FlyBase Allele Report: Dmel\eya[WT.UAS]

General Information

Symbol

Dmel\eya^WT.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0287989

Feature type

allele

Associated gene

Dmel\eya

Associated Insertion(s)

Carried in Construct

P{UAS-eya.WT}

Key Links

Transgenic product class

wild_type

(Xiong et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Xiong et al., 2009)

Mutagen

in vitro construct

(Xiong et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-eya.WT}

Cytology

Description

UAS regulates expression of wild type eya.

(Xiong et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

eya

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^GMR.PU

(Xiong et al., 2009)

Phenotype Manifest In

eye | ectopic, with Scer\GAL4^dpp.blk1

(Xiong et al., 2009)

larval brain | third instar larval stage, with Scer\GAL4^GMR.PU

(Xiong et al., 2009)

Detailed Description

Statement

Reference

Scer\GAL4^dpp.blk1-mediated expression of eya^WT.Scer\UAS induces ectopic eye tissue on the head with a frequency of 49%.

Scer\GAL4^GMR.PU eya^WT.Scer\UAS eye/brain complexes show an average of 25.7 overshooting axon bundles per brain, compared to 8.4 in controls.

(Xiong et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, eya^WT.UAS has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Abl^GD1344, Scer\GAL4^GMR.PU

(Xiong et al., 2009)

Other

Statement

Reference

Abl^UAS.cFa, Scer\GAL4^dpp.blk1, eya^WT.UAS has lethal phenotype

(Xiong et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^dpp.blk1, eya^WT.UAS has eye | ectopic phenotype, suppressible by Abl⁴/Abl[+]

(Xiong et al., 2009)

Scer\GAL4^dpp.blk1, eya^WT.UAS has eye | ectopic phenotype, suppressible by Abl⁰⁴⁶⁷⁴/Abl[+]

(Xiong et al., 2009)

Scer\GAL4^dpp.blk1, eya^WT.UAS has eye | ectopic phenotype, suppressible by Abl^K417N.UAS, Scer\GAL4^dpp.blk1

(Xiong et al., 2009)

Scer\GAL4^GMR.PU, eya^WT.UAS has larval brain | third instar larval stage phenotype, suppressible by Abl^GD1344, Scer\GAL4^GMR.PU

(Xiong et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Scer\GAL4^dpp.blk1-mediated co-expression of eya^WT.Scer\UAS and Abl^Scer\UAS.cFa leads to synthetic lethality.

Coexpression of Abl^GD1344 decreases the number of axon targeting defects in Scer\GAL4^GMR.PU eya^WT.Scer\UAS eye/brain complexes from 25.7 to 12.4 axon bundles per brain.

(Xiong et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

eya^WT.UAS/Scer\GAL4^dpp.blk1 rescues eya²

(Xiong et al., 2009)

Comments

Scer\GAL4^dpp.blk1-mediated expression of eya^WT.Scer\UAS fully rescues the eyeless phenotype of eya² animals.

(Xiong et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

eya^WT.Scer\UAS

eya^WT.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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