FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DysbUAS.cSa
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General Information
Symbol
Dmel\DysbUAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0268975
Feature type
allele
Associated gene
Dmel\Dysb
Associated Insertion(s)
Carried in Construct
P{UAS-Dysb.S}
Also Known As
UAS-Ddysb
Key Links
Transgenic product class
genomic_DNA
(Shao et al., 2011)
wild_type
(Shao et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Shao et al., 2011)
wild_type
(Shao et al., 2011)
Mutagen
in vitro construct
(Shao et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Dysb.S}
Cytology
Description

UAS regulatory sequences drive expression of full length Dysb genomic DNA.

(Shao et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dysb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neuronal expression of dysbScer\UAS.cSa under the control of Scer\GAL4elav-C155 results in an increase in excitatory junctional current amplitude in the larval neuromuscular junction. Adult flies exhibit defects in memory retention following exposure to an odor previously associated without electric shock. A similar defect in memory is seen when dysbScer\UAS.cSa is expressed in glutamatergic neurons under the control of Scer\GAL4VGlut-OK371.

      (Shao et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      DysbUAS.cSa/Scer\GAL4VGlut1-OK371 rescues Dysbe01028

      (Shao et al., 2011)

      DysbUAS.cSa/Scer\GAL4hs.PU rescues Dysbe01028

      (Shao et al., 2011)
      Partially rescues

      Scer\GAL4elav-C155/DysbUAS.cSa partially rescues Dysbe01028

      (Shao et al., 2011)

      DysbUAS.cSa/Scer\GAL4repo partially rescues Dysbe01028

      (Shao et al., 2011)
      Comments

      Expression of dysbScer\UAS.cSa under the control of Scer\GAL4elav-C155 rescues the attenuated excitatory junctional currents recorded in the larval neuromuscular junction in dysbe01028 mutants. The short term memory defects are also rescued. The locomotor and mating disorientation phenotypes are not rescued, nor is the dopamine level in dysbe01028 mutant heads.

      Expression of dysbScer\UAS.cSa in glia under the control of Scer\GAL4repo fails to rescue the short term memory defects seen in dysbe01028 mutant flies. However, glial expression of dysbScer\UAS.cSa is able to rescue the locomotor and mating disorientation phenotypes. The increased dopamine levels in the head are also rescued.

      Expression of dysbScer\UAS.cSa in glutamatergic neurons under the control of Scer\GAL4VGlut-OK371 rescues the short-term memory defects seen in dysbe01028 mutant flies.

      Acute expression of dysbScer\UAS.cSa under the control of Scer\GAL4hs.PU rescues the short-term memory defects and mating disorientation seen in dysbe01028 mutant flies. The increase in dopamine levels seen in dysbe01028 mutant heads is also suppressed.

      (Shao et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DysbScer\UAS.cSa
      DysbUAS.cSa
      dysbScer\UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)