FlyBase Allele Report: Dmel\bsk[LL02244]

General Information

Symbol

Dmel\bsk^LL02244

Species

D. melanogaster

Name

FlyBase ID

FBal0318345

Feature type

allele

Associated gene

Dmel\bsk

Associated Insertion(s)

PBac{SAstopDsRed}bsk^LL02244

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

piggyBac activity

Nature of the Allele

Allele class

loss of function allele

(Bornstein et al., 2015)

Mutagen

piggyBac activity

(Bornstein et al., 2015)

Progenitor genotype

Associated Insertion(s)

PBac{SAstopDsRed}bsk^LL02244

Cytology

Description

PBac{SAstopDsRed} insertion in the first intron.

(Bornstein et al., 2015)

Allele components

Component

Use(s)

Inserted element

PBac{SAstopDsRed}

gene trap

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Meltzer et al., 2019)

abnormal neuroanatomy | somatic clone

(Bornstein et al., 2015)

Phenotype Manifest In

axon | adult stage

(Meltzer et al., 2019)

axon | somatic clone

(Bornstein et al., 2015)

gamma Kenyon cell | adult stage | somatic clone

(Meltzer et al., 2019)

Detailed Description

Statement

Reference

bsk^LL02244 mushroom body gamma neuron clones frequently show pruning defects.

(Meltzer et al., 2019)

bsk^LL02244/bsk^LL02244 clones (in the mushroom body γ lobe at 18hr after puparium formation and in adult) are deficient in axon (but not dendrite) pruning compared to wild type.

(Bornstein et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

bsk^LL02244 has abnormal neuroanatomy | somatic clone phenotype, suppressible by Fas2^EB112/Fas2^EB112

(Bornstein et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

bsk^LL02244 has axon | somatic clone phenotype, suppressible by Fas2^EB112/Fas2^EB112

(Bornstein et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Fas2^EB112/Fas2^EB112 significantly suppresses the axon pruning defect caused by bsk^LL02244/bsk^LL02244 (mushroom body clones).

(Bornstein et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bsk^LL02244 is rescued by Scer\GAL4^Tab2-201Y/bsk^UAS.cBa

(Bornstein et al., 2015)

bsk^LL02244 is rescued by Scer\GAL4^Tab2-201Y/bsk^UAS.cAYa

(Bornstein et al., 2015)

Comments

Expressing bsk^Scer\UAS.cBa or bsk^{Scer\UAS.cAYa} in bsk^LL02244/bsk^LL02244 clones (with Scer\GAL4^Tab2-201Y) rescues axon-pruning defects.

(Bornstein et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bsk^LL02244

(Meltzer et al., 2019, Bornstein et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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