FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RokUAS.cMa
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General Information
Symbol
Dmel\RokUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Mizuno
FlyBase ID
FBal0137096
Feature type
allele
Associated gene
Dmel\Rok
Associated Insertion(s)
Carried in Construct
P{UAS-Rok.M}
Key Links
Transgenic product class
cDNA
(Mizuno et al., 2002)
wild_type
(Mizuno et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Mizuno et al., 2002)
wild_type
(Mizuno et al., 2002)
Mutagen
in vitro construct
(Mizuno et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-Rok.M}
Cytology
Description

UASt regulatory sequences drive expression of a full length Rok cDNA.

(Mizuno et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rok
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of rokScer\UAS.cMa under the control of Scer\GAL4GMR.PU results in small, rough eyes.

      (Moon and Matsuzaki, 2013)

      Wing discs overexpressing rokScer\UAS.cMa under the control of Scer\GAL4Bx-MS1096 are multi-layered and show malformed disc shapes.

      In contrast to the columnar wild-type cells, wing disc cells in clones overexpressing rokScer\UAS.cMa driven by Scer\GAL4Act5C.PI shrink basally and show abnormal apical-basal polarity.

      In contrast to wild-type controls, cells overexpressing rokScer\UAS.cMa under the control of Scer\GAL4ptc-559.1 appear to migrate out from the Scer\GAL4ptc-559.1-expression domain.

      (Mitonaka et al., 2007)

      Expression of rokScer\UAS.cMa under the control of Scer\GAL4OK107 does not result in axon growth defects in the mushroom body.

      (Ng and Luo, 2004)

      Expression of rokScer\UAS.cMa under the control of Scer\GAL4arm.PS results in about 80% embryonic lethality. Embryos expressing rokScer\UAS.cMa under the control of Scer\GAL4unspecified usually have a dorsal open or dorsal hole phenotype and the pattern of dorsal hairs along the dorsal midline is disturbed. Embryos expressing rokScer\UAS.cMa under the control of Scer\GAL469B have polygonal shaped leading edge cells which show an abnormal accumulation of F-actin.

      (Mizuno et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      RokUAS.cMa, Scer\GAL4arm.PS has lethal | embryonic stage phenotype, suppressible by zip[+]/zipEbr

      (Mizuno et al., 2002)
      Enhancer of
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      RokUAS.cMa, Scer\GAL4GMR.PU has eye phenotype, suppressible by zip[+]/zip1

      (Moon and Matsuzaki, 2013)
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A zip1 heterozygous background suppresses the small, rough eye phenotype found upon expression of rokScer\UAS.cMa under the control of Scer\GAL4GMR.PU.

      (Moon and Matsuzaki, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      RokScer\UAS.cMa
      RokUAS.cMa
      rokScer\UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Mizuno
      (Mizuno et al., 2002)
      Secondary FlyBase IDs
        References (4)