FlyBase Allele Report: Dmel\lin[unspecified]

General Information

Symbol

Dmel\lin^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0086412

Feature type

allele

Associated gene

Dmel\lin

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

cercus

(Tearle and Nusslein-Volhard, 1987)

disc epithelium proper & dorsal mesothoracic disc | somatic clone

(Nusinow et al., 2008)

embryonic/larval spiracle primordium

(Tearle and Nusslein-Volhard, 1987)

embryonic abdominal segment 8

(Tearle and Nusslein-Volhard, 1987)

embryonic dorsal epidermis

(Hatini et al., 2005)

embryonic epidermis | dorsal

(Hatini et al., 2000)

embryonic foregut

(Johansen et al., 2003, Green et al., 2002)

embryonic head

(Tearle and Nusslein-Volhard, 1987)

embryonic hindgut

(Johansen et al., 2003, Green et al., 2002)

embryonic large intestine

(Green et al., 2002)

embryonic proventriculus

(Green et al., 2002)

embryonic segment | anterior

(Tearle and Nusslein-Volhard, 1987)

hindgut

(Inaki et al., 2024)

keyhole structure

(Johansen et al., 2003)

wing hinge primordium | somatic clone

(Nusinow et al., 2008)

Detailed Description

Statement

Reference

Homozygous clones generated at the early first larval instar in the peripodial epithelium of the wing disc survive.

Homozygous clones generated at the early first larval instar in the disc proper of the wing disc show reduced survival compared to wild-type twin spots. Those that do survive are much smaller than their respective wild-type twin spots.

Homozygous clones generated at the second larval instar in the disc proper of the wing disc survive poorly compared to their wild-type twin spots. The surviving clones extrude basally from the disc proper. Occasionally, clones that originate in the disc proper grow to a large size.

Homozygous clones generated at the mid- to late third larval instar in the disc proper and the posterior lateral margin of the hinge of the wing disc minimise contact with their wild-type neighbours are form round vesicles that extrude basally.

(Nusinow et al., 2008)

The 4^o fate of the dorsal epidermis is replaced with 1^o-3^o fates in mutant embryos.

(Hatini et al., 2005)

In lin^unspecified homozygous embryos, both the foregut and the hindgut are bloated, boundary cells are missing from the hindgut, and the keyhole region of the foregut is expanded.

(Johansen et al., 2003)

The hindgut is wider and shorter than normal in mutant embryos. The hindgut appears distended, the large intestine is missing and the boundary cell rows that normally run along the length of the large intestine are missing. The foregut is shorter and wider than normal and the proventriculus does not form.

(Green et al., 2002)

The cuticle phenotype of embryos lacking both maternal and zygotic lin activity is indistinguishable from that of zygotic lin mutants.

(Hatini et al., 2000)

A small anterior portion of each segment is deleted in lin^unspecified mutant embryos. Segment A8, spiracles and anal plates are absent. The head is abnormal.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

lin^unspecified has embryonic foregut phenotype, non-enhanceable by drm^unspecified

(Johansen et al., 2003)

lin^unspecified has keyhole structure phenotype, non-enhanceable by drm^unspecified

(Johansen et al., 2003)

bowl¹, lin^unspecified has embryonic foregut phenotype, non-enhanceable by Df(2L)drm-P2

(Johansen et al., 2003)

bowl¹, lin^unspecified has keyhole structure phenotype, non-enhanceable by Df(2L)drm-P2

(Johansen et al., 2003)

bowl¹, lin^unspecified has embryonic foregut phenotype, non-enhanceable by drm³

(Johansen et al., 2003)

bowl¹, lin^unspecified has keyhole structure phenotype, non-enhanceable by drm³

(Johansen et al., 2003)

NOT suppressed by

Statement

Reference

bowl¹, lin^unspecified has embryonic foregut phenotype, non-suppressible by Df(2L)drm-P2

(Johansen et al., 2003)

bowl¹, lin^unspecified has embryonic foregut phenotype, non-suppressible by drm³

(Johansen et al., 2003)

bowl¹, lin^unspecified has keyhole structure phenotype, non-suppressible by Df(2L)drm-P2

(Johansen et al., 2003)

bowl¹, lin^unspecified has keyhole structure phenotype, non-suppressible by drm³

(Johansen et al., 2003)

lin^unspecified has embryonic foregut phenotype, non-suppressible by drm^unspecified

(Johansen et al., 2003)

lin^unspecified has keyhole structure phenotype, non-suppressible by drm^unspecified

(Johansen et al., 2003)

lin^unspecified has phenotype, non-suppressible by wg^UAS.cLa/Scer\GAL4^arm.PS

(Hatini et al., 2000)

lin^unspecified has embryonic epidermis | dorsal phenotype, non-suppressible by wg^UAS.cLa/Scer\GAL4^arm.PS

(Hatini et al., 2000)

NOT Enhancer of

Statement

Reference

lin^unspecified is a non-enhancer of embryonic foregut phenotype of bowl¹

(Johansen et al., 2003)

lin^unspecified is a non-enhancer of keyhole structure phenotype of bowl¹

(Johansen et al., 2003)

NOT Suppressor of

Statement

Reference

lin^unspecified is a non-suppressor of keyhole structure phenotype of bowl¹

(Johansen et al., 2003)

lin^unspecified is a non-suppressor of embryonic foregut phenotype of bowl¹

(Johansen et al., 2003)

Other

Statement

Reference

bowl¹, lin^unspecified has keyhole structure phenotype

(Johansen et al., 2003)

bowl¹, lin^unspecified has embryonic foregut phenotype

(Johansen et al., 2003)

drm^unspecified, lin^unspecified has keyhole structure phenotype

(Johansen et al., 2003)

drm^unspecified, lin^unspecified has embryonic foregut phenotype

(Johansen et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The dorsal cuticle phenotype of lin^unspecified bowl^unspecified double mutant embryos is the same as that of bowl^unspecified single mutant embryos. The dorsal cuticle phenotype of drm^unspecified lin^unspecified double mutant embryos is the same as that of lin^unspecified single mutant embryos.

(Hatini et al., 2005)

lin^unspecified; drm^unspecified double homozygous embryos have a foregut phenotype identical to those of lin^unspecified homozygotes (bloated and with an expanded keyhole structure), rather than drm^unspecified homozygotes (narrow and lacking a keyhole structure). lin^unspecified; bowl¹ double homozygous embryos have a foregut phenotype identical to those of bowl¹ homozygotes (narrow and lacking a keyhole structure), rather than lin^unspecified homozygotes (bloated and with an expanded keyhole structure).

(Johansen et al., 2003)

lin^unspecified drm^unspecified double mutant embryos have the same mutant hindgut and foregut phenotypes as lin^unspecified single mutant embryos.

(Green et al., 2002)

The dorsal patterning defects in lin^unspecified embryos are not rescued by the expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^arm.PS.

(Hatini et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

lin^unspecified is rescued by lin^+t24

(Hatini et al., 2000)

lin^unspecified is rescued by lin^+t24.KpnICu

(Hatini et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lin^unspecified

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close