
No
No
Rnor\Cyp2c80
3 of 14
No
No
Rnor\Cyp2d1
3 of 14
No
No
Rnor\Cyp2d2
3 of 14
No
No
Rnor\Cyp2d3
3 of 14
No
No
Rnor\Cyp2d4
3 of 14
No
No
Rnor\Cyp2d5
3 of 14
No
No
Rnor\Cyp2e1
3 of 14
No
No
Rnor\Cyp2f4
3 of 14
No
No
Rnor\Cyp2j3
3 of 14
No
No
Rnor\Cyp2j4
3 of 14
No
No
Rnor\Cyp2j10
3 of 14
No
No
Rnor\Cyp2j16
3 of 14
No
No
Rnor\Cyp2r1
3 of 14
No
No
Rnor\Cyp2u1
3 of 14
No
No
Rnor\Cyp2w1
3 of 14
No
Yes
Rnor\LOC100361492
3 of 14
No
No
Rnor\Cyp1a2
2 of 14
No
No
Rnor\Cyp2a3
2 of 14
No
No
Rnor\Cyp2ab1
2 of 14
No
No
Rnor\Cyp2b1
2 of 14
No
No
Rnor\Cyp2b2
2 of 14
No
No
Rnor\Cyp2b3
2 of 14
No
No
Rnor\Cyp2b12
2 of 14
No
No
Rnor\Cyp2b15
2 of 14
No
No
Rnor\Cyp2b21
2 of 14
No
No
Rnor\Cyp2c6v1
2 of 14
No
No
Rnor\Cyp2c12
2 of 14
No
No
Rnor\Cyp2c22
2 of 14
No
No
Rnor\Cyp2c23
2 of 14
No
No
Rnor\Cyp2g1
2 of 14
No
No
Rnor\Cyp2s1
2 of 14
No
No
Rnor\Cyp2t1
2 of 14
No
No
Rnor\LOC100361547
2 of 14
No
No
Rnor\LOC103691072
2 of 14
No
No
Rnor\LOC103691092
2 of 14
No
No
Rnor\Cyp17a1
1 of 14
No
No
Rnor\Cyp21a1
1 of 14
No
No
Rnor\LOC100912265
1 of 14
No
Yes
Mus musculus (laboratory mouse) (54)
Mmus\Cyp1a1
3 of 14
Yes
Yes
Mmus\Cyp1a2
3 of 14
Yes
Yes
Mmus\Cyp1b1
3 of 14
Yes
Yes
Mmus\Cyp2a12
3 of 14
Yes
No
Mmus\Cyp2a22
3 of 14
Yes
No
Mmus\Cyp2c29
3 of 14
Yes
No
Mmus\Cyp2c37
3 of 14
Yes
No
Mmus\Cyp2c38
3 of 14
Yes
No
Mmus\Cyp2c39
3 of 14
Yes
No
Mmus\Cyp2c40
3 of 14
Yes
No
Mmus\Cyp2c50
3 of 14
Yes
No
Mmus\Cyp2c54
3 of 14
Yes
No
Mmus\Cyp2c55
3 of 14
Yes
No
Mmus\Cyp2c65
3 of 14
Yes
No
Mmus\Cyp2c66
3 of 14
Yes
No
Mmus\Cyp2c67
3 of 14
Yes
No
Mmus\Cyp2c69
3 of 14
Yes
No
Mmus\Cyp2c70
3 of 14
Yes
No
Mmus\Cyp2d9
3 of 14
Yes
No
Mmus\Cyp2d10
3 of 14
Yes
No
Mmus\Cyp2d11
3 of 14
Yes
No
Mmus\Cyp2d12
3 of 14
Yes
No
Mmus\Cyp2d22
3 of 14
Yes
No
Mmus\Cyp2d26
3 of 14
Yes
No
Mmus\Cyp2d34
3 of 14
Yes
No
Mmus\Cyp2f2
3 of 14
Yes
No
Mmus\Cyp2j5
3 of 14
Yes
No
Mmus\Cyp2j6
3 of 14
Yes
No
Mmus\Cyp2j8
3 of 14
Yes
No
Mmus\Cyp2j11
3 of 14
Yes
No
Mmus\Cyp2j12
3 of 14
Yes
No
Mmus\Cyp2j13
3 of 14
Yes
No
Mmus\Cyp2r1
3 of 14
Yes
No
Mmus\Cyp2u1
3 of 14
Yes
No
Mmus\Cyp2w1
3 of 14
Yes
Yes
Mmus\Cyp2a4
2 of 14
No
No
Mmus\Cyp2a5
2 of 14
No
No
Mmus\Cyp2ab1
2 of 14
No
No
Mmus\Cyp2b9
2 of 14
No
No
Mmus\Cyp2b10
2 of 14
No
No
Mmus\Cyp2b13
2 of 14
No
No
Mmus\Cyp2b19
2 of 14
No
No
Mmus\Cyp2b23
2 of 14
No
No
Mmus\Cyp2c23
2 of 14
No
No
Mmus\Cyp2c68
2 of 14
No
No
Mmus\Cyp2d40
2 of 14
No
No
Mmus\Cyp2e1
2 of 14
No
No
Mmus\Cyp2g1
2 of 14
No
No
Mmus\Cyp2j7
2 of 14
No
No
Mmus\Cyp2j9
2 of 14
No
No
Mmus\Cyp2s1
2 of 14
No
No
Mmus\Cyp2t4
2 of 14
No
No
Mmus\Cyp17a1
1 of 14
No
No
Mmus\Cyp21a1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (52)
Xtro\cyp1b1
4 of 13
Yes
Yes
Xtro\cyp1c1
4 of 13
Yes
Yes
Xtro\cyp1a1
3 of 13
No
Yes
Xtro\cyp1d1
3 of 13
No
Yes
Xtro\cyp2a6.1
3 of 13
No
No
Xtro\cyp2a6.3
3 of 13
No
No
Xtro\cyp2a6.4
3 of 13
No
No
Xtro\cyp2a6.7
3 of 13
No
No
Xtro\cyp2a6.8
3 of 13
No
No
Xtro\cyp2c8l
3 of 13
No
No
Xtro\cyp2u1
3 of 13
No
No
Xtro\LOC100495359
3 of 13
No
No
Xtro\LOC100497899
3 of 13
No
No
Xtro\LOC116406634
3 of 13
No
No
Xtro\LOC116406636
3 of 13
No
No
Xtro\MGC69353
3 of 13
No
No
Xtro\XB5880541
3 of 13
No
No
Xtro\XB5919979
3 of 13
No
No
Xtro\crlf3
2 of 13
No
No
Xtro\cyp2a6.9
2 of 13
No
No
Xtro\cyp2c8.1
2 of 13
No
No
Xtro\cyp21a2.1
2 of 13
No
No
Xtro\LOC100491603
2 of 13
No
No
Xtro\LOC100495200
2 of 13
No
No
Xtro\LOC100497503
2 of 13
No
No
Xtro\LOC100497808
2 of 13
No
No
Xtro\panx3
2 of 13
No
No
Xtro\cyp2a6.2
1 of 13
No
No
Xtro\cyp2a6.5
1 of 13
No
No
Xtro\cyp2a6.6
1 of 13
No
No
Xtro\cyp2a13l
1 of 13
No
No
Xtro\cyp2b6
1 of 13
No
No
Xtro\cyp2c8.2
1 of 13
No
No
Xtro\cyp2c19
1 of 13
No
No
Xtro\cyp2d6
1 of 13
No
No
Xtro\cyp2e1
1 of 13
No
No
Xtro\cyp2g1p
1 of 13
No
No
Xtro\cyp2r1
1 of 13
No
No
Xtro\cyp2w1
1 of 13
No
No
Xtro\cyp17a1
1 of 13
No
Yes
Xtro\LOC100491773
1 of 13
No
No
Xtro\LOC100494106
1 of 13
No
No
Xtro\LOC100495056
1 of 13
No
No
Xtro\LOC100497034
1 of 13
No
No
Xtro\sh3glb1
1 of 13
No
No
Xtro\XB5761350
1 of 13
No
No
Xtro\XB5769266
1 of 13
No
No
Xtro\XB5798854
1 of 13
No
No
Xtro\XB5815362
1 of 13
No
No
Xtro\XB5848842
1 of 13
No
No
Xtro\XB5935727
1 of 13
No
No
Xtro\XB5952314
1 of 13
No
No
Danio rerio (Zebrafish) (48)
Drer\cyp1b1
4 of 14
Yes
Yes
Drer\cyp1c1
4 of 14
Yes
Yes
Drer\cyp1a
3 of 14
No
Yes
Drer\cyp1c2
3 of 14
No
No
Drer\cyp2aa11
3 of 14
No
No
Drer\cyp2aa12
3 of 14
No
No
Drer\cyp2ae1
3 of 14
No
No
Drer\cyp2j20
3 of 14
No
No
Drer\cyp2n13
3 of 14
No
No
Drer\cyp2p6
3 of 14
No
No
Drer\cyp2p7
3 of 14
No
No
Drer\cyp2p8
3 of 14
No
No
Drer\cyp2p9
3 of 14
No
No
Drer\cyp2p10
3 of 14
No
No
Drer\cyp2r1
3 of 14
No
No
Drer\cyp2u1
3 of 14
No
No
Drer\cyp2v1
3 of 14
No
No
Drer\cyp2x6
3 of 14
No
No
Drer\cyp2x7
3 of 14
No
No
Drer\cyp2x8
3 of 14
No
No
Drer\cyp2x9
3 of 14
No
No
Drer\cyp2x10.2
3 of 14
No
No
Drer\cyp2y3
3 of 14
No
No
Drer\cyp17a2
3 of 14
No
Yes
Drer\LOC100148115
3 of 14
No
No
Drer\cyp1d1
2 of 14
No
No
Drer\cyp2aa1
2 of 14
No
No
Drer\cyp2aa2
2 of 14
No
No
Drer\cyp2aa3
2 of 14
No
No
Drer\cyp2aa4
2 of 14
No
No
Drer\cyp2aa7
2 of 14
No
No
Drer\cyp2aa8
2 of 14
No
No
Drer\cyp2aa9
2 of 14
No
No
Drer\cyp2ad2
2 of 14
No
No
Drer\cyp2ad3
2 of 14
No
No
Drer\cyp2ad6
2 of 14
No
No
Drer\cyp2k6
2 of 14
No
No
Drer\cyp2k8
2 of 14
No
No
Drer\cyp2k16
2 of 14
No
No
Drer\cyp2k17
2 of 14
No
No
Drer\cyp2k18
2 of 14
No
No
Drer\cyp2k19
2 of 14
No
No
Drer\cyp2k22
2 of 14
No
No
Drer\cyp2x12
2 of 14
No
No
Drer\cyp17a1
2 of 14
No
Yes
Drer\LOC103909721
2 of 14
No
No
Drer\cyp21a2
1 of 14
No
No
Drer\si:dkey-286h2.3
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (44)
Cele\cyp-33B1
3 of 14
Yes
No
Cele\cyp-33C3
3 of 14
Yes
No
Cele\cyp-33C4
3 of 14
Yes
No
Cele\cyp-33C5
3 of 14
Yes
No
Cele\cyp-33C6
3 of 14
Yes
No
Cele\cyp-33C8
3 of 14
Yes
No
Cele\cyp-33C9
3 of 14
Yes
No
Cele\cyp-14A1
2 of 14
No
No
Cele\cyp-14A2
2 of 14
No
No
Cele\cyp-14A3
2 of 14
No
No
Cele\cyp-14A4
2 of 14
No
No
Cele\cyp-14A5
2 of 14
No
No
Cele\cyp-23A1
2 of 14
No
No
Cele\cyp-33A1
2 of 14
No
No
Cele\cyp-33C1
2 of 14
No
No
Cele\cyp-33C2
2 of 14
No
No
Cele\cyp-33C7
2 of 14
No
No
Cele\cyp-33C11
2 of 14
No
No
Cele\cyp-33C12
2 of 14
No
No
Cele\cyp-33D1
2 of 14
No
No
Cele\cyp-33D3
2 of 14
No
No
Cele\cyp-33E1
2 of 14
No
No
Cele\cyp-33E2
2 of 14
No
No
Cele\cyp-34A1
2 of 14
No
No
Cele\cyp-34A2
2 of 14
No
No
Cele\cyp-34A5
2 of 14
No
No
Cele\cyp-34A6
2 of 14
No
No
Cele\cyp-34A7
2 of 14
No
No
Cele\cyp-34A8
2 of 14
No
No
Cele\cyp-34A9
2 of 14
No
No
Cele\cyp-34A10
2 of 14
No
No
Cele\cyp-35A1
2 of 14
No
No
Cele\cyp-35A2
2 of 14
No
No
Cele\cyp-35A3
2 of 14
No
No
Cele\cyp-35A4
2 of 14
No
No
Cele\cyp-35A5
2 of 14
No
No
Cele\cyp-35B1
2 of 14
No
No
Cele\cyp-35B2
2 of 14
No
No
Cele\cyp-35B3
2 of 14
No
No
Cele\cyp-35C1
2 of 14
No
No
Cele\cyp-35D1
2 of 14
No
No
Cele\cyp-36A1
2 of 14
No
No
Cele\dach-1
2 of 14
No
No
Cele\daf-9
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (12)
Agam\AgaP_AGAP001039
11 of 12
Yes
Yes
Agam\AgaP_AGAP008682
5 of 12
No
Yes
Agam\AgaP_AGAP010077
3 of 12
No
No
Agam\AgaP_AGAP004665
2 of 12
No
No
Agam\AgaP_AGAP005656
2 of 12
No
No
Agam\AgaP_AGAP005657
2 of 12
No
No
Agam\AgaP_AGAP005658
2 of 12
No
No
Agam\AgaP_AGAP005660
2 of 12
No
No
Agam\AgaP_AGAP012667
2 of 12
No
No
Agam\AgaP_AGAP003065
1 of 12
No
No
Agam\AgaP_AGAP003066
1 of 12
No
No
Agam\AgaP_AGAP003067
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (150)
Atha\C4H
2 of 13
Yes
No
Atha\CYP71A13
2 of 13
Yes
No
Atha\CYP71B10
2 of 13
Yes
No
Atha\CYP71B34
2 of 13
Yes
No
Atha\CYP76C1
2 of 13
Yes
No
Atha\CYP81F2
2 of 13
Yes
No
Atha\CYP84A4
2 of 13
Yes
No
Atha\CYP98A3
2 of 13
Yes
No
Atha\CYP706A6
2 of 13
Yes
No
Atha\AT1G66540
1 of 13
No
No
Atha\AT2G12190
1 of 13
No
No
Atha\AT3G32047
1 of 13
No
No
Atha\CYP71A12
1 of 13
No
No
Atha\CYP71A14
1 of 13
No
No
Atha\CYP71A15
1 of 13
No
No
Atha\CYP71A16
1 of 13
No
No
Atha\CYP71A18
1 of 13
No
No
Atha\CYP71A19
1 of 13
No
No
Atha\CYP71A20
1 of 13
No
No
Atha\CYP71A21
1 of 13
No
No
Atha\CYP71A22
1 of 13
No
No
Atha\CYP71A23
1 of 13
No
No
Atha\CYP71A24
1 of 13
No
No
Atha\CYP71A25
1 of 13
No
No
Atha\CYP71A26
1 of 13
No
No
Atha\CYP71A27
1 of 13
No
No
Atha\CYP71A28
1 of 13
No
No
Atha\CYP71B2
1 of 13
No
No
Atha\CYP71B3
1 of 13
No
No
Atha\CYP71B4
1 of 13
No
No
Atha\CYP71B5
1 of 13
No
No
Atha\CYP71B6
1 of 13
No
No
Atha\CYP71B7
1 of 13
No
No
Atha\CYP71B8
1 of 13
No
No
Atha\CYP71B9
1 of 13
No
No
Atha\CYP71B11
1 of 13
No
No
Atha\CYP71B12
1 of 13
No
No
Atha\CYP71B13
1 of 13
No
No
Atha\CYP71B14
1 of 13
No
No
Atha\CYP71B16
1 of 13
No
No
Atha\CYP71B17
1 of 13
No
No
Atha\CYP71B19
1 of 13
No
No
Atha\CYP71B20
1 of 13
No
No
Atha\CYP71B21
1 of 13
No
No
Atha\CYP71B22
1 of 13
No
No
Atha\CYP71B23
1 of 13
No
No
Atha\CYP71B24
1 of 13
No
No
Atha\CYP71B25
1 of 13
No
No
Atha\CYP71B26
1 of 13
No
No
Atha\CYP71B28
1 of 13
No
No
Atha\CYP71B29
1 of 13
No
No
Atha\CYP71B31
1 of 13
No
No
Atha\CYP71B32
1 of 13
No
No
Atha\CYP71B35
1 of 13
No
No
Atha\CYP71B36
1 of 13
No
No
Atha\CYP71B37
1 of 13
No
No
Atha\CYP71B38
1 of 13
No
No
Atha\CYP76C2
1 of 13
No
No
Atha\CYP76C3
1 of 13
No
No
Atha\CYP76C4
1 of 13
No
No
Atha\CYP76C5
1 of 13
No
No
Atha\CYP76C6
1 of 13
No
No
Atha\CYP76C7
1 of 13
No
No
Atha\CYP76G1
1 of 13
No
No
Atha\CYP77A4
1 of 13
No
No
Atha\CYP77A6
1 of 13
No
No
Atha\CYP77A9
1 of 13
No
No
Atha\CYP77B1
1 of 13
No
No
Atha\CYP78A5
1 of 13
No
No
Atha\CYP78A6
1 of 13
No
No
Atha\CYP78A7
1 of 13
No
No
Atha\CYP78A8
1 of 13
No
No
Atha\CYP78A9
1 of 13
No
No
Atha\CYP78A10
1 of 13
No
No
Atha\CYP79A2
1 of 13
No
No
Atha\CYP79B2
1 of 13
No
No
Atha\CYP79B3
1 of 13
No
No
Atha\CYP79C1
1 of 13
No
No
Atha\CYP79C2
1 of 13
No
No
Atha\CYP79F1
1 of 13
No
No
Atha\CYP79F2
1 of 13
No
No
Atha\CYP81D1
1 of 13
No
No
Atha\CYP81D2
1 of 13
No
No
Atha\CYP81D3
1 of 13
No
No
Atha\CYP81D4
1 of 13
No
No
Atha\CYP81D5
1 of 13
No
No
Atha\CYP81D6
1 of 13
No
No
Atha\CYP81D7
1 of 13
No
No
Atha\CYP81D8
1 of 13
No
No
Atha\CYP81D11
1 of 13
No
No
Atha\CYP81F3
1 of 13
No
No
Atha\CYP81F4
1 of 13
No
No
Atha\CYP81G1
1 of 13
No
No
Atha\CYP81H1
1 of 13
No
No
Atha\CYP81K1
1 of 13
No
No
Atha\CYP81K2
1 of 13
No
No
Atha\CYP82C2
1 of 13
No
No
Atha\CYP82C3
1 of 13
No
No
Atha\CYP82C4
1 of 13
No
No
Atha\CYP82F1
1 of 13
No
No
Atha\CYP82G1
1 of 13
No
No
Atha\CYP83A1
1 of 13
No
No
Atha\CYP83B1
1 of 13
No
No
Atha\CYP89A2
1 of 13
No
No
Atha\CYP89A3
1 of 13
No
No
Atha\CYP89A5
1 of 13
No
No
Atha\CYP89A6
1 of 13
No
No
Atha\CYP89A7
1 of 13
No
No
Atha\CYP89A9
1 of 13
No
No
Atha\CYP91A2
1 of 13
No
No
Atha\CYP93D1
1 of 13
No
No
Atha\CYP98A8
1 of 13
No
No
Atha\CYP98A9
1 of 13
No
No
Atha\CYP703A2
1 of 13
No
No
Atha\CYP705A1
1 of 13
No
No
Atha\CYP705A2
1 of 13
No
No
Atha\CYP705A3
1 of 13
No
No
Atha\CYP705A4
1 of 13
No
No
Atha\CYP705A5
1 of 13
No
No
Atha\CYP705A6
1 of 13
No
No
Atha\CYP705A8
1 of 13
No
No
Atha\CYP705A9
1 of 13
No
No
Atha\CYP705A12
1 of 13
No
No
Atha\CYP705A13
1 of 13
No
No
Atha\CYP705A15
1 of 13
No
No
Atha\CYP705A18
1 of 13
No
No
Atha\CYP705A19
1 of 13
No
No
Atha\CYP705A20
1 of 13
No
No
Atha\CYP705A21
1 of 13
No
No
Atha\CYP705A22
1 of 13
No
No
Atha\CYP705A23
1 of 13
No
No
Atha\CYP705A24
1 of 13
No
No
Atha\CYP705A25
1 of 13
No
No
Atha\CYP705A27
1 of 13
No
No
Atha\CYP705A28
1 of 13
No
No
Atha\CYP705A30
1 of 13
No
No
Atha\CYP705A32
1 of 13
No
No
Atha\CYP705A33
1 of 13
No
No
Atha\CYP706A1
1 of 13
No
No
Atha\CYP706A2
1 of 13
No
No
Atha\CYP706A3
1 of 13
No
No
Atha\CYP706A4
1 of 13
No
No
Atha\CYP706A5
1 of 13
No
No
Atha\CYP706A7
1 of 13
No
No
Atha\CYP712A1
1 of 13
No
No
Atha\CYP712A2
1 of 13
No
No
Atha\FAH1
1 of 13
No
No
Atha\PAD3
1 of 13
No
No
Atha\TT7
1 of 13
No
No
Atha\UNE9
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DIT2
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:spo. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
spok
10 of 13
Cyp18a1
3 of 13
Cyp303a1
3 of 13
Cyp304a1
3 of 13
Cyp305a1
3 of 13
phtm
2 of 13
Cyp6t1
1 of 13
Cyp28c1
1 of 13
Cyp309a2
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYP1B1; cytochrome P450 family 1 subfamily B member 1
    4 of 14
    601771
    CYP1A1; cytochrome P450 family 1 subfamily A member 1
    3 of 14
    108330
        CYP1A2; cytochrome P450 family 1 subfamily A member 2
        3 of 14
        124060
            CYP2A6; cytochrome P450 family 2 subfamily A member 6
            3 of 14
            122720
            CYP2A13; cytochrome P450 family 2 subfamily A member 13
            3 of 14
            608055
                CYP2B6; cytochrome P450 family 2 subfamily B member 6
                3 of 14
                123930
                  CYP2C8; cytochrome P450 family 2 subfamily C member 8
                  3 of 14
                  601129
                    CYP2C9; cytochrome P450 family 2 subfamily C member 9
                    3 of 14
                    601130
                    CYP2C18; cytochrome P450 family 2 subfamily C member 18
                    3 of 14
                    601131
                        CYP2C19; cytochrome P450 family 2 subfamily C member 19
                        3 of 14
                        124020
                          CYP2D6; cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
                          3 of 14
                          124030
                             
                            CYP2D7; cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
                            3 of 14
                                CYP2E1; cytochrome P450 family 2 subfamily E member 1
                                3 of 14
                                124040
                                    CYP2F1; cytochrome P450 family 2 subfamily F member 1
                                    3 of 14
                                    124070
                                        CYP2J2; cytochrome P450 family 2 subfamily J member 2
                                        3 of 14
                                        601258
                                            CYP2R1; cytochrome P450 family 2 subfamily R member 1
                                            3 of 14
                                            608713
                                            CYP2S1; cytochrome P450 family 2 subfamily S member 1
                                            3 of 14
                                            611529
                                                CYP2U1; cytochrome P450 family 2 subfamily U member 1
                                                3 of 14
                                                610670
                                                CYP2W1; cytochrome P450 family 2 subfamily W member 1
                                                3 of 14
                                                615967
                                                    Functional Complementation Data
                                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                    Interactions
                                                    Summary of Physical Interactions
                                                    Interaction Browsers
                                                    Summary of Genetic Interactions
                                                    Interaction Browsers
                                                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                    Please look at the allele data for full details of the genetic interactions
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    Starting gene(s)
                                                    Interaction type
                                                    Interacting gene(s)
                                                    Reference
                                                    ouib
                                                    suppressible
                                                    spo
                                                    (Komura-Kawa et al., 2015)
                                                    spok
                                                    suppressible
                                                    spo
                                                    (Komura-Kawa et al., 2015)
                                                    External Data
                                                    Linkouts
                                                    BioGRID - A database of protein and genetic interactions.
                                                    DroID - A comprehensive database of gene and protein interactions.
                                                    Pathways
                                                    Signaling Pathways (FlyBase)
                                                    Metabolic Pathways
                                                    FlyBase
                                                    External Links
                                                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                    External Data
                                                    Linkouts
                                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                    Class of Gene
                                                    Genomic Location and Detailed Mapping Data
                                                    Chromosome (arm)
                                                    3L
                                                    Recombination map
                                                    3-14
                                                    Cytogenetic map
                                                    64D5-64D5
                                                    Sequence location
                                                    FlyBase Computed Cytological Location
                                                    Cytogenetic map
                                                    Evidence for location
                                                    64D5-64D5
                                                    Limits computationally determined from genome sequence between P{PZ}sinu06524 and P{PZ}Bre101640
                                                    Experimentally Determined Cytological Location
                                                    Cytogenetic map
                                                    Notes
                                                    References
                                                    64E-64E
                                                    (Dunkov, 2000.6.29)
                                                    Experimentally Determined Recombination Data
                                                    Location

                                                    3-14

                                                    (FlyBase, 2016)

                                                    3-13.3

                                                    (Comeron et al., 2012)

                                                    3-19

                                                    (Tearle and Nusslein-Volhard, 1987)
                                                    Left of (cM)
                                                    Right of (cM)
                                                    Notes
                                                    Stocks and Reagents
                                                    Stocks (14)
                                                    Genomic Clones (16)
                                                     

                                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                    cDNA Clones (21)
                                                     

                                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                    cDNA clones, fully sequenced
                                                    BDGP DGC clones
                                                    Other clones
                                                    Drosophila Genomics Resource Center cDNA clones

                                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                    cDNA Clones, End Sequenced (ESTs)
                                                    BDGP DGC clones
                                                    Other clones
                                                    RNAi and Array Information
                                                    Linkouts
                                                    DRSC - Results frm RNAi screens
                                                    Antibody Information
                                                    Laboratory Generated Antibodies
                                                     
                                                    Commercially Available Antibodies
                                                     
                                                    Cell Line Information
                                                    Publicly Available Cell Lines
                                                     
                                                      Other Stable Cell Lines
                                                       
                                                        Other Comments

                                                        Four EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo.

                                                        (Hummel et al., 1999)

                                                        spo mutants display no differentiation of the head skeleton or cuticle.

                                                        (Jurgens et al., 1984)
                                                        Relationship to Other Genes
                                                        Source for database merge of

                                                        Source for merge of: spo Cyp307a1

                                                        (FlyBase, 1996-)
                                                        Additional comments

                                                        spok is paralogous to spo.

                                                        (Ono et al., 2006)

                                                        Source for merge of spo Cyp307a1 was sequence comparison ( date:040503 ).

                                                        (FlyBase, 1996-)
                                                        Nomenclature History
                                                        Source for database identify of
                                                        Nomenclature comments
                                                        Etymology
                                                        Synonyms and Secondary IDs (10)
                                                        Datasets (0)
                                                        Study focus (0)
                                                        Experimental Role
                                                        Project
                                                        Project Type
                                                        Title
                                                        Study result (0)
                                                        Result
                                                        Result Type
                                                        Title
                                                        External Crossreferences and Linkouts ( 44 )
                                                        Sequence Crossreferences
                                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                        Other crossreferences
                                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                        FlyMine - An integrated database for Drosophila genomics
                                                        InterPro - A database of protein families, domains and functional sites
                                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                                        Linkouts
                                                        BioGRID - A database of protein and genetic interactions.
                                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                        DroID - A comprehensive database of gene and protein interactions.
                                                        DRSC - Results frm RNAi screens
                                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                        Flygut - An atlas of the Drosophila adult midgut
                                                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                        References (95)