FlyBase Allele Report: Dmel\Myc[P0]

dm^P0 males are characterised by a slightly delayed development, thin bristles, and a weak reduction in body size and viability (to 54%). dm^P0 males exhibit a weak eye phenotype with small, irregularly shaped, slightly rough eyes. dm^P0 males exhibit a significant reduction in ommatidial size. All dm^P0 male mutant eye disc clones are significantly smaller than control discs.

(Bellosta et al., 2005)

dm^P0 homozygous mutant first instar larvae are the same size as wild-type controls. dm^P0 homozygous mutant cells generated by Flp/FRT recombination in the wing disc exhibit a decrease in nucleolar size compared with surrounding heterozygote cells.

(Grewal et al., 2005)

When homozygous somatic clones are made in the wing disc, they exhibit signs of apoptosis and the clones themselves appear to be extruded basally on both sides of the lumen.

(Moreno and Basler, 2004)

Oogenesis in dm^P0 homozygous females is arrested between stages 10 and 11: cytoplasmic actin bundles failed to develop around stage 11 nurse cell nuclei, and nurse cell death fails to occur.

(Quinn et al., 2004)

More severe phenotype than dm¹. Thin and shortened bristles. Small body size. Size of wing cells, wing width and wing length are reduced. Developmental rate is reduced and flies occasionally have small, roughened eyes. Dissociated wing disc cells are reduced in size compared to wild type. Twin spot analysis of mutant clones shows that dm mutant cells grow very poorly, particularly in the posterior compartment of the wing disc.

(Johnston et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Myc^P0 has decreased size | adult stage phenotype, enhanceable by Scer\GAL4^αTub84B.PBb/Spt5^HMS00153

(Hofstetter et al., 2024)

Myc^P0 has visible | adult stage phenotype, enhanceable by Scer\GAL4^αTub84B.PBb/Spt5^HMS00153

(Hofstetter et al., 2024)

Myc^P0 has abnormal developmental rate phenotype, enhanceable by pont[+]/pont^5.1

(Bellosta et al., 2005)

Myc^P0 has partially lethal - majority die phenotype, enhanceable by pont[+]/pont^5.1

(Bellosta et al., 2005)

NOT Enhanced by

Statement

Reference

Myc^P0 has abnormal developmental rate phenotype, non-enhanceable by Spt5^SIE-27

(Hofstetter et al., 2024)

Suppressed by

Statement

Reference

Myc^P0 has decreased body size | third instar larval stage phenotype, suppressible by hay[+]/hay^nc2rv1

(Lee et al., 2015)

Myc^P0 has lethal | female limited phenotype, suppressible by sisA^unspecified

(Kappes et al., 2011)

Myc^P0 has lethal | female limited phenotype, suppressible by sc^sisB-1

(Kappes et al., 2011)

Myc^P0 has lethal | female limited phenotype, suppressible by run³

(Kappes et al., 2011)

Myc^P0 has decreased cell death | recessive phenotype, suppressible by pUf68[+]/hfp^EP3058

(Quinn et al., 2004)

Myc^P0 has female sterile | recessive phenotype, suppressible by pUf68[+]/hfp^EP3058

(Quinn et al., 2004)

NOT suppressed by

Statement

Reference

Myc^P0 has abnormal developmental rate phenotype, non-suppressible by Spt5^SIE-27

(Hofstetter et al., 2024)

Myc^P0 has abnormal size phenotype, non-suppressible by ago^unspecified

(Moberg et al., 2004)

Enhancer of

Statement

Reference

Myc^P0 is an enhancer of decreased body weight | adult stage | dominant phenotype of Spt5^SIE-27

(Hofstetter et al., 2024)

Myc^P0 is an enhancer of partially lethal phenotype of Kdm5^k06801/Kdm5¹⁰⁴²⁴

(Secombe et al., 2007)

Myc^P0/Myc[+] is an enhancer of abnormal size | adult stage phenotype of Hsap\CDKN1A^GMR.PH

(Quinn et al., 2004)

Suppressor of

Statement

Reference

Myc^P0/Myc[+] is a suppressor of increased body size | third instar larval stage phenotype of hfp^EP3058

(Lee et al., 2015)

Myc^P0 is a suppressor of increased body size | third instar larval stage phenotype of hay[+]/hay^nc2rv1, hfp^EP3058

(Lee et al., 2015)

Myc^P0 is a suppressor of viable phenotype of Sxl^fP7B0

(Kappes et al., 2011)

Myc^P0/Myc[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

Myc^P0/Myc[+] is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

Myc^P0/Myc[+] is a suppressor of lethal - all die before end of larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

Myc^P0/Myc[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

Other

Statement

Reference

Myc^P0, scny^C181S-2/scny^C181S-1 has increased mortality during development phenotype

(Coirry et al., 2025)

Max^RNAi.UAS, Myc^P0, Scer\GAL4^da.G32 has lethal phenotype

(Steiger et al., 2008)

Max¹, Myc^P0 has abnormal developmental rate phenotype

(Steiger et al., 2008)

Brf^c07161/Brf[+], Myc^P0 has visible | somatic clone phenotype

(Steiger et al., 2008)

Myc^P0, pont^5.1 has decreased cell number phenotype

(Bellosta et al., 2005)

Myc^P0, pont^5.1 has decreased cell size phenotype

(Bellosta et al., 2005)

Myc^P0, Scer\GAL4^Tub.PU, pont^UAS.Tag:MYC has decreased cell number phenotype

(Bellosta et al., 2005)

Myc^P0, Scer\GAL4^Tub.PU, pont^UAS.Tag:MYC has decreased cell size phenotype

(Bellosta et al., 2005)

Myc^P0, pont[+]/pont^5.1 has decreased cell number phenotype

(Bellosta et al., 2005)

Myc^P0, pont[+]/pont^5.1 has decreased cell size phenotype

(Bellosta et al., 2005)

Myc^P0, ft^k07918 has abnormal cell growth | somatic clone phenotype

(Garoia et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Myc^P0 has eye phenotype, enhanceable by Scer\GAL4^αTub84B.PBb/Spt5^HMS00153

(Hofstetter et al., 2024)

Myc^P0 has eye phenotype, enhanceable by pont[+]/pont^5.1

(Bellosta et al., 2005)

Myc^P0 has ommatidium phenotype, enhanceable by pont[+]/pont^5.1

(Bellosta et al., 2005)

Suppressed by

Statement

Reference

Myc^P0 has ommatidium phenotype, suppressible by pont^UAS.Tag:MYC/Scer\GAL4^Tub.PU

(Bellosta et al., 2005)

Myc^P0 has eye phenotype, suppressible by pont^UAS.Tag:MYC/Scer\GAL4^Tub.PU

(Bellosta et al., 2005)

Myc^P0 has nurse cell & actin filament phenotype, suppressible by pUf68[+]/hfp^EP3058

(Quinn et al., 2004)

Myc^P0 has nurse cell phenotype, suppressible by pUf68[+]/hfp^EP3058

(Quinn et al., 2004)

Myc^P0 has oocyte | oogenesis stage S11 phenotype, suppressible by pUf68[+]/hfp^EP3058

(Quinn et al., 2004)

Enhancer of

Statement

Reference

Myc^P0/Myc[+] is an enhancer of eye phenotype of Hsap\CDKN1A^GMR.PH

(Quinn et al., 2004)

Myc^P0/Myc[+] is an enhancer of ommatidium phenotype of Hsap\CDKN1A^GMR.PH

(Quinn et al., 2004)

Suppressor of

Statement

Reference

Myc^P0 is a suppressor of glial cell | increased number | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

Myc^P0 is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Read et al., 2009)

Myc^P0/Myc[+] is a suppressor of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

Other

Statement

Reference

Myc^P0, Spt5^SIE-27 has eye phenotype

(Hofstetter et al., 2024)

Hcf^RNAi.2.UAS, Myc^P0, Scer\GAL4^αTub84B.PBb has ommatidium | somatic clone phenotype

(Furrer et al., 2010)

Hcf^RNAi.3.UAS, Myc^P0, Scer\GAL4^αTub84B.PBb has ommatidium | somatic clone phenotype

(Furrer et al., 2010)

Brf^c07161/Brf[+], Myc^P0 has eye | somatic clone phenotype

(Steiger et al., 2008)

Myc^P0, Scer\GAL4^Tub.PU, rept^UAS.Tag:AU1 has eye phenotype

(Bellosta et al., 2005)

Myc^P0, Scer\GAL4^Tub.PU, rept^UAS.Tag:AU1 has ommatidium phenotype

(Bellosta et al., 2005)

Myc^P0, pont^5.1 has wing phenotype

(Bellosta et al., 2005)

Myc^P0, pont^5.1 has wing margin phenotype

(Bellosta et al., 2005)

Myc^P0, pont[+]/pont^5.1 has wing phenotype

(Bellosta et al., 2005)

Myc^P0, pont[+]/pont^5.1 has wing margin phenotype

(Bellosta et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The large body size characteristic for hfp^EP3058/hfp^EP3058 third instar larvae is rescued by combination with Myc^P0 in heterozygous state.

The small body size characteristic for Myc^P0/+ third instar larvae can be suppressed by combination with hay^nc2rv1 in heterozygous state.

The severe body overgrowth seen in hfp^EP3058/hfp^EP3058;hay^nc2rv1/+ third instar larvae can be rescued by combination with Myc^P0 in heterozygous state.

(Lee et al., 2015)

Approximately 88% of sisA^unspecified dm^P0 trans-heterozygous female offspring from dm^P0 fathers mated to sisA^unspecified mothers survive.

Approximately 90% of sc^sisB-1 dm^P0 trans-heterozygous female offspring from dm^P0 fathers mated to sc^sisB-1 mothers survive.

Approximately 79% of run³ dm^P0 trans-heterozygous female offspring from dm^P0 fathers mated to run³ mothers survive.

Females trans-heterozygous for Sxl^fP7B0 and dm^P0 are approximately two-thirds as viable as their dm^P0/+ siblings.

Sxl^M4, dm^P0/dm^P0 females are fully viable. While a Sxl^M4/+ background rescues the female-specific lethality of dm^P0, it does not rescue the dm^P0 bristle or female sterility phenotypes. No Sxl^M4, dm^P0/dm^P0 males are recovered from the cross.

(Kappes et al., 2011)

Clonal expression of either Hcf^{dsRNA.IR-2.Scer\UAS} or Hcf^{dsRNA.IR-3.Scer\UAS} under the control of Scer\GAL4^αTub84B.PBb in a dm^P0 background results in flies with smaller ommatidia than normal.

(Furrer et al., 2010)

One copy of dm^P0 suppresses the glial neoplasia seen in third instar larvae when btl::Egfr^{Scer\UAS.T:λ\cI-DD} and Pi3K92E^{Scer\UAS.T:Hsap\MYC,T:Hsap\CAAX} are co-expressed under the control of Scer\GAL4^repo.PU. The late larval lethality is also partially suppressed.

(Read et al., 2009)

The reduced size of the posterior compartment of the wing that is seen in animals expressing crol^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is suppressed if they are also heterozygous for dm^P0.

(Mitchell et al., 2008)

dm^P0/Y ; Max¹/+ flies take slightly longer for their development than controls.

dm^P0/Y ; flies expressing Max^{dsRNA.Scer\UAS.IR} under the control of Scer\GAL4^da.G32 show a strong reduction in viability compared to controls.

(Steiger et al., 2008)

Eyes consisting of dm^P0 homozygous clones (induced using the ey-FLP method) that are also heterozygous for Brf^c07161 show a significant reduction in eye size compared to controls and clear eye defects (rough eye) are seen in 17% of the animals.

(Steiger et al., 2008)

The dm^P0 ; lid^k06801/lid¹⁰⁴²⁴ combination results in almost complete lethality.

(Secombe et al., 2007)

dm^P0 males carrying one copy of pont^5.1 suffer a drop in viability from 54% to 12%, along with the surviving flies taking 2.4 days longer for their development and, despite the extended period, ultimately eclose with a significantly lower weight. dm^P0 males, heterozygous for pont^5.1 occasionally exhibit notches in the posterior wing margin. There is a significant decrease in the total wing area of dm^P0 males heterozygous for pont^5.1, compared to the control.A large part of this size difference can be attributed to a decrease in cell size. Approximately 90% of dm^P0 males, heterozygous for pont^5.1 have small, irregularly shaped, and slightly rough eyes. Penetrance and expressivity of the phenotype are variable, but the anterior and ventral portions of the eye are always most defective. The significant reduction of ommatidial size in dm^P0 males is exacerbated by heterozygosity of pont^5.1. In addition, these flies contain a reduced number of ommatidia. Comparison of control, dm^P0 males, and dm^P0 males in a pont^5.1 heterozygous background in third instar larval eye imaginal discs does not reveal any obvious defects in any of the three genotypes with respect to overall shape and the pattern of differentiating ommatidia, although eye discs of dm^P0 males in a pont^5.1 heterozygous background are significantly smaller than those of the controls or dm^P0 males. The ectopic expression of rept^{Scer\UAS.T:BPV-1\AU1}, under the regulation of Scer\GAL4^tub in dm^P0 somatic clones enhances the penetrance and expressivity of their eye defects. Even when over-expressed in an dm^P0 eye somatic clones or a wild-type background. The ectopic expression of pont^{Scer\UAS.T:Hsap\MYC}, under the regulation of Scer\GAL4^tub in dm^P0 clones suppresses the dm^P0 eye defects of ommatidia decreased size and number.

(Bellosta et al., 2005)

ft^k07918 clones are induced in a dm^P0 background at 72+-2h are severely reduced compared to those induced in wild-type.

(Garoia et al., 2005)

The female sterility and oogenesis phenotypes of dm^P0 flies are suppressed by pUf68^EP3058/+.

(Quinn et al., 2004)

Xenogenetic Interactions

Statement

Reference

The small, rough eye phenotype of Hsap\CDKN1A^GMR.PH flies is enhanced by dm^P0/+.

(Quinn et al., 2004)

Complementation and Rescue Data

Rescued by

Myc^P0 is rescued by Myc^UAS.cZa/Scer\GAL4^C-765

(Johnston et al., 1999)

Myc^P0 is rescued by Scer\GAL4^en-e16E/Myc^UAS.cZa

(Johnston et al., 1999)

Myc^P0 is rescued by Myc^UAS.cZa/Scer\GAL4^sca-109-68

(Johnston et al., 1999)

Myc^P0 is rescued by Myc^hs.PSA

(Johnston et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11298

P{P-Sal}Myc^P0/C(1)DX, y¹ f¹; bw¹; st¹

64755

P{ey-FLP.N}2, w^* P{P-Sal}Myc^P0 P{αTub84B(FRT.Myc)GAL4.Bb}1/FM7a; rept³⁵/MKRS

Notes on Origin

Discoverer

Comments

Alleles can be ranked in a phenotypic series. Going from weakest to strongest phenotype: dm¹ < dm^P0 < dm^P1.

(Johnston et al., 1999)

Maintained in compound-X stock; female viability and fertility not specified.

(Engels, 1990.8.1)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Myc^P0

(Hofstetter et al., 2024, Zielke et al., 2022)

dMyc^P0

(Coirry et al., 2025)

dm^P0

(Hofstetter et al., 2024, Lee et al., 2015, de la Cova et al., 2014, Kappes et al., 2011, Furrer et al., 2010, Read et al., 2009, Schwinkendorf and Gallant, 2009, Mitchell et al., 2008, Steiger et al., 2008, Steiger et al., 2008, Secombe et al., 2007)

dmyc^P0

(Galletti et al., 2009, Rhiner et al., 2009, Montero et al., 2008, Moreno and Basler, 2004, Johnston et al., 1999)

dmyc^p0

(Jaklevic et al., 2006)

myc^P0

(Wang et al., 2019, Gamberi et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (27)

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