FlyBase Allele Report: Dmel\Moe[K.UAS.Tag:MYC]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\Moe^{K.UAS.Tag:MYC}

General Information

Symbol

Dmel\Moe^{K.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0176071

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-Moe.MYC.K}

Also Known As

UAS-moe-Myc

Key Links

Transgenic product class

(Karagiosis and Ready, 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Karagiosis and Ready, 2004)

Mutagen

in vitro construct

(Karagiosis and Ready, 2004)

Progenitor genotype

(Karagiosis and Ready, 2004)

Carried in construct

P{UAS-Moe.MYC.K}

Cytology

Description

UASt regulatory sequences drive expression of Moe fused at the C-terminus to Tag:MYC.

(Karagiosis and Ready, 2004)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^GMR.PF

(Ruan et al., 2013)

Phenotype Manifest In

lamina plexus | third instar larval stage, with Scer\GAL4^GMR.PF

(Ruan et al., 2013)

medulla | third instar larval stage, with Scer\GAL4^GMR.PF

(Ruan et al., 2013)

Detailed Description

Statement

Reference

Expression of Moe^{K.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF results in R cell axon targeting defects in third instar larvae. Abnormal R8 growth cones are seen and the lamina plexus is disrupted.

(Ruan et al., 2013)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^elav.PU/Moe^{K.UAS.Tag:MYC} partially rescues Moe^G0415

(Ruan et al., 2013)

Moe^{K.UAS.Tag:MYC}/Scer\GAL4^sca-109-68 partially rescues Moe^G0323

(Ruan et al., 2013)

Comments

Expression of Moe^{K.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^elav.PU rescues the R2-R5 axon targeting defects seen in Moe^G0415 hemizygotes in 55% of cases.

Expression of Moe^{K.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^sca-109-68 rescues the R2-R5 axon targeting defects seen in Moe^G0323 hemizygotes in 38% of cases.

(Ruan et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

8631

w¹¹¹⁸; P{UAS-Moe.MYC.K}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Moe^{K.Scer\UAS.T:Hsap\MYC}

Moe^{K.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections