FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DroncNIG.8091R
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General Information
Symbol
Dmel\DroncNIG.8091R
Species
D. melanogaster
Name
FlyBase ID
FBal0261069
Feature type
allele
Associated gene
Dmel\Dronc
Associated Insertion(s)
Carried in Construct
P{NIG.8091R}
Also Known As
UAS-DroncRNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.8091R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-8091R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by Ras85DV12.UAS
      (Waghmare et al., 2024)
      modeled by hidUAS.cUa, BacA\p35UAS.cHa
      (Rudrapatna et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of NcNIG.8091R with hpoΔauto.Scer\UAS in the developing wing discs (under the control of Scer\GAL4nub-AC-62) dramatically reduces the level of cell death, with a concomitant rescue of adult wing size.

      (Verghese et al., 2012)

      Clones of cells expressing nabEP642 in the wing imaginal disc (under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C) co-expressing NcNIG.8091-R1 display strong JNK activity associated with robust extra tissue growth.

      Co-expression of NcNIG.8091-R1 in clones of cells expressing nabEP642 in the wing imaginal disc (under the control of Scer\GAL4Scer\FRT.Rnor\CD2.Act5C) efficiently suppresses effector caspase activity but compensatory proliferation of neighboring cells still occurs.

      (Suissa et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference

      Knockdown of Nc, through expression of NcNIG.8091R completely suppresses the invasive cell phenotype found upon co-expression of BacA\p35Scer\UAS.cHa-WScer\UAS.cUa under the control of Scer\GAL4ptc-559.1.

      (Rudrapatna et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DroncNIG.8091R
      NcNIG.8091-R1
      NcNIG.8091R
      Name Synonyms
      Secondary FlyBase IDs
        References (8)