FlyBase Allele Report: Dmel\Gp150[4]

General Information

Symbol

Dmel\Gp150⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0144862

Feature type

allele

Associated gene

Dmel\Gp150

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Fetchko et al., 2002)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Fetchko et al., 2002)

Amino acid replacement: W94term.

(Fetchko et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:22,325,474..22,325,474 [+]

Nucleotide change:

G22325474A

Reported nucleotide change:

G?A

Amino acid change:

Reported amino acid change:

W94term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Li et al., 2003, Fetchko et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Fetchko et al., 2002)

Phenotype Manifest In

eye

(Fetchko et al., 2002)

eye (with Gp150³)

(Li et al., 2003)

eye photoreceptor cell (with Gp150³)

(Li et al., 2003)

ommatidium (with Gp150³)

(Li et al., 2003)

wing margin bristle

(Fetchko et al., 2002)

wing margin bristle | ectopic

(Fetchko et al., 2002)

wing vein L3 | ectopic

(Fetchko et al., 2002)

Detailed Description

Statement

Reference

In Gp150³/Gp150⁴ animals the spacing of ommatidia is abnormal and some ommatidia have fewer or more photoreceptor cells. Mutants have 'rough' eyes.

(Li et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Gp150⁴/Gp150³ is a non-enhancer of eye phenotype of sca^BP2

(Li et al., 2003)

Gp150⁴/Gp150³ is a non-enhancer of ommatidium phenotype of sca^BP2

(Li et al., 2003)

Suppressor of

Statement

Reference

Gp150⁴/Gp150³ is a suppressor of wing margin phenotype of Scer\GAL4^dpp.blk1, sca^UAS.cEa

(Li et al., 2003)

NOT Suppressor of

Statement

Reference

Gp150⁴/Gp150³ is a non-suppressor of ommatidium phenotype of sca^BP2

(Li et al., 2003)

Gp150⁴/Gp150³ is a non-suppressor of eye phenotype of sca^BP2

(Li et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Gp150³/Gp150⁴ has no effect on the sca^BP2 eye phenotype. When sca^Scer\UAS.cEa is driven by Scer\GAL4^dpp.blk1 in a Gp150⁴/Gp150⁴ background, no wing margin loss is seen.

(Li et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Gp150⁴

gp1504

(Li et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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