FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LnkUAS.cSa
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General Information
Symbol
Dmel\LnkUAS.cSa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Song
FlyBase ID
FBal0248907
Feature type
allele
Associated gene
Dmel\Lnk
Associated Insertion(s)
Carried in Construct
P{UAS-Lnk.S}
Key Links
Transgenic product class
cDNA
(Song et al., 2010)
wild_type
(Song et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Song et al., 2010)
wild_type
(Song et al., 2010)
Mutagen
in vitro construct
(Song et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Lnk.S}
Cytology
Description

UASt regulatory sequences drive expression of a full-length Lnk cDNA.

(Song et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lnk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Total triglycerides are decreased by 35% in adults expressing LnkScer\UAS.cSa under the control of Scer\GAL4Act.PU compared to wild type. The median lifespan is decreased by 19% in male and 16% in female flies compared to wild-type.

      Animals expressing LnkScer\UAS.cSa under the control of Scer\GAL4Act.PU show reduced survival under starvation conditions compared to wild type.

      Animals expressing LnkScer\UAS.cSa under the control of Scer\GAL4Adh.PF have reduced lipid levels, reduced hemolymph sugar levels and reduced starvation resistance compared to wild type. The median lifespan and survival curves of these flies is not altered compared to wild type.

      Animals expressing LnkScer\UAS.cSa under the control of either Scer\GAL4Lsp2.PH or Scer\GAL4ppl.PP have reduced lipid levels and hemolymph carbohydrates compared to wild type.

      Animals expressing LnkScer\UAS.cSa under the control of Scer\GAL4elav.PU have normal total triglyceride and hemolymph glucose levels, but show marginally decreased starvation resistance compared to wild type. The median lifespan is decreased by 10% in male and 11% in female flies compared to wild-type.

      Animals expressing LnkScer\UAS.cSa under the control of either Scer\GAL4Act.PU or Scer\GAL4elav.PU show increased sensitivity to paraquat compared to wild type.

      (Song et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      LnkScer\UAS.cSa
      LnkUAS.cSa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Song
      Secondary FlyBase IDs
        References (1)