FlyBase Allele Report: Dmel\dally[GD5918]

General Information

Symbol

Dmel\dally^GD5918

Species

D. melanogaster

Name

FlyBase ID

FBal0209329

Feature type

allele

Associated gene

Dmel\dally

Associated Insertion(s)

Carried in Construct

P{GD5918}

Also Known As

UAS-dallyRNAi, dally RNAi, UAS.dally-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD5918}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD5918

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | cell non-autonomous | third instar larval stage, with Scer\GAL4^hh-Gal4

(Poe et al., 2017)

decreased size | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Merino et al., 2022)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of dally^GD5918 in epidermic cells under the control of Scer\GAL4^hh-Gal4 results in a mild reduction in the terminal dendrite density and number in the adjacent class IV dendritic arborizing neurons within the intersegmental area of third instar larvae.

(Poe et al., 2017)

Expression of dally^GD5918 RNAi under the control of either Scer\GAL4^pnr-MD237 or Scer\GAL4^tub.PU does not significantly alter levels of pigmentation on the abdominal tergite 5 or 6 in adult females compared to controls.

(Dembeck et al., 2015)

Adults expressing dally^GD5918 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression of dally^GD5918 under the control of Scer\GAL4^bab1-Pgal4-2 results in the loss of the germline stem cells (GSCs), with 29% of ovarioles containing no GSCs in the niche at day 10 after eclosion.

(Guo and Wang, 2009)

Expression of dally^GD5918 in the posterior of the wing disc, under the control of Scer\GAL4^en-e16E, results in a decrease in the posterior:anterior size ratio of the appendage-forming region of the wing disc from the wild-type ratio of 1.04 to 0.65. Adult wings in flies of this genotype are 19% smaller than controls and wing vein L4 is shifted posteriorly.

Expression of dally^GD5918 in the anterior of the wing disc, under the control of Scer\GAL4^ci.PC, results in an increase of the posterior:anterior size ratio from 0.93 to 1.39. In adult wings, wing vein L4 is shifted anteriorly although overall wing size is not significantly affected.

(Crickmore and Mann, 2007)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5918

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, dally^GD5918 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, enhanceable by Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, dally^GD5918 has abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Enhancer of

Statement

Reference

dally^GD5918/Scer\GAL4^hh-Gal4 is an enhancer of abnormal neuroanatomy | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

Suppressor of

Statement

Reference

dally^GD5918/Scer\GAL4^elav.PU is a suppressor | partially of long lived phenotype of Scer\GAL4^elav.PU, sfl^UAS.Tag:HA

(Weigelt et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, dally^GD5918 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, enhanceable by Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, dally^GD5918 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, enhanceable by Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, dally^GD5918 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, enhanceable by Sdc^RNAi.WIZ.UAS/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

NOT Enhanced by

Statement

Reference

Scer\GAL4^hh-Gal4, dally^GD5918 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, dally^GD5918 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has dendritic tree | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS, dally^GD5918 has distal dendrite | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Scer\GAL4^hh-Gal4, dally^GD5918 has larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype, non-enhanceable by dlp^GD3592/Scer\GAL4^hh-Gal4

(Poe et al., 2017)

Enhancer of

Statement

Reference

dally^GD5918/Scer\GAL4^hh-Gal4 is an enhancer of larval multidendritic class IV neuron | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

dally^GD5918/Scer\GAL4^hh-Gal4 is an enhancer of dendritic tree | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

dally^GD5918/Scer\GAL4^hh-Gal4 is an enhancer of distal dendrite | third instar larval stage | cell non-autonomous phenotype of Scer\GAL4^hh-Gal4, Sdc^RNAi.WIZ.UAS

(Poe et al., 2017)

Suppressor of

Statement

Reference

dally^GD5918/Scer\GAL4^unspecified is a suppressor of germarium phenotype of stet^1A3

(Liu et al., 2010)

dally^GD5918/Scer\GAL4^unspecified is a suppressor of spectrosome | increased number phenotype of stet^1A3

(Liu et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either dally^GD5918 or Sdc^{dsRNA.WIZ.Scer\UAS} alone in epidermic cells under the control of Scer\GAL4^hh-Gal4 results in only a mild reduction in the terminal dendrite density and number within the intersegmental area in the adjacent class IV dendritic arborizing neurons in third instar larvae, but the severity of the phenotype is much increased (the growth of high-order dendrites is almost completely abolished) if both dally^GD5918 and Sdc^{dsRNA.WIZ.Scer\UAS} are expressed simultaneously. Co-expression of dlp^GD3592 does not enhance the dally^GD5918-induced dendritic phenotype neither can further worsen the phenotype in larvae expressing both dally^GD5918 and Sdc^{dsRNA.WIZ.Scer\UAS}.

(Poe et al., 2017)

Expression of dally^GD5918 driven by Scer\GAL4^unspecified in escort stem cells and escort cells partially suppresses the supernumerary spectrosome-containing cell phenotype in stet^1A3 mutant germaria.

(Liu et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v14136

w¹¹¹⁸; P{GD5918}v14136

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

5918

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dally^GD5918

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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