FlyBase Allele Report: Dmel\daw[Δ1]

General Information

Symbol

Dmel\daw^Δ1

Species

D. melanogaster

Name

FlyBase ID

FBal0211069

Feature type

allele

Associated gene

Dmel\daw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Parker et al., 2006)

Progenitor genotype

P{EP}daw^EP1039

(Parker et al., 2006)

Cytology

Description

Imprecise excision of the P{EP} element, resulting in deletion of 2.1kb of the daw gene, including the first exon and the translation start site in the second exon.

(Parker et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Pentek et al., 2009, Parker et al., 2006)

Phenotype Manifest In

larval abdominal segmental nerve

(Parker et al., 2006)

larval intersegmental nerve

(Parker et al., 2006)

larval intersegmental nerve branch ISNb of A1-7

(Pentek et al., 2009)

leg | pharate adult stage

(Pentek et al., 2009)

Detailed Description

Statement

Reference

25% of mutant pharate adults have a bent leg phenotype.

Mutant embryos show ISNb axon pathfinding defects.

(Pentek et al., 2009)

Motorneuron pathfinding is disrupted in these embryos as although the ISNb and SNa axons exit the ventral nerve cord correctly and extend into their target field, they fail to advance far enough to innervate the appropriate muscle. The ISNb axons commonly stall at muscle 6 and fail to form synapses on muscles 12 and 13, or reach muscle 12 but are unable to form a synapse. The SNa usually extends into the target muscle but frequently exhibits the loss of one or both branches.

(Parker et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

daw⁴

(Parker et al., 2006)

daw³

(Parker et al., 2006)

Rescued by

daw^Δ1 is rescued by daw^+t7.8

(Parker et al., 2006)

daw^Δ1/daw³ is rescued by daw^UAS.cPa/Scer\GAL4^repo

(Parker et al., 2006)

daw^Δ1/daw³ is rescued by daw^UAS.cPa/Scer\GAL4^Mef2.PR

(Parker et al., 2006)

daw^Δ1/daw³ is rescued by daw^UAS.cPa/Scer\GAL4^RapGAP1-OK6

(Parker et al., 2006)

Comments

Two copies of daw^Scer\UAS.cPa, under the control of Scer\GAL4^repo or Scer\GAL4^Mef2.PR, rescues the axon guidance defects of daw³/daw^δ1 embryos, while one copy provides partial rescue. Expression driven by Scer\GAL4^OK6 also reverses the defects.

(Parker et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

daw^Δ1

(Ellis et al., 2010, Pentek et al., 2009)

daw^δ1

(Parker et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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