FlyBase Allele Report: Dmel\l(2)efl[UAS.cWa]

General Information

Symbol

Dmel\l(2)efl^UAS.cWa

Species

D. melanogaster

Name

FlyBase ID

FBal0190457

Feature type

allele

Associated gene

Dmel\l(2)efl

Associated Insertion(s)

Carried in Construct

P{UAS-l(2)efl.W}

Key Links

Transgenic product class

cDNA

(Wang et al., 2005)

wild_type

(Wang et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Wang et al., 2005)

wild_type

(Wang et al., 2005)

Mutagen

in vitro construct

(Wang et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-l(2)efl.W}

Cytology

Description

Expression of full length l(2)efl cDNA is under the control of UASt sequences.

(Wang et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

l(2)efl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

long lived, with Scer\GAL4^arm.PS

(Wang et al., 2005)

long lived, with Scer\GAL4^elav-C155

(Wang et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

l(2)efl^Scer\UAS.cWa adults carrying Scer\GAL4^arm.PS or Scer\GAL4^elav-C155 have significantly increased lifespan.

(Wang et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

l(2)efl^UAS.cWa, Scer\GAL4^repo is a suppressor of increased cell death | progressive phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

l(2)efl^UAS.cWa, Scer\GAL4^repo is a suppressor of paralytic phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Phenotype Manifest In

Suppressor of

Statement

Reference

l(2)efl^UAS.cWa, Scer\GAL4^repo is a suppressor of lamina phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

l(2)efl^UAS.cWa, Scer\GAL4^repo is a suppressor of adult brain phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

l(2)efl^UAS.cWa, Scer\GAL4^repo is a suppressor of neuron | cell non-autonomous phenotype of Hsap\GFAP^UAS.cWa, Scer\GAL4^repo

(Wang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Overexpression of l(2)efl^Scer\UAS.cWa in flies expressing Hsap\GFAP^{R79H.Scer\UAS} under the control of Scer\GAL4^repo results in a significant reduction in cell death. In addition, expression of l(2)efl^Scer\UAS.cWa also decreases the number of seizures. Protection from cellular toxicity is accompanied by a significant reduction in the number of inclusion bodies and in activation of autophagy.

(Wang et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

l(2)efl^Scer\UAS.cWa

l(2)efl^UAS.cWa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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