FlyBase Gene Report: Dmel\a

General Information

Symbol

Dmel\a

Species

D. melanogaster

Name

arc

Annotation Symbol

CG6741

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000008

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

arc (a) encodes a protein involved in eye development. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Also Known As

bran, broad angular

Key Links

Genomic Location

Cytogenetic map

58C1-58C5

Sequence location

2R:22,136,968..22,172,834 [+]

Recombination map

2-98

RefSeq locus

NT_033778 REGION:22136968..22172834

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Liu and Lengyel, 2000)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Liu and Lengyel, 2000)

located_in apical plasma membrane

inferred from direct assay

(Liu and Lengyel, 2000)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

arc (a) encodes a protein involved in eye development. [Date last reviewed: 2019-09-12]

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

a: arc

a: arc

From Bridges and Morgan, 1919, Carnegie Inst. Washington Publ. No. 278: 148.

Wings broader; bent downward in slight, even arc; edges drawn down to diamond shape. Sometimes in stock, wings are bent upward instead of downward. Crossveins closer together. RK2.

aba: arc-broad angular

Wings broader and shorter than wild type, blunt at the tip. Frequently shows upturned posterior scutellar bristles. In combination with svrpoi, produces soft blistered wing. Other interactions described by Goldschmidt, 1945, table 74. Wing grows in pupal stage to full length and then retracts, possibly with histolysis [Goldschmidt, 1934, Z. Indukt. Abstamm. Vererbungsl. 69: 38-131 (fig.)]. RK2.

Summary (Interactive Fly)

PDZ domain protein involved in structuring epithelia - affects eye development by modulating adherens junctions of the developing ommatidium.

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W283)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

5' UTR(s) contain an ORF that is conserved among Drosophila species;potential peptide 13 aa in length; no initiating methionine.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

a-RA

FBtr0071763

NM_166514

4847

1329

a-RB

FBtr0071764

NM_079902

5173

1329

a-RC

FBtr0100521

NM_001014543

4665

1329

a-RD

FBtr0342981

NM_001299777

3897

1087

Additional Transcript Data and Comments

Reported size (kB)

5.5, 4.826, 4.644 (compiled cDNA)

(Liu and Lengyel, 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

a-PA

FBpp0071677

142.9

1329

9.85

FBpp0071678

142.9

1329

9.85

FBpp0099961

142.9

1329

9.85

FBpp0309745

117.0

1087

9.95

A0A0B4LG21

NP_001286706

AHN56501

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1329 aa isoforms: a-PA, a-PB, a-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

1329 (aa); 143 (kD predicted)

(Liu and Lengyel, 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval salivary gland

(Liu and Lengyel, 2000)

embryonic/larval foregut

(Liu and Lengyel, 2000)

embryonic stage 2

organism | anterior posterior gradient

(Liu and Lengyel, 2000)

embryonic stage 6 -- 17

posterior midgut primordium

(Liu and Lengyel, 2000)

embryonic stage 10 -- 17

Malpighian tubule

(Liu and Lengyel, 2000)

embryonic stage 13 -- 17

embryonic/larval hindgut

(Liu and Lengyel, 2000)

third instar larval stage

eye disc morphogenetic furrow

(Liu and Lengyel, 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Liu and Lengyel, 2000)

Additional Descriptive Data

a transcripts are distributed uniformly in the embryo shortly after egg laying. This maternal RNA is rapidly converted to an anterior-posterior gradient. a transcripts are expressed dynamically in the embryo in regions that are about to or in the process of undergoing morphogenetic movements. Zygotic a transcripts are first detected in the posterior midgut primordium, prior to and during invagination. They are detected in the Malpighian tubule primordium prior to evagination of the tubule buds and during evagination and elongation. They are also found in the hindgut, foregut, salivary gland, and trachea after they have formed and while they are elongating. In larvae, a transcripts are expressed in repeating clusters of cells along the morphogenetic furrow.

(Liu and Lengyel, 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval salivary gland

(Liu and Lengyel, 2000)

embryonic/larval foregut

(Liu and Lengyel, 2000)

embryonic stage 6 -- 17

posterior midgut primordium

(Liu and Lengyel, 2000)

embryonic stage 10 -- 17

Malpighian tubule

(Liu and Lengyel, 2000)

embryonic stage 14 -- 17

embryonic/larval hindgut

(Liu and Lengyel, 2000)

third instar larval stage

eye disc morphogenetic furrow

(Liu and Lengyel, 2000)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

a protein is expressed dynamically in the embryo in morphogenetically active epithelia. Zygotic a protein is first detected in the posterior midgut primordium, prior to and during invagination. It is detected in the Malpighian tubule primordium prior to evagination of the tubule buds and during evagination and elongation. It is also found in the hindgut, foregut, salivary gland, and trachea after they have formed and while they are elongating. In larvae a protein is expressed in repeating clusters of cells along the morphogenetic furrow.

(Liu and Lengyel, 2000)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in adherens junction

inferred from direct assay

(Liu and Lengyel, 2000)

located_in apical plasma membrane

inferred from direct assay

(Liu and Lengyel, 2000)

Expression Deduced from Reporters

Reporter: P{lacW}a^k11011b

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

Malpighian tubule

(Liu and Lengyel, 2000)

embryonic/larval hindgut

(Liu and Lengyel, 2000)

embryonic/larval foregut

(Liu and Lengyel, 2000)

third instar larval stage

wing disc

(Liu and Lengyel, 2000)

eye disc morphogenetic furrow

(Liu and Lengyel, 2000)

eye-antennal disc

(Liu and Lengyel, 2000)

antennal disc

(Liu and Lengyel, 2000)

leg disc

(Liu and Lengyel, 2000)

adult stage

adult Malpighian tubule | restricted

(Wang et al., 2004)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\a

View exonic expression by tissue for Dmel\a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43852/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000008

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000008

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000008

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6741

Flygut - An atlas of the Drosophila adult midgut

FBgn0000008

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

FBgn0000008

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 41 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of a

Transgenic constructs containing regulatory region of a

Aberrations (Deficiencies and Duplications) ( 14 )

Inferred from experimentation ( 14 )

Gene not duplicated in

Dp(2;3)P

Gene disrupted in

Df(2R)a⁷

(Liu and Lengyel, 2000)

Df(2R)a^EX1

(Liu and Lengyel, 2000)

Df(2R)a^EX2

(Liu and Lengyel, 2000)

Df(2R)a-ba2

(Goldschmidt, 1945, Goldschmidt, 1944)

Df(2R)Exel6078

(Ryder, 2004.4.26)

Df(2R)Exel7171

(Ryder, 2004.4.26)

Df(2R)M58F

(Bridges, 1937, Dunn and Mossige, 1937)

In(2LR)a^M60

(Meyer, 1963)

Gene not disrupted in

Df(2R)E3578

(BDGP Project Members, 1994-1999)

Df(2R)nap16

(BDGP Project Members, 1994-1999)

Df(2R)P

(Bridges, 1937)

Df(2R)ST1

(BDGP Project Members, 1994-1999)

Df(2R)XE-916

(BDGP Project Members, 1994-1999)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

a^yUAS

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

a^GD1369

viable

Sterility

Allele

sterile | recessive

a^Bay

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

a^GD1369

Phenotype manifest in

Allele

crossvein

eye

a^k11011b

eye, with Scer\GAL4^Act5C.PI

a^yUAS

eye, with Scer\GAL4^GMR.PF

a^yUAS

eye (with Df(2R)a^EX1)

a⁷

macrochaeta

a^Ba

ommatidium, with Scer\GAL4^Act5C.PI

a^yUAS

ommatidium (with Df(2R)a^EX1)

a⁷

posterior scutellar bristle

wing

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\PDZD2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SYNJ2BP

1 of 14

Hsap\TAMALIN

1 of 14

Hsap\TJP1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (30)

Rnor\Pdzd2

4 of 14

Yes

Rnor\Il16

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tamalin

1 of 14

Rnor\Ush1c

1 of 14

Rnor\Whrn

1 of 14

Mus musculus (laboratory mouse) (33)

Mmus\Mpdz

3 of 14

Yes

Mmus\Pdzd2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\il16

2 of 13

Yes

Xtro\mpdz

2 of 13

Yes

Xtro\pdzd2

2 of 13

Yes

Xtro\spring1

2 of 13

Yes

Xtro\adcyap1r1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\thra

1 of 13

Yes

Xtro\whrn

1 of 13

Xtro\XB5786944

1 of 13

Danio rerio (Zebrafish) (38)

Drer\grip1

2 of 14

Yes

Drer\il16

2 of 14

Yes

Drer\lnx1

2 of 14

Yes

Drer\lnx2a

2 of 14

Yes

Drer\lnx2b

2 of 14

Yes

Drer\pdzd2

2 of 14

Yes

Drer\si:dkey-92j12.5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tamalin

1 of 14

Drer\ush1c

1 of 14

Drer\whrna

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\mpz-1

2 of 14

Yes

Cele\C46H11.6

1 of 14

Yes

Cele\C50F7.3

1 of 14

Yes

Cele\C52A11.3

1 of 14

Cele\F16G10.5

1 of 14

Cele\F20D6.1

1 of 14

Yes

Cele\F28E10.4

1 of 14

Yes

Cele\F40F9.3

1 of 14

Yes

Cele\frm-5.1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\smz-1

1 of 14

Yes

Cele\smz-2

1 of 14

Yes

Cele\T19B10.5

1 of 14

Yes

Cele\txt-1

1 of 14

Yes

Cele\ZK849.1

1 of 14

Anopheles gambiae (African malaria mosquito) (26)

Agam\AgaP_AGAP010808

10 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012008

1 of 12

Agam\AgaP_AGAP012354

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

3 of 13

2 of 13

2 of 13

2 of 13

baz

1 of 13

bbg

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

a^HMC03685

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDZD2; PDZ domain containing 2

3 of 14

610697

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

a - egl

anti tag coimmunoprecipitation, full identification by DNA sequencing, quantitative reverse transcription pcr

(Vazquez-Pianzola et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brm

suppressible

(Tegeder et al., 2019)

Snr1

suppressible

(Tegeder et al., 2019)

svr

enhanceable

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68671

DroID - A comprehensive database of gene and protein interactions.

FBgn0000008

MIST (protein-protein) - An integrated Molecular Interaction Database

43852

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Antigen processing: Ubiquitination & Proteasome degradation

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W283

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-98

Cytogenetic map

58C1-58C5

Sequence location

2R:22,136,968..22,172,834 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

58C1-58C5

Limits computationally determined from genome sequence between P{EP}CG6393^EP2457 and P{PZ}ari-2⁰⁷⁷⁶⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-98

(FlyBase, 2016)

2-103.8

(Comeron et al., 2012)

2-99.2

(Meyer, 1963)

(Goldschmidt, 1944)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

1554

a¹ px¹ or¹

7075

w^*; P{lacW}a^k11011b

25344

w¹¹¹⁸; Mi{ET1}a^MB06991

26995

y¹ w^*; P{EP}a^G2432

55529

y¹ w^*; Mi{MIC}a^MI10698

7071

y¹ w^*; P{Mae-UAS.6.11}a^yUAS

14010

y¹ w^67c23; P{SUPor-P}a^KG05532

7150

cn¹ a^EM1 bw¹ speck¹/SM6b

Kyoto

101278

a^ba

105851

hy¹ a¹ px¹ speck¹/SM1

VDRC

v330373

P{VSH330373}attP40

v16826

w¹¹¹⁸ P{GD1369}v16826

More stocks available...

Genomic Clones (31)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH21134

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000008

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000008

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liu and Lengyel, 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

a may affect eye development by modulating adherens junctions of the developing ommatidia.

(Liu and Lengyel, 2000)

Defined by recessive mutations that result in a broad, often bent, wing.

(Lindsley and Grell, 1968)

Relationship to Other Genes

Source for database merge of

Source for merge of: a CG6741

(Lengyel, 2000.3.26)

Source for merge of: a CG13505

(Millburn, 2000.5.31)

Source for merge of: a CG13505 CG6741

(Lengyel, 2000.8.1)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Name Synonyms

arc

(Kim et al., 2025, Miyashita et al., 2018, Khokhar et al., 2008, Firth and Baker, 2007, Liu et al., 1998, Liu and Lengyel, 1997)

broad angular

(Goldschmidt, 1944)

Secondary FlyBase IDs

FBgn0034701
FBgn0034702

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

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GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

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UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W283

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43852/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

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FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

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FlyMine - An integrated database for Drosophila genomics

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GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

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InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6741

MARRVEL_MODEL - MARRVEL (model organism gene)

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Linkouts

BioGRID - A database of protein and genetic interactions.

68671

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

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DroID - A comprehensive database of gene and protein interactions.

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DRSC - Results frm RNAi screens

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Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

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FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000008

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6741

Flygut - An atlas of the Drosophila adult midgut

FBgn0000008

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000008

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43852

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Antigen processing: Ubiquitination & Proteasome degradation

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9W283

References (72)

The following external sites may use different assemblies or annotations than FlyBase.

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