FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TMTC3UAS.cFa
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General Information
Symbol
Hsap\TMTC3UAS.cFa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Farhan
FlyBase ID
FBal0336331
Feature type
allele
Associated gene
Hsap\TMTC3
Associated Insertion(s)
Carried in Construct
P{UAS-hTMTC3.F}
Key Links
Transgenic product class
cDNA
(Farhan et al., 2017)
wild_type
(Farhan et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Farhan et al., 2017)
wild_type
(Farhan et al., 2017)
Mutagen
in vitro construct
(Farhan et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-hTMTC3.F}
Cytology
Description

UAS regulates expression of a Hsap\TMTC3 cDNA (Internal ID 53914 of the hORFeome V5.1 of the CCSB Human Orfeome Collection and Entrez Gene ID 160418).

(Farhan et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\TMTC3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  epilepsy
      modeled by Tmtc3GD2121
      (Farhan et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The susceptibility to seizures induced by mechanical stress (flies remain immobilized after vortexing) characteristic for adult flies expressing Tmtc3GD2121 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4elav.PU is rescued by co-expression of Hsap\TMTC3Scer\UAS.cFa.

      (Farhan et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\TMTC3Scer\UAS.cFa
      Hsap\TMTC3UAS.cFa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Farhan
      Secondary FlyBase IDs
        References (1)