FlyBase Allele Report: Dmel\InR[del.UAS]

General Information

Symbol

Dmel\InR^del.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0156354

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{UAS-InR.del}

Also Known As

UAS-InR.del, UAS-InR^CA, UAS-InR-del, UAS-InR^DEL

Key Links

Transgenic product class

inframe_deletion

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-InR.del}

Cytology

Description

UAS regulatory sequences drive expression of InR in which most of the alpha subunit has been deleted. This mimics a constitutively active human InR described by Ellis et al., 1987 (PMID:2842659).

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

InR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Vita et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | chemical conditional, with Scer\GAL4^repo

(Nelson and Broadie, 2025)

decreased cell number | adult stage | somatic clone, with Scer\GAL4^Tub.PU

(Mattila et al., 2018)

visible, with Scer\GAL4^Bx-MS1096

(Cliffe et al., 2009)

visible, with Scer\GAL4^GMR.PF

(Werz et al., 2009)

Phenotype Manifest In

adult midgut | somatic clone, with Scer\GAL4^Tub.PU

(Mattila et al., 2018)

adult olfactory receptor neuron Or42a | chemical conditional, with Scer\GAL4^repo

(Nelson and Broadie, 2025)

eye, with Scer\GAL4^GMR.PF

(Werz et al., 2009)

wing, with Scer\GAL4^Bx-MS1096

(Cliffe et al., 2009)

Detailed Description

Statement

Reference

Expression of InR^del.UAS under the control of Scer\GAL4^Tub.PU in MARCM clones leads to a significant decrease in midgut cell number when compared to control adults.

(Mattila et al., 2018)

Ectopic expression of InR^del.Scer\UAS in the larval body, under the control of Scer\GAL4^c564, results in a 2.4-fold increase in cell size, compared to controls.

(Powis and Macdougall, 2011)

Expression of InR^del.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 results in a down-curled wing phenotype in 95.5% of flies.

(Cliffe et al., 2009)

Expression of InR^del.Scer\UAS under the control of Scer\GAL4^GMR.PF results in an eye overgrowth phenotype.

(Werz et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

InR^del.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Lnk^6S2/Lnk^4Q3

(Werz et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

InR^del.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Lnk^6S2/Lnk^4Q3

(Werz et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The eye overgrowth phenotype caused by expression of InR^del.Scer\UAS under the control of Scer\GAL4^GMR.PF is suppressed by Lnk^4Q3/Lnk^6S2.

(Werz et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8248

y¹ w¹¹¹⁸; P{UAS-InR.del}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

InR^del.Scer\UAS

InR^del.UAS

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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