FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dap160Δ3
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General Information
Symbol
Dmel\Dap160Δ3
Species
D. melanogaster
Name
FlyBase ID
FBal0160633
Feature type
allele
Associated gene
Dmel\Dap160
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Koh et al., 2004)
Progenitor genotype
Dap160EP2543
(Koh et al., 2004)
Cytology
Description

Imprecise excision of the P{EP} element.

(Koh et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junction (NMJ) morphology is abnormal in Dap160Δ1/Dap160Δ3 third instar larvae; boutons are irregularly spaced and large boutons are surrounded by smaller satellite boutons. Extra branches and boutons are apparent in the mutant larvae. In 5mM Ca2+ at 22oC, the amplitude of the excitatory junctional potential (EJP) at the neuromuscular junction (NMJ) in Dap160Δ1/Dap160Δ3 third instar larvae is not different from that of controls. The EJP amplitude at the NMJ of Dap160Δ1/Dap160Δ3 third instar larvae is normal in 5mM Ca2+ at 36oC. In 0.5mM Ca2+, the frequency of miniature EJPs (mEJPs) at the NMJ is increased more than 2 fold in Dap160Δ1/Dap160Δ3 larvae compared to controls at 22oC. mEJPs with an unusually large amplitude are seen at both 22oC and 36oC. Dap160Δ1/Dap160Δ3 larvae show a mild defect in endocytosis at 22oC (assayed by dye uptake in third instar fillet preparations), which is exacerbated at 36oC. Dap160Δ1/Dap160Δ3 larvae show a stimulation-dependent decrease in EJP amplitude when stimulated at 10Hz. This decrease is more severe at 36oC than at 22oC.

      (Koh et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced with: l(2)05287Δ3.

      (Koh et al., 2004)
      Comments
      Comments

      Allelic series (based on protein expression data, complementation data and lethal phase): Dap160Δ1 = Dap160Δ2 > Dap160Δ3 = Dap160Δ4 = Dap160Δ5 > Dap160EMS > Dap160Δ6.

      (Koh et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dap160Δ3
      Name Synonyms
      Secondary FlyBase IDs
        References (1)