FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sin3A187.UAS.Tag:HA
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General Information
Symbol
Dmel\Sin3A187.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0247923
Feature type
allele
Associated gene
Dmel\Sin3A
Associated Insertion(s)
Carried in Construct
P{UAS-Sin3A.187HA}
Key Links
Transgenic product class
wild_type
(Spain et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Spain et al., 2010)
Mutagen
in vitro construct
(Spain et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Sin3A.187HA}
Cytology
Description

UAS regulatory sequences drive expression of the 187 Sin3A isoform which is tagged with a Tag:HA epitope.

(Spain et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sin3A
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sin3A187.Scer\UAS.T:Ivir\HA1 via Scer\GAL4twi.PB and Scer\GAL4how-24B results in embryos with a range of defects in the somatic musculature. While half are wild type, half show missing and misshapen muscles. A VA2 to VA1 muscle transformation is observed in 14% of embryos.

      (Dobi et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Sin3A220.UAS.Tag:HA, Sin3A187.UAS.Tag:HA, Scer\GAL4αTub84B.PL partially rescues Sin3Ae374

      (Spain et al., 2010)

      Sin3A220.UAS.Tag:HA, Sin3A187.UAS.Tag:HA, Scer\GAL4αTub84B.PL partially rescues Sin3A08269

      (Spain et al., 2010)
      Fails to rescue

      Sin3A187.UAS.Tag:HA/Scer\GAL4αTub84B.PL fails to rescue Sin3Ae374

      (Spain et al., 2010)

      Sin3A187.UAS.Tag:HA/Scer\GAL4αTub84B.PL fails to rescue Sin3A08269

      (Spain et al., 2010)
      Comments

      The lethality of Sin3A08269 and Sin3Ae374 homozygotes is not rescued by expression of Sin3A187.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL.

      The lethality of Sin3A08269 and Sin3Ae374 homozygotes is partially rescued by co-expression of both Sin3A187.Scer\UAS.T:Ivir\HA1 and Sin3A220.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL (88% and 81% viability respectively).

      (Spain et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sin3A187.Scer\UAS.T:Ivir\HA1
      Sin3A187.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)